Tag: 100-200

Five new mononuclear complexes of 2-(5-methyl-1H-pyrazol-3-yl)pyridine: Synthesis, crystalline architectures through supramolecular interactions and spectroscopy was written by Zhu, Guang-Zhou;Xing, Bei-Bei;Yang, Feng-Lei;Li, Xiu-Ling. And the article was included in Polyhedron in 2014.Recommanded Product: 19959-77-4 This article mentions the following:

Five new mononuclear complexes with 2-(5-methyl-1H-pyrazol-3-yl)pyridine (L) were synthesized, namely [ZnLCl₂] (1), [NiL₂(H₂O)₂]Cl₂·0.5N₂H₄ (2), [MnL₂Cl₂]·3H₂O (3), [CdL₂(NO₃)₂] (4) and [MnL₂(Pa)₂] (5, Pa = m-phthalic acid). All these compounds were characterized by elemental anal., IR and UV-visible spectroscopy, and x-ray single crystal diffraction. The crystal structures reveal that compounds 2, 3 and 5 afford six-coordinated octahedral spheres, while compound 1 displays a four-coordinated tetrahedral core and compound 4 forms an eight-coordinated geometry. Furthermore, the 3D supramol. networks, formed through plentiful H-bonds and weak mol. interactions, were analyzed. The photoluminescent properties of the ligand L, together with compounds 1 and 4, were also studied in methanol solution at room temperature In the experiment, the researchers used many compounds, for example, 2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4Recommanded Product: 19959-77-4).

2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Recommanded Product: 19959-77-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Mass spectrometry of nitroazoles. I. The mass spectra of methyl substituted nitropyrazoles was written by Luijten, W. C. M. M.;Van Thuijl, J.. And the article was included in Organic Mass Spectrometry in 1979.COA of Formula: C4H5N3O2 This article mentions the following:

The mass spectra of all isomers of methylnitropyrazoles are reported. Generally, the spectra are characteristic of nitropyrazoles. In some cases however, ortho effects occur, which were recognizable by the primary loss of •OH, H₂O, •CHO and HCHO. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4COA of Formula: C4H5N3O2).

3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.COA of Formula: C4H5N3O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Diene synthesis in the pyrazole series. Preparation of 6-anilinopyridines was written by Abjean, Francois. And the article was included in Comptes Rendus des Seances de l’Academie des Sciences, Serie C: Sciences Chimiques in 1974.Electric Literature of C6H9N3O This article mentions the following:

The anilinopyridinium tetrafluoroborates I (R = Ph, p-O2NC6H4), p-ClC6H4) were formed by treating BF3 complexes of the pyrazoles II with MeO2CCCCO2Me. Treatment of I with KOH gave the pyridineamines III. The pyrazoles II (R = Ac, Bz, CONH2) also formed BF3 complexes which did not undergo diene synthesis, giving instead II (R = H). In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Electric Literature of C6H9N3O).

3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Electric Literature of C6H9N3O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Effects of hydrogen bond on the melting point of azole explosives was written by Wang, Jian-Hua;Shen, Chen;Liu, Yu-Cun;Luo, Jin;Duan, Yingjie. And the article was included in Journal of Molecular Structure in 2018.Recommanded Product: 54210-32-1 This article mentions the following:

M.p. is an important index to determine whether an explosive can be a melt cast carrier. In this study, the relationship among the mol. structure, crystal structure, and m.p. of explosives was investigated by using nitroazole compounds Hydrogen bonds influence crystal packing modes in chem. understandable ways. Hydrogen bonds also affect the changes in entropy and enthalpy in balancing melting process. Hence, different types of hydrogen bonds in explosive crystal structures were compared when the relationship between the mol. structure and the m.p. of nitroazole explosives were analyzed. The effects of Me and amino groups on intermol. hydrogen bonds were also compared. Results revealed that the Me and amino groups connected on the N(1) of the heterocyclic compound can reduce the m.p. of azole explosive. This finding is possible because Me and amino groups destroy the intermol. hydrogen bond of the heterocyclic compound In the experiment, the researchers used many compounds, for example, 1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1Recommanded Product: 54210-32-1).

1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Recommanded Product: 54210-32-1

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthesis and characterisation of palladium(II) and platinum(II) compounds containing pyrazole-derived ligands: crystal structure of [PdCl₂(HL¹)] (HL¹ = 3-phenyl-5-(2-pyridyl)pyrazole) was written by Perez, Jose Antonio;Pons, Josefina;Solans, Xavier;Font-Bardia, Merce;Ros, Josep. And the article was included in Inorganica Chimica Acta in 2005.Related Products of 19959-77-4 This article mentions the following:

Reaction of the ligands 3-phenyl-5-(2-pyridyl)pyrazole (HL¹), 3,5-bis(2-pyridyl)pyrazole (HL²), 3-methyl-5-(2-pyridyl)pyrazole (HL³) and 3-methyl-5-phenylpyrazole (HL⁴) with [MCl₂(MeCN)₂] (M = Pd(II), Pt(II)) or [PdCl₂(cod)] gives [PdCl₂(HL)₂] (HL = HL¹, HL², HL³), [Pt(L)₂] (L = L¹, L², L³) and [MCl₂(HL⁴)₂] (M = Pd(II), Pt(II)). The new complexes were characterized by elemental analyses, conductivity measurements, IR and ¹H NMR spectroscopies. The crystal and mol. structure of [PdCl₂(HL¹)] was resolved by x-ray diffraction, and consists of monomeric cis-[PdCl₂(HL¹)] mols. The Pd center has a typical square planar geometry, with a slight tetrahedral distortion. The tetracoordinated metal atom is bonded to one pyridine N, one pyrazolic N and two chloro ligands in a cis disposition. The ligand HL¹ is not completely planar. In the experiment, the researchers used many compounds, for example, 2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4Related Products of 19959-77-4).

2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Related Products of 19959-77-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Weak C-H…O and C-H…N interactions in nitropyrazoles was written by Foces-Foces, C.;Jagerovic, N.;Elguero, J.. And the article was included in Acta Crystallographica, Section C: Crystal Structure Communications in 2000.Name: 1-Methyl-3-nitro-1H-pyrazole This article mentions the following:

The structures of 1-methyl-3-nitropyrazole and 1-methyl-4-nitropyrazole, C₄H₅N₃O₂, were determined The 3-nitro derivative has crystallog. m-symmetry while the 4-nitro compound has no imposed symmetry. The significant differences in bond distances and angles between the structures are ascribable to the electron-withdrawing effects of the nitro group attached to C3 or C4, resp. In both structures, the mols. are organized into layers by an extensive network of C-H…O or C-H…N H interactions. Within a layer, the mols. are arranged in a similar way, although differences of up to 0.3 Å in the analogous H…O or H…N intermol. distances are observed The cohesion of the layers is due to van der Waals and C-H…O contacts. Crystallog. data are given. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1Name: 1-Methyl-3-nitro-1H-pyrazole).

1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Name: 1-Methyl-3-nitro-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Acidity constants of some biheterocycles was written by Tjiou, El Mostafa;Fruchier, Alain;Pellegrin, Valdo;Tarrago, Georges. And the article was included in Journal of Heterocyclic Chemistry in 1989.Category: pyrazoles-derivatives This article mentions the following:

The pKa₁ and pKa₂ of 19 biheterocycles of the form R(CH₂)_nR¹ [R, R¹ = (un)substituted imidazolyl, (un)substituted pyrazolyl, 2-pyridyl; n = 0, 1] were determined in H₂O at 25° by potentiometry and UV spectroscopy. In the experiment, the researchers used many compounds, for example, 2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4Category: pyrazoles-derivatives).

2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Category: pyrazoles-derivatives

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthesis of vicinal aminoiodo- and (acetylamino)iodo-1-alkylpyrazoles was written by Tretyakov, E. V.;Vasilevsky, S. F.. And the article was included in Izvestiya Akademii Nauk, Seriya Khimicheskaya in 1996.Safety of 1-Methyl-3-nitro-1H-pyrazole This article mentions the following:

One-pot acylation-iodination of 3- and 5-amino-1-alkylpyrazoles gave 3- and 5-acetamido-4-iodo-1-alkylpyrazoles. Reduction of iodonitropyrazoles with SnCl₂ in HCl gave 3- and 5-iodo- and 3,5-diiodo-4-amino-1-methylpyrazole. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1Safety of 1-Methyl-3-nitro-1H-pyrazole).

1-Methyl-3-nitro-1H-pyrazole (cas: 54210-32-1) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Safety of 1-Methyl-3-nitro-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reactions of β-aminoenones with acetylhydrazine, semicarbazide and methoxycarbonylhydrazine. Synthesis of 1-acetyl-, 1-carboxamide- or methyl 1-carboxylated pyrazole derivatives was written by Alberola, Angel;Calvo, Luis;Ortega, Alfonso Gonzalez;Sadaba, M. Luisa;Sanudo, M. Carmen;Granda, Santiago Garcia;Rodriguez, Elena Garcia. And the article was included in Heterocycles in 1999.Product Details of 934-48-5 This article mentions the following:

Acetylhydrazine, semicarbazide and methoxycarbonylhydrazine react with β-aminoenones to give regioselectively the corresponding N-acetyl- or N-carboxypyrazole derivatives The reactions are highly regioselective and occur via 5-hydroxypyrazolines, which in several cases can be isolated and characterized. In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Product Details of 934-48-5).

3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Product Details of 934-48-5

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Pd-Catalyzed N-Arylation of Heteroarylamines was written by Yin, Jingjun;Zhao, Matthew M.;Huffman, Mark A.;McNamara, James M.. And the article was included in Organic Letters in 2002.Reference of 3528-58-3 This article mentions the following:

The palladium-catalyzed N-(hetero)arylation of a number of heteroarylamines including 2-aminopyridines, 2-aminothiazoles, and their analogs has been realized using Xantphos as the ligand. Weak bases such as Cs₂CO₃, Na₂CO₃, and K₃PO₄ were used in most cases to allow for the introduction of functional groups. Choice of the base and solvent was critical for the success of these reactions. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3Reference of 3528-58-3).

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.Reference of 3528-58-3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics