Month: October 2022

The author of 《A new synthesis of azolooxazines》 were Lupo, B.; Tarrago, G.. And the article was published in Synthetic Communications in 1982. COA of Formula: C5H8N2O The author mentioned the following in the article:

Pyrazolooxazine derivative I was prepared from 3(5)-hydroxymethyl-5(3)-methylpyrazole (II) in two steps. II was heated with propargyl bromide in DMF to yield a mixture of III (R = CH2OH, R1 = Me) and III (R = Me, R1 = CH2OH) (IV). A mixture of IV, Bu4N+ Br-, and NaOH in C6H6 was stirred 4 h at 60° to give I. In the experiment, the researchers used many compounds, for example, (3-methyl-1H-pyrazol-5-yl)methanol(cas: 29004-73-7COA of Formula: C5H8N2O)

(3-methyl-1H-pyrazol-5-yl)methanol(cas: 29004-73-7) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. COA of Formula: C5H8N2O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 1959,Graner, R. Franquesa published 《Synthesis of 2-acetamido-5-nitrothiazole, an oral bactericide》.Galenica Acta published the findings.Application In Synthesis of Methyl 1H-pyrazole-3-carboxylate The information in the text is summarized as follows:

Tech. 2-aminothiazole-HCl was purified by neutralizing with NaOH at 50°, cooling with the addition of the solid amine to prevent supercooling, washing at pH 11-12, then with a saturated solution of NaCl, and then H2O. The solid was air-dried and distilled, b12 139-43°; 65% 2-aminothiazole (I) was recovered. Preparation of 2-acetamido-5-nitrothiazole (II) (CA 46, 10285h; 40, 40583) was accomplished by acetylation, then nitration of I (78.2% over-all yield), and by the reverse steps (62.8% over-all). Ac2O (1.3 mole), 1 mole I, and 0.1 mole H2SO4 was refluxed 10 min., poured on ice, and the solid recrystallized m. 209-10°, for a 92% yield of 2-acetamidothiazole (III). III (142 g.) was dissolved in 450 ml. concentrated H2SO4 at 10° with the addition of 46 ml. (d. 1.5) fuming HNO3 over 40 min.; allowing the temperature to reach 50° for 30 min., pouring on ice, filtering, and washing with water, EtOH, and recrystallizing from AcOH (50 ml./5 g.) gave 152 g. II, m. 265-6°. I (100 g.) was dissolved in 300 ml. concentrated H2SO4 at 10°, and 46 ml. (d. 1.5) fuming HNO3 was added dropwise with agitation at 12°. The temperature was kept 3 hrs. at 0°, then at 25° for 24 hrs. The mass was poured onto 5000 ml. icewater, and the filtrate neutralized with 600 g. Na2CO3 in 2000 ml. H2O. The product was water-washed, and recrystallized from EtOH (100 ml./5 g.) to give 100 g. 2-amino-5-nitrothiazole (IV), m. 202-3°. IV (7 g.), 50 ml. Ac2O, and 3 drops of concentrated H2SO4 were refluxed 7 min., and cooled to 0°. Recrystallization of the solid from AcOH gave 8.5 g. II, m. 265°. In the experiment, the researchers used Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Application In Synthesis of Methyl 1H-pyrazole-3-carboxylate)

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Application In Synthesis of Methyl 1H-pyrazole-3-carboxylate

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 2015,Liao, Jia-Ling; Chi, Yun; Sie, Zong-Ting; Ku, Chia-Hao; Chang, Chih-Hao; Fox, Mark A.; Low, Paul J.; Tseng, Meu-Rurng; Lee, Gene-Hsiang published 《Ir(III)-Based Phosphors with Bipyrazolate Ancillaries; Rational Design, Photophysics, and Applications in Organic Light-Emitting Diodes》.Inorganic Chemistry published the findings.Recommanded Product: 20154-03-4 The information in the text is summarized as follows:

Three charge-neutral Ir(III) complexes bearing both neutral chelating ligands 4,4′-di-t-butyl-2,2′-bipyridine (dtbbpy) and monoanionic cyclometalated ligands derived from 2-phenylpyridine (ppyH), together with either 2 monoanionic ligands (i.e., chloride and monodentate pyrazolate) or a single dianionic chelate derived from 5,5′-di(trifluoromethyl)-3,3′-bipyrazole (bipzH2) or 5,5′-(1-methylethylidene)-bis-(3-trifluoromethyl-1H-pyrazole) (mepzH2), was successfully synthesized. These complexes are derived from a common, structurally characterized, Ir(III) intermediate complex [Ir(dtbbpy)(ppy)Cl2] (1), from treatment of IrCl3·3H2O with equal amount of the diimine (NN̂) and precursor of the cyclometalated (C^N) ligands in a form of 1-pot reaction. Treatment of 1 with various functional pyrazoles afforded [Ir(dtbbpy)(ppy)(pz)Cl] (2), [Ir(dtbbpy)(ppy)(bipz)] (3), and [Ir(dtbbpy)(ppy)(mepz)] (4), which display intense room-temperature emission with λmax spanning 532-593 nm in both fluid and solid states. The Ir(III) complexes, 3 and 4, showcase rare examples of 3 distinctive chelates (i.e., neutral, anionic, and dianionic) assembled around the central Ir(III) cation. Hybrid d. functional theory (DFT; B3LYP) electronic structure calculations on 1-4 reveal the LUMO to be π*(bpy) in character for all complexes and HOMO offering d(Ir)-π(phenyl) character for 1, 2, and 4 and π(bipz) character for 3. The different HOMO composition of 3 and 4 is also predicted by calculations using pure DFT (BLYP) and wave function (MP2) methods. From time-dependent DFT calculations, the emissive processes are dominated by the Ph group-to-bipyridine, ligand(ppy)-to-ligand(bpy) charge transfer admixed with metal-to-ligand transition for all Ir(III) complexes. Organic light emitting diodes were successfully fabricated. A double emitting layer design was adopted in the device architecture using Ir(III) metal complexes 3 and 4, attaining peak external quantum efficiencies, luminance efficiencies, and power efficiencies of 18.1% (59.0 cd/A and 38.6 lm/W) and 16.6% (53.3 cd/A and 33.5 lm/W), resp. The experimental process involved the reaction of 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Recommanded Product: 20154-03-4)

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Recommanded Product: 20154-03-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 2016,Aitha, Anjaiah; Yennam, Satyanarayana; Behera, Manoranjan; Anireddy, Jaya Shree published 《Design and synthesis of diaziridinyl quinone thiadiazole hybrids via nitrile sulfide cycloaddition reaction as a key step》.Tetrahedron Letters published the findings.Quality Control of 3-(Trifluoromethyl)-1H-pyrazole The information in the text is summarized as follows:

A series of novel diaziridinyl quinone thiadiazole hybrids (I; R = N-heterocycle) were synthesized starting from 2-hydroxy-5-methoxybenzoic acid in a 7 step synthetic sequence. The key step in the scheme involves the nitrile sulfide cycloaddition reaction of oxathiazolone II with p-tosyl cyanide to obtain 1,2,4-thiadiazole derivative III. We have demonstrated that p-tosyl group of thiadiazole 5 can be displaced with various nitrogen heterocycles to generate unknown 3,5-disubstituted thiadiazole derivatives In the experiment, the researchers used 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Quality Control of 3-(Trifluoromethyl)-1H-pyrazole)

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Quality Control of 3-(Trifluoromethyl)-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 2017,Al Mousawi, Assi; Kermagoret, Anthony; Versace, Davy-Louis; Toufaily, Joumana; Hamieh, Tayssir; Graff, Bernadette; Dumur, Frederic; Gigmes, Didier; Fouassier, Jean Pierre; Lalevee, Jacques published 《Copper photoredox catalysts for polymerization upon near UV or visible light: structure/reactivity/efficiency relationships and use in LED projector 3D printing resins》.Polymer Chemistry published the findings.Recommanded Product: 3-(Trifluoromethyl)-1H-pyrazole The information in the text is summarized as follows:

Copper complexes (CuCs) bearing pyridine-pyrazole ligands are synthesized and evaluated as new photocatalysts/photoinitiators in combination with an iodonium salt (Iod) for the free radical polymerization of (meth)acrylates and the cationic polymerization of epoxides upon visible light exposure using Light Emitting Diode (LED)@405nm. The structure/reactivity/efficiency relationships for the copper complexes are studied as well as the chem. mechanisms involved. The different substituents on the pyrazole moiety of the ligand allow to tune the oxidation potential and the visible light absorbance of the complexes and to optimize the performance of the polymerization photocatalysts. The use of a novel additive (CARET) in a three-component system (CuC/Iod/CARET) highly improves the performance. Finally, the high performances of the Cu(I) complexes for the development of new 3D printing resins using LED projector are demonstrated. Currently, LED projector printing is really advantageous in 3D printing i.e. this technol. projects the profile of an entire layer at one time.3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Recommanded Product: 3-(Trifluoromethyl)-1H-pyrazole) was used in this study.

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Recommanded Product: 3-(Trifluoromethyl)-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The author of 《Rapid Identification of Novel Allosteric PRC2 Inhibitors》 were Read, Jon A.; Tart, Jonathan; Rawlins, Philip B.; Gregson, Clare; Jones, Karen; Gao, Ning; Zhu, Xiahui; Tomlinson, Ron; Code, Erin; Cheung, Tony; Chen, Huawei; Kawatkar, Sameer P.; Bloecher, Andy; Bagal, Sharan; O’Donovan, Daniel H.; Robinson, James. And the article was published in ACS Chemical Biology in 2019. Name: 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole The author mentioned the following in the article:

Enhancer of zeste homolog 2 (EZH2), the catalytic subunit of polycomb repressive complex 2 (PRC2), regulates chromatin state and gene expression by methylating histone H3 lysine 27. EZH2 is overexpressed or mutated in various hematol. malignancies and solid cancers. Our previous efforts to identify inhibitors of PRC2 methyltransferase activity by high-throughput screening (HTS) resulted in large numbers of false positives and thus a significant hit deconvolution challenge. More recently, others have reported compounds that bind to another PRC2 core subunit, EED, and allosterically inhibit EZH2 activity. This mechanism is particularly appealing as it appears to retain potency in cell lines that have acquired resistance to ortho steric EZH2 inhibition. By designing a fluorescence polarization probe based on the reported EED binding compounds, we were able to quickly and cleanly re-triage our previously challenging HTS hit list and identify novel allosteric PRC2 inhibitors. The experimental process involved the reaction of 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 847818-74-0Name: 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole)

1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 847818-74-0) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, monoamine oxidase inhibitory, anti-inflammatory, antipyretic, neuroleptic, anticonvulsant, antiarrhythmic, sedative, muscle relaxant, antidiabetic and antibacterial activities. Name: 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application In Synthesis of Methyl 1H-pyrazole-3-carboxylateIn 2002 ,《Product class 1: pyrazoles》 appeared in Science of Synthesis. The author of the article were Stanovnik, B.; Svete, J.. The article conveys some information:

A review. Methods for preparing pyrazoles are reviewed including cyclization, ring transformation, aromatization and substituent modifications. The results came from multiple reactions, including the reaction of Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Application In Synthesis of Methyl 1H-pyrazole-3-carboxylate)

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Application In Synthesis of Methyl 1H-pyrazole-3-carboxylate

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Related Products of 15366-34-4In 2005 ,《A Theoretical Study on the Tautomerism of C-Carboxylic and Methoxycarbonyl Substituted Azoles》 was published in Structural Chemistry. The article was written by Alkorta, Ibon; Elguero, Jose. The article contains the following contents:

DFT calculations (B3LYP/6-31+G**) have been carried out on 106 tautomers and conformers of NH-azoles bearing CO2H and CO2CH3 groups. The following azoles systems have been studied: 2-substituted pyrroles, 2-substituted indoles, 2-substituted imidazoles, 2-substituted benzimidazoles, 4(5)-substituted imidazoles, 3(5)-substituted pyrazoles, 3-substituted indazoles (1H and 2H), 3,4(5)-substituted-1,2,3(5)-triazoles, 2,3(5)-substituted-1,2(3),4-triazoles, 4(5)-1,2,3,4(5)-tetrazoles. In the case of pyrazole, 3,5-disubstituted derivatives have also been computed, including four dimers. The results came from multiple reactions, including the reaction of Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Related Products of 15366-34-4)

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Related Products of 15366-34-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Kublicki, Marcin; Ogonowski, Blazej; Wieczorkowski, Dariusz; Durka, Krzysztof; Klis, Tomasz published an article in Tetrahedron Letters. The title of the article was 《1,4-Phenylenebis((1-methyl-1H-pyrazol-5-yl)borinic 8-oxyquinolinate) as a photoredox catalyst in the atom transfer radical addition of iodoperfluoroalkanes to alkenyl groups bearing organoboron compounds》.Reference of 1-Methylpyrazole The author mentioned the following in the article:

The key photocatalytic properties of a transition-metal-free heteroleptic complex I (1) derived from 1,4-phenyldiboronic acid were evaluated. This compound was utilized in the atom transfer radical addition of iodoperfluoroalkanes CnF2n+1I (n = 1-4) to a series of allylic arylboronate compounds CH2:CHCH2XAr[B] [X = bond, O, CH2; Ar = phenylene, thiophenediyl; [B] = B(OH)2, BF3K] to give C-I activation products, [B]ArXCH2CHICH2CnF2n+1 (2-14). The products of these reactions retained the B-C bond, and Suzuki-Miyaura coupling of one product gave biphenyl derivatives The X-ray anal. of one of the obtained perfluoroalkylated boronic acids revealed the presence of open star-shaped channels. In the experiment, the researchers used many compounds, for example, 1-Methylpyrazole(cas: 930-36-9Reference of 1-Methylpyrazole)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Reference of 1-Methylpyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 2013,Chen, Xu-Lin; Yu, Rongmin; Zhang, Qi-Kai; Zhou, Liu-Jiang; Wu, Xiao-Yuan; Zhang, Qing; Lu, Can-Zhong published 《Rational Design of Strongly Blue-Emitting Cuprous Complexes with Thermally Activated Delayed Fluorescence and Application in Solution-Processed OLEDs》.Chemistry of Materials published the findings.Recommanded Product: 20154-03-4 The information in the text is summarized as follows:

Strongly greenish-blue to blue emitting Cu-(NN)(POP)+ (POP = bis[2-(diphenylphosphino)phenyl] ether) complexes containing N-linked 2-pyridylpyrazolate diimine ligands [Cu(pypz)(POP)]BF4 (1), [Cu(pympz)(POP)]BF4 (2), and [Cu(pytfmpz)(POP)]BF4 (3) (pypz = 1-(2-pyridyl)pyrazole, pympz = 3-Me-1-(2-pyridyl)pyrazole, and pytfmpz = 3-trifluoromethyl-1-(2-pyridyl)pyrazole) were designed and synthesized. Their structural, electrochem., and photophys. properties were characterized. The complexes 1-3 exhibit high luminescence quantum yields (PLQYs) at room temperature both in N-saturated CH2Cl2 (≤45%) and in neat solid (≤87%), which are comparable to the reported highest values for the cuprous complexes. The temperature dependence of spectroscopic properties and emission decay behaviors reveal 2 thermally equilibrated emitting states. At temperatures <150 K, the lowest triplet state (T1) is the predominant emitting state resulting in the typical phosphorescence with the emission decay times in the order of hundreds of μs. At ambient temperature, the lowest singlet state (S1), which lies only ∼0.17-0.18 eV above the T1 state, is populated thermally and in turn generates efficient thermally activated delayed fluorescence (TADF), and the emission decay times are reduced dramatically to, e.g., 12.2 μs for 2. Solution-processed OLEDs containing 1-3 in the emissive layer demonstrated excellent device performances by taking advantage of the singlet harvesting mechanism, among which the electroluminescent device using 3 shows a peak external quantum efficiency (EQE) of 8.47%, a peak current efficiency (CE) of 23.68 cd/A, and a maximum brightness of 2033 cd/m2. Crystallog. data are given. The experimental process involved the reaction of 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Recommanded Product: 20154-03-4)

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Recommanded Product: 20154-03-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics