pyrazoles-derivatives

An article Pd(ii)-Catalyzed alkyne annulation through allylic isomerization: synthesis of spiro-cyclopentadiene pyrazolones WOS:000653779300001 published article about PHOTOPHYSICAL PROPERTIES; ACTIVATION; FUNCTIONALIZATION; MECHANISM in [Changmai, Sumi; Sultana, Sabera; Gogoi, Sanjib] North East Inst Sci & Technol, CSIR, Chem Sci & Technol Div, Appl Organ Chem, Jorhat 785006, Assam, India; [Changmai, Sumi; Sultana, Sabera; Gogoi, Sanjib] AcSIR, Ghaziabad 201002, India; [Sarma, Bipul] Tezpur Univ, Dept Chem Sci, Tezpur 784028, Assam, India in 2021, Cited 30. Recommanded Product: 86-92-0. The Name is 3-Methyl-1-p-tolyl-5-pyrazolone. Through research, I have a further understanding and discovery of 86-92-0

The Pd(ii)-catalyzed activation of Csp(2)-H bond and double alkyne annulation which proceeds via allylic isomerization is reported for the first time. This reaction of antipyrines with alkynes provides an efficient synthetic route for the biologically important spiro-cyclopentadiene pyrazolones. In the presence of Lawesson’s reagent, this Pd(ii)-catalyzed annulation reaction affords another spiro-cyclopentadiene pyrazolone which displays very good fluorescence properties.

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Reference:
Article; Zhang, Yong; Nie, Long-Jun; Luo, Liang; Mao, Jia-Xin; Liu, Jin-Xiang; Xu, Guo-Hai; Chen, Deliang; Luo, Hai-Qing; Tetrahedron; vol. 76; 7; (2020);,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Product Details of 67-51-6. Authors Horiuchi, S; Tanaka, S; Moon, S; Sakuda, E; Ito, A; Arikawa, Y; Umakoshi, K in AMER CHEMICAL SOC published article about in [Horiuchi, Shinnosuke; Tanaka, Seiya; Moon, Sangjoon; Sakuda, Eri; Arikawa, Yasuhiro; Umakoshi, Keisuke] Nagasaki Univ, Grad Sch Engn, Div Chem & Mat Sci, Nagasaki 8528521, Japan; [Ito, Akitaka] Kochi Univ Technol, Grad Sch Engn, Kami, Kochi 7821502, Japan in 2021.0, Cited 52.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6

The synthesis and photophysical properties of the heteropolynuclear Pt-Ag complex having cyclometalated rollover bipyridine ligands (bpy*) and bridging pyrazolato ligands are reported. The Pt2Ag2 complex was synthesized by two step reactions from a Pt(II) complex precursor having the rollover bpy* ligand, [Pt(bpy*)(dmso)Cl], with 3,5-dimethylpyrazole (Me(2)pzH) and a subsequent replacement of NH protons in the Me(2)pzH moieties with the Ag(I) ion. The Pt2Ag2 complex exists as a mixture of U- and Z-shaped isomers in solution, whose structures were clearly determined by single-crystal X-ray structural analyses. NMR studies using the single crystals revealed rapid isomerization of the Pt2Ag2 complexes in solution, although the Pt2Ag2 structures were supported effectively by the multiple metal-metal interactions. Furthermore, the Pt2Ag2 framework can capture a Ag(I) ion during the U-Z isomerization to afford a Pt2Ag3 core with the formation of Pt. Ag dative bonds. The Pt2Ag3 complex showed further aggregation to form a dimer structure in the presence of coordinating solvent via the crystallization process. The formation of Pt. Ag dative bonds significantly changes the emission energy from the Pt2Ag2 complex, while the emission spectra of U- and Z-isomers of Pt2Ag2 complex almost coincide with each other and their emissive properties are very similar. The density functional theory (DFT) and time-dependent DFT (TD-DFT) calculations revealed the effects of additional Ag(I) ion on the photophysical properties of the heteropolynuclear Pt-Ag complexes bearing the rollover bpy* ligands.

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Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

I found the field of Materials Science very interesting. Saw the article Tumor microenvironment and NIR laser dual-responsive release of berberine 9-O-pyrazole alkyl derivative loaded in graphene oxide nanosheets for chemo-photothermal synergetic cancer therapy published in 2020.0. Application In Synthesis of 3,5-Dimethyl-1H-pyrazole, Reprint Addresses Liu, YF (corresponding author), Cent South Univ, Coll Chem & Chem Engn, Dept Pharmaceut Engn, Changsha 410083, Hunan, Peoples R China.; Liu, ZB (corresponding author), Cent South Univ, Xiangya Sch Pharmaceut Sci, 172 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China.; Liu, ZB (corresponding author), Cent South Univ, Mol Imaging Res Ctr, Changsha 410008, Hunan, Peoples R China.. The CAS is 67-51-6. Through research, I have a further understanding and discovery of 3,5-Dimethyl-1H-pyrazole

A berberine 9-O-pyrazole alkyl derivative, a chemical compound (called B3) previously synthesized by our group, shows anti-cancer activity. However, B3 lacks targeting cytotoxicity to cancer cells, leading to obvious toxic side effects on normal cells. To solve this problem, here, we prepared a drug delivery system, namely, AS1411-GO/B3 for tumor targeting, in which nano-graphene oxide (GO) sheets were employed as the drug carrier, and the aptamer AS1411 was conjugated onto GO for tumor targeting. GO also had a photothermal effect, which helped the release of B3 from GO as well as the thermal cytotoxicity to cells. We found that the release of B3 could respond to acid conditions, indicating that the tumor intracellular environment could promote the release of B3, thus allowing it to perform chemotherapy effects. This system could also release B3 in response to photothermal heating, moreover, combined photothermal therapy and chemotherapy to improve the anticancer activity was achieved. This AS1411-GO/B3 platform with chemo-photothermal synergetic therapy provides a very promising treatment for tumors.

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Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

An article Effective and Reversible Carbon Dioxide Insertion into Cerium Pyrazolates WOS:000510194800001 published article about METAL-ORGANIC FRAMEWORK; CYCLOHEXENE OXIDE; ALTERNATING COPOLYMERIZATION; REDUCTIVE DISPROPORTIONATION; STRUCTURAL-CHARACTERIZATION; BETA-DIKETIMINATO; CYCLIC CARBONATES; CO2 INSERTION; COMPLEXES; CAPTURE in [Bayer, Uwe; Werner, Daniel; Maichle-Moessmer, Caecilia; Anwander, Reiner] Eberhard Karls Univ Tubingen, Inst Anorgan Chem, Morgenstelle 18, D-72076 Tubingen, Germany in 2020.0, Cited 90.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6. Category: pyrazoles-derivatives

The homoleptic pyrazolate complexes [Ce-4(III)(Me(2)pz)(12)] and [Ce-IV(Me(2)pz)(4)](2) quantitatively insert CO2 to give [Ce-4(III)(Me(2)pzCO(2))(12)] and [Ce-IV(Me(2)pzCO(2))(4)], respectively (Me(2)pz=3,5-dimethylpyrazolato). This process is reversible for both complexes, as observed by in situ IR and NMR spectroscopy in solution and by TGA in the solid state. By adjusting the molar ratio, one molecule of CO2 per [Ce-IV(Me(2)pz)(4)] complex could be inserted to give trimetallic [Ce-3(Me(2)pz)(9)(Me(2)pzCO(2))(3)(thf)]. Both the cerous and ceric insertion products catalyze the formation of cyclic carbonates from epoxides and CO2 under mild conditions. In the absence of epoxide, the ceric catalyst is prone to reduction by the co-catalyst tetra-n-butylammonium bromide (TBAB).

Welcome to talk about 67-51-6, If you have any questions, you can contact Bayer, U; Werner, D; Maichle-Mossmer, C; Anwander, R or send Email.. Category: pyrazoles-derivatives

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Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Name: 3,5-Dimethyl-1H-pyrazole. In 2020.0 MOL CATAL published article about HIGHLY EFFICIENT SYNTHESIS; X-RAY STRUCTURE; BENZOFURAN DERIVATIVES; ARYLBORONIC ACIDS; ROOM-TEMPERATURE; WATER OXIDATION; PHENOLS; LIGAND; COMPLEXES; ETHYLENE in [Marais, Lindie; Vosloo, Hermanus C. M.; Swarts, Andrew J.] North West Univ, Focus Area Chem Resource Beneficiat, Catalysis & Synth Res Grp, 11 Hoffman St, ZA-2520 Potchefstroom, South Africa in 2020.0, Cited 49.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6.

A catalyst system comprising of pyrazolylpyridineamine/Cu(I)/CsOH is reported. for the hydroxylation of aryl iodides and bromides with moderate to outstanding yields, without the use of an inert atmosphere. A comprehensive parameter optimisation study established optimum component concentrations: [Cu(MeCN)(4)]BF4 and 2-(1H-pyrazol-1-yl)-N-(pyridine-2-ylmethyl)ethan-1-amine (L01) (2 mol %), substrate (1 mmol), CsOH (4 mmol) and DMSO:H2O (1:1, 3 mL). Monitoring substrate conversion as a function of time revealed an induction period of 90 min, which could be eliminated through the initial in situ formation of the proposed [(L01)Cu-OH] intermediate. Eliminating the induction period resulted in complete conversion within one hour, with turnover numbers exceeding that of the benchmark catalyst system operating at an optimal catalyst loading of 0.05 mol %.

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Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Application In Synthesis of 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid. Authors Zhou, L; Yan, JX; Huang, JL; Wang, HB; Wang, XG; Wang, ZJ in ELSEVIER SCI LTD published article about in [Zhou, Liang; Yan, Junxiao; Huang, Julong; Wang, Hongbo; Wang, Xingang; Wang, Zhenjun] Changan Univ, Sch Mat Sci & Engn, Xian 710064, Peoples R China; [Zhou, Liang; Wang, Hongbo; Wang, Xingang; Wang, Zhenjun] Changan Univ, Minist Educ, Engn Res Ctr Transportat Mat, Xian 710061, Peoples R China in 2021, Cited 46. The Name is 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid. Through research, I have a further understanding and discovery of 83-10-3

Here in, the effects of FeSiAl particle size on the dielectric and microwave absorption properties of FeSiAl/Al2O3 composites were studied. FeSiAl/Al2O3 composites containing 18-25 mu m, 25-48 mu m, and 48-75 mu m FeSiAl particles were prepared by hot-pressed sintering based on uniformly mixed FeSiAl and Al2O3 powders. Results show that the real permittivity and the imaginary permittivity are significantly promoted with increasing FeSiAl particle size, which is ascribed to the enhanced interfacial polarization and conductance loss. In addition, the favorable matching impedance and suitable attenuation coefficient enabled the composite containing 25-48 mu m FeSiAl powder to show a minimum reflection loss of -34.4 dB at 11.7 GHz and an effective absorption bandwidth (<-10 dB) of 1.4 GHz in 11.0-12.4 GHz, when the thickness is 1.1 mm. By adjusting the thickness to 1.4 mm, the effective absorption bandwidth of the composite reaches a maximum value of 2.0 GHz in the 8.3-10.3 GHz range, indicating tunable, strong, and highly efficient microwave absorption performance. Welcome to talk about 83-10-3, If you have any questions, you can contact Zhou, L; Yan, JX; Huang, JL; Wang, HB; Wang, XG; Wang, ZJ or send Email.. Application In Synthesis of 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid

Reference:
Patent; Shanghai Pharmaceutical Industry Institute; China Pharmaceutical Industry Zongyuan; Li Jianqi; Huang Daowei; Wang Wenya; Zhang Zhiguo; Jiang Ling; (45 pag.)CN107286140; (2017); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

HPLC of Formula: C11H12N2O. I found the field of Chemistry very interesting. Saw the article Synthesis of pyrazolones and pyrazoles via Pd-catalyzed aerobic oxidative dehydrogenation published in 2019, Reprint Addresses Xuan, LJ (corresponding author), Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China.. The CAS is 86-92-0. Through research, I have a further understanding and discovery of 3-Methyl-1-p-tolyl-5-pyrazolone.

A palladium-catalyzed oxidative dehydrogenation reaction in the presence of AMS and base to synthesize pyrazolones and pyrazoles was identified. This method can be utilized to a wide range of substrates, operates under mild react conditions and can give high yields. We believe it could be used as an alternative protocol for the classical dehydrogenation reactions. (C) 2019 Published by Elsevier Ltd.

Welcome to talk about 86-92-0, If you have any questions, you can contact Zhu, YF; Wei, BL; Wei, JJ; Wang, WQ; Song, WB; Xuan, LJ or send Email.. HPLC of Formula: C11H12N2O

Reference:
Article; Zhang, Yong; Nie, Long-Jun; Luo, Liang; Mao, Jia-Xin; Liu, Jin-Xiang; Xu, Guo-Hai; Chen, Deliang; Luo, Hai-Qing; Tetrahedron; vol. 76; 7; (2020);,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article Molecular squares, coordination polymers and mononuclear complexes supported by 2,4-dipyrazolyl-6H-1,3,5-triazine and 4,6-dipyrazolylpyrimidine ligands published in 2019.0. Application In Synthesis of 3,5-Dimethyl-1H-pyrazole, Reprint Addresses Halcrow, MA (corresponding author), Univ Leeds, Sch Chem, Woodhouse Lane, Leeds LS2 9JT, W Yorkshire, England.. The CAS is 67-51-6. Through research, I have a further understanding and discovery of 3,5-Dimethyl-1H-pyrazole

The Fe[BF4](2) complex of 2,4-di(pyrazol-1-yl)-6H-1,3,5-triazine (L-1) is a high-spin molecular square, [{Fe(L-1)}(4)(mu-L-1)(4)][BF4](8), whose crystals also contain the unusual HPzBF(3) (HPz = pyrazole) adduct. Three other 2,4-di(pyrazol-1-yl)-6H-1,3,5-triazine derivatives with different pyrazole substituents (L-2-L-4) are unstable in the presence of first row transition ions, but form mononuclear, polymeric or molecular square complexes with silver(i). Most of these compounds involve bis-bidentate di(pyrazolyl)triazine coordination, which is unusual for that class of ligand, and the molecular squares encapsulate one or two BF4-, ClO4- or SbF6- ions through combinations of anion pi, AgX and/or C-HX (X = O or F) interactions. Treatment of Fe[NCS](2) or Fe[NCSe](2) with 4,6-di(pyrazol-1-yl)-2H-pyrimidine (L-5) or its 2-methyl and 2-amino derivatives (L-6 and L-7) yields mononuclear [Fe(NCE)(2)L-2] and/or the 1D coordination polymers catena-[Fe(NCE)(2)(mu-L)] (E = S or Se, L = L-5-L-7). Alcohol solvates of isomorphous [Fe(NCS)(2)L-2] and [Fe(NCSe)(2)L-2] compounds show different patterns of intermolecular hydrogen bonding, reflecting the acceptor properties of the anion ligands. These iron compounds are all high-spin, although annealing solvated crystals of [Fe(NCSe)(2)(L-5)(2)] affords a new phase exhibiting an abrupt, low-temperature spin transition. Catena-[Fe(H2O)(2)(mu-L-5)][ClO4](2) is a coordination polymer of alternating cis and trans iron centres.

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Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Authors Vafaee, A; Davoodnia, A; Nakhaei, A; Yadegarian, S; Nejatianfar, M in MAIK NAUKA/INTERPERIODICA/SPRINGER published article about in [Vafaee, A.; Davoodnia, A.] Islamic Azad Univ, Dept Chem, Mashhad Branch, Mashhad 9175687119, Razavi Khorasan, Iran; [Davoodnia, A.; Nakhaei, A.] Islamic Azad Univ, Young Researchers & Elite Club, Mashhad Branch, Mashhad 9175687119, Razavi Khorasan, Iran; [Nejatianfar, M.] Ferdowsi Univ Mashhad, Dept Chem, Fac Sci, Mashhad 9177948974, Razavi Khorasan, Iran in 2021.0, Cited 33.0. Recommanded Product: 67-51-6. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6

Two novel room-temperature disulfonic acid functionalized ionic liquids derived from 3,5-dimethyl-1H-pyrazole consisting of chloride and trichlorostannate anions, 3,5-dimethyl-1,2-disulfonic acid-1H-pyrazolium chloride and 3,5-dimethyl-1,2-disulfonic acid-1H-pyrazolium trichlorostannate, have been synthesized, characterized and evaluated for their catalytic efficiency in the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones by the one-pot, three-components reaction of phthalhydrazide, an aromatic aldehyde and malononitrile or ethyl cyanoacetate under solvent-free conditions. The results have demonstrated high catalytic activity of these novel ionic liquids containing acidic SO3H groups in producing high yields of the desired products in short reaction time. The ionic liquids can be used at least four times without any noticeable decrease in catalytic activity.

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Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Gokalp, M; Dede, B; Tilki, T; Atay, CK in [Gokalp, Merve; Dede, Bulent; Tilki, Tahir] Suleyman Demirel Univ, Fac Sci & Arts, Dept Chem, TR-32260 Isparta, Turkey; [Atay, Cigdem Karabacak] Mehmet Akif Ersoy Univ, Fac Educ, Dept Basic Educ, TR-15030 Burdur, Turkey published Triazole based azo molecules as potential antibacterial agents: Synthesis, characterization, DFT, ADME and molecular docking studies in 2020.0, Cited 40.0. Name: 3,5-Dimethyl-1H-pyrazole. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6.

In this study, three triazole based azo molecules [3-amino-4-[1H-1,2,4-triazole-3-yldiazenyl]-1H-pyrazole-5-ol (1), 3-[(3,5-dimethyl-1H-pyrazole-4-yl)diazenyl]-1H-1,2,4-triazole (2) and 4-[1H-1,2,4triazole-3yldiazenyl]benzene-1,3-diol (3)] were, synthesized and characterized by using 1H NMR, FTIR, UV-vis and mass spectra. The molecular structure, vibrational spectroscopic data, electronic transition absorption wavelengths, HOMOs and LUMOs analyses, molecular electrostatic potential (MEP) and potential energy surface (PES) diagrams were calculated by using DFT/B3LYP method with 6-311G(d,p) basis set. NMR chemical shift calculations were performed by using the gauge-invariant atomic orbital (GIAO) method. The spectroscopic results obtained from quantum chemical calculations of the 1, 2 and 3 molecules were in good agreement with the experimental data. Antibacterial activities of the 1, 2 and 3 were investigated against four different bacterial cultures. Although 1 molecule did not show very good antibacterial activity, 2 and 3 showed good activity against Staphylococcus aureus at a MIC of 250 and 62.5 mg/mL, respectively. Druglikeness and some of the pharmacokinetic properties of the 1, 2 and 3 were also examined. In addition, molecular docking studies were performed to investigate the antibacterial properties of synthesized compounds by in silico method. For this purpose, beta-ketoacyl-acyl carrier protein (ACP) synthase III (KAS III) and lipoteichoic acid synthase (LtaS) inhibitory properties of 1, 2 and 3 molecules were investigated. Although all of the synthesized compounds showed antibacterial properties according to the results of the molecular docking studies, the best results were obtained by the compound 3 which interacts with both KAS III and LtaS with binding energy of -7.17 and -7.53 kcal/mol, respectively. (C) 2020 Elsevier B.V. All rights reserved.

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Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics