Category: 52287-51-1

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Chemistry – An Asian Journal called Sequential SNAr Reaction/Suzuki-Miyaura Coupling/C-H Direct Arylations Approach for the Rapid Synthesis of Tetraaryl-Substituted Pyrazoles, Author is Morita, Taiki; Kobayashi, Daisuke; Matsumura, Keisuke; Johmoto, Kohei; Uekusa, Hidehiro; Fuse, Shinichiro; Takahashi, Takashi, which mentions a compound: 52287-51-1, SMILESS is BrC1=CC=C2OCCOC2=C1, Molecular C8H7BrO2, Category: pyrazoles-derivatives.

The rapid synthesis of 1,3,4,5-tetraaryl-substituted pyrazoles I (R1 = CN, NO2; R2 = 4-CF3, 4-MeO, 2-Me; R3 = CN, Me, CO2Et; R4 = 4-O2NC6H4, naphthalen-2-yl, 2,3-dihydro-1,4-benzodioxin-6-yl, etc.) was achieved through a sequence of SNAr reaction/Suzuki-Miyaura coupling/Pd-catalyzed direct arylations that used 3-iodo-1H-pyrazole as a scaffold. Compounds I were synthesized in a straightforward manner with no extra synthetic steps, such as protection/deprotection or the introduction of activating/directing groups, using readily available substrates and reagents. The developed synthetic approach enabled the structurally diverse synthesis of multiaryl-substituted pyrazoles without using glovebox techniques.

The article 《Sequential SNAr Reaction/Suzuki-Miyaura Coupling/C-H Direct Arylations Approach for the Rapid Synthesis of Tetraaryl-Substituted Pyrazoles》 also mentions many details about this compound(52287-51-1)Category: pyrazoles-derivatives, you can pay attention to it or contacet with the author([email protected]; [email protected]) to get more information.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Palladium-catalyzed direct reductive cross-coupling of aryltrimethylammonium salts with aryl bromides, published in 2021, which mentions a compound: 52287-51-1, Name is 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine, Molecular C8H7BrO2, Related Products of 52287-51-1.

An efficient palladium-catalyzed direct reductive cross-coupling of aryltrimethylammonium salts with aryl bromides was developed. The reactions proceeded smoothly in the presence of a palladium catalyst, magnesium turnings, LiCl, and TMEDA in THF at room temperature, leading to the corresponding biaryl compounds in moderate to good yields with reasonable functional group tolerance. The one-pot reaction using cheap and readily available aryl bromide as a coupling partner were simple to handle, thereby avoiding the use of pre-prepared organometallic reagents.

The article 《Palladium-catalyzed direct reductive cross-coupling of aryltrimethylammonium salts with aryl bromides》 also mentions many details about this compound(52287-51-1)Related Products of 52287-51-1, you can pay attention to it, because details determine success or failure

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Oxalic Acid Monothioester for Palladium-Catalyzed Decarboxylative Thiocarbonylation and Hydrothiocarbonylation, published in 2019-12-06, which mentions a compound: 52287-51-1, Name is 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine, Molecular C8H7BrO2, Formula: C8H7BrO2.

Oxalic acid monothioester (OAM), an easily accessible and storable reagent, was reported herein as a thioester synthetic equivalent for palladium-catalyzed decarboxylative thiocarbonylation of organohalides and hydrothiocarbonylation of unsaturated carbon-carbon bonds at room temperature with high chemo- and regioselectivity. The reaction is applicable to the synthesis of cysteine-derived thioesters, thus allowing chem. modification of cysteine-containing peptides. Decarboxylation of OAM proceeds through oxidative addition of Pd(0) to the acyl-S bond, which accounts for the very mild reaction conditions.

The article 《Oxalic Acid Monothioester for Palladium-Catalyzed Decarboxylative Thiocarbonylation and Hydrothiocarbonylation》 also mentions many details about this compound(52287-51-1)Formula: C8H7BrO2, you can pay attention to it, because details determine success or failure

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Recommanded Product: 52287-51-1. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine, is researched, Molecular C8H7BrO2, CAS is 52287-51-1, about 6-(4-Benzylpiperazin-1-yl)benzodioxanes as selective ligands at cloned primate dopamine D4 receptors. Author is Hodgetts, Kevin J.; Kieltyka, Andrzej; Brodbeck, Robbin; Tran, Jennifer N.; Wasley, Jan W. F.; Thurkauf, Andrew.

A series of novel 6-(4-benzylpiperazin-1-yl)benzodioxanes were prepared and screened at selected dopamine receptor subtypes. 6-(4-[4-Chlorobenzyl]piperazin-1-yl)benzodioxane had high affinity and selectivity for the D4 dopamine receptor subtype and was identified as a D4 antagonist via its attenuation of dopamine-induced GTPγ35S binding at the D4 receptor.

After consulting a lot of data, we found that this compound(52287-51-1)Recommanded Product: 52287-51-1 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Computed Properties of C8H7BrO2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine, is researched, Molecular C8H7BrO2, CAS is 52287-51-1, about Rhodium-Catalyzed Direct Arylation of Furopyridine: Synthesis and the Cardiac Effects of Dictamnine Derivatives. Author is Du, Yufeng; Huang, Linyu; Wang, Neng; Li, Xiaohuan; Zhou, Xian-Li; Zhang, Lan; Huang, Shuai; Walsh, Patrick J.; Gao, Feng.

Synthesis of Rh2(OAc)4/IMes·HCl system promotes the chemoselective installation of aryl groups at the 2-position of furo[2,3-b]pyridines I (R = Ph, naphthalen-1-yl, 2,3-dihydro-1,4-benzodioxin-6-yl, etc.) (53-94% yields). The method is applicable to the direct modification of the natural furoquinoline alkaloid dictamnine. The cardiac effects of the fluorinated analogs II were improved, and compared to dictamnine at 160 μg/mL. Preliminary mechanism of action studies indicate that the effects might be related to epinephrine αreceptors, M-receptor and calcium channel receptor.

After consulting a lot of data, we found that this compound(52287-51-1)Computed Properties of C8H7BrO2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Zorina, L. N.; Safiev, O. G.; Chanyshev, R. R.; Zorin, V. V.; Rakhmankulov, D. L. published the article 《Preparation of halogenated benzodioxacycloalkanes》. Keywords: benzodioxole sodium hypochlorite halogenation; benzodioxan sodium hypobromite halogenation; halobenzodioxole preparation; halobenzodioxan preparation.They researched the compound: 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine( cas:52287-51-1 ).Recommanded Product: 52287-51-1. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:52287-51-1) here.

Reaction of 1,3-benzodioxole (I) and 1,4-benzodioxan (II) with NaOCl and NaOBr in presence of sulfuric acid resulted in mono- and dihalogenated derivatives of I and II. Regioselectivity of this reaction depended on the reagents ratio.

After consulting a lot of data, we found that this compound(52287-51-1)Recommanded Product: 52287-51-1 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 52287-51-1. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine, is researched, Molecular C8H7BrO2, CAS is 52287-51-1, about Synthesis and structure-activity relationships of new antiproliferative and proapoptotic retinoid-related biphenyl-4-yl-acrylic acids. Author is Cincinelli, Raffaella; Dallavalle, Sabrina; Nannei, Raffaella; Merlini, Lucio; Penco, Sergio; Giannini, Giuseppe; Pisano, Claudio; Vesci, Loredana; Ferrara, Fabiana Fosca; Zuco, Valentina; Zanchi, Chiara; Zunino, Franco.

Atypical retinoids, or retinoid-related mols. (RRMs), represent a class of proapoptotic agents with a promising potential in the treatment of neoplastic diseases. In the present work, the synthesis and structure-activity relationship of a series of 3′-adamantan-1-yl-biphenyl-4-yl-acrylic acids substituted in ring A were studied. The synthesized compounds were evaluated for their antiproliferative activity in a human promyelocytic leukemia cell line (NB4), and in an ovarian carcinoma cell system including IGROV-1, carrying a functional wild-type p53, and a cisplatin-resistant subline, IGROV-1/Pt-1. The presence of at least one oxygenated substituent in positions 4′ or 5′ appears determinant for the antiproliferative activity. With two substituents of this kind the activity increases, particularly in the case of alkylenedioxy compounds The activation of DNA damage response as indicated by phosphorylation of H2AX histone, RPA-2 protein, and p53 at serine 15 by the most apoptotic compounds provides addnl. support to the hypothesis that the genotoxic stress is a critical event mediating apoptosis induction by compounds of this group.

After consulting a lot of data, we found that this compound(52287-51-1)Application of 52287-51-1 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Catalytic asymmetric addition of an amine N-H bond across internal alkenes, published in 2020-12-10, which mentions a compound: 52287-51-1, mainly applied to iridium catalyzed enantioselective hydroamination internal alkene, Safety of 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine.

Hydroamination of alkenes, the addition of the N-H bond of an amine across an alkene, is a fundamental, yet challenging, organic transformation that creates an alkylamine from two abundant chem. feedstocks, alkenes and amines, with full atom economy. The reaction is particularly important because amines, especially chiral amines, are prevalent substructures in a wide range of natural products and drugs. Although extensive efforts have been dedicated to developing catalysts for hydroamination, the vast majority of alkenes that undergo intermol. hydroamination have been limited to conjugated, strained, or terminal alkenes; only a few examples occur by the direct addition of the N-H bond of amines across unactivated internal alkenes, including photocatalytic hydroamination, and no asym. intermol. additions to such alkenes are known. In fact, current examples of direct, enantioselective intermol. hydroamination of any type of unactivated alkene lacking a directing group occur with only moderate enantioselectivity. Here we report a cationic iridium system that catalyzes intermol. hydroamination of a range of unactivated, internal alkenes, including those in both acyclic and cyclic alkenes, to afford chiral amines with high enantioselectivity. The catalyst contains a phosphine ligand bearing trimethylsilyl-substituted aryl groups and a triflimide counteranion, and the reaction design includes 2-amino-6-methylpyridine as the amine to enhance the rates of multiple steps within the catalytic cycle while serving as an ammonia surrogate. These design principles point the way to the addition of N-H bonds of other reagents, as well as O-H and C-H bonds, across unactivated internal alkenes to streamline the synthesis of functional mols. from basic feedstocks.

Although many compounds look similar to this compound(52287-51-1)Safety of 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine, numerous studies have shown that this compound(SMILES:BrC1=CC=C2OCCOC2=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 52287-51-1, is researched, Molecular C8H7BrO2, about Pd-Catalyzed Direct Diversification of Natural Anti-Alzheimer’s Disease Drug: Synthesis and Biological Evaluation of N-Aryl Huperzine A Analogues, the main research direction is aryl huperzine preparation anti Alzheimer activity acetylcholinesterase SAR chemoselective; huperzine aryl bromide Buchwald Hartwig coupling palladium catalyst.Recommanded Product: 52287-51-1.

The first systematic direct diversification of a complex natural product by metal-catalyzed N-H functionalization was carried out. A new series of N-(hetero)aryl analogs I (Ar = Ph, 2-naphthyl, 4-methylpyridin-2-yl, etc.) of the natural anti-Alzheimer’s disease drug huperzine A (HPA) was prepared via palladium-catalyzed Buchwald-Hartwig cross-coupling reactions of HPA with various aryl bromides ArBr in good yields. Most of the N-aryl-huperzine A (N-aryl-HPA) analogs showed good acetylcholinesterase (AChE) inhibitory activity in in vitro experiments Three arylated huperzine A analogs I (Ar = 4-FC6H4, 4-methoxy-2,6-dimethylphenyl, 5-methoxypyridin-2-yl) exhibited stronger anti-AChE activity than HPA. The 5-methoxy-2-pyridyl analog I (Ar = 5-methoxypyridin-2-yl) displayed the most potent AChE inhibition activity, with an IC50 value of 1.5μM, which was 7.6-fold more active than HPA. Compound I (Ar = 5-methoxypyridin-2-yl) also exhibited better neuroprotective activity for H2O2-induced damage in SH-SY5Y cells than HPA. Structure-activity relationship anal. suggested that the electron d. of the installed aromatic ring or heteroaromatic ring played a significant role in inducing the AChE inhibition activity. Overall, compound I (Ar = 5-methoxypyridin-2-yl) showed the advantages of easy synthesis, high potency and selectivity, and improved neuroprotection, making it a potential huperzine-type lead compound for Alzheimer’s disease drug development.

Although many compounds look similar to this compound(52287-51-1)Recommanded Product: 52287-51-1, numerous studies have shown that this compound(SMILES:BrC1=CC=C2OCCOC2=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Formula: C8H7BrO2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine, is researched, Molecular C8H7BrO2, CAS is 52287-51-1, about (R)-3,5-diCF3-SYNPHOS and (R)-p-CF3-SYNPHOS, Electron-Poor Diphosphines for Efficient Room Temperature Rh-Catalyzed Asymmetric Conjugate Addition of Arylboronic Acids. Author is Berhal, Farouk; Esseiva, Olivier; Martin, Charles-Henri; Tone, Hitoshi; Genet, Jean-Pierre; Ayad, Tahar; Ratovelomanana-Vidal, Virginie.

Two new atropisomeric electron-poor chiral diphosphine ligand analogs of SYNPHOS were prepared, and their electronic properties described. These two ligands afforded high performance for the Rh-catalyzed asym. 1,4-addition of arylboronic acids to α,β-unsaturated carbonyl compounds at room temperature

Although many compounds look similar to this compound(52287-51-1)Formula: C8H7BrO2, numerous studies have shown that this compound(SMILES:BrC1=CC=C2OCCOC2=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics