Month: April 2022

Name: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate, is researched, Molecular C18H14N2Na2O8S2, CAS is 25956-17-6, about Quick monitoring of coloring agents in highly consumed candies using multivariate calibration. Author is Abdelghani, Jafar I.; Al-Degs, Yahya S.; El-Sheikh, Amjad H.; Fasfous, Ismail I.; Al-Asafrah, Ammar A..

Multivariate calibration are gaining popularity in assaying food matrixes. Partial least squares is a powerful multivariate calibration method that used to build a quant. relationship between measured variables and a property of interest (i.e., concentration) of the system under study. Partial least squares PLS calibration along with UV/vis spectral data was efficient to account for indirect food matrix and direct interference effects resulted from overlapping food dyes. PLS was able to quantify tartrazine TAT, allura red AR, sunset yellow SY and brilliant black BB that added to wide selection sugar-based candies. The results indicated that 70% of samples containing single dye while 8% containing TAT-SY mix and certain samples containing TAT + SY + AR + BB. Lollypops were found to contain high levels of AR (77-120 mg/kg) and TAT (56-166 mg/kg). The maximum adulteration was 50% observed in lollypops. PLS calibration was workable to predict colorants with prediction Errors of 7%. Using PLS, dyes were detected down to 0.1 mg/L with acceptable accuracy and precision. PLS showed comparable performance with liquid chromatog. for dyes quantification and can substitute laborious chromatog. for quick detection of coloring agents in candies.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Name: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate, is researched, Molecular C18H14N2Na2O8S2, CAS is 25956-17-6, about Biodegradability assessment of food additives using OECD 301F respirometric test. Author is Gatidou, Georgia; Vazaiou, Niki; Thomaidis, Nikolaos S.; Stasinakis, Athanasios S..

The ready biodegradability of twenty food additives, belonging to the classes of artificial sweeteners, natural sweeteners, preservatives and colorings, was investigated using activated sludge as inoculum and OECD 301F respirometric test. According to the results, saccharin, aspartame, sodium cyclamate, xylitol, erythritol, maltitol, potassium sorbate, benzoic acid and sodium ascorbate are characterized as readily biodegradable compounds, partial biodegradation (<60% during the test) was noticed for steviol, inulin, alitame, curcumin, ponceau 4R and tartrazine, while no biodegradation was observed for the other five compounds The duration of lag phase before the start of biodegradation varied between the target compounds, while their ultimate biodegradation half-life values ranged between 0.7 ± 0.1 days (benzoic acid) and 24.6 ± 1.0 days (curcumin). The expected removal of target compounds due to ultimate biodegradation mechanism was estimated for a biol. wastewater treatment system operated at a retention time of one day and percentages higher than 40% were calculated for sodium cyclamate, potassium sorbate and benzoic acid. Higher removal percentages are expected in full-scale Sewage Treatment Plants (STPs) due to the contribution of other mechanisms such as sorption to suspended solids, (bio)transformation and co-metabolic phenomena. Further biodegradation experiments should be conducted under different exptl. conditions for the food additives that did not fulfill the requirements of the applied protocol. Future studies should also focus on the occurrence and fate of food colorants and natural sweeteners in full-scale STPs. As far as I know, this compound(25956-17-6)Name: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Electric Literature of C9H9NO. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Study of the enantioselectivity of the CAL-B-catalyzed transesterification of α-substituted α-propylmethanols and α-substituted benzyl alcohols. Author is Garcia-Urdiales, Eduardo; Rebolledo, Francisca; Gotor, Vicente.

A study of the enantioselectivity exhibited by the lipase B from Candida antarctica in the transesterification of different α-substituted α-propylmethanols with vinyl acetate is shown. The best results are obtained when the large-sized (L) substituent of the alc. is either a Ph group or more especially a cyclohexyl group, although the reaction rates are lower than when linear or slightly branched groups are present. It is also found that ramification at the β-position of the L substituent has a deleterious effect on both lipase activity and enantioselectivity. Moreover, some α-substituted benzyl alcs. bearing medium-sized (M) substituents larger than an Et and smaller than a Pr group are resolved by means of this methodol. with moderate-good enantioselectivities (E = 46-57) and similar reaction rates.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Novel synthesis of p-benzoquinone ethylene acetal, published in 1975, which mentions a compound: 52287-51-1, Name is 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine, Molecular C8H7BrO2, Quality Control of 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine.

PhO(CH2)2OH (I) reacted with HgO-iodine reagent (II) in the dark to give 4-RC6H4O(CH2)2OH (III; R = I). Irradiation of III (R = I) in the presence of II gave 84% title compound (IV). In contrast, irradiation of I directly, in the presence of II, gave in addition to 34% IV, 31% III (R = I), 9-14% benzodioxins V (R = H, I), and 6% p-benzoquinone. NMR studies showed that III (R = Br, Cl) were stable to II in the dark but on irradiation gave 16% IV and 30-5% V (R = Br, Cl, resp.). The mechanism for the formation of IV involved formation of an alkoxyl radical followed by cyclization and halo-elimination.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3-Hydroxy-3-phenylpropanenitrile( cas:17190-29-3 ) is researched.COA of Formula: C9H9NO.Yang, Zhiheng; Cheng, Weiyan; Li, Zeyun published the article 《Iridium catalysed highly efficient transfer hydrogenation reduction of aldehydes and ketones in water》 about this compound( cas:17190-29-3 ) in Catalysis Communications. Keywords: alc preparation; aldehyde iridium catalyst transfer hydrogenation; ketone iridium catalyst transfer hydrogenation. Let’s learn more about this compound (cas:17190-29-3).

A new transfer hydrogenation of structurally diverse aldehydes and ketones in water using formic acid as hydride donor was developed, to get the corresponding alcs. The iridium complex of 4,4′,5,5′-tetrahydro-1H,1’H-2,2′-biimidazole, was used as an efficient catalyst. The S/C ratios in aldehyde and ketone reductions were as low as 20,000 and 10,000 resp. The TOF value in aldehyde reduction was as high as 60,000 h-1. A number of functional groups such as (hetero)aryl, alkenyl, halogen, phenolic and alc. hydroxyls, trifluromethyl, cyano, nitro, ester, carboxylic acid and acidic methylenes were well tolerated.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (1,10-Phenanthroline)(trifluoromethyl)copper(I)(SMILESS: F[C-](F)([Cu+]1[N]2=C3C4=[N]1C=CC=C4C=CC3=CC=C2)F,cas:1300746-79-5) is researched.HPLC of Formula: 17190-29-3. The article 《Radical Anions of Trifluoromethylated Perylene and Naphthalene Imide and Diimide Electron Acceptors》 in relation to this compound, is published in Organic Letters. Let’s take a look at the latest research on this compound (cas:1300746-79-5).

A series of electron-deficient perylene and naphthalene imides and diimides with varying degrees of trifluoromethylation were synthesized. Single crystal X-ray anal. afforded detailed structural information, while spectroelectrochem. and EPR spectroscopy provided characterization of the radical anions . This study reveals that trifluoromethylation of the imides and diimides makes their one-electron reduction potentials substantially more pos. relative to the unsubstituted counterparts, while their other properties remain largely unchanged.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

HPLC of Formula: 17190-29-3. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Glucosinolate turnover in Brassicales species to an oxazolidin-2-one, formed via the 2-thione and without formation of thioamide. Author is Agerbirk, Niels; Matthes, Annemarie; Erthmann, Pernille Oe.; Ugolini, Luisa; Cinti, Susanna; Lazaridi, Eleni; Nuzillard, Jean-Marc; Muller, Caroline; Bak, Soeren; Rollin, Patrick; Lazzeri, Luca.

Glucosinolates are found in plants of the order Brassicales and hydrolyzed to different breakdown products, particularly after tissue damage. In Barbarea vulgaris R.Br. (Brassicaceae), the dominant glucosinolate in the investigated “”G-type”” is glucobarbarin [(S)-2-hydroxy-2-phenylethylglucosinolate]. The formation of the nitrile from glucobarbarin was observed in vitro, while a previously suggested thioamide (synonym thionamide) was not confirmed. Resedine (5-phenyl-1,3-oxazolidin-2-one) was detected after glucobarbarin hydrolysis in crushed B. vulgaris leaves and siliques, but not in intact parts. The abundance increased for several hours after completion of hydrolysis. The corresponding 1,3-oxazolidine-2-thione (OAT), with the common name barbarin, was also formed, and appeared to be the precursor of resedine. The addition of each of 2 non-endogenous OATs, (S)-5-ethyl-5-methylOAT and (R)-5-vinylOAT (R-goitrin), to a leaf homogenate resulted in formation of the corresponding 1,3-oxazolidin-2-ones (OAOs), confirming the metabolic connection of OAT to OAO. The formation of OAOs was inhibited by prior brief heating of the homogenate, suggesting enzymic involvement. We suggest the conversion of OATs to OAOs to be catalyzed by an enzyme (“”oxazolidinethionase””) responsible for turnover of OAT formed in intact plants. Resedine had been reported as an alkaloid from another species, Reseda luteola L. (Resedaceae), which naturally contains glucobarbarin. However, resedine was not detected in intact R. luteola plants, but formed after tissue damage. The formation of resedine in 2 families suggests a broad distribution of putative OATases in the Brassicales; potentially involved in glucosinolate turnover that needs myrosinase activity as the committed step. In agreement with the proposed function of OATase, several candidate genes for myrosinases in glucosinolate turnover in intact plants were discovered in the B. vulgaris genome. We also suggest that biotechnol. conversion of OATs to OAOs might improve the nutritional value of Brassicales protein. HPLC-MS/MS methods for detection of these glucobarbarin products are described.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Electron Donor-Acceptor Complex-Initiated Photochemical Cyanation for the Preparation of α-Amino Nitriles, published in 2020-12-18, which mentions a compound: 52287-51-1, Name is 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine, Molecular C8H7BrO2, Product Details of 52287-51-1.

An electron donor-acceptor complex-initiated α-cyanation of tertiary amines has been described. The reaction protocol provides a novel method to synthesize various α-amino nitriles under mild conditions. The reaction can proceed smoothly without the presence of photocatalysts and transition metal catalysts, and either oxidants are unnecessary or O2 is the only oxidant. The practicality of this method is showcased not only by the late-stage functionalization of natural alkaloid derivatives and pharmaceutical intermediate, but also by the applicability of a stop-flow microtubing reactor.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Hull, R.; Lovell, B. J.; Openshaw, H. T.; Todd, A. R. published the article 《Synthetic antimalarials. XI. Effect of variation of substituents in derivatives of mono- and dialkylpyrimidines》. Keywords: MALARIA/therapy; PYRIMIDINES.They researched the compound: 2-Amino-4,6-dichloro-5-methylpyrimidine( cas:7153-13-1 ).Synthetic Route of C5H5Cl2N3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:7153-13-1) here.

cf. C.A. 41, 134b. Following the discovery that certain 2-amino-4-dialkylaminoalkylamino-5, 6-dialkylpyrimidines (C.A. 40, 5057.4) have marked antimalarial activity, a more extended investigation has been made of the effects of variation of substituents in compounds of this type; several other series of simple mono- and dimethylpyrimidine derivatives have been synthesized. 2-Amino-4-hydroxy-5-methylpyrimidine (m. 277-9°; preparation in 17% yield given) (5 g.) and 30 cc. POCl3, refluxed 45 min., give 68% 4-chloro-2-amino-5-methylpyrimidine, m. 184-5°; 4-(2-diethylaminoethylamino) analog, straw color, b. 170° (bath temperature)/3 × 10-4 mm. (dipicrate, yellow, m. 195-6°); 4-(3-diethylaminopropylamino) analog m. 70-1°. HCO2Et and PhOCH2CO2Et with Na in absolute Et2O, followed by guanidine, give 55% 2-amino-4-hydroxy-5-phenoxypyrimidine (I), m. 255-6°; 5 g. with POCl3 (refluxed 15 min.) gives 4.4 g. of the 4-Cl analog, m. 157.5°. I (3 g.), 1.53 cc. Ac2O, and 15 cc. anhydrous C5H5N, refluxed 2 h., give 2.05 g. of a compound, C24H20O5N6, m. 239-40°; with POCl3, 13.3 g. gives 13.5 g. 4-chloro-2-acetamido-5-phenoxypyrimidine (II), m. 163°. II (1.5 g.) and Et2N(CH2)2NH2, refluxed 5 h. and the product refluxed with 30 cc. 10% HCl 6 h., give 89% 2-amino-4-(2-diethylaminoethylamino)-5-phenoxypyrimidine, m. 114-15°; 4-(3-diethylaminopropylamino) homolog, m. 130.5-1°, 98%. Dropwise addition of 17 cc. Br to 40 g. 2-amino-4-hydroxy-6-methylpyrimidine in 350 cc. AcOH during 30 min. gives the 5-Br derivative, m. 250° (decomposition); POCl3 gives 79% 4-chloro-5-bromo-2-amino-6-methylpyrimidine, m. 206-7°; 4-(2-diethylaminoethylamino) analog, yellow viscous oil, b. 200°/10-2 mm. (bath temperature), 80%; 4-(3-diethylaminopropylamino) analog m. 105.5-7°, 91.5%. 4-Chloro-2,6-diaminopyrimidine (III) (preparation in 84% yield given) (5.78 g.) and 4.45 g Et2N(CH2)2NH2 in 13 cc. dry C5H5N, refluxed 16 h., give 62% 2,6-diamino-4-(2-diethylaminoethylamino)pyrimidine, b. 270°/10-3 (bath temperature) (dipicrate, m. 204-6°); the 4-(3-diethylaminopropylamino) homolog b. 250°/10-3 (dipicrate, m. 202.-3°). III (6.5 g.) and 20.8 g. Et2N(CH2) 2NH2, refluxed 6 h., give 9.25 g. (crude) 2-amino-4,6-bis(2-diethylaminoethylamino) pyrimidine, m. 58-60° (picrate m. 177.5-8.5°); this results also from 4-chloro-2-amino-6-(2-diethylaminoethylamino)pyrimidine and Et2N(CH2)2NH2 on heating 6 h. at 150°; 4,6-bis(3-diethylaminopropylamino) homolog b. 270°/4 × 10-4 mm. (bath temperature). 4-Chloro-2,6-diamino-5-methylpyrimidine gives 88% of the 4-(2-diethylaminoethylamino) analog, m. 102°, and 81% of the 4-(3-diethylaminopropylamino) analog, yellow, b. 250-70°/10-2 mm. (bath temperature) [bis-(3,5-dinitrobenzoate), m. 213°], which forms a hygroscopic, waxy solid. 4,6-Dichloro-2-amino-5-methylpyrimidine (9.0 g.) and 5.8 g. Et2N(CH2) 2NH2 in 25 cc. C5H5N, refluxed 15 h., give 55% 4-chloro-2-amino-6-(2-diethylaminoethylamino)-5-methylpyrimidine, m. 99-101°; 6-(3-diethylaminopropylamino) homolog, m. 121-2°, results in 76% yield on heating the components in AcOH 4 h. at 110° and 2 h. at 130°. 4-Hydroxy-2-methylmercapto-5,6-dimethylpyrimidine (IV) and POCl3, warmed 5 min. on the steam bath, give 92% of the 4-Cl analog, m. 35-6°; an excess saturated anhydrous EtOH-NH3 6 h. at 115-25° gives 50% 4-amino-2-methylmercapto-5,6-dimethylpyrimidine (V), m. 158-9.5°. V (5.6 g.) and 8.6 g. Et2N (CH2)3NH2, heated 22 h. at 200-10°, give (after repeated distillation) 39% 4-amino-2-(3-diethylaminopropylamino)-5,6-dimethylpyrimidine, a viscous oil [bis-(3,5-dinitrobenzoate), pale yellow, m. 210-12°]. IV (5.7 g.) and 4.3 g. Et2N(CH2)2NH2, heated 3 h. at 160-70°, give 98% 2-(2-diethylaminoethylamino)-4-hydroxy-5,6-dimethylpyrimidine, m. 86.5-8°; POCl3 gives 81% of the 4-Cl analog, m. 46.5-7.5°, sublimes 90°/10-4 mm., which with saturated EtOH-NH3 (3 h. at 180-90°) yields 49% 4-amino-2-(2-diethylaminoethylamino)-5,6-dimethylpyrimidine, m. 130-1.5°; this results also from 0.85 g. V and 2.3 g. Et2N(CH2)2NH2 on heating 22 h. at 190-200°. 2-(3-Dibutylaminopropylamino)-4-hydroxy-5,6-dimethylpyrimidine was a pale yellow oil, b. 260-80°/2 × 10-4 mm. (bath temperature), which slowly solidified (96%) (dipicrate, m. 199-202°); POCl3 gives the 4-Cl analog, b. 185-90°/4 × 10-3 mm. (bath temperature) (dipicrate, bright yellow, m. 167.5-8.5°); EtOH-NH3 (4 h. at 200°) gives 74% of the 4-NH2 analog, yellow oil, b. 210-20°/2 × 10-3 mm. (bath temperature) (dipicrate, yellow, m. 167-9°). 2-(3-Dimethylaminopropylamino)-4-hydroxy-5,6-dimethylpyrimidine m. 113.5-15°; 4-Cl analog m. 36-8°, 55%; 4-NH2 analog, yellow, b. 180-90°/2 × 10-3, 28% (tartrate, m. 168-71°). The following 2-substituted 4-amino-6-methylpyrimidines were prepared from the appropriate 4-Cl derivatives (C.A. 40, 5060.6): 3-dimethylaminopropylamino (VI) as the bis(3,5-dinitrobenzoate), m. 223-5°; 2-diethylaminoethylamino, m. 98-100°; 3-diethylaminopropylamino as the bis(3,5-dinitrobenzoate), m. 218-20°; 3-dibutylaminopropylamino as the bis(3,5-dinitrobenzoate), m. 200-2°. 4-Chloro-2-methylmercapto-6-methylpyrimidine and concentrated EtOH-NH3, 5.5 h. at 125-35°, give 74% 4-amino-2-methylmercapto-6-methylpyrimidine, m. 133.5-5°; with Me2N(CH2)3NH2 (14 h. at 160-70°) this yields 93% VI. 4-Substituted 6-amino-2,5-dimethylpyrimidines: 2-diethylaminoethylamino, m. 82-2.5°; 3-dimethylaminopropylamino, m. 89-91° [bis(3,5-dinitrobenzoate) , m. 207.5-9°]; 3-diethylaminopropylamino, m. 99.5°. 4-Substituted 6-amino-5-methylpyrimidines: 2-diethylaminoethylamino, m. 95.5-6.5°; 3-diethylaminopropylamino, m. 93-4°. HC(:NH)NH2.HCl (42 g.) and 91 g. MeCH(CO2Et)2, added successively to 24.5 g. Na in 360 cc. EtOH at 20-5°, kept overnight at room temperature, and boiled 1 h., give 61% 4,6-dihydroxy-5-methylpyrimidine, decompose 320°; refluxed with POCl3 40 min., there results 66% 4,6-dichloro-5-methylpyrimidine, m. 56.5-7.5°; with EtOH-NH3 at 140° (3 h.) this yields 4-chloro-6-amino-5-methylpyrimidine, m. 237-8°. 5-Amino-4-hydroxy-2,6-dimethylpyrimidine (VII) (13.5 g.) in 75 cc. 98% HCO2H, refluxed 15 min., gives 92% 5-formamido-4-hydroxy-2,6-dimethylpyrimidine (VIII), m. 238-9° (decomposition); 9 g. VIII, added to 75 cc. ice-cold POCl3 and followed (below 50°) with 20 cc. PhNMe2 (3-4 cc. portions), gives 45% of the 4-Cl analog, m. 158-9.5°; ice-cold concentrated HCl gives 85% 4-chloro-5-amino-2,6-dimethylpyrimidine, m. 79-80°; 4-(3-diethylaminopropylamino) analog m. 68-70°, 78%; 4-(2-diethylaminoethylamino) analog m. 95-6°, 64%; 4-(3-dibutylaminopropylamino) analog, pale yellow oil, b. 230-40°/0.25 mm. (bath temperature). VII (6.2 g.) in 220 cc. Ac2O, heated on the steam bath 30 min., gives 88% of the 5-acetamido derivative, m. 275° (decomposition); POCl3 gives 54% 4-chloro-5-acetamido-2,6-dimethylpyrimidine, m. 141-2°; 4-(3-diethylaminopropylamino) analog (IX), pale yellow oil, b. 150-60°/10-4 (bath temperature) (flavianate-1H2O, bright yellow, m. 160°). IX (5.5 g.) in 30 cc. 30% H2SO4, heated 2 h. on the steam bath, gives 9-(3-diethylaminopropyl)-2,6,8-trimethylpurine, pale yellow, b. 140-50°/10-4 mm. (bath temperature) (dipicrate, pale yellow, m. 187-8°); the 2-diethylaminoethyl homolog, pale yellow, b. 130-5°/2 × 10-3 mm. (bath temperature) (flavianate, bright yellow, m. 248° (decomposition)); 3-diethylamino-1-methylbutyl analog b. 150-5°/10-4 mm. (bath temperature) (a crystalline derivative could not be prepared). Guanidine and PhN2CHAc2 in EtOH, kept 20 days at room temperature, give 58.5% 2-amino-5-phenylazo-4,6-dimethylpyrimidine (X), bright orange, m. 228-30°; reduction in absolute EtOH over Pd-BaSO4 at 90° and 75 atm. gives 100% 2,5-diamino-4,6-dimethylpyrimidine (XI), m. 183.5-4.5°. XI (8 g.) and 19.6 g. Et2N(CH2)2Cl in 40 cc. anhydrous C5H5N, refluxed 7 h., give 26% 2-amino-5-(2-diethylaminoethylamino)-4,6-dimethylpyrimidine, m. 95-6.5°; dipicrate, yellow, m. 187-9° (decomposition). X (1.1 g.) and 0.6 g. NaNH2 in 10 cc. PhMe, refluxed 10 h., treated with 8.8 g. Et2N(CH2)2Cl, and the refluxing continued 18 h. (160-70°), give 58% 2-(2-diethylaminoethylamino)-5-phenylazo-4,6-dimethylpyrimidine, red, m. 87-8°; catalytic reduction in EtOH over Pt oxide at room temperature and atm. pressure give 60% 5-amino-2-(2-diethylaminoethylamino)-4,6-dimethylpyrimidine, yellow oil, b. 160°/2 × 10-3 mm. (bath temperature) (dipicrate, bright yellow, m. 185-6°). H2NC(SMe):NH.HI (33 g.) and 18 g. Et2N(CH2)2NH2 in 150 cc. EtOH, refluxed 2 h., give 50% 2-diethylamino-ethylguanidine-2HI, m. 140-2°. 4-Amino-6-(3-diethylaminopropylamino)-2,5-dimethylpyrimidine is the most active of the simple pyrimidines prepared, appreciable activity being observed at a dose of 20 mg./kg. Data are given for the other compounds described above. No generalizations can be made about structure and antimalarial activity, but the most active compounds have structures which are compatible with the hypothetical mode of action advanced in Part III (C.A. 40, 5057.4). It is clearly impossible to argue the validity of any concept of action based on interference with the synthesis or functioning of enzyme components in the absence of extensive biol. investigations, but there would seem to be some justification for its retention as a basis for future work.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

HPLC of Formula: 25956-17-6. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate, is researched, Molecular C18H14N2Na2O8S2, CAS is 25956-17-6, about Performance evaluation of photolytic and electrochemical oxidation processes for enhanced degradation of food dyes laden wastewater. Author is Sartaj, Seema; Ali, Nisar; Khan, Adnan; Malik, Sumeet; Bilal, Muhammad; Khan, Menhad; Ali, Nauman; Hussain, Sajjad; Khan, Hammad; Khan, Sabir.

Wastewater containing dyes is considered as the top-priority pollutant when discharged into the environment. Herein, we report for the applicability of 254 nm UV light and electrochem. process using a titanium ruthenium oxide anode for the degradation of Allura red and erythrosine dyes. During the photolytic process, 95% of Allura red dye (50 ppm) was removed after 1 h at pH 12 and 35°C, whereas 90% color removal of erythrosine dye (50 ppm) was achieved after 6 h of treatment at pH 6.0 and 30°C. On the other hand, 99.60% of Allura red dye (200 ppm) was removed within 5 min by the electrochem. process applying a c.d. (5 mA cm-2) at pH 5.0 and 0.1 mol L-1 sodium chloride (NaCl) electrolytic medium. Similarly, 99.61% of erythrosine dye (50 ppm) degradation was achieved after 10 min at a c.d. of 8 mA cm-2, pH 6.0, and 0.1 mol L-1 of NaCl electrolyte. The min. energy consumption value for Allura red and erythrosine dyes (0.196 and 0.941 kWh m-3, resp.) was calculated at optimum current densities of 5 and 8 mA cm-2. The results demonstrated that the electrochem. process is more efficient at removing dyes in a shorter time than the photolytic process since it generates powerful oxidants like the chlorine mol., hypochlorous acid, and hypochlorite on the surface of the anode and initiates a chain reaction to oxidize the dyes mols.

As far as I know, this compound(25956-17-6)HPLC of Formula: 25956-17-6 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics