Category: 14580-22-4

Tang, Cheng-Ke published the artcileCombining Organocatalysis and Iodine Catalysis: One-Pot Sequential Catalytic Synthesis of Chiral Spirodihydrobenzofuran Pyrazolones and Spirodihydrobenzofuran Oxindoles, Formula: C10H9ClN2O, the publication is Organic Letters (2018), 20(18), 5840-5844, database is CAplus and MEDLINE.

O-Hydroxystyrenes such as (E)-2-HOC₆H₄CH:CHNO₂ underwent diastereoselective and enantioselective oxidative spirocyclization reactions (via sequential Michael addition, iodination, and cyclization reactions) with pyrazolones and N-Boc oxindoles in the presence of a nonracemic squaramide and a nonracemic alkaloid-derived thiourea to give spirobenzofuranpyrazolones such as I and spirobenzofuranoxindoles such as II, resp.

Organic Letters published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is CBF6K, Formula: C10H9ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Yang, Zhong-Tao published the artcileOrganocatalytic Enantioselective aza-Friedel-Crafts Reactions of Pyrazolinone Ketimines with Hydroxyindoles and Electron-Rich Phenols, Related Products of pyrazoles-derivatives, the publication is Advanced Synthesis & Catalysis (2018), 360(10), 2049-2054, database is CAplus.

A variety of enantioenriched indole derivatives substituted in the benzene ring were synthesized via an organocatalytic asym. aza-Friedel-Crafts reaction of pyrazolinone ketimines with hydroxyindoles. This reaction was also applicable to electron-rich phenols, yielding the desired products in high yields (up to 99%) and excellent stereo-selectivities (91-99% ee). Moreover, this method presents its potential in the synthesis of structurally novel indole-pyrazolinone conjugate derivatives

Advanced Synthesis & Catalysis published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C12H23N3S, Related Products of pyrazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Ma, Jing published the artcileElectrochemical-Induced C(sp³)-H Dehydrogenative Trimerization of Pyrazolones to Tripyrazolones, Computed Properties of 14580-22-4, the publication is European Journal of Organic Chemistry (2021), 2021(40), 5491-5496, database is CAplus.

The electrochem.-induced three-component C(sp³)-H dehydrogenative trimerization of pyrazolones to tripyrazolones with hydrogen evolution has been accomplished under the metal- and external-oxidant-free conditions. This protocol provides an efficient and eco-friendly method for the synthesis of tripyrazolones, which avoids the use of metals and stoichiometric chem. oxidants. A wide range of functional groups was tolerated to give selectively the desired products in high yields. Importantly, such an electrochem.-oxidation-induced dehydrogenative trimerization reaction could be easily scaled up with excellent efficiency.

European Journal of Organic Chemistry published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C10H9ClN2O, Computed Properties of 14580-22-4.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Sun, Pengfei published the artcileDMSO-promoted regioselective synthesis of sulfenylated pyrazoles via a radical pathway, Application of 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, the publication is Organic Chemistry Frontiers (2017), 4(7), 1367-1371, database is CAplus.

A green and eco-friendly protocol for the construction of C-4 sulfenylated pyrazoles I [R¹ = Me, t-Bu, Ph, COOH; R² = Me, Ph, 4-MeC₆H₄, 4-ClC₆H₄, 2-ClC₆H₄; R³= Ph, 4-MeC₆H₄, 4-ClC₆H₄, etc.; R⁴ = OH] via a radical pathway was established for the first time. When 1,3-diphenyl-1H-pyrazol-5-amine was reacted with aryl thiols the corresponding 2,5-diphenyl-4-arylsulfanyl-pyrazol-3-amines I [R¹ = R² = Ph; R³ = 4-MeC₆H₄, 4-MeOC₆H₄, 4-BrC₆H₄; R⁴ = NH₂] were also obtained in moderate to good yields. The reaction worked smoothly under catalyst and solvent-free conditions to afford wide range of sulfenylated pyrazole derivatives in good to excellent yields. The thiyl free radical generated in situ, served as a single electron transfer medium for the present transformation. This reaction provided a new strategy for the formation of C-S bond.

Organic Chemistry Frontiers published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C13H10O3, Application of 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Wu, Gengxin published the artcileAsymmetric Organocatalysis Combined with Palladium Catalysis: Synergistic Effect on Enantioselective Mannich/α-Allylation Sequential Reactions of Pyrazolones in Constructing Vicinal Quaternary Stereocenters, Product Details of C10H9ClN2O, the publication is Organic Letters (2019), 21(19), 7708-7712, database is CAplus and MEDLINE.

In this letter, an efficient one-pot asym. sequential reaction is achieved by organo/transition metal relay catalysis in constructing two consecutive C-C bonds, which involves enantioselective amino squaramide catalytic Mannich-type addition of pyrazolones to isatin-derived ketimines and a subsequent palladium catalyzed diastereoselective allylic alkylation of pyrazolones with allylic acetates. An array of novel pyrazolone-aminooxindole-propylene structural motifs are obtained in a high level of yield and with excellent enantio- and diastereoselectivity (up to 95% yield, >20:1 dr, >99% ee). This methodol. features the formation of vicinal quaternary carbon-stereocenters, and the second all-carbon tetrasubstituted stereogenic center is induced by joint action of the achiral palladium catalysis and the chiral environment generated from the Mannich step. Moreover, the usefulness of this methodol. is highlighted by converting the allylic product into the carbonyl compound

Organic Letters published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C15H14Cl2S2, Product Details of C10H9ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Zhu, Ye-Fu published the artcileSynthesis of pyrazolones and pyrazoles via Pd-catalyzed aerobic oxidative dehydrogenation, Formula: C10H9ClN2O, the publication is Tetrahedron Letters (2019), 60(17), 1202-1205, database is CAplus.

A novel, ligand free and easily accessible approach for the synthesis of pyrazolones I [R¹ = Me, t-Bu, Ph, etc.; R² = H, 4-Me, 2-Cl, etc.] and pyrazoles II [R³ = H, 4-Me, 3,4,5-tri-OMe; R⁴ = Me, CF₃; R⁵ = H, 4-Me, 4-SO₂NH₂, etc.] was developed via Pd-catalyzed oxidative dehydrogenation of phenylpyrazolidines/substituted hydrazones in the presence of anthradione (AMS) as a cocatalyst. This method can be utilized to a wide range of substrates, operates under mild reaction conditions and could give high yields.

Tetrahedron Letters published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C38H74Cl2N2O4, Formula: C10H9ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Wu, Nan published the artcileSyntheses of pyrazole derivatives, Product Details of C10H9ClN2O, the publication is Daxue Huaxue (2014), 29(3), 63-66, database is CAplus.

Through the synthesis experiments of pyrazole derivatives, the students were led to use chem. open experiment time, search literatures, determine exptl. contents, complete experiment process and verify experiment results. A new rapid and simple method to synthesize pyrazole derivatives was found, and the creative consciousness and comprehensive abilities of students were improved.

Daxue Huaxue published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C9H9ClO4, Product Details of C10H9ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Zhang, Rong published the artcileIodine-Catalyzed Construction of Dihydrooxepines via 3-Methyl-5-Pyrazolones C-H Oxidation/Functionalization of Quinolines Cascade, COA of Formula: C10H9ClN2O, the publication is European Journal of Organic Chemistry (2021), 2021(27), 3807-3811, database is CAplus.

An efficient iodine-catalyzed [3+3+1] annulation for the construction of dihydrooxepine scaffolds with quinoline units was developed. This strategy involved a seven-membered dihydrooxepine with a broad substrate scope through a formal three-component tandem reaction. Further derivation of the target product produced a trioxabicycle scaffold, which formed the basic core of natural products and pharmaceutical mols.

European Journal of Organic Chemistry published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C9H9BrO2, COA of Formula: C10H9ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Maquestiau, A. published the artcileTautomerism in the pyrazolinone series. II. Solvent influence on the prototropic equilibrium of N1 substituted pyrazolin-5-ones, Related Products of pyrazoles-derivatives, the publication is Bulletin des Societes Chimiques Belges (1973), 82(3-4), 215-31, database is CAplus.

The solvent effect on the tautomerism of N-1 substituted pyrazolin-5-ones was determined by ir. The % keto form (I) was larger than the % enol form in nonpolar solvents; the % keto form decreased in aprotic solvents with their increasing basicity. In aprotic solvents, the concentration of the NH form (II) was related to the solvent acidity.

Bulletin des Societes Chimiques Belges published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C10H9ClN2O, Related Products of pyrazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Simov, D. published the artcileAzo dye from 10-methyl-2-aminophenothiazine, Safety of 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, the publication is Godishnik na Sofiiskiya Universitet Sv. Kliment Okhridski, Khimicheski Fakultet (1975), 543-54, database is CAplus.

Azo dyes (I, R = pyrazolone, hydroxynaphthalene, aniline, aminonaphthalene residues) were prepared by coupling diazotized 2-amino-10-methylphenothiazine [2031-24-5] with RH and dyed protein and synthetic fibers wetfast and, in some cases, lightfast shades. All dyes were characterized by elementary anal., m.p., visible, uv, and ir spectra, and Rf. In I where R is not a pyrazolone residue the equilibrium between the azo enol form and the quinone hydrazone form is fully shifted to the azo enol form.

Godishnik na Sofiiskiya Universitet Sv. Kliment Okhridski, Khimicheski Fakultet published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C8H17Br, Safety of 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics