Month: November 2021

An article Regorafenib for Metastatic Colorectal Cancer: An Analysis of a Registry-Based Cohort of 555 Patients WOS:000548281000003 published article about CLINICAL-PRACTICE; SURVIVAL; MULTICENTER; ANTITUMOR; SAFETY; SITE; SEX in [Novakova-Jiresova, Alena; Boublikova, Ludmila; Buchler, Tomas] Charles Univ Prague, Fac Med 1, Dept Oncol, Videnska 800, Prague 14059, Czech Republic; [Novakova-Jiresova, Alena; Boublikova, Ludmila; Buchler, Tomas] Charles Univ Prague, Thomayer Hosp, Videnska 800, Prague 14059, Czech Republic; [Kopeckova, Katerina; Batko, Stanislav; Linke, Zdenek; Prausov, Jana] Charles Univ Prague, Univ Hosp Motol, Dept Oncol, Prague, Czech Republic; [Chloupkov, Renata] Masaryk Univ, Fac Med, Inst Biostat & Anal, Brno, Czech Republic; [Melichar, Bohuslav] Palacky Univ Med, Dept Oncol, Olomouc, Czech Republic; [Melichar, Bohuslav] Teaching Hosp, Olomouc, Czech Republic; [Petruzelka, Lubos] Charles Univ Prague, Gen Fac Hosp, Dept Oncol, Prague, Czech Republic; [Finek, Jindrich; Fiala, Ondrej] Charles Univ Prague, Med Sch, Dept Oncol & Radiotherapy, Plzen, Czech Republic; [Finek, Jindrich; Fiala, Ondrej] Charles Univ Prague, Univ Hosp Pilsen, Plzen, Czech Republic; [Fiala, Ondrej] Charles Univ Prague, Fac Med Pilsen, Biomed Ctr, Plzen, Czech Republic; [Grell, Peter; Kiss, Igor] Masaryk Mem Canc Inst, Dept Comprehens Canc Care, Brno, Czech Republic in 2020, Cited 30. The Name is 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid. Through research, I have a further understanding and discovery of 83-10-3. SDS of cas: 83-10-3

Purpose: Regorafenib is an oral multikinase inhibitor approved for the therapy of previously treated metastatic colorectal carcinoma (mCRC). The aim of the present study was to analyze the outcomes of treatment with regorafenib in real-world clinical practice based on data from a national registry. Methods: The CORECT registry, the Czech non-interventional database of patients with mCRC treated with targeted agents, searched for patients with metastatic CRC treated with regorafenib. In total, 555 evaluable patients were identified. Results: The median age at diagnosis was 61.7 years. All patients had disease progression on or after previous systemic treatment. Most patients were treated with an initial dose of 160 mg daily (n = 463; 83.6%). The median duration of treatment was 2.7 months (range 0.023.4 months). By the data cut-off date, 472 patients (85%) had completed treatment with regorafenib and were evaluable for treatment response evaluation. Partial response was reported in 13 patients (2.8%) and disease stabilization in 130 patients (27.5%). Median progression-free survival (PFS) and overall survival (OS) were 3.5 months (95% confidence interval [CI] 3.2-3.7 months) and 9.3 months (95% CI 8.3-10.3 months), respectively. The 6-month OS rate was 67.7% (95% CI 63.4-72.1%). Multivariable analysis showed that female gender, longer interval from diagnosis of metastatic disease, MO stage at diagnosis, and Eastern Cooperative Oncology Group performance status (ECOG PS) 0 were associated with longer PFS, while higher body-mass index (BMI), longer interval from diagnosis of metastatic disease, and ECOG PS of 0 were associated with longer OS. Conclusion: OS of patients treated with regorafenib in the real-world clinical practice in this cohort exceeded that reported in randomized trials. Regorafenib is a safe and active treatment option for a subgroup of patients with mCRC who are progressing after other systemic therapies and maintain good performance status.

SDS of cas: 83-10-3. Welcome to talk about 83-10-3, If you have any questions, you can contact Novakova-Jiresova, A; Kopeckova, K; Boublikova, L; Chloupkov, R; Melichar, B; Petruzelka, L; Finek, J; Fiala, O; Grell, P; Batko, S; Linke, Z; Kiss, I; Prausov, J; Buchler, T or send Email.

Reference:
Patent; Shanghai Pharmaceutical Industry Institute; China Pharmaceutical Industry Zongyuan; Li Jianqi; Huang Daowei; Wang Wenya; Zhang Zhiguo; Jiang Ling; (45 pag.)CN107286140; (2017); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

COA of Formula: C5H8N2. I found the field of Chemistry very interesting. Saw the article Cross-Coupling between Hydrazine and Aryl Halides with Hydroxide Base at Low Loadings of Palladium by Rate-Determining Deprotonation of Bound Hydrazine published in 2021.0, Reprint Addresses Hartwig, JF (corresponding author), Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA.. The CAS is 67-51-6. Through research, I have a further understanding and discovery of 3,5-Dimethyl-1H-pyrazole.

Reported here is the Pd-catalyzed C-N coupling of hydrazine with (hetero)aryl chlorides and bromides to form aryl hydrazines with catalyst loadings as low as 100 ppm of Pd and KOH as base. Mechanistic studies revealed two catalyst resting states: an arylpalladium(II) hydroxide and arylpalladium(II) chloride. These compounds are present in two interconnected catalytic cycles and react with hydrazine and base or hydrazine alone to give the product. The selectivity of the hydroxide complex with hydrazine to form aryl over diaryl hydrazine was lower than that of the chloride complex, as well as the catalytic reaction. In contrast, the selectivity of the chloride complex closely matched that of the catalytic reaction, indicating that the aryl hydrazine is derived from this complex. Kinetic studies showed that the coupling process occurs by rate-limiting deprotonation of a hydrazine-bound arylpalladium(II) chloride complex to give an arylpalladium(II) hydrazido complex.

Welcome to talk about 67-51-6, If you have any questions, you can contact Wang, JY; Choi, K; Zuend, SJ; Borate, K; Shinde, H; Goetz, R; Hartwig, JF or send Email.. COA of Formula: C5H8N2

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Product Details of 67-51-6. In 2020.0 EUR UROL FOCUS published article about RESISTANCE in [Cimino, Sebastiano; Verze, Paolo; Venturino, Luca; Alessio, Paolo; Migliara, Alfonso; Imbimbo, Ciro; Mirone, Vincenzo; Russo, Giorgio Ivan; Morgia, Giuseppe] Univ Catania, Dept Urol, Urol Sect, Catania, Italy; [Cimino, Sebastiano; Verze, Paolo; Venturino, Luca; Alessio, Paolo; Migliara, Alfonso; Imbimbo, Ciro; Mirone, Vincenzo; Russo, Giorgio Ivan; Morgia, Giuseppe] Univ Naples Federico II, Dept Neurosci Reprod Sci & Odontostomatol, Naples, Italy in 2020.0, Cited 18.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6.

Background: Transrectal ultrasound-guided prostate biopsy (TRBx) or transperineal Bx (TPBx) are considered alternative approaches for the diagnosis of prostate cancer (PCa). However, urinary tract infection (UTI) or other complications could be more frequent in the TRBx approach. Objective: To determine the complication rate following different antimicrobial prophylaxis (AMP; fosfomycin trometamol [FT] vs beta-lactame or fluorochinolones [FQ]) in patients undergoing TRBx or TPBx. Design, setting, and participants: The analyses were based on prospectivelycollected data of a cohort of patients who underwent TRBx or TPBx for elevated prostate-specific antigen (PSA; >= 4 ng/ml) or clinical suspicion of PCa, between September 2016 and March 2017. Patients received a single dose of 3 g oral FT (group A) or, alternatively, FQ or beta-lactame (group B). Intervention:TRBx versus TPBx. Outcome measurements and statistical analysis: Adjustment variables consisted of age, PSA, biopsy technique (TPBx vs TRBx), and antibiotic prophylaxis (FT vs beta-lactame or FQ) using 1:1 propensity-score matching. Overall, 526 patients were considered, of whom 258 received FT (group A) and the other 258 received beta-lactame or FQ (group B). Results and limitations: Overall complications occurred in 390 (75.58%) and major complications in 67/516 (12.98%). Lower prevalence of UTIs was detected in group A (34.1%) compared with that in group B (43.4%; p = 0.03), while similar rates of haematuria (54.7% vs 55.4%), haemospermia (39.5% vs 33.0%), and acute urinary retention (11.6% vs 9.3%) were detected in groups A and B. We found that group B (odds ratio [OR]: 1.54; p = 0.03), I grade haematuria (OR: 6.17; p < 0.01), and II grade haematuria (OR: 5.13; p < 0.01) were significantly associated with increased risk of UTIs. Conclusions: AMP with fluoroquinoles or beta-lactam antibiotics increased the rate of UTIs, when compared with FT, in patients undergoing TRBx or TPBx. The appearance of haematuria or haemospermia is associated with UTIs, suggesting the possibility of tailoring the strategy for prophylaxis in this category of patients. Patient summary: In this study, comparing complications after transrectal ultrasound-guided prostate biopsy versus transperineal biopsy, prophylaxis with fluoroquinoles or beta-lactam antibiotics increased the rate of urinary tract infections when compared with fosfomycin trometamol, regardless of the type of biopsy approach. (C) 2018 European Association of Urology. Published by Elsevier B.V. All rights reserved. Product Details of 67-51-6. Bye, fridends, I hope you can learn more about C5H8N2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Recently I am researching about ALLYLIC DEAROMATIZATION REACTION; STEREOCONTROLLED CONSTRUCTION; MICHAEL ADDITION; ALKYLATION; ACID; PYRAZOLIN-5-ONES; PYRAZOL-5-ONES; ALCOHOLS; BEARING, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21462042, 21262036]. Name: 3-Methyl-1-p-tolyl-5-pyrazolone. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Wu, GX; Xu, HH; Liu, ZR; Liu, YH; Yang, X; Zhang, XL; Huang, Y. The CAS is 86-92-0. Through research, I have a further understanding and discovery of 3-Methyl-1-p-tolyl-5-pyrazolone

In this letter, an efficient one-pot asymmetric sequential reaction is achieved by organo/transition metal relay catalysis in constructing two consecutive C-C bonds, which involves enantioselective amino squaramide catalytic Mannich-type addition of pyrazolones to isatin-derived ketimines and a subsequent palladium catalyzed diastereoselective allylic alkylation of pyrazolones with allylic acetates. An array of novel pyrazolone-aminooxindole-propylene structural motifs are obtained in a high level of yield and with excellent enantio- and diastereoselectivity (up to 95% yield, >20:1 dr, >99% ee). This methodology features the formation of vicinal quarternary carbon-stereocenters, and the second all-carbon tetrasubstituted stereogenic center is induced by joint action of the achiral palladium catalysis and the chiral environment generated from the Mannich step. Moreover, the usefulness of this methodology is highlighted by converting the allylic product into the carbonyl compound.

Name: 3-Methyl-1-p-tolyl-5-pyrazolone. Bye, fridends, I hope you can learn more about C11H12N2O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Zhang, Yong; Nie, Long-Jun; Luo, Liang; Mao, Jia-Xin; Liu, Jin-Xiang; Xu, Guo-Hai; Chen, Deliang; Luo, Hai-Qing; Tetrahedron; vol. 76; 7; (2020);,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Product Details of 86-92-0. Ibrahim, HM; Behbehani, H in [Ibrahim, Hamada Mohamed; Behbehani, Haider] Kuwait Univ, Fac Sci, Chem Dept, POB 5969, Safat 13060, Kuwait; [Ibrahim, Hamada Mohamed] Fayoum Univ, Fac Sci, Chem Dept, POB 63514, Al Fayyum, Egypt published Sustainable Synthetic Approach for (Pyrazol-4-ylidene) pyridines By Metal Catalyst-Free Aerobic C(sp(2))-C(sp(3)) Coupling Reactions between 1-Amino-2-imino-pyridines and 1-Aryl-5-pyrazolones in 2019, Cited 99. The Name is 3-Methyl-1-p-tolyl-5-pyrazolone. Through research, I have a further understanding and discovery of 86-92-0.

A novel, metal catalyst-free, and efficient method has been developed for the synthesis of (pyrazol-4-ylidene) pyridine derivatives. The process involves dehydrogenative coupling of 1-amino-2-imino-pyridines with 1-aryl-5pyrazolone derivatives utilizing O-2 as the sole oxidant. The new method benefits from a high atom economy, efficiency, and substrate scope, as well as the simplicity of reaction and product purification procedures.

Welcome to talk about 86-92-0, If you have any questions, you can contact Ibrahim, HM; Behbehani, H or send Email.. Product Details of 86-92-0

Reference:
Article; Zhang, Yong; Nie, Long-Jun; Luo, Liang; Mao, Jia-Xin; Liu, Jin-Xiang; Xu, Guo-Hai; Chen, Deliang; Luo, Hai-Qing; Tetrahedron; vol. 76; 7; (2020);,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

An article Nucleophilic Aromatic Substitution of Unactivated Fluoroarenes Enabled by Organic Photoredox Catalysis WOS:000579087600032 published article about ARYL FLUORIDES; BOND FORMATION; AMINATION; ACTIVATION in [Pistritto, Vincent A.; Schutzbach-Horton, Megan E.; Nicewicz, David A.] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA in 2020.0, Cited 41.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6. Computed Properties of C5H8N2

Nucleophilic aromatic substitution (SNAr) is a classical reaction with well-known reactivity toward electron-poor fluoroarenes. However, electron-neutral and electron-rich fluoro(hetero)arenes are considerably underrepresented. Herein, we present a method for the nucleophilic defluorination of unactivated fluoroarenes enabled by cation radical-accelerated nucleophilic aromatic substitution. The use of organic photoredox catalysis renders this method operationally simple under mild conditions and is amenable to various nucleophile classes, including azoles, amines, and carboxylic acids. Select fluorinated heterocycles can be functionalized using this method. In addition, the late-stage functionalization of pharmaceuticals is also presented. Computational studies demonstrate that the site selectivity of the reaction is dictated by arene electronics.

Computed Properties of C5H8N2. Welcome to talk about 67-51-6, If you have any questions, you can contact Pistritto, VA; Schutzbach-Horton, ME; Nicewicz, DA or send Email.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

In 2021.0 SUSTAIN ENERG FUELS published article about O BOND FORMATION; COPPER(II) COMPLEX; MOLECULAR CATALYSTS; IRIDIUM COMPLEXES; II COMPLEXES; NEUTRAL PH; LIGANDS; EFFICIENT; SYSTEMS; DESIGN in [Makhado, T.; Vosloo, H. C. M.; Swarts, A. J.] Northwest Univ, Res Focus Area Chem Resource Beneciat, Catalysis & Synth Res Grp, 11 Hoffman St, ZA-2531 Potchefstroom, South Africa; [Das, B.] Stockholm Univ, Arrhenius Lab, Dept Organ Chem, Svante Arrhenius Vag 16C, S-10691 Stockholm, Sweden; [Kriek, R. J.] Northwest Univ, Electrochem Energy & Environm Grp, Res Focus Area Chem Resource Beneficat, 11 Hoffman St, ZA-2531 Potchefstroom, South Africa; [Swarts, A. J.] Univ Witwatersrand, Sch Chem, Mol Sci Inst, ZA-2050 Johannesburg, South Africa in 2021.0, Cited 69.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6. COA of Formula: C5H8N2

Herein a series of novel bis(pyrazol-1-ylmethyl)pyridine-ligated Cu(i) complexes, C1-C4, bearing different donating groups [[H(C1), Me(C2), t-Bu(C3), Ph(C4)])] on the pyrazole rings, were synthesized and investigated as pre-catalysts in chemical and electrocatalytic water oxidation reactions. Ligands, 2,6-bis((1H-pyrazol-1-yl)methyl)pyridine (L1), 2,6-bis((1H-pyrazol-1-yl)methyl)pyridine (L2), 2,6-bis((3,5-di-tert-butyl-1H-pyrazol-1-yl)methyl)pyridine (L3), and 2,6-bis((3,5-diphenyl-1H-pyrazol-1-yl)methyl)pyridine (L4) were reacted with Cu(MeCN)(4)PF6 to form complexes C1-C4 respectively. Cerium ammonium nitrate (CAN), sodium m-periodate, and sodium persulfate were investigated as chemical oxidants in chemical water oxidation. Complexes C1-C4 showed catalytic activity towards chemical water oxidation in the presence of CAN as the primary oxidant at 25 degrees C. Complex C2 was the most active with a turnover number (TON) of 4.6 and a turnover frequency (TOF) of 0.31 s(-1). The least active catalyst was complex C4, with a TON of 2.3 and a TOF of 0.0086 s(-1). This observed difference in catalytic activity between the complexes illustrated the key role that electronic effects play during catalysis. Other oxidants evaluated with C2 were sodium m-periodate (TON, 3.77; TOF 0.14 s(-1)) and sodium persulfate (TON, 4.02; TOF 0.044 s(-1)) however, CAN exhibited the greatest activity. Complexes C1-C4 were investigated in electrocatalytic water oxidation at a neutral pH of 6.5. Complex C2 was the most active in electrocatalytic water oxidation as well, exhibiting an overpotential of 674 mV and TOF of 9.77 s(-1) (at 1.7 V vs. NHE), which is better than most reported copper(ii) complexes. These Cu(i) complexes C1-C4 show potential as efficient chemical and electrocatalytic water oxidation catalysts, which can be achieved by fine-tuning the steric and electronic properties of the catalysts.

Welcome to talk about 67-51-6, If you have any questions, you can contact Makhado, T; Das, B; Kriek, RJ; Vosloo, HCM; Swarts, AJ or send Email.. COA of Formula: C5H8N2

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Recently I am researching about AGENTS; DERIVATIVES, Saw an article supported by the State Key Laboratory of Drug Research [SIMM1601ZZ-03]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81602995, 21702219]. COA of Formula: C11H12N2O. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Zhu, YF; Wei, BL; Wei, JJ; Wang, WQ; Song, WB; Xuan, LJ. The CAS is 86-92-0. Through research, I have a further understanding and discovery of 3-Methyl-1-p-tolyl-5-pyrazolone

A palladium-catalyzed oxidative dehydrogenation reaction in the presence of AMS and base to synthesize pyrazolones and pyrazoles was identified. This method can be utilized to a wide range of substrates, operates under mild react conditions and can give high yields. We believe it could be used as an alternative protocol for the classical dehydrogenation reactions. (C) 2019 Published by Elsevier Ltd.

Welcome to talk about 86-92-0, If you have any questions, you can contact Zhu, YF; Wei, BL; Wei, JJ; Wang, WQ; Song, WB; Xuan, LJ or send Email.. COA of Formula: C11H12N2O

Reference:
Article; Zhang, Yong; Nie, Long-Jun; Luo, Liang; Mao, Jia-Xin; Liu, Jin-Xiang; Xu, Guo-Hai; Chen, Deliang; Luo, Hai-Qing; Tetrahedron; vol. 76; 7; (2020);,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

An article Pulse Rate Variability in Emergency Physicians During Shifts: Pilot Cross-Sectional Study WOS:000488533300001 published article about HEART-RATE-VARIABILITY; WORK-LIFE BALANCE; BURNOUT; SURGEONS; STRESS; SATISFACTION; TONE in [Peters, Gregory Andrew; Wong, Matthew L.; Joseph, Joshua W.; Sanchez, Leon D.] Beth Israel Deaconess Med Ctr, Dept Emergency Med, 1 Deaconess Rd, Boston, MA 02215 USA; [Peters, Gregory Andrew; Wong, Matthew L.; Joseph, Joshua W.; Sanchez, Leon D.] Harvard Med Sch, Boston, MA 02115 USA in 2019, Cited 40. SDS of cas: 83-10-3. The Name is 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid. Through research, I have a further understanding and discovery of 83-10-3

Background: The high prevalence of physician burnout, particularly in emergency medicine, has garnered national attention in recent years. Objective means of measuring stress while at work can facilitate research into stress reduction interventions, and wearable photoplethysmography (PPG) technology has been proposed as a potential solution. However, the use of low-burden wearable biosensors to study training and clinical practice among emergency physicians (EP) remains untested. Objective: This pilot study aimed to (1) determine the feasibility of recording on-shift photoplethysmographic data from EP, (2) assess the quality of these data, and (3) calculate standard pulse rate variability (PRV) metrics from the acquired dataset and examine patterns in these variables over the course of an academic year. Methods: A total of 21 EP wore PPG biosensors on their wrists during clinical work in the emergency department during a 9-hour shift. Recordings were collected during the first quarter of the academic year, then again during the fourth quarter of the same year for comparison. The overall rate of usable data collection per time was computed. Standard pulse rate (PR) and PRV metrics from these two time points were calculated and entered into Student t tests. Results: More than 400 hours of data were entered into these analyses. Interpretable data were captured during 8.54% of the total recording time overall. In the fourth quarter of the academic year compared with the first quarter, there was no significant difference in median PR (75.8 vs 76.8; P=.57), mean R-R interval (0.81 vs 0.80; P=.32), SD of R-R interval (0.11 vs 0.11; P=.93), root mean square of successive difference of R-R interval (0.81 vs 0.80; P=.96), low-frequency power (3.5×103 vs 3.4×103; P=.79), high-frequency power (8.5×103 vs 8.3×103; P=.91), or low-frequency to high-frequency ratio (0.42 vs 0.41; P=.43), respectively. Power estimates for each of these tests exceeded .90. A secondary analysis of the resident-only subgroup similarly showed no significant differences over time, despite power estimates greater than .80. Conclusions: Although the use of PPG biosensors to record real-time physiological data from EP while providing clinical care seems operationally feasible, this study fails to support the notion that such an approach can efficiently provide reliable estimates of metrics of interest. No significant differences in PR or PRV metrics were found at the end of the year compared with the beginning. Although these methods may offer useful applications to other domains, it may currently have limited utility in the contexts of physician training and wellness.

SDS of cas: 83-10-3. Bye, fridends, I hope you can learn more about C12H12N2O3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Patent; Shanghai Pharmaceutical Industry Institute; China Pharmaceutical Industry Zongyuan; Li Jianqi; Huang Daowei; Wang Wenya; Zhang Zhiguo; Jiang Ling; (45 pag.)CN107286140; (2017); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

An article One-Pot Asymmetric Synthesis of Spiropyrazolone-Linked Cyclopropanes and Benzofurans through a General Michael Addition/Chlorination/Nucleophilic Substitution Sequence WOS:000481979200038 published article about N-HETEROCYCLIC CARBENE; ENANTIOSELECTIVE CONSTRUCTION; ORGANOCATALYSIS; PYRAZOLONES; ANNULATION; SCAFFOLDS; OXINDOLES; CATALYSIS in [Lu, Hong; Zhang, Huan-Xin; Tan, Chang-Yin; Liu, Jin-Yu; Xu, Peng-Fei] Lanzhou Univ, Sch Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China; [Lu, Hong; Wei, Hao] Northwest Univ, Coll Chem & Mat Sci, Natl Demonstrat Ctr Expt Chem Educ, Key Lab Synthet & Nat Funct Mol Chem,Minist Educ, Xian 710127, Shaanxi, Peoples R China in 2019, Cited 45. HPLC of Formula: C11H12N2O. The Name is 3-Methyl-1-p-tolyl-5-pyrazolone. Through research, I have a further understanding and discovery of 86-92-0

A sequential and general strategy has been successfully developed for the synthesis of spiropyrazolone scaffolds. This intriguing transformation of the asymmetric multicomponent catalysis process was realized with the combination of Michael addition/chlorination/nucleophilic substitution in a one-pot sequence, giving rise to a series of spiropyrazolones with fully substituted cyclopropanes and spiro-dihydrobenzofurans containing continuous stereogenic centers in good yields with excellent stereoselectivities.

Bye, fridends, I hope you can learn more about C11H12N2O, If you have any questions, you can browse other blog as well. See you lster.. HPLC of Formula: C11H12N2O

Reference:
Article; Zhang, Yong; Nie, Long-Jun; Luo, Liang; Mao, Jia-Xin; Liu, Jin-Xiang; Xu, Guo-Hai; Chen, Deliang; Luo, Hai-Qing; Tetrahedron; vol. 76; 7; (2020);,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics