Day: December 2, 2022

Kumari, N. published the artcileExtractant mediated nano-aggregate formation in Triton X-114 aided cloud formation: structural insights from TEM and SANS studies, Formula: C17H14N2O2, the publication is RSC Advances (2015), 5(116), 95613-95617, database is CAplus.

Nanoaggregate formation by self assembly was noticed during the cloud formation of Triton X-114 ((1,1,3,3-tetramethylbutyl)phenyl-polyethylene glycol) in the presence of dibenzoylmethane (DBM), thenoyltrifluoroacetone (HTTA) and 1-phenyl-3-methyl-4-benzoyl-5-pyrazolone (PMBP) and tri-Bu phosphate (TBP). Transmission Electron Microscopy (TEM) measurements showed that the nature of the extractant influences the clouding behavior of Triton X-114 and the formation of vesicles of different orientations. SANS studies suggested that the majority of Triton X 114 participated in the cloud formation process. Viscosity measurements at different temperatures were used to calculate the activation energy for viscous flow.

RSC Advances published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C17H14N2O2, Formula: C17H14N2O2.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Patel, Rashmi B. published the artcileSynthesis of Metal Catalysts from Industrial Waste Effluents and its Catalytic Application in Biginelli Reaction, Safety of 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, the publication is Current Organocatalysis (2016), 3(3), 270-276, database is CAplus.

Background: Industries are using various metals containing salts, for various purposes. However, some amount of metal salts is leached, which creates environmental pollution. Removal of these pollutants is essential. Various groups are working to remove them by different techniques, but here we have applied simple techniques to extract and then these materials are used as a catalyst for the synthesis of organic compounds Presently, as per our knowledge, this type of approach is adopted by us. Method: The ligand pyrazole-thiosemicarbazide was prepared by green chem. method, which was well characterized by various anal. techniques. This ligand is used for the extraction of various salts of metal from the effluent. The metal salts are converted into metal complexes. The metal complexes from the waste are used for the preparation of important biol. active derivatives Results: The ligand extracts the metals very fast. We have also studied the metal – ligand ratio and found that it is 1:1. These complexes are used as a catalyst for Biginalli reaction and in the presence of the catalysts the reaction is faster as compared to the absence of a catalyst. Conclusion: Based on a study we conclude that the ligand can work efficiently for the extraction of metal from the waste water. The formed complexes are the efficient catalysts for the preparation of dihydropyrimidines and its recycle and reuse.

Current Organocatalysis published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C17H14N2O2, Safety of 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Caldwell, John J. published the artcileDesign and synthesis of 2(1H)-pyrazinones as inhibitors of protein kinases, Category: pyrazoles-derivatives, the publication is Tetrahedron (2012), 68(47), 9713-9728, database is CAplus.

Kinase enzymes play a key role in the development and progression of cancer. Inhibitors of deregulated kinases are effective small mol. anticancer drugs. The 2(1H)-pyrazinone heterocycle is a previously unexploited motif that can fulfil the structural requirements for ATP-competitive inhibition of kinases. Rapid solution-phase syntheses of novel 3,5- and 3,6-disubstituted-2(1H)-pyrazinones were developed through selective, sequential substitution of 2,5-dihalo-3-benzyloxypyrazine and 3,5-dihalo-2(1H)-pyrazinone intermediates. Palladium-catalyzed cross-couplings and S_NAr reactions were used to introduce substituents chosen on the basis of the calculated physicochem. properties of the target pyrazinones. Representative compounds, e.g., I, demonstrated good solubility, kinase inhibitory activity and antiproliferative activity in human tumor cells, confirming the suitability of this chem. class as a kinase-focused library.

Tetrahedron published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C3H5BN2O2, Category: pyrazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Caldwell, John J. published the artcileDesign and synthesis of 2(1H)-pyrazinones as inhibitors of protein kinases, Category: pyrazoles-derivatives, the publication is Tetrahedron (2012), 68(47), 9713-9728, database is CAplus.

Kinase enzymes play a key role in the development and progression of cancer. Inhibitors of deregulated kinases are effective small mol. anticancer drugs. The 2(1H)-pyrazinone heterocycle is a previously unexploited motif that can fulfil the structural requirements for ATP-competitive inhibition of kinases. Rapid solution-phase syntheses of novel 3,5- and 3,6-disubstituted-2(1H)-pyrazinones were developed through selective, sequential substitution of 2,5-dihalo-3-benzyloxypyrazine and 3,5-dihalo-2(1H)-pyrazinone intermediates. Palladium-catalyzed cross-couplings and S_NAr reactions were used to introduce substituents chosen on the basis of the calculated physicochem. properties of the target pyrazinones. Representative compounds, e.g., I, demonstrated good solubility, kinase inhibitory activity and antiproliferative activity in human tumor cells, confirming the suitability of this chem. class as a kinase-focused library.

Tetrahedron published new progress about 724710-02-5. 724710-02-5 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Pyrazole,Boronic Acids,Boronic acid and ester, name is (1H-Pyrazol-5-yl)boronic acid, and the molecular formula is C3H5BN2O2, Category: pyrazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics