Month: January 2022

I found the field of Chemistry very interesting. Saw the article The selective condensation of pyrazolones to isatins in aqueous medium published in 2020. Recommanded Product: 86-92-0, Reprint Addresses Zhang, Y; Luo, HQ (corresponding author), Garman Normal Univ, Key Lab Organopharmaceut Chem, Ganzhou 341000, Peoples R China.. The CAS is 86-92-0. Through research, I have a further understanding and discovery of 3-Methyl-1-p-tolyl-5-pyrazolone

The selective condensation of pyrazolones with isatins using water as the reaction medium is presented. This strategy provides an environmentally benign synthetic route to synthesize various potentially bioactive pyrazolone substituted oxindoles. (C) 2020 Elsevier Ltd. All rights reserved.

Recommanded Product: 86-92-0. Welcome to talk about 86-92-0, If you have any questions, you can contact Zhang, Y; Nie, LJ; Luo, L; Mao, JX; Liu, JX; Xu, GH; Chen, DL; Luo, HQ or send Email.

Reference:
Article; Zhang, Yong; Nie, Long-Jun; Luo, Liang; Mao, Jia-Xin; Liu, Jin-Xiang; Xu, Guo-Hai; Chen, Deliang; Luo, Hai-Qing; Tetrahedron; vol. 76; 7; (2020);,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article Molecular squares, coordination polymers and mononuclear complexes supported by 2,4-dipyrazolyl-6H-1,3,5-triazine and 4,6-dipyrazolylpyrimidine ligands published in 2019.0. Application In Synthesis of 3,5-Dimethyl-1H-pyrazole, Reprint Addresses Halcrow, MA (corresponding author), Univ Leeds, Sch Chem, Woodhouse Lane, Leeds LS2 9JT, W Yorkshire, England.. The CAS is 67-51-6. Through research, I have a further understanding and discovery of 3,5-Dimethyl-1H-pyrazole

The Fe[BF4](2) complex of 2,4-di(pyrazol-1-yl)-6H-1,3,5-triazine (L-1) is a high-spin molecular square, [{Fe(L-1)}(4)(mu-L-1)(4)][BF4](8), whose crystals also contain the unusual HPzBF(3) (HPz = pyrazole) adduct. Three other 2,4-di(pyrazol-1-yl)-6H-1,3,5-triazine derivatives with different pyrazole substituents (L-2-L-4) are unstable in the presence of first row transition ions, but form mononuclear, polymeric or molecular square complexes with silver(i). Most of these compounds involve bis-bidentate di(pyrazolyl)triazine coordination, which is unusual for that class of ligand, and the molecular squares encapsulate one or two BF4-, ClO4- or SbF6- ions through combinations of anion pi, AgX and/or C-HX (X = O or F) interactions. Treatment of Fe[NCS](2) or Fe[NCSe](2) with 4,6-di(pyrazol-1-yl)-2H-pyrimidine (L-5) or its 2-methyl and 2-amino derivatives (L-6 and L-7) yields mononuclear [Fe(NCE)(2)L-2] and/or the 1D coordination polymers catena-[Fe(NCE)(2)(mu-L)] (E = S or Se, L = L-5-L-7). Alcohol solvates of isomorphous [Fe(NCS)(2)L-2] and [Fe(NCSe)(2)L-2] compounds show different patterns of intermolecular hydrogen bonding, reflecting the acceptor properties of the anion ligands. These iron compounds are all high-spin, although annealing solvated crystals of [Fe(NCSe)(2)(L-5)(2)] affords a new phase exhibiting an abrupt, low-temperature spin transition. Catena-[Fe(H2O)(2)(mu-L-5)][ClO4](2) is a coordination polymer of alternating cis and trans iron centres.

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Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

SDS of cas: 67-51-6. In 2020.0 CRYSTALS published article about SPECTROSCOPIC PROPERTIES; MULTINUCLEAR SILVER(I); OPTICAL-PROPERTIES; CHARGE-TRANSFER; DESIGN; BIS(DIPHENYLPHOSPHINO)METHANE; MECHANISM; PHOSPHINE; LIGANDS in [Baranova, Kristina F.; Titov, Aleksei A.; Filippov, Oleg A.; Smol’yakov, Alexander F.; Shubina, Elena S.] Russian Acad Sci, AN Nesmeyanov Inst Organoelement Cpds, Vavilov Str 28, Moscow 119991, Russia; [Baranova, Kristina F.] Lomonosov Moscow State Univ, Fac Chem, 1-3 Leninskie Gory, Moscow 119991, Russia; [Filippov, Oleg A.] Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Miklukho Maklaya St 16-10, Moscow 117997, Russia; [Averin, Alexey A.] Russian Acad Sci, AN Frumkin Inst Phys Chem & Electrochem, Leninsky Prosp 31-4, Moscow 199071, Russia in 2020.0, Cited 37.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6.

Two silver nitrate complexes with bisphosphines were obtained and characterized: [Ag(dcypm)](2)(NO3)(2) (1; dcypm = bis(dicyclohexylphosphino)methane) and [Ag(dppm)](2)(Me(2)Pz(H))(n)(NO3)(2) (n = 1, 2a; n = 2, 2b; dppm = bis(diphenylphosphino)methane, Me(2)Pz(H) = 3,5-dimethylpyrazole). The steric repulsions of bulky cyclohexyl substituents prevent additional ligand coordination to the silver atoms in 1. Compounds obtained feature the bimetallic eight-member cyclic core [AgPCP](2). The intramolecular argenthophilic interaction (d(Ag center dot center dot center dot Ag) = 2.981 angstrom) was observed in complex 1. In contrast, the coordination of pyrazole led to the elongation of Ag center dot center dot center dot Ag distance to 3.218(1) angstrom in 2a and 3.520 angstrom in 2b. Complexes 1 and 2a possess phosphorescence both in the solution and solid state. Time-dependent density-functional theory (TD-DFT) calculations demonstrate the origin of their different emission profile. In the case of 1, upon excitation, the electron leaves the Ag-P bonding orbital and locates on the intramolecular Ag center dot center dot center dot Ag bond (metal-centered character). Complex 2a at room temperature exhibits a phosphorescence originating from the (3)(M + LP+N)(LCT)-C-Ph state. At 77 K, the photoluminescence spectrum of complex 2a shows two bands of two different characters: (3)(M + LP+N)(LCT)-C-Ph and (LCPh)-L-3 transitions. The contribution of Ag atoms to the excited state in both complexes 2a and 2b decreased relative to 1 in agreement with the structural changes caused by pyrazole coordination.

SDS of cas: 67-51-6. Bye, fridends, I hope you can learn more about C5H8N2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

An article Asymmetric Synthesis of 1,4-Dicarbonyl Compounds from Aldehydes by Hydrogen Atom Transfer Photocatalysis and Chiral Lewis Acid Catalysis WOS:000495739600024 published article about INTERMOLECULAR STETTER REACTION; DUAL-CATALYSIS; CONVERGENT; RADICALS; NICKEL; ENALS in [Kuang, Yulong; Wang, Kai; Shi, Xiangcheng; Wu, Jie] Natl Univ Singapore, Dept Chem, 3 Sci Dr 3, Singapore 117543, Singapore; [Wu, Jie] Natl Univ Singapore Suzhou Res Inst, 377 Lin Quan St,Suzhou Ind Pk, Suzhou 215123, Jiangsu, Peoples R China; [Huang, Xiaoqiang; Meggers, Eric] Philipps Univ Marburg, Fachbereich Chem, Hans Meerwein Str 4, D-35043 Marburg, Germany in 2019.0, Cited 59.0. Name: 3,5-Dimethyl-1H-pyrazole. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6

Enantioenriched 1,4-dicarbonyl compounds are versatile synthons in natural product and pharmaceutical drug synthesis. We herein report a mild pathway for the efficient enantioselective synthesis of these compounds directly from aldehydes through synergistic cooperation between a neutral eosinY hydrogen atom transfer photocatalyst and a chiral rhodium Lewis acid catalyst. This method is distinguished by its operational simplicity, abundant feedstocks, atom economy, and ability to generate products in high yields (up to 99%) and high enantioselectivity (up to 99% ee).

Welcome to talk about 67-51-6, If you have any questions, you can contact Kuang, YL; Wang, K; Shi, XC; Huang, XQ; Meggers, E; Wu, J or send Email.. Name: 3,5-Dimethyl-1H-pyrazole

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

An article The selective condensation of pyrazolones to isatins in aqueous medium WOS:000515447100005 published article about HENRY NITROALDOL REACTIONS; ORGANIC-SYNTHESIS; ON-WATER; DERIVATIVES; ANTIPYRINE; ALCOHOLS; HETEROCYCLES; CHEMISTRY; CYCLIZATION; EFFICIENT in [Zhang, Yong; Nie, Long-Jun; Luo, Lang; Mao, Jia-Xin; Liu, Jin-Xiang; Xu, Guo-Hai; Chen, Deliang; Luo, Hai-Qing] Garman Normal Univ, Key Lab Organopharmaceut Chem, Ganzhou 341000, Peoples R China in 2020, Cited 69. Computed Properties of C11H12N2O. The Name is 3-Methyl-1-p-tolyl-5-pyrazolone. Through research, I have a further understanding and discovery of 86-92-0

The selective condensation of pyrazolones with isatins using water as the reaction medium is presented. This strategy provides an environmentally benign synthetic route to synthesize various potentially bioactive pyrazolone substituted oxindoles. (C) 2020 Elsevier Ltd. All rights reserved.

Bye, fridends, I hope you can learn more about C11H12N2O, If you have any questions, you can browse other blog as well. See you lster.. Computed Properties of C11H12N2O

Reference:
Article; Zhang, Yong; Nie, Long-Jun; Luo, Liang; Mao, Jia-Xin; Liu, Jin-Xiang; Xu, Guo-Hai; Chen, Deliang; Luo, Hai-Qing; Tetrahedron; vol. 76; 7; (2020);,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Product Details of 83-10-3. Delgado, J; Jones, L; Bradley, MC; Allan, LM; Ballard, C; Clare, L; Fortinsky, RH; Hughes, CM; Melzer, D in [Delgado, Joao; Jones, Lindsay; Ballard, Clive; Melzer, David] Univ Exeter, Coll Med & Hlth, Epidemiol & Publ Hlth, Exeter EX1 2LU, Devon, England; [Bradley, Marie C.] US FDA, Off Surveillance & Epidemiol, Ctr Drug Evaluat & Res, Silver Spring, MD 20993 USA; [Allan, Louise M.; Clare, Linda] Univ Exeter, Coll Med & Hlth, Ctr Res Ageing & Cognit Hlth, Exeter EX1 2LU, Devon, England; [Fortinsky, Richard H.] Univ Connecticut, Sch Med, Ctr Aging, Mansfield, CT 06030 USA; [Hughes, Carmel M.] Queens Univ Belfast, Med Biol Ctr, Sch Pharm, Belfast BT9 7BL, Antrim, North Ireland published Potentially inappropriate prescribing in dementia, multi-morbidity and incidence of adverse health outcomes in 2021, Cited 30. The Name is 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid. Through research, I have a further understanding and discovery of 83-10-3.

Importance: treatment of dementia in individuals with comorbidities is complex, leading to potentially inappropriate prescribing (PIP). The impact of PIP in this population is unknown. Objective: to estimate the rate of PIP and its effect on adverse health outcomes (AHO). Design: retrospective cohort. Setting: primary care electronic health records linked to hospital discharge data from England. Subjects: 11,175 individuals with dementia aged over 65 years in 2016 and 43,463 age- and sex-matched controls. Methods: Screening Tool of Older Persons’ Prescriptions V2 defined PIP. Logistic regression tested associations with comorbidities at baseline, and survival analyses risk of incident AHO, adjusted for age, gender, deprivation and 14 comorbidities. Results: the dementia group had increased risk of PIP (73% prevalence; odds ratio [OR]: 1.92; confidence interval [CI]: 83-103%; P < 0.01) after adjusting for comorbidities. Most frequent PIP criteria were related to anti-cholinergic drugs and therapeutic duplication. Risk of PIP was higher in patients also diagnosed with coronary-heart disease (odds OR: 2.17; CI: 1.91-2.46; P < 0.01), severe mental illness (OR: 2.09; CI: 1.62-2.70; P < 0.01); and depression (OR: 1.81; CI: 1.62-2.01; P < 0.01). During follow-up (1 year), PIP was associated with increased all-cause mortality (hazard ratio: 1.14; CI: 1.021.26; P < 0.02), skin ulcer and pressure sores (hazard ratio: 1.66; CI: 1.12-2.46; P< 0.01), falls (hazard ratio: 1.37; CI: 1.15-1.63; P < 0.01), anaemia (hazard ratio: 1.61; CI: 1.10-2.38; P < 0.02) and osteoporosis (hazard ratio: 1.62; CI: 1.022.57; P < 0.04). Conclusion: patients with dementia frequently receive PIPs, and those who do are more likely to experience AHO. These results highlight the need to optimise medication in dementia patients, especially those with comorbidities. About 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid, If you have any questions, you can contact Delgado, J; Jones, L; Bradley, MC; Allan, LM; Ballard, C; Clare, L; Fortinsky, RH; Hughes, CM; Melzer, D or concate me.. Product Details of 83-10-3

Reference:
Patent; Shanghai Pharmaceutical Industry Institute; China Pharmaceutical Industry Zongyuan; Li Jianqi; Huang Daowei; Wang Wenya; Zhang Zhiguo; Jiang Ling; (45 pag.)CN107286140; (2017); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

An article Regioselectivity Switch in Palladium-Catalyzed Allenylic Cycloadditions of Allenic Esters: [4+1] or [4+3] Cycloaddition/Cross-Coupling WOS:000462622700046 published article about ASYMMETRIC-SYNTHESIS; SPIROPYRAZOLONES; ISOXAZOLINONES; DENDRALENES; ANNULATION; GENERATION; REACTIVITY; YLIDES in [Li, Long; Luo, Pengfei; Deng, Yuhua; Shao, Zhihui] Yunnan Univ, Key Lab Med Chem Nat Resource, State Key Lab Conservat & Utilizat Bioresources Y, Minist Educ,Sch Chem Sci & Technol, Kunming 650091, Yunnan, Peoples R China in 2019, Cited 65. Recommanded Product: 3-Methyl-1-p-tolyl-5-pyrazolone. The Name is 3-Methyl-1-p-tolyl-5-pyrazolone. Through research, I have a further understanding and discovery of 86-92-0

The first Pd-catalyzed asymmetric allenylic [4+1] cycloaddition was successfully developed. Alternatively, tuning the Pd catalyst switched the reactivity toward an unprecedented [4+3] cycloaddition/cross-coupling. Ligands play a vital role in controlling the reaction pathway, allowing highly selective access to different products from identical substrates. Biological evaluation of the obtained compounds led to the discovery of new antitumor targets. A possible mechanism is proposed, suggesting two interesting catalytic cycles for the cycloaddition with palladium-butadienyls. This study also demonstrated the potential and utility of allenic esters as 1,4-biselectrophiles and C-4 synthons for participating in cycloaddition reactions.

Recommanded Product: 3-Methyl-1-p-tolyl-5-pyrazolone. Welcome to talk about 86-92-0, If you have any questions, you can contact Li, L; Luo, PF; Deng, YH; Shao, ZH or send Email.

Reference:
Article; Zhang, Yong; Nie, Long-Jun; Luo, Liang; Mao, Jia-Xin; Liu, Jin-Xiang; Xu, Guo-Hai; Chen, Deliang; Luo, Hai-Qing; Tetrahedron; vol. 76; 7; (2020);,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Authors Lu, PN; Lin, KD; Huang, XW; Yuan, DX in ELSEVIER SCIENCE BV published article about DISINFECTION BY-PRODUCTS; FREE CHLORINE; HALOGENATION; HETEROCYCLES; CHEMISTRY; RADICALS; SEAWATER; ACID in [Lu, Peining; Lin, Kunde; Yuan, Dongxing] Xiamen Univ, Coll Environm & Ecol, Fujian Prov Key Lab Coastal Ecol & Environm Studi, Xiamen 361102, Peoples R China; [Huang, Xinwen] Zhejiang Univ Technol, Coll Environm, Hangzhou 310032, Zhejiang, Peoples R China in 2019.0, Cited 25.0. SDS of cas: 67-51-6. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6

The purpose of this study was to develop and validate a sensitive method for the determination of ultra trace levels of reactive bromine species (RBS) in water. To derivatized RBS, water samples were transferred into vials pre-fortified with an appropriate dose of derivative reagent 3,5-dimethyl-1H-pyrazole (DMPZ). RBS in water samples could be rapidly and stoichiometrically (1:1) derivatized to 4-bromo-3,5-dimethyl-1H-pyrazole, which was directly analyzed on an ultra performance liquid chromatography coupled with triple quadrupole tandem mass spectrometry. Parameters influencing the derivatization efficiency including reaction time, temperature, DMPZ dose, and pH were optimized to be: a molar concentration ratio of DMPZ to RBS a 100:1, pH 5-10, and reaction for 10 min at room temperature. In addition, near 100% of RBS was recovered when using water with salinity of 0-55 as the spiking matrices, suggesting that salinity had negligible effect on the derivatization efficiency. Under the optimized conditions, interday and intraday analyses showed that the recoveries of RBS ranged from 88.0% to 109.8% for samples spiked with 18.0-540 pmol L-1 of RBS, with relative standard deviations less than 3.7%. The method limit of detection and limit of quantification for RBS were 5.8 pmol L-1 and 18.0 pmol L-1, respectively. Compared with currently available methods, our method greatly improved the analytical sensitivity by lowering the limit of detection for more than 100 times. The developed method displayed high reliability and reproducibility in the analysis of ultra trace levels of RBS in seawater and other real fresh water samples.

SDS of cas: 67-51-6. Welcome to talk about 67-51-6, If you have any questions, you can contact Lu, PN; Lin, KD; Huang, XW; Yuan, DX or send Email.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Solubility of solid intermediate of pharmaceutical compounds in pure organic solvents using semi-empirical models published in 2020. Formula: C11H12N2O, Reprint Addresses Akbari, F (corresponding author), Eram Inst Higher Educ, Dept Chem, POB 71957-46733, Shiraz, Iran.. The CAS is 86-92-0. Through research, I have a further understanding and discovery of 3-Methyl-1-p-tolyl-5-pyrazolone

A new semi-theoretical equation is suggested for correlation of solid-liquid solubility data with temperature. The (solid + liquid) equilibrium for Terephthaldialdehyde, 4-Nitro-o-phennylenediamine, 2,4-dihydro- 5-methyl-2(4-methylphenyl)-3H-pyrazol-3-one (also named 1-(p-toly1)-3-methyl-5pyrazolone (PTMP)), 2-Amino-5-methylthiazole and 5-chloro-1-methyl-4-nitroimidazole in 18 solvents is correlated with semi-empirical models at temperatures T = 273.15 – 318.15 K under a pressure of 101.2 kPa. Moreover, a modified Apelblat model, lambda h model, Wilson model, NRTL model, new flexible equation as Akbari, Dideban and Farhang model (ADF) and for first time the modified Scatchard-Hildebrand equation were utilized to calculate the experiment values. The performance of both ADF and modified Scatchard-Hildebrand equation have been checked by calculating the solubility data with the AARD% of 1.3808% (for 775 data points) and 0.65% (for 100 data points), respectively. The Wilson model is applied to estimate the mixing Gibbs energy, mixing enthalpy, mixing entropy, activity coefficient (ln gamma(infinity)(1)) and reduced excess enthalpy (H-I(E,infinity)) at infinitesimal concentration were calculated.

Welcome to talk about 86-92-0, If you have any questions, you can contact Akbari, F; Didehban, K; Farhang, M or send Email.. Formula: C11H12N2O

Reference:
Article; Zhang, Yong; Nie, Long-Jun; Luo, Liang; Mao, Jia-Xin; Liu, Jin-Xiang; Xu, Guo-Hai; Chen, Deliang; Luo, Hai-Qing; Tetrahedron; vol. 76; 7; (2020);,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Recently I am researching about DNA-BINDING; PLASMODIUM-FALCIPARUM; COPPER(II) COMPLEXES; CU(II) COMPLEXES; DERIVATIVES; ANTICANCER; BINARY, Saw an article supported by the . Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Shaikh, I; Jadeja, RN; Patel, R. The CAS is 86-92-0. Through research, I have a further understanding and discovery of 3-Methyl-1-p-tolyl-5-pyrazolone. Name: 3-Methyl-1-p-tolyl-5-pyrazolone

Three novel mixed ligand Zn(II) complexes {complex 1 = [Zn(L1)(2)(bpy)], complex 2 = [Zn(L2)(2)(bPY)], complex 3 = [Zn(L2)(2)(phen)], where bpy = 2,2′-bipyridine and phen = 1,10-phenanthroline} of 4-(4-chlorobenzoyl)-2-(3-chlorophenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one (HL1) and 4-(4-chlorobenzoyl)-5-methyl-2-(p-tolyl)-2,4-dihydro-3H-pyrazol-3-one (HL2) were synthesized and characterized by H-1 and C-13 NMR, FTIR, TG-DTA, UV-Vis, elemental analysis, molar conductance and single crystal X-ray structure determination. Based on analytical and spectroscopic techniques, all the three Zn(II) complexes were found to have a distorted octahedral geometry. The ligands and the complexes were screened for antimalarial activity against plasmodium falciparum. The zinc(II) complexes showed greater antimalarial activity than their parent ligands. (C) 2020 Elsevier Ltd. All rights reserved.

Name: 3-Methyl-1-p-tolyl-5-pyrazolone. Bye, fridends, I hope you can learn more about C11H12N2O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Zhang, Yong; Nie, Long-Jun; Luo, Liang; Mao, Jia-Xin; Liu, Jin-Xiang; Xu, Guo-Hai; Chen, Deliang; Luo, Hai-Qing; Tetrahedron; vol. 76; 7; (2020);,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics