Month: October 2022

In 2010,Sandoval, Angel; Chokshi, Aalap; Jesch, Elliot D.; Black, Paul N.; Di Russo, Concetta C. published 《Identification and characterization of small compound inhibitors of human FATP2》.Biochemical Pharmacology published the findings.Application In Synthesis of 3-(Trifluoromethyl)-1H-pyrazole The information in the text is summarized as follows:

Fatty acid transport proteins (FATPs) are bifunctional proteins, which transport long chain fatty acids into cells and activate very long chain fatty acids by esterification with CoA. In an effort to understand the linkage between cellular fatty acid transport and the pathol. associated with excessive accumulation of exogenous fatty acids, we targeted FATP-mediated fatty acid transport in a high throughput screen of more than 100,000 small diverse chem. compounds in yeast expressing human FATP2 (hsFATP2). Compounds were selected for their ability to depress the transport of the fluorescent long chain fatty acid analog, C1-BODIPY-C12. Among 234 hits identified in the primary screen, 5 compounds, each representative of a structural class, were further characterized in the human Caco-2 and HepG2 cell lines, each of which normally expresses FATP2, and in 3T3-L1 adipocytes, which do not. These compounds were effective in inhibiting uptake with IC50s in the low micromolar range in both Caco-2 and HepG2 cells. Inhibition of transport was highly specific for fatty acids and there were no effects of these compounds on cell viability, trans-epithelial elec. resistance, glucose transport, or long chain acyl-CoA synthetase activity. The compounds were less effective when tested in 3T3-L1 adipocytes suggesting selectivity of inhibition. These results suggest fatty acid transport can be inhibited in a FATP-specific manner without causing cellular toxicity. In addition to this study using 3-(Trifluoromethyl)-1H-pyrazole, there are many other studies that have used 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Application In Synthesis of 3-(Trifluoromethyl)-1H-pyrazole) was used in this study.

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Application In Synthesis of 3-(Trifluoromethyl)-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 2012,Sandoval, Angel; Chokshi, Aalap; Jesch, Elliot D.; Black, Paul N.; DiRusso, Concetta C. published 《Identification and characterization of small compound inhibitors of human FATP2 [Erratum to document cited in CA152:421565]》.Biochemical Pharmacology published the findings.Reference of 3-(Trifluoromethyl)-1H-pyrazole The information in the text is summarized as follows:

On page 997, Compound CB-5 in Table 3B contained a structure error; the corrected structure is given. In the experimental materials used by the author, we found 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Reference of 3-(Trifluoromethyl)-1H-pyrazole)

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Reference of 3-(Trifluoromethyl)-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

《Preparation of Chiral Photosensitive Organocatalysts and Their Application for the Enantioselective Synthesis of 1,2-Diamines》 was published in Journal of Organic Chemistry in 2020. These research results belong to Lyu, Jiyuan; Claraz, Aurelie; Vitale, Maxime R.; Allain, Clemence; Masson, Geraldine. Formula: C4H3F3N2 The article mentions the following:

Chiral phosphoric acid based organocatalysis and visible-light photocatalysis have both emerged as promising technologies for the sustainable production of fine chems. In this context, we have envisioned the design and the synthesis of a new class of chimeric catalytic entities that would feature both catalytic capabilities. Given their multitask nature, such catalysts would be particularly attractive for the development of new catalytic transformations, tandem processes in particular. Toward this goal, several BINOL-based chiral phosphoric acid backbones presenting one or two visible-light-sensitive thioxanthone moieties have been prepared and studied. The utility of these new photoactive chiral organocatalysts is then demonstrated in the enantioselective tandem three-component electrophilic amination of enecarbamates. Of note, the C1-sym. organo/photocatalyst has shown a better catalytic activity than those presenting a C2 symmetry. After reading the article, we found that the author used 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Formula: C4H3F3N2)

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Formula: C4H3F3N2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 2016,Aitha, Anjaiah; Yennam, Satyanarayana; Behera, Manoranjan; Anireddy, Jaya Shree published 《Design and synthesis of diaziridinyl quinone thiadiazole hybrids via nitrile sulfide cycloaddition reaction as a key step》.Tetrahedron Letters published the findings.Quality Control of 3-(Trifluoromethyl)-1H-pyrazole The information in the text is summarized as follows:

A series of novel diaziridinyl quinone thiadiazole hybrids (I; R = N-heterocycle) were synthesized starting from 2-hydroxy-5-methoxybenzoic acid in a 7 step synthetic sequence. The key step in the scheme involves the nitrile sulfide cycloaddition reaction of oxathiazolone II with p-tosyl cyanide to obtain 1,2,4-thiadiazole derivative III. We have demonstrated that p-tosyl group of thiadiazole 5 can be displaced with various nitrogen heterocycles to generate unknown 3,5-disubstituted thiadiazole derivatives In the experiment, the researchers used 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Quality Control of 3-(Trifluoromethyl)-1H-pyrazole)

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Quality Control of 3-(Trifluoromethyl)-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 2017,Al Mousawi, Assi; Kermagoret, Anthony; Versace, Davy-Louis; Toufaily, Joumana; Hamieh, Tayssir; Graff, Bernadette; Dumur, Frederic; Gigmes, Didier; Fouassier, Jean Pierre; Lalevee, Jacques published 《Copper photoredox catalysts for polymerization upon near UV or visible light: structure/reactivity/efficiency relationships and use in LED projector 3D printing resins》.Polymer Chemistry published the findings.Recommanded Product: 3-(Trifluoromethyl)-1H-pyrazole The information in the text is summarized as follows:

Copper complexes (CuCs) bearing pyridine-pyrazole ligands are synthesized and evaluated as new photocatalysts/photoinitiators in combination with an iodonium salt (Iod) for the free radical polymerization of (meth)acrylates and the cationic polymerization of epoxides upon visible light exposure using Light Emitting Diode (LED)@405nm. The structure/reactivity/efficiency relationships for the copper complexes are studied as well as the chem. mechanisms involved. The different substituents on the pyrazole moiety of the ligand allow to tune the oxidation potential and the visible light absorbance of the complexes and to optimize the performance of the polymerization photocatalysts. The use of a novel additive (CARET) in a three-component system (CuC/Iod/CARET) highly improves the performance. Finally, the high performances of the Cu(I) complexes for the development of new 3D printing resins using LED projector are demonstrated. Currently, LED projector printing is really advantageous in 3D printing i.e. this technol. projects the profile of an entire layer at one time.3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Recommanded Product: 3-(Trifluoromethyl)-1H-pyrazole) was used in this study.

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Recommanded Product: 3-(Trifluoromethyl)-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The author of 《Rapid Identification of Novel Allosteric PRC2 Inhibitors》 were Read, Jon A.; Tart, Jonathan; Rawlins, Philip B.; Gregson, Clare; Jones, Karen; Gao, Ning; Zhu, Xiahui; Tomlinson, Ron; Code, Erin; Cheung, Tony; Chen, Huawei; Kawatkar, Sameer P.; Bloecher, Andy; Bagal, Sharan; O’Donovan, Daniel H.; Robinson, James. And the article was published in ACS Chemical Biology in 2019. Name: 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole The author mentioned the following in the article:

Enhancer of zeste homolog 2 (EZH2), the catalytic subunit of polycomb repressive complex 2 (PRC2), regulates chromatin state and gene expression by methylating histone H3 lysine 27. EZH2 is overexpressed or mutated in various hematol. malignancies and solid cancers. Our previous efforts to identify inhibitors of PRC2 methyltransferase activity by high-throughput screening (HTS) resulted in large numbers of false positives and thus a significant hit deconvolution challenge. More recently, others have reported compounds that bind to another PRC2 core subunit, EED, and allosterically inhibit EZH2 activity. This mechanism is particularly appealing as it appears to retain potency in cell lines that have acquired resistance to ortho steric EZH2 inhibition. By designing a fluorescence polarization probe based on the reported EED binding compounds, we were able to quickly and cleanly re-triage our previously challenging HTS hit list and identify novel allosteric PRC2 inhibitors. The experimental process involved the reaction of 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 847818-74-0Name: 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole)

1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 847818-74-0) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, monoamine oxidase inhibitory, anti-inflammatory, antipyretic, neuroleptic, anticonvulsant, antiarrhythmic, sedative, muscle relaxant, antidiabetic and antibacterial activities. Name: 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application In Synthesis of Methyl 1H-pyrazole-3-carboxylateIn 2002 ,《Product class 1: pyrazoles》 appeared in Science of Synthesis. The author of the article were Stanovnik, B.; Svete, J.. The article conveys some information:

A review. Methods for preparing pyrazoles are reviewed including cyclization, ring transformation, aromatization and substituent modifications. The results came from multiple reactions, including the reaction of Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Application In Synthesis of Methyl 1H-pyrazole-3-carboxylate)

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Application In Synthesis of Methyl 1H-pyrazole-3-carboxylate

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Related Products of 15366-34-4In 2005 ,《A Theoretical Study on the Tautomerism of C-Carboxylic and Methoxycarbonyl Substituted Azoles》 was published in Structural Chemistry. The article was written by Alkorta, Ibon; Elguero, Jose. The article contains the following contents:

DFT calculations (B3LYP/6-31+G**) have been carried out on 106 tautomers and conformers of NH-azoles bearing CO2H and CO2CH3 groups. The following azoles systems have been studied: 2-substituted pyrroles, 2-substituted indoles, 2-substituted imidazoles, 2-substituted benzimidazoles, 4(5)-substituted imidazoles, 3(5)-substituted pyrazoles, 3-substituted indazoles (1H and 2H), 3,4(5)-substituted-1,2,3(5)-triazoles, 2,3(5)-substituted-1,2(3),4-triazoles, 4(5)-1,2,3,4(5)-tetrazoles. In the case of pyrazole, 3,5-disubstituted derivatives have also been computed, including four dimers. The results came from multiple reactions, including the reaction of Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Related Products of 15366-34-4)

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Related Products of 15366-34-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Kublicki, Marcin; Ogonowski, Blazej; Wieczorkowski, Dariusz; Durka, Krzysztof; Klis, Tomasz published an article in Tetrahedron Letters. The title of the article was 《1,4-Phenylenebis((1-methyl-1H-pyrazol-5-yl)borinic 8-oxyquinolinate) as a photoredox catalyst in the atom transfer radical addition of iodoperfluoroalkanes to alkenyl groups bearing organoboron compounds》.Reference of 1-Methylpyrazole The author mentioned the following in the article:

The key photocatalytic properties of a transition-metal-free heteroleptic complex I (1) derived from 1,4-phenyldiboronic acid were evaluated. This compound was utilized in the atom transfer radical addition of iodoperfluoroalkanes CnF2n+1I (n = 1-4) to a series of allylic arylboronate compounds CH2:CHCH2XAr[B] [X = bond, O, CH2; Ar = phenylene, thiophenediyl; [B] = B(OH)2, BF3K] to give C-I activation products, [B]ArXCH2CHICH2CnF2n+1 (2-14). The products of these reactions retained the B-C bond, and Suzuki-Miyaura coupling of one product gave biphenyl derivatives The X-ray anal. of one of the obtained perfluoroalkylated boronic acids revealed the presence of open star-shaped channels. In the experiment, the researchers used many compounds, for example, 1-Methylpyrazole(cas: 930-36-9Reference of 1-Methylpyrazole)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Reference of 1-Methylpyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 2013,Chen, Xu-Lin; Yu, Rongmin; Zhang, Qi-Kai; Zhou, Liu-Jiang; Wu, Xiao-Yuan; Zhang, Qing; Lu, Can-Zhong published 《Rational Design of Strongly Blue-Emitting Cuprous Complexes with Thermally Activated Delayed Fluorescence and Application in Solution-Processed OLEDs》.Chemistry of Materials published the findings.Recommanded Product: 20154-03-4 The information in the text is summarized as follows:

Strongly greenish-blue to blue emitting Cu-(NN)(POP)+ (POP = bis[2-(diphenylphosphino)phenyl] ether) complexes containing N-linked 2-pyridylpyrazolate diimine ligands [Cu(pypz)(POP)]BF4 (1), [Cu(pympz)(POP)]BF4 (2), and [Cu(pytfmpz)(POP)]BF4 (3) (pypz = 1-(2-pyridyl)pyrazole, pympz = 3-Me-1-(2-pyridyl)pyrazole, and pytfmpz = 3-trifluoromethyl-1-(2-pyridyl)pyrazole) were designed and synthesized. Their structural, electrochem., and photophys. properties were characterized. The complexes 1-3 exhibit high luminescence quantum yields (PLQYs) at room temperature both in N-saturated CH2Cl2 (≤45%) and in neat solid (≤87%), which are comparable to the reported highest values for the cuprous complexes. The temperature dependence of spectroscopic properties and emission decay behaviors reveal 2 thermally equilibrated emitting states. At temperatures <150 K, the lowest triplet state (T1) is the predominant emitting state resulting in the typical phosphorescence with the emission decay times in the order of hundreds of μs. At ambient temperature, the lowest singlet state (S1), which lies only ∼0.17-0.18 eV above the T1 state, is populated thermally and in turn generates efficient thermally activated delayed fluorescence (TADF), and the emission decay times are reduced dramatically to, e.g., 12.2 μs for 2. Solution-processed OLEDs containing 1-3 in the emissive layer demonstrated excellent device performances by taking advantage of the singlet harvesting mechanism, among which the electroluminescent device using 3 shows a peak external quantum efficiency (EQE) of 8.47%, a peak current efficiency (CE) of 23.68 cd/A, and a maximum brightness of 2033 cd/m2. Crystallog. data are given. The experimental process involved the reaction of 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Recommanded Product: 20154-03-4)

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Recommanded Product: 20154-03-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics