pyrazoles-derivatives

An article Regorafenib for Metastatic Colorectal Cancer: An Analysis of a Registry-Based Cohort of 555 Patients WOS:000548281000003 published article about CLINICAL-PRACTICE; SURVIVAL; MULTICENTER; ANTITUMOR; SAFETY; SITE; SEX in [Novakova-Jiresova, Alena; Boublikova, Ludmila; Buchler, Tomas] Charles Univ Prague, Fac Med 1, Dept Oncol, Videnska 800, Prague 14059, Czech Republic; [Novakova-Jiresova, Alena; Boublikova, Ludmila; Buchler, Tomas] Charles Univ Prague, Thomayer Hosp, Videnska 800, Prague 14059, Czech Republic; [Kopeckova, Katerina; Batko, Stanislav; Linke, Zdenek; Prausov, Jana] Charles Univ Prague, Univ Hosp Motol, Dept Oncol, Prague, Czech Republic; [Chloupkov, Renata] Masaryk Univ, Fac Med, Inst Biostat & Anal, Brno, Czech Republic; [Melichar, Bohuslav] Palacky Univ Med, Dept Oncol, Olomouc, Czech Republic; [Melichar, Bohuslav] Teaching Hosp, Olomouc, Czech Republic; [Petruzelka, Lubos] Charles Univ Prague, Gen Fac Hosp, Dept Oncol, Prague, Czech Republic; [Finek, Jindrich; Fiala, Ondrej] Charles Univ Prague, Med Sch, Dept Oncol & Radiotherapy, Plzen, Czech Republic; [Finek, Jindrich; Fiala, Ondrej] Charles Univ Prague, Univ Hosp Pilsen, Plzen, Czech Republic; [Fiala, Ondrej] Charles Univ Prague, Fac Med Pilsen, Biomed Ctr, Plzen, Czech Republic; [Grell, Peter; Kiss, Igor] Masaryk Mem Canc Inst, Dept Comprehens Canc Care, Brno, Czech Republic in 2020, Cited 30. Name: 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid. The Name is 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid. Through research, I have a further understanding and discovery of 83-10-3

Purpose: Regorafenib is an oral multikinase inhibitor approved for the therapy of previously treated metastatic colorectal carcinoma (mCRC). The aim of the present study was to analyze the outcomes of treatment with regorafenib in real-world clinical practice based on data from a national registry. Methods: The CORECT registry, the Czech non-interventional database of patients with mCRC treated with targeted agents, searched for patients with metastatic CRC treated with regorafenib. In total, 555 evaluable patients were identified. Results: The median age at diagnosis was 61.7 years. All patients had disease progression on or after previous systemic treatment. Most patients were treated with an initial dose of 160 mg daily (n = 463; 83.6%). The median duration of treatment was 2.7 months (range 0.023.4 months). By the data cut-off date, 472 patients (85%) had completed treatment with regorafenib and were evaluable for treatment response evaluation. Partial response was reported in 13 patients (2.8%) and disease stabilization in 130 patients (27.5%). Median progression-free survival (PFS) and overall survival (OS) were 3.5 months (95% confidence interval [CI] 3.2-3.7 months) and 9.3 months (95% CI 8.3-10.3 months), respectively. The 6-month OS rate was 67.7% (95% CI 63.4-72.1%). Multivariable analysis showed that female gender, longer interval from diagnosis of metastatic disease, MO stage at diagnosis, and Eastern Cooperative Oncology Group performance status (ECOG PS) 0 were associated with longer PFS, while higher body-mass index (BMI), longer interval from diagnosis of metastatic disease, and ECOG PS of 0 were associated with longer OS. Conclusion: OS of patients treated with regorafenib in the real-world clinical practice in this cohort exceeded that reported in randomized trials. Regorafenib is a safe and active treatment option for a subgroup of patients with mCRC who are progressing after other systemic therapies and maintain good performance status.

Welcome to talk about 83-10-3, If you have any questions, you can contact Novakova-Jiresova, A; Kopeckova, K; Boublikova, L; Chloupkov, R; Melichar, B; Petruzelka, L; Finek, J; Fiala, O; Grell, P; Batko, S; Linke, Z; Kiss, I; Prausov, J; Buchler, T or send Email.. Name: 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid

Reference:
Patent; Shanghai Pharmaceutical Industry Institute; China Pharmaceutical Industry Zongyuan; Li Jianqi; Huang Daowei; Wang Wenya; Zhang Zhiguo; Jiang Ling; (45 pag.)CN107286140; (2017); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application In Synthesis of 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid. Authors Fan, LL; Zhang, YY; Tarin, MWK; He, TY; Rong, JD; Zheng, YS in TAYLOR & FRANCIS LTD published article about in [Fan, Lili; Zhang, Yangyang; Rong, Jundong; Zheng, Yushan] Fujian Agr & Forestry Univ, Coll Forestry, Fuzhou, Peoples R China; [Tarin, Muhammad Waqqas Khan; He, Tianyou; Zheng, Yushan] Fujian Agr & Forestry Univ, Coll Landscape, Fuzhou, Peoples R China in 2020, Cited 7. The Name is 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid. Through research, I have a further understanding and discovery of 83-10-3

Ampelocalamus scandens is native to Guizhou Province, China, and grows at an altitude of 260-320 m. It can be used as a raw material for weaving and papermaking. In the current study, the complete chloroplast (cp) genome of A. scandens was sequenced and is reported for the first time. The complete cp sequence was 139,504 bp, include large single-copy (LSC), small single-copy (SSC), and a pair of invert repeats (IR) region of 83,103 bp, 12,813 bp, and 21,793 bp, respectively. Besides, the plastid genome comprised a total of 132 genes, including protein-coding, tRNA, and rRNA genes as 85, 39, and 8 genes, respectively. Phylogenetic analysis based on 28 cp genomes reveals that A. scandens is closely associated with Ampelocalamus melicoideus in Arundinarodae.

Welcome to talk about 83-10-3, If you have any questions, you can contact Fan, LL; Zhang, YY; Tarin, MWK; He, TY; Rong, JD; Zheng, YS or send Email.. Application In Synthesis of 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid

Reference:
Patent; Shanghai Pharmaceutical Industry Institute; China Pharmaceutical Industry Zongyuan; Li Jianqi; Huang Daowei; Wang Wenya; Zhang Zhiguo; Jiang Ling; (45 pag.)CN107286140; (2017); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Robinson, H; Stillibrand, J; Simelis, K; Macdonald, SJF; Nortcliffe, A in [Robinson, Henry; Stillibrand, Joe; Simelis, Klemensas; Nortcliffe, Andrew] Univ Nottingham, Sch Chem, GlaxoSmithKline Carbon Neutral Labs Sustainable C, Triumph Rd, Nottingham NG7 2TU, England; [Macdonald, Simon J. F.] GlaxoSmithKline, Med Res Ctr, Gunnels Wood Rd, Stevenage SG1 2NY, Herts, England published Iridium-catalysed C-H borylation of beta-aryl-aminopropionic acids in 2020.0, Cited 29.0. Category: pyrazoles-derivatives. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6.

Iridium-catalysed catalytic, regioselective C-H borylation of beta-aryl-aminopropionic acid derivatives gives access to 3,5-functionalised protected beta-aryl-aminopropionic acid boronates. The synthetic versatility of these new boronates is demonstrated through sequential one-pot functionalisation reactions to give diverse building blocks for medicinal chemistry. The C-H borylation is also effective for dipeptide substrates. We have exemplified this methodology in the synthesis of a pan alpha(v)integrin antagonist.

Category: pyrazoles-derivatives. Bye, fridends, I hope you can learn more about C5H8N2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Formula: C12H12N2O3. Authors Rodrigues, T; Helene, O in AMER PHYSICAL SOC published article about in [Rodrigues, Tulio; Helene, Otaviano] Univ Sao Paulo, Phys Inst, Expt Phys Dept, POB 66318, BR-05315970 Sao Paulo, Brazil in 2020, Cited 43. The Name is 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid. Through research, I have a further understanding and discovery of 83-10-3

This study provides a phenomenological method to describe the exponential growth, saturation, and decay of coronavirus disease 2019 (COVID-19) deaths and infections via a Monte Carlo approach. The calculations connect Gompertz-type trial distributions of infected people per day with the distribution of deaths adopting two gamma distributions to account for the elapsed time that encompass the incubation and symptom onset to death periods. The analyses include death data from the USA, Brazil, Mexico, the United Kingdom (UK), India, and Russia, which comprise the four countries with the highest number of deaths and the four countries with the highest number of confirmed cases, as of August 07, 2020, according to theWorld Health Organization webpage. The Gompertz functions were fitted to the data of weekly averaged confirmed deaths per day by mapping the chi(2) values. The uncertainties, variances, and covariances of the model parameters were calculated by propagation, taking into account the standard errors of the data for each epidemiological week. The fitted functions for the average deaths per day for the USA and India have an upward trend, with the former having a higher growth rate and quite huge uncertainties. For Mexico, the UK, and Russia, the fits are consistent with a downward-sloping pattern. For Brazil we found a subtle trend down but with significant uncertainties. The USA, UK, and India data showed first peaks with higher growth rates compared with the second ones (4.2, 2.2, and 3.5 times higher, respectively), demonstrating the benefits of nonpharmacological interventions of sanitary measures and social distance flattening the secondary peaks of the pandemic. For the case of the USA, however, a third peak seems quite plausible, most likely related with the recent relaxation policies. Brazil’s data are satisfactorily described by two highly overlapped Gompertz functions with similar growth rates, suggesting a two-step process for the pandemic spreading. For the cases of Mexico and Russia single peaks with smoother slopes fitted the data satisfactorily. The 95% confidence intervals for the total number of deaths (x10(3)) predicted by the model for August 31, 2020, are 160 to 220, 110 to 130, 59 to 62, 41.3 to 41.4, 54 to 63, and 16.0 to 16.7 for the USA, Brazil, Mexico, the UK, India, and Russia, respectively. Our estimates for the point prevalences of infections are compared with some preliminary data from serological studies and/or model calculations focused on the USA, Brazil, and UK scenarios. The point prevalences and 95% confidence intervals for August 1, 2020, were estimated to be 5.7 (3.9-7.5)%, 8.9 (7.4-10.3)%, 9.3 (8.3-10.3)%, 5.7 (4.5-6.9)%, 0.9 (0.8-1.0%), and 1.2 (1.0-1.3)% for the USA, Brazil, Mexico, the UK, India, and Russia, respectively. The method represents an effective few-parameter framework to estimate the line shape of the infection curves and the uncertainties of the relevant parameters based on the actual death data of a pandemic.

Welcome to talk about 83-10-3, If you have any questions, you can contact Rodrigues, T; Helene, O or send Email.. Formula: C12H12N2O3

Reference:
Patent; Shanghai Pharmaceutical Industry Institute; China Pharmaceutical Industry Zongyuan; Li Jianqi; Huang Daowei; Wang Wenya; Zhang Zhiguo; Jiang Ling; (45 pag.)CN107286140; (2017); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Name: 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid. Authors Milne, IA; Graham, JMR in CAMBRIDGE UNIV PRESS published article about in [Milne, I. A.] Univ Western Australia, Oceans Grad Sch, Crawley 6009, Australia; [Graham, J. M. R.] Imperial Coll London, Dept Aeronaut, London SW7 2AZ, England in 2019, Cited 13. The Name is 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid. Through research, I have a further understanding and discovery of 83-10-3

The changes in spectra and intensities of the streamwise component of turbulent velocity are calculated in the inflow of a turbine rotor. The flow is initially calculated in the limit when the turbulence is of small scale compared with the rotor diameter. Rapid distortion theory (RDT), Batchelor & Proudman (Q. J. Mech. Appl. Maths, vol. 7 (1), 1954, pp. 83-103) (BP), for small-scale turbulence is combined with the effect of the fluctuating potential flow field on the turbulence caused by the direct interaction of the incident turbulence with the rotor as a sheet of resistance. A second computation is then carried out for turbulence of larger length scale. The results of the calculations are compared with velocity measurements in the inflow of both a commercial wind turbine and a tidal turbine rotor.

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Reference:
Patent; Shanghai Pharmaceutical Industry Institute; China Pharmaceutical Industry Zongyuan; Li Jianqi; Huang Daowei; Wang Wenya; Zhang Zhiguo; Jiang Ling; (45 pag.)CN107286140; (2017); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

An article Enantio- and Site-Selective alpha-Fluorination of N-Acyl 3,5-Dimethylpyrazoles Catalyzed by Chiral pi-Cu-II Complexes WOS:000557994700001 published article about DIELS-ALDER; ENANTIOSELECTIVE FLUORINATION; CRYSTAL-STRUCTURE; CATION; PROPIOLOYLPYRAZOLES; CYCLOADDITION; ACYLPYRAZOLES; DESIGN; ROUTE; SET in [Ishihara, Kazuaki; Nishimura, Kazuki; Yamakawa, Katsuya] Nagoya Univ, Grad Sch Engn, Chikusa Ku, B2-3 611,Furo Cho, Nagoya, Aichi 4648603, Japan in 2020.0, Cited 49.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6. Quality Control of 3,5-Dimethyl-1H-pyrazole

Catalytic enantioselective alpha-fluorination reactions of carbonyl compounds are among the most powerful and efficient synthetic methods for constructing optically active alpha-fluorinated carbonyl compounds. Nevertheless, alpha-fluorination of alpha-nonbranched carboxylic acid derivatives is still a big challenge because of relatively high pK(a)values of their alpha-hydrogen atoms and difficulty of subsequent synthetic transformation without epimerization. Herein we show that chiral copper(II) complexes of 3-(2-naphthyl)-l-alanine-derived amides are highly effective catalysts for the enantio- and site-selective alpha-fluorination ofN-(alpha-arylacetyl) andN-(alpha-alkylacetyl) 3,5-dimethylpyrazoles. The substrate scope of the transformation is very broad (25 examples including a quaternary alpha-fluorinated alpha-amino acid derivative). alpha-Fluorinated products were converted into the corresponding esters, secondary amides, tertiary amides, ketones, and alcohols with almost no epimerization in high yield.

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Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Safety of 3-Methyl-1-p-tolyl-5-pyrazolone. In 2019 J ORG CHEM published article about N-HETEROCYCLIC CARBENE; ENANTIOSELECTIVE CONSTRUCTION; ORGANOCATALYSIS; PYRAZOLONES; ANNULATION; SCAFFOLDS; OXINDOLES; CATALYSIS in [Lu, Hong; Zhang, Huan-Xin; Tan, Chang-Yin; Liu, Jin-Yu; Xu, Peng-Fei] Lanzhou Univ, Sch Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China; [Lu, Hong; Wei, Hao] Northwest Univ, Coll Chem & Mat Sci, Natl Demonstrat Ctr Expt Chem Educ, Key Lab Synthet & Nat Funct Mol Chem,Minist Educ, Xian 710127, Shaanxi, Peoples R China in 2019, Cited 45. The Name is 3-Methyl-1-p-tolyl-5-pyrazolone. Through research, I have a further understanding and discovery of 86-92-0.

A sequential and general strategy has been successfully developed for the synthesis of spiropyrazolone scaffolds. This intriguing transformation of the asymmetric multicomponent catalysis process was realized with the combination of Michael addition/chlorination/nucleophilic substitution in a one-pot sequence, giving rise to a series of spiropyrazolones with fully substituted cyclopropanes and spiro-dihydrobenzofurans containing continuous stereogenic centers in good yields with excellent stereoselectivities.

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Reference:
Article; Zhang, Yong; Nie, Long-Jun; Luo, Liang; Mao, Jia-Xin; Liu, Jin-Xiang; Xu, Guo-Hai; Chen, Deliang; Luo, Hai-Qing; Tetrahedron; vol. 76; 7; (2020);,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Safety of 3,5-Dimethyl-1H-pyrazole. Authors Sun, ML; Zhou, YH; Li, LQ; Wang, L; Ma, YM; Li, PH in ROYAL SOC CHEMISTRY published article about in [Sun, Mingli; Zhou, Yuhui; Wang, Lei; Ma, Yongmin] Taizhou Univ, Adv Res Inst, Taizhou 318000, Zhejiang, Peoples R China; [Sun, Mingli; Zhou, Yuhui; Wang, Lei; Ma, Yongmin] Taizhou Univ, Dept Chem, Taizhou 318000, Zhejiang, Peoples R China; [Sun, Mingli; Li, Laiqiang; Wang, Lei; Li, Pinhua] Huaibei Normal Univ, Dept Chem, Huaibei 235000, Anhui, Peoples R China; [Wang, Lei] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China in 2021.0, Cited 42.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6

This paper reports a metal-free and external oxidant-free electrochemical method for the C-3 amination of 2H-indazoles. The protocol employs commercially available azoles and aliphatic amines as amination reagents and has a broad substrate scope, providing the corresponding C3-amination products in high yields at room temperature. Mechanistic studies indicate that an oxidative addition/elimination sequence is involved under electrochemical conditions.

Welcome to talk about 67-51-6, If you have any questions, you can contact Sun, ML; Zhou, YH; Li, LQ; Wang, L; Ma, YM; Li, PH or send Email.. Safety of 3,5-Dimethyl-1H-pyrazole

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Authors Kang, HJ; Lee, JH; Kim, DH; Cho, CG in AMER CHEMICAL SOC published article about DEFICIENT 1,3-CONJUGATED ENYNES; STEREOSELECTIVE HYDROAMINATION; CATALYZED HYDROAMINATION; ALKENES; ACCESS; 2,3-DIHYDROISOXAZOLES; CYCLOADDITION; CONSTRUCTION; DERIVATIVES in [Kang, Hyung-Joon; Lee, Joon-Ho; Kim, Dong-Hyun; Cho, Cheon-Gyu] Hanyang Univ, Ctr New Direct Organ Synth, Dept Chem, Seoul 04763, South Korea in 2020.0, Cited 47.0. Safety of 3,5-Dimethyl-1H-pyrazole. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6

Imidazole-selective intermolecular hydroamination reaction has been discovered. This unprecedented additive-free addition reaction proceeds in an exclusively regioselective and stereoselective manner with high atom economy under extremely mild reaction conditions.

Safety of 3,5-Dimethyl-1H-pyrazole. Welcome to talk about 67-51-6, If you have any questions, you can contact Kang, HJ; Lee, JH; Kim, DH; Cho, CG or send Email.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

SDS of cas: 86-92-0. I found the field of Chemistry; Crystallography very interesting. Saw the article Three mixed ligand mononuclear Zn(II) complexes of 4-acyl pyrazolones: Synthesis, characterization, crystal study and anti-malarial activity published in 2020, Reprint Addresses Jadeja, RN (corresponding author), Maharaja Sayajirao Univ Baroda, Fac Sci, Dept Chem, Vadodara 390002, India.. The CAS is 86-92-0. Through research, I have a further understanding and discovery of 3-Methyl-1-p-tolyl-5-pyrazolone.

Three novel mixed ligand Zn(II) complexes {complex 1 = [Zn(L1)(2)(bpy)], complex 2 = [Zn(L2)(2)(bPY)], complex 3 = [Zn(L2)(2)(phen)], where bpy = 2,2′-bipyridine and phen = 1,10-phenanthroline} of 4-(4-chlorobenzoyl)-2-(3-chlorophenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one (HL1) and 4-(4-chlorobenzoyl)-5-methyl-2-(p-tolyl)-2,4-dihydro-3H-pyrazol-3-one (HL2) were synthesized and characterized by H-1 and C-13 NMR, FTIR, TG-DTA, UV-Vis, elemental analysis, molar conductance and single crystal X-ray structure determination. Based on analytical and spectroscopic techniques, all the three Zn(II) complexes were found to have a distorted octahedral geometry. The ligands and the complexes were screened for antimalarial activity against plasmodium falciparum. The zinc(II) complexes showed greater antimalarial activity than their parent ligands. (C) 2020 Elsevier Ltd. All rights reserved.

Welcome to talk about 86-92-0, If you have any questions, you can contact Shaikh, I; Jadeja, RN; Patel, R or send Email.. SDS of cas: 86-92-0

Reference:
Article; Zhang, Yong; Nie, Long-Jun; Luo, Liang; Mao, Jia-Xin; Liu, Jin-Xiang; Xu, Guo-Hai; Chen, Deliang; Luo, Hai-Qing; Tetrahedron; vol. 76; 7; (2020);,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics