February 2022 | Page 2 of 2 | pyrazoles-derivatives

What I Wish Everyone Knew About 3-Methyl-1-p-tolyl-5-pyrazolone

Welcome to talk about 86-92-0, If you have any questions, you can contact Shaikh, I; Jadeja, RN; Patel, R or send Email.. Name: 3-Methyl-1-p-tolyl-5-pyrazolone

Authors Shaikh, I; Jadeja, RN; Patel, R in PERGAMON-ELSEVIER SCIENCE LTD published article about DNA-BINDING; PLASMODIUM-FALCIPARUM; COPPER(II) COMPLEXES; CU(II) COMPLEXES; DERIVATIVES; ANTICANCER; BINARY in [Shaikh, Irfan; Jadeja, R. N.] Maharaja Sayajirao Univ Baroda, Fac Sci, Dept Chem, Vadodara 390002, India; [Patel, Rajesh] Veer Narmad South Gujarat Univ, Dept Biosci, Surat 395007, India in 2020, Cited 33. Name: 3-Methyl-1-p-tolyl-5-pyrazolone. The Name is 3-Methyl-1-p-tolyl-5-pyrazolone. Through research, I have a further understanding and discovery of 86-92-0

Three novel mixed ligand Zn(II) complexes {complex 1 = [Zn(L1)(2)(bpy)], complex 2 = [Zn(L2)(2)(bPY)], complex 3 = [Zn(L2)(2)(phen)], where bpy = 2,2′-bipyridine and phen = 1,10-phenanthroline} of 4-(4-chlorobenzoyl)-2-(3-chlorophenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one (HL1) and 4-(4-chlorobenzoyl)-5-methyl-2-(p-tolyl)-2,4-dihydro-3H-pyrazol-3-one (HL2) were synthesized and characterized by H-1 and C-13 NMR, FTIR, TG-DTA, UV-Vis, elemental analysis, molar conductance and single crystal X-ray structure determination. Based on analytical and spectroscopic techniques, all the three Zn(II) complexes were found to have a distorted octahedral geometry. The ligands and the complexes were screened for antimalarial activity against plasmodium falciparum. The zinc(II) complexes showed greater antimalarial activity than their parent ligands. (C) 2020 Elsevier Ltd. All rights reserved.

Welcome to talk about 86-92-0, If you have any questions, you can contact Shaikh, I; Jadeja, RN; Patel, R or send Email.. Name: 3-Methyl-1-p-tolyl-5-pyrazolone

Reference:
Article; Zhang, Yong; Nie, Long-Jun; Luo, Liang; Mao, Jia-Xin; Liu, Jin-Xiang; Xu, Guo-Hai; Chen, Deliang; Luo, Hai-Qing; Tetrahedron; vol. 76; 7; (2020);,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Archives for Chemistry Experiments of 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid

Application In Synthesis of 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid. About 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid, If you have any questions, you can contact Milne, IA; Graham, JMR or concate me.

Application In Synthesis of 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid. Authors Milne, IA; Graham, JMR in CAMBRIDGE UNIV PRESS published article about in [Milne, I. A.] Univ Western Australia, Oceans Grad Sch, Crawley 6009, Australia; [Graham, J. M. R.] Imperial Coll London, Dept Aeronaut, London SW7 2AZ, England in 2019, Cited 13. The Name is 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid. Through research, I have a further understanding and discovery of 83-10-3

The changes in spectra and intensities of the streamwise component of turbulent velocity are calculated in the inflow of a turbine rotor. The flow is initially calculated in the limit when the turbulence is of small scale compared with the rotor diameter. Rapid distortion theory (RDT), Batchelor & Proudman (Q. J. Mech. Appl. Maths, vol. 7 (1), 1954, pp. 83-103) (BP), for small-scale turbulence is combined with the effect of the fluctuating potential flow field on the turbulence caused by the direct interaction of the incident turbulence with the rotor as a sheet of resistance. A second computation is then carried out for turbulence of larger length scale. The results of the calculations are compared with velocity measurements in the inflow of both a commercial wind turbine and a tidal turbine rotor.

Reference:
Patent; Shanghai Pharmaceutical Industry Institute; China Pharmaceutical Industry Zongyuan; Li Jianqi; Huang Daowei; Wang Wenya; Zhang Zhiguo; Jiang Ling; (45 pag.)CN107286140; (2017); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Interesting scientific research on 83-10-3

Welcome to talk about 83-10-3, If you have any questions, you can contact Novakova-Jiresova, A; Kopeckova, K; Boublikova, L; Chloupkov, R; Melichar, B; Petruzelka, L; Finek, J; Fiala, O; Grell, P; Batko, S; Linke, Z; Kiss, I; Prausov, J; Buchler, T or send Email.. Category: pyrazoles-derivatives

An article Regorafenib for Metastatic Colorectal Cancer: An Analysis of a Registry-Based Cohort of 555 Patients WOS:000548281000003 published article about CLINICAL-PRACTICE; SURVIVAL; MULTICENTER; ANTITUMOR; SAFETY; SITE; SEX in [Novakova-Jiresova, Alena; Boublikova, Ludmila; Buchler, Tomas] Charles Univ Prague, Fac Med 1, Dept Oncol, Videnska 800, Prague 14059, Czech Republic; [Novakova-Jiresova, Alena; Boublikova, Ludmila; Buchler, Tomas] Charles Univ Prague, Thomayer Hosp, Videnska 800, Prague 14059, Czech Republic; [Kopeckova, Katerina; Batko, Stanislav; Linke, Zdenek; Prausov, Jana] Charles Univ Prague, Univ Hosp Motol, Dept Oncol, Prague, Czech Republic; [Chloupkov, Renata] Masaryk Univ, Fac Med, Inst Biostat & Anal, Brno, Czech Republic; [Melichar, Bohuslav] Palacky Univ Med, Dept Oncol, Olomouc, Czech Republic; [Melichar, Bohuslav] Teaching Hosp, Olomouc, Czech Republic; [Petruzelka, Lubos] Charles Univ Prague, Gen Fac Hosp, Dept Oncol, Prague, Czech Republic; [Finek, Jindrich; Fiala, Ondrej] Charles Univ Prague, Med Sch, Dept Oncol & Radiotherapy, Plzen, Czech Republic; [Finek, Jindrich; Fiala, Ondrej] Charles Univ Prague, Univ Hosp Pilsen, Plzen, Czech Republic; [Fiala, Ondrej] Charles Univ Prague, Fac Med Pilsen, Biomed Ctr, Plzen, Czech Republic; [Grell, Peter; Kiss, Igor] Masaryk Mem Canc Inst, Dept Comprehens Canc Care, Brno, Czech Republic in 2020, Cited 30. The Name is 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid. Through research, I have a further understanding and discovery of 83-10-3. Category: pyrazoles-derivatives

Purpose: Regorafenib is an oral multikinase inhibitor approved for the therapy of previously treated metastatic colorectal carcinoma (mCRC). The aim of the present study was to analyze the outcomes of treatment with regorafenib in real-world clinical practice based on data from a national registry. Methods: The CORECT registry, the Czech non-interventional database of patients with mCRC treated with targeted agents, searched for patients with metastatic CRC treated with regorafenib. In total, 555 evaluable patients were identified. Results: The median age at diagnosis was 61.7 years. All patients had disease progression on or after previous systemic treatment. Most patients were treated with an initial dose of 160 mg daily (n = 463; 83.6%). The median duration of treatment was 2.7 months (range 0.023.4 months). By the data cut-off date, 472 patients (85%) had completed treatment with regorafenib and were evaluable for treatment response evaluation. Partial response was reported in 13 patients (2.8%) and disease stabilization in 130 patients (27.5%). Median progression-free survival (PFS) and overall survival (OS) were 3.5 months (95% confidence interval [CI] 3.2-3.7 months) and 9.3 months (95% CI 8.3-10.3 months), respectively. The 6-month OS rate was 67.7% (95% CI 63.4-72.1%). Multivariable analysis showed that female gender, longer interval from diagnosis of metastatic disease, MO stage at diagnosis, and Eastern Cooperative Oncology Group performance status (ECOG PS) 0 were associated with longer PFS, while higher body-mass index (BMI), longer interval from diagnosis of metastatic disease, and ECOG PS of 0 were associated with longer OS. Conclusion: OS of patients treated with regorafenib in the real-world clinical practice in this cohort exceeded that reported in randomized trials. Regorafenib is a safe and active treatment option for a subgroup of patients with mCRC who are progressing after other systemic therapies and maintain good performance status.

What I Wish Everyone Knew About 3,5-Dimethyl-1H-pyrazole

Name: 3,5-Dimethyl-1H-pyrazole. Bye, fridends, I hope you can learn more about C5H8N2, If you have any questions, you can browse other blog as well. See you lster.

Khan, E; Khalid, M; Gul, Z; Shahzad, A; Tahir, MN; Asif, HM; Asim, S; Braga, AAC in [Khan, Ezzat; Gul, Zarif] Univ Malakand, Dept Chem, Lower Dir 18800, Khyber Pakhtunk, Pakistan; [Shahzad, Adnan] Univ Swat, Inst Chem Sci, Khyber Pakhtunkhwa, Pakistan; [Tahir, Muhammad Nawaz] Univ Sargodha, Dept Phys, Punjab 40100, Pakistan; [Khalid, Muhammad; Asif, Hafiz Muhammad; Asim, Sumreen] Khwaja Farid Univ Engn & Informat Technol, Dept Chem, Rahim Yar Khan 64200, Pakistan; [Carmo Braga, Ataualpa Albert] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, Ave Prof Lineu Prestes 748, BR-05508000 Sao Paulo, Brazil published Molecular structure of 1,4-bis(substituted-carbonyl)benzene: A combined experimental and theoretical approach in 2020.0, Cited 68.0. Name: 3,5-Dimethyl-1H-pyrazole. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6.

The reaction of pyrazole derivatives ( pyrazole (Pz), 3-methylpyrazole (MPz) and 3,5-dimethylpyrazole (DMPz)) with terephthaloyl dichloride (TD) in the presence of Et3N afforded the desired products, 1,4-bis(pyrazolylcarbonyl)benzene (1), 1,4-bis(3-methylpyrazolylcarbonyl)benzene (2) and 1,4-bis(3,5-dimethylpyrazolylcarbonyl)benzene (3). Good quality crystals were isolated and diffraction data for single crystal were collected which revealed that compounds 1-3 are monoclinic with space group P21/n, C2/c and P21/c, respectively. These compounds were obtained as a result of C-N coupling reaction between the acid chloride and pyrazol derivatives with the intent to explore their structure in solution as well as solid state. Density function theory (DFT) calculations using B3LYP and CAM-B3LYP functionals with 6-311G(d,p) basis set were performed to explore geometric and electronic properties of compounds. The Root Mean Square Error (RMSE) has also been calculated for the values of geometric parameters, indicating a good agreement with experimental findings. Moreover, frontier molecular orbitals (FMOs) and natural bond orbitals (NBOs) analyses were carried out through B3LYP/6-311G(d,p) level of theory. The linear polarizability (alpha) values of nonlinear optical (NLO) analysis were calculated with the same level of theory and basis set as FMO but under different solvent conditions. Time Dependent Density Functional Theory (TD-DFT) study of these pyrazole substituted derivatives was performed aiming to investigate UV-Visible behavior. The stability of molecule has been additionally analyzed by Hirshfeld surface analysis in addition to NBO analysis. The calculated HOMO and LUMO energies from FMO assisted in calculating global reactivity parameters (Chemical hardness, chemical softness, electronegativity, EA, IP and electrophilicity). Natural population analysis (NPA) and Molecular electrostatic potential (MEP) were also performed to obtain insights about the reactivity of compounds 1-3. Theoretical calculations indicate that these compounds have considerable low reactivity and can be used for development of coordination chemistry under optimum conditions. (c) 2019 Elsevier B.V. All rights reserved.

Name: 3,5-Dimethyl-1H-pyrazole. Bye, fridends, I hope you can learn more about C5H8N2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Why Are Children Getting Addicted To C12H12N2O3

Formula: C12H12N2O3. Bye, fridends, I hope you can learn more about C12H12N2O3, If you have any questions, you can browse other blog as well. See you lster.

Formula: C12H12N2O3. Authors Fan, LL; Zhang, YY; Tarin, MWK; He, TY; Rong, JD; Zheng, YS in TAYLOR & FRANCIS LTD published article about in [Fan, Lili; Zhang, Yangyang; Rong, Jundong; Zheng, Yushan] Fujian Agr & Forestry Univ, Coll Forestry, Fuzhou, Peoples R China; [Tarin, Muhammad Waqqas Khan; He, Tianyou; Zheng, Yushan] Fujian Agr & Forestry Univ, Coll Landscape, Fuzhou, Peoples R China in 2020, Cited 7. The Name is 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid. Through research, I have a further understanding and discovery of 83-10-3

Ampelocalamus scandens is native to Guizhou Province, China, and grows at an altitude of 260-320 m. It can be used as a raw material for weaving and papermaking. In the current study, the complete chloroplast (cp) genome of A. scandens was sequenced and is reported for the first time. The complete cp sequence was 139,504 bp, include large single-copy (LSC), small single-copy (SSC), and a pair of invert repeats (IR) region of 83,103 bp, 12,813 bp, and 21,793 bp, respectively. Besides, the plastid genome comprised a total of 132 genes, including protein-coding, tRNA, and rRNA genes as 85, 39, and 8 genes, respectively. Phylogenetic analysis based on 28 cp genomes reveals that A. scandens is closely associated with Ampelocalamus melicoideus in Arundinarodae.

Formula: C12H12N2O3. Bye, fridends, I hope you can learn more about C12H12N2O3, If you have any questions, you can browse other blog as well. See you lster.

The Shocking Revelation of C5H8N2

Recommanded Product: 3,5-Dimethyl-1H-pyrazole. Welcome to talk about 67-51-6, If you have any questions, you can contact Saju, A; Mondal, A; Chattopadhyay, T; Kolliyedath, G; Kundu, S or send Email.

Recommanded Product: 3,5-Dimethyl-1H-pyrazole. Authors Saju, A; Mondal, A; Chattopadhyay, T; Kolliyedath, G; Kundu, S in AMER CHEMICAL SOC published article about in [Saju, Ananya; Mondal, Aditesh; Chattopadhyay, Taraknath; Kolliyedath, Gayathri; Kundu, Subrata] Indian Inst Sci Educ & Res Thiruvananthapuram IIS, Sch Chem, Thiruvananthapuram 695551, Kerala, India in 2020.0, Cited 37.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6

The controlled generation of hydrogen sulfide (H2S) under biologically relevant conditions is of paramount importance due to therapeutic interests. Via exploring the reactivity of a structurally characterized phenolate-bridged dinuclear zinc(II)-aqua complex {LZnII(OH2)}(2)(ClO4)(2) (1a) as a hydrolase model, we illustrate in this report that complex 1a readily hydrolyses CS2 in the presence of Et3N to afford H2S. In contrast, penta-coordinated [Zn-II] sites in dinuclear {(LZnII)(2)(mu-X)}(ClO4) complexes (7, X = OAc; 8, X = dimethylpyrazolyl) do not mediate CS2 hydrolysis in the presence of externally added water and Et3N presumably due to the unavailability of a coordination site for water at the [Zn-II] centers. Moreover, [Zn-II]-OH sites present in the isolated tetranuclear zinc(II) complex {(LZnII)(2)(mu-OH)}(2)(ClO4)(2) (4) react with CS2, thereby suggesting that the [Zn-II]-OH site serves as the active nucleophile. Furthermore, mass spectrometric analyses on the reaction mixture consisting of 1a/Et3N and CS2 suggest the involvement of zinc(II)-thiocarbonate (3a) and COS species, thereby providing mechanistic insights into CS2 hydrolysis mediated by the dinuclear [Zn-II] hydrolase model complex 1a.

Recommanded Product: 3,5-Dimethyl-1H-pyrazole. Welcome to talk about 67-51-6, If you have any questions, you can contact Saju, A; Mondal, A; Chattopadhyay, T; Kolliyedath, G; Kundu, S or send Email.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

What unique challenges do researchers face in 3,5-Dimethyl-1H-pyrazole

Product Details of 67-51-6. Welcome to talk about 67-51-6, If you have any questions, you can contact Vafaee, A; Davoodnia, A; Nakhaei, A; Yadegarian, S; Nejatianfar, M or send Email.

Product Details of 67-51-6. Authors Vafaee, A; Davoodnia, A; Nakhaei, A; Yadegarian, S; Nejatianfar, M in MAIK NAUKA/INTERPERIODICA/SPRINGER published article about in [Vafaee, A.; Davoodnia, A.] Islamic Azad Univ, Dept Chem, Mashhad Branch, Mashhad 9175687119, Razavi Khorasan, Iran; [Davoodnia, A.; Nakhaei, A.] Islamic Azad Univ, Young Researchers & Elite Club, Mashhad Branch, Mashhad 9175687119, Razavi Khorasan, Iran; [Nejatianfar, M.] Ferdowsi Univ Mashhad, Dept Chem, Fac Sci, Mashhad 9177948974, Razavi Khorasan, Iran in 2021.0, Cited 33.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6

Two novel room-temperature disulfonic acid functionalized ionic liquids derived from 3,5-dimethyl-1H-pyrazole consisting of chloride and trichlorostannate anions, 3,5-dimethyl-1,2-disulfonic acid-1H-pyrazolium chloride and 3,5-dimethyl-1,2-disulfonic acid-1H-pyrazolium trichlorostannate, have been synthesized, characterized and evaluated for their catalytic efficiency in the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones by the one-pot, three-components reaction of phthalhydrazide, an aromatic aldehyde and malononitrile or ethyl cyanoacetate under solvent-free conditions. The results have demonstrated high catalytic activity of these novel ionic liquids containing acidic SO3H groups in producing high yields of the desired products in short reaction time. The ionic liquids can be used at least four times without any noticeable decrease in catalytic activity.

Product Details of 67-51-6. Welcome to talk about 67-51-6, If you have any questions, you can contact Vafaee, A; Davoodnia, A; Nakhaei, A; Yadegarian, S; Nejatianfar, M or send Email.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

What I Wish Everyone Knew About 67-51-6

Welcome to talk about 67-51-6, If you have any questions, you can contact Cuellar, E; Pastor, L; Garcia-Herbosa, G; Nganga, J; Angeles-Boza, AM; Diez-Varga, A; Torroba, T; Martin-Alvarez, JM; Miguel, D; Villafane, F or send Email.. Product Details of 67-51-6

Recently I am researching about CARBON-DIOXIDE; ACID-BASE; ELECTROCATALYTIC REDUCTION; PYRAZOLYL COMPLEXES; MOLECULAR-STRUCTURE; METAL-COMPLEXES; RUTHENIUM(II); CATALYSTS; PH; FORMATE, Saw an article supported by the Junta de Castilla y LeonJunta de Castilla y Leon [VA130618]; UVa; Spanish MINECO, Spain [PGC2018-099470-B-I00]; Consejeria de Educacion y Cultura; Fondo Social EuropeoEuropean Social Fund (ESF)European Commission [BU263P18]; National Science Foundation CAREER GrantNational Science Foundation (NSF) [CHE-1652606]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Cuellar, E; Pastor, L; Garcia-Herbosa, G; Nganga, J; Angeles-Boza, AM; Diez-Varga, A; Torroba, T; Martin-Alvarez, JM; Miguel, D; Villafane, F. The CAS is 67-51-6. Through research, I have a further understanding and discovery of 3,5-Dimethyl-1H-pyrazole. Product Details of 67-51-6

New cis-(1,2-azole)-aquo bis(2,2′-bipyridyl)-ruthenium(II) (1,2-azole (az*H) = pzH (pyrazole), dmpzH (3,5-dimethylpyrazole), and indzH (indazole)) complexes are synthesized via chlorido abstraction from cis-[Ru(bipy)(2)Cl(az*H)]OTf. The latter are obtained from cis-[Ru(bipy)(2)Cl-2] after the subsequent coordination of the 1,2-azole. All the compounds are characterized by H-1, C-13, N-15 NMR spectroscopy as well as IR spectroscopy. Two chlorido complexes (pzH and indzH) and two aquo complexes (indzH and dmpzH) are also characterized by X-ray diffraction. Photophysical and electrochemical studies were carried out on all the complexes. The photophysical data support the phosphorescence of the complexes. The electrochemical behavior of all the complexes in an Ar atmosphere indicate that the oxidation processes assigned to Ru(II) -> Ru(III) occurs at higher potentials in the aquo complexes. The reduction processes under Ar lead to several waves, indicating that the complexes undergo successive electron-transfer reductions that are centered in the bipy ligands. The first electron reduction is reversible. The electrochemical behavior in CO2 media is consistent with CO2 electrocatalyzed reduction, where the values of the catalytic activity [i(cat)(CO2)/i(p)(Ar)] ranged from 2.9 to 10.8. Controlled potential electrolysis of the chlorido and aquo complexes affords CO and formic acid, with the latter as the major product after 2 h. Photocatalytic experiments in MeCN with [Ru(bipy)(3)]Cl-2 as the photosensitizer and TEOA as the electron donor, which were irradiated with >300 nm light for 24 h, led to CO and HCOOH as the main reduction products, achieving a combined turnover number (TONCO+HCOO-) as high as 107 for 2c after 24 h of irradiation.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Why do aromatic interactions matter of compound:1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid

What Kind of Chemistry Facts Are We Going to Learn About 86-92-0

About 3-Methyl-1-p-tolyl-5-pyrazolone, If you have any questions, you can contact Wu, GX; Xu, HH; Liu, ZR; Liu, YH; Yang, X; Zhang, XL; Huang, Y or concate me.. Application In Synthesis of 3-Methyl-1-p-tolyl-5-pyrazolone

Wu, GX; Xu, HH; Liu, ZR; Liu, YH; Yang, X; Zhang, XL; Huang, Y in [Wu, Gengxin; Xu, Haohan; Liu, Ziran; Liu, Yonghong; Yang, Xiang; Huang, Yan] Xinjiang Univ, Coll Chem & Chem Engn, Key Lab Oil & Gas Fine Chem, Minist Educ & Xinjiang Uyghur Autonomous Reg, Urumqi 830000, Xinjiang, Peoples R China; [Zhang, Xulong] Xinjiang Uygur Autonomous Reg Prod Qual Supervis, Urumqi 830000, Xinjiang, Peoples R China published Asymmetric Organocatalysis Combined with Palladium Catalysis: Synergistic Effect on Enantioselective Mannich/alpha-Allylation Sequential Reactions of Pyrazolones in Constructing Vicinal Quaternary Stereocenters in 2019, Cited 46. Application In Synthesis of 3-Methyl-1-p-tolyl-5-pyrazolone. The Name is 3-Methyl-1-p-tolyl-5-pyrazolone. Through research, I have a further understanding and discovery of 86-92-0.

In this letter, an efficient one-pot asymmetric sequential reaction is achieved by organo/transition metal relay catalysis in constructing two consecutive C-C bonds, which involves enantioselective amino squaramide catalytic Mannich-type addition of pyrazolones to isatin-derived ketimines and a subsequent palladium catalyzed diastereoselective allylic alkylation of pyrazolones with allylic acetates. An array of novel pyrazolone-aminooxindole-propylene structural motifs are obtained in a high level of yield and with excellent enantio- and diastereoselectivity (up to 95% yield, >20:1 dr, >99% ee). This methodology features the formation of vicinal quarternary carbon-stereocenters, and the second all-carbon tetrasubstituted stereogenic center is induced by joint action of the achiral palladium catalysis and the chiral environment generated from the Mannich step. Moreover, the usefulness of this methodology is highlighted by converting the allylic product into the carbonyl compound.