Month: February 2021

Synthetic Route of 948570-75-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 948570-75-0, name is 1-(2-Methoxyethyl)-4-nitro-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows.

Intermediate 33.2 (90 mg, 0.53 mmol, 1.00 equiv) in methanol (5 mL) was added 10% palladium on carbon (18 mg) under nitrogen. The flask was degassed three times with hydrogen (2 atm) and the mixture was stirred 1 h at room temperature. The solids were filtered out and the filtrate was concentrated under vacuum to give 74 mg (crude) of intermediate 33.2 as a yellow solid. LCMS (ES, mlz): 142 [M+H].

The chemical industry reduces the impact on the environment during synthesis 1-(2-Methoxyethyl)-4-nitro-1H-pyrazole. I believe this compound will play a more active role in future production and life.

These common heterocyclic compound, 92933-47-6, name is 5-Isopropyl-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C7H10N2O2

Example 1. Synthesis of 5-(propan-2-yl)-N-{4-[(pyrimidin-2- yl)sulfamoyl]phenyl}-lH-pyrazole-3-carboxamide, 1-17 1-17 [00265] HATU (460mg, 1.2 mmol) and DIPEA (0.42 ml, 2.4 mmol) were added at Rt to a stirred solution of 3-(propan-2-yl)-lH-pyrazole-5-carboxylic acid (120mg, 0.8 mmol) in DMF (HPLC grade, 7 ml) followed by 4-amino-N-(pyrimidin-2-yl)benzenesulfonamide (200mg, 0.8 mmol). The resulting mixture was stirred at Rt for 20h. The solvent was removed in vacuo and the remaining material was purified by prep HPLC (MeCN/Water, 0.1% formic acid) to afford lOmg (3%) of 5-(propan-2-yl)-N-{4-[(pyrimidin-2-yl)sulfamoyl]phenyl}-lH-pyrazole-3- carboxamide 1-17 as a colourless solid. 1H NMR (500 MHz, DMSO-d6) delta 13.15 (s, 1H), 10.29 (s, 1H), 8.48 (d, J = 4.8 Hz, 2H), 7.98 (d, J = 8.6 Hz, 2H), 7.91 (d, J = 8.6 Hz, 2H), 7.01 (s, 1H), 6.54 (s, 1H), 3.11 – 2.77 (m, 1H), 1.25 (d, J = 6.9 Hz, 6H).

The synthetic route of 5-Isopropyl-1H-pyrazole-3-carboxylic acid has been constantly updated, and we look forward to future research findings.

Synthetic Route of 20154-03-4, These common heterocyclic compound, 20154-03-4, name is 3-(Trifluoromethyl)-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

NaH (33.08 g (19.85, 60percent), 1.5 equiv.) was added to a small amount of n-hexane and the mixture was stirred for 10 minutes. The n-hexane was decanted, dry DMF (500 mL) was added under an N2 atmosphere and the mixture was stirred. A solution of the product obtained in step b (75 g, 550 mmol) in DMF (125 mL) was added dropwise under an N2 atmosphere. A solution of 4-methoxyl benzoyl chloride (86.3 g, 550 mmol, 1 equiv.) in DMF (125 mL) was then added dropwise and the mixture was stirred for 12 h at RT and then poured into iced water (500 mL), and the mixture was extracted with EA (2.x.400 mL). The mixture was then dried over Na2SO4 and concentrated under reduced pressure, the crude product being obtained as a brown oil (125 g, 88percent yield).

Statistics shows that 3-(Trifluoromethyl)-1H-pyrazole is playing an increasingly important role. we look forward to future research findings about 20154-03-4.

Application of 1613191-73-3, The chemical industry reduces the impact on the environment during synthesis 1613191-73-3, name is Allyl 3,5-diamino-1H-pyrazole-4-carboxylate, I believe this compound will play a more active role in future production and life.

[0450] To a suspension ofallyl3,5-diamino-1H-pyrazole-4-carboxylate 3 ( 42.72 g, 234.5 mmol) in DMSO (270.8mL)/Water(270.8 mL), was added p-TsOHhydrate (46.72 g,245.6 mmol) and 3-( diisopropylamino )-2-fluoro-prop-2-enal(described in Tetrahedron Letters, 33(3), 357-60; 1992) (38.69 g, 223.3 mmol). The reaction mixture was heated to 100C. for 3 hr. during which time a solid slowly precipitated outof solution. The orange suspension was allowed to cool downto RT overnight. The solid was filtered, washed with waterand dried under vacuum to give allyl2-amino-6-fluoro-pyrazolo[1,5-a]pyrimidine-3-carboxylate 4a as a sand solid (45.05 g, 85% yield).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Allyl 3,5-diamino-1H-pyrazole-4-carboxylate, other downstream synthetic routes, hurry up and to see.

Related Products of 1904-31-0, A common heterocyclic compound, 1904-31-0, name is 1-Methyl-1H-pyrazol-3-amine, molecular formula is C4H7N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example E (0238) N-Hydroxy-4-(((1 -methyl-1 H-pyrazol-3-yl)(pyridin-2-yl)amino)methyl)benzamide (0239) (0240) 2-Bromopyridine (1 ) (1.0g, 6.3mmol), 1-methyl-1 H-pyrazol-3-amine (2) (0.79g, 8.2mmol), Xantphos (0.37g, 0.63mmol), and Cs2C03 (4.1g, 12.6mmol) were combined in dry 1 ,4-dioxane (15ml_). The reaction mixture was then degassed with N2(g), and placed under vacuum for 10min. Pd2(dba)3 (0.29g, 0.31 mmol) was added and the resulting reaction mixture was heated at 90¡ãC for 30h. It was then poured onto demineralised water (200ml_), and extracted with EtOAc (3 x 100ml_). The organic phases were combined, dried over Na2S04, filtered and subsequently concentrated in vacuo. The resulting residue was purified by flash chromatography with EtOAc/Hexane (1 : 1) to provide N-(1-methyl-1 H-pyrazol-3-yl)pyridin-2-amine (3) as a yellow solid (0.75g, 68percent). (0241) LCMS (ES): Found 175.2 [M+H]+.

The synthetic route of 1904-31-0 has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 151049-87-5 as follows. Quality Control of 3-Bromo-1-methyl-1H-pyrazole

To a solution of 3-bromo-1-methyl-1H-pyrazole (40 g, 248 mmol) (see the Supporting Information for the synthesis) in THF (1 L) was added dropwise a solution of t-BuLi (200 mL, 1.3 M, 260 mmol) in hexane at -90 C under N2 with stirring over 2 h. The reaction mixture was stirred at -90 C for further 0.5 h. Then a solution of (SS)-4 (58 g, 209 mmol) in THF (0.2 L) was added dropwise to the reaction mixture at -90 C. The mixture was stirred and warmed slowly to r.t. overnight. TLC showed the desired spot with Rf = 0.25 (EtOAc). Then the solution was quenched with sat. aq NH4Cl (1 L) and extracted with Et2O (3 ¡Á 0.8 L). The combined organic layers were dried (Na2SO4) concentrated. The crude product was purified by column chromatography over silica gel (PE-EtOAc, 20:1 ? 2:1) to give the title product; yield: 22.9 g (30%); brown oil; Rf = 0.25 (EtOAc).

According to the analysis of related databases, 151049-87-5, the application of this compound in the production field has become more and more popular.

Related Products of 95162-14-4, A common heterocyclic compound, 95162-14-4, name is 4-Bromo-1-tritylpyrazole, molecular formula is C22H17BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 2) Synthesis of 4- (4-fluorophenyl) -1-trityl-lH- pyrazole To a suspension of 4-bromo-trityl-l.H-pyrazole (0.7 g) in N, N-dimethylformamide (14 ml) was added 4- fluorophenylboronic acid (0.377 g) , cesium carbonate (1.758 g) , and tetrakis triphenylphosphine palladium (0.208 g) . The resulting suspension was stirred at room temperature for 10 min. The irradiation of microwaves at 1600C for 10 min was sufficient to complete a reaction in the suspension. The product was filtered through silica gel, diluted in ethyl acetate (30 ml) and washed with saturated ammonium chloride solution (30 ml) and then with brine (30 ml) . The washed organic layer thus formed was dried over anhydrous magnesium sulfate and concentrated by evaporation in a vacuum. The residue thus obtained was separated using silica gel chromatography to produce 4- (4-fluorophenyl) -1- trityl-lH-pyrazole (yield 51%) .1H-NMROOOMHZ, CDCl3): 57.93 (s, IH), 7.62 (s, IH), 7.36-7.29(m, HH), 7.21-7.18(m, 6H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 930-36-9, name is 1-Methylpyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 930-36-9, category: pyrazoles-derivatives

Preparation 4 Preparation of 5-(5,5-dimethyl-1 ,3,2-dioxaborinan-2-yl)-1 -methyl-1 H-pyrazoleTo a solution of 1 -methyl pyrazole (4.1 g, 50 mmole) in THF (100 ml.) at 00C was added n-BuLi (2.2M in THF, 55 mmole). The reaction solution was stirred for 1 hour at RT and then cooled to -78C [J. Heterocyclic Chem. 41 , 931 (2004)]. To the reaction solution was added 2-isopropoxy-4,4,5,5-tetramethyl-1 ,3,2-dioxaborolane (12.3 ml_, 60 mmole). After 15 min at -78C, the reaction was allowed to warm to 00C over 1 hour. The reaction was diluted with saturated NH4CI solution and extracted with DCM. The organics were dried over Na2SO4 and concentrated under vacuum to afford a tan solid (8.0 g, 77%) which was used without further purification. LCMS (ES) m/z 127 (M+H)+ for [RB(OH)2]; 1H NMR (CDCI3, 400 MHz) delta 7.57 (s, 1 H), 6.75 (s, 1 H), 4.16 (s, 3H), and 1.41 (s, 12H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methylpyrazole, other downstream synthetic routes, hurry up and to see.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 34334-96-8 as follows. Safety of 3-Methyl-5-nitro-1H-pyrazole

In a sealed tube, 2-(tributylphosphoranylidene)-acetonitrile (7.30 g, 30.25 mmol) was added to a solution of 5-Methyl-3-nitro-lH-pyrazole (2.00 g, 15.74 mmol) and 2- cyclopropylethanol (2.04 g, 23.68 mmol) in toluene (70 mL). The mixture was heated at 60 C for 19 h. After cooling down to rt, the mixture was diluted with EtOAc and water. The organic layer was decanted and the solvent was evaporated in vacuo. The residue was purified by column chromatography on silica gel (Irregular SiOH, 20-45 muiotaeta, 40 g, mobile phase: heptane/EtOAc, gradient from 60:40 EtOAc to 50:50). The pure fractions were combined and the solvent was evaporated until dryness to give 2.10 g of intermediate 232′ (68% yield) and 330 mg of intermediate 232 (11% yield).

According to the analysis of related databases, 34334-96-8, the application of this compound in the production field has become more and more popular.

These common heterocyclic compound, 110860-60-1, name is Methyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 110860-60-1

(6) Synthesis of alpha-type crystal form azo pigment (1)-1 20.5 mL of acetic acid is cooled with ice to an internal temperature of 10C. 16.8 g of nitrosylfulfic acid is added with keeping the internal temperature at 15C or lower, and successively 9.5 g of the intermediate (b) is added thereto by portions with keeping the internal temperature at 15C or lower. After stirring for 15 minutes at an internal temperature of 15C, the internal temperature is increased to 25C in 15 minutes. After stirring for 90 minutes at the same temperature, 0.4 g of urea is added by portions at the same temperature, followed by stirring for 15 minutes at the same temperature to obtain a diazonium salt solution. Separately, 11.6 g of the intermediate (e) is completely dissolved in 405 mL of methanol at room temperature, and then the solution is cooled with ice to an internal temperature of -3C. At the same temperature, the above-described diazonium salt solution is added thereto by portions with keeping the internal temperature at 3C or lower and, after completion of the addition, the mixture is stirred for 2 hours to obtain an azo compound reaction solution. Separately, 810 mL of water is prepared, and the azo compound reaction solution is added thereto. The resulting mixture is stirred for 30 minutes at room temperature, and crystals precipitated are collected by filtration, spray-washed with 150 mL of methanol and, further, with 100 mL of water. The thus-obtained crystals are suspended in 750 mL of water without drying, and a 8-N potassium hydroxide aqueous solution is added thereto to adjust the pH to 5.7. After stirring for 20 minutes at room temperature, resulting crystals are collected by filtration, sufficiently spray-washed with water, and then spray-washed with 80 mL of methanol to obtain a crude pigment (1-1).

The synthetic route of Methyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate has been constantly updated, and we look forward to future research findings.