Category: 27412-71-1

Jung, Jae-Chul published the artcileSynthesis of 3-substituted and 3,4-disubstituted pyrazolin-5-ones, Application In Synthesis of 27412-71-1, the main research area is acetoacetate acid chloride acylation; malonate acid chloride acylation; hydroxybutenoate preparation hydrazine cyclocondensation; alkylidenemalonate preparation hydrazine cyclocondensation; pyrazolinone preparation.

The synthesis of 3-substituted and 3,4-disubstituted pyrazolin-5-ones from acylated Et acetoacetates and di-Et malonates is described. The reaction of acylated Et acetoacetates and di-Et acetylmalonate with hydrazine (98%) gave 3-substituted pyrazolin-5-ones and malonyldihydrazide, resp., following a deacetylation-condensation sequence. The reaction of Et 2-acetyl-3-hydroxy-2-butenoate (I; R = Me) and di-Et 2-(1-hydroxyethylidene)malonate (I; R = EtO) with hydrazine monohydrochloride yielded Et 3,5-dimethyl-1H-pyrazole-4-carboxylate (II) and 4-ethoxycarbonyl-3-methylpyrazolin-5-one (III), resp., following a dehydration-cyclocondensation sequence, in high yields.

Tetrahedron published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Application In Synthesis of 27412-71-1.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Ahmadi, Tahereh published the artcileDomino synthesis of quinoxaline derivatives using SBA-Pr-NH2 as a nanoreactor and their spectrophotometric complexation studies with some metals ions, Computed Properties of 27412-71-1, the main research area is diamine aryl multicomponent spirocyclization ninhydrin malononitrile cyanoacetate active methylene; indenoquinoxaline spirocyclic preparation amino SBA catalyst; quinoxaline complexation transition metal.

Amino-functionalized SBA-15 (SBA-Pr-NH2) with a pore size of 6 nm has been used as a basic nanocatalyst in the domino one-pot synthesis of indenoquinoxaline derivatives via the four-component reaction of ninhydrin, 1,2-diaminoarenes, malonodinitrile or Et cyanoacetate, and active methylene compounds using microwave irradiation The solid basic catalyst plays a significant role in catalysis, enhancing the rate and yield of the reaction, it can be easily handled and removed from the reaction mixture by simple filtration and also reused several times without substantial loss of reactivity. Moreover, the complexation reaction between quinoxaline as a model ligand and some metal ions including Cd2+, Co2+, Cu2+, Fe3+, Hg2+, Ni2+, Pb2+, and Zn2+ ions was examined spectrophotometrically in DMF solution at 25 °C. The formation constants of the resulting complexes were calculated from the computer fitting of the molar absorbance measurements in different mole ratios. The obtained data indicated that the stability constant of the resulting complexes varied in the following order Pb2+> Hg2+> Cd2+> Ni2+> Cu2+> Fe3+> Zn2+> Co2+.

Journal of the Iranian Chemical Society published new progress about Active methylene compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Computed Properties of 27412-71-1.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Aromi, Guillem published the artcileA systematic exploration of nickel-pyrazolinato chemistry with alkali metals: New cages from serendipitous assembly, Synthetic Route of 27412-71-1, the main research area is crystal structure alkali metal nickel pyrazolinolato pivalato multinuclear cluster; alkali metal nickel pyrazolinolato pivalato multinuclear cluster preparation structure; magnetic property nickel pyrazolinolato pivalato multinuclear cluster.

The preparation and properties of fourteen novel paramagnetic [NiIIx] aggregates bridged by pivalate, pyrazolinolate and in most cases hydroxide are reported. A rich structural diversity was achieved by changing the nature of the alkali of the base used during the synthesis, leading to the nuclearities [NiII4NaI4] (2, 3, 4), [NiII5NaI4] (5, 6, 7), [NiII5LiI6] (8), [NiII8MI2] [M = K (9, 10), Rb (11, 12), Cs (13, 14)] and [NiII8] (15). All compounds were characterized by single-crystal x-ray diffraction; however, full crystallog. details are given only for the representative mols. [Ni4Na4(fpo)4(piv)8(Hpiv)8] (2), [Ni5Na4(OH)2(mpo)4(piv)8(Hpiv)2(MeCN)2] (5), [Ni5Li6(OH)2(fpo)2(piv)12(Hpiv)4] (8), [Ni8K2(OH)4(ppo)4(piv)10(Hppo)2(Hpiv)2(MeCN)2] (9), [Ni8Rb2(OH)4(ppo)4(piv)10(Hppo)2(Hpiv)2(MeCN)2] (11), [Ni8Cs2(OH)4(ppo)4(piv)10(Hppo)2(Hpiv)2(MeCN)2] (13) and [Ni8(OH)4(mpo)2(PhCH2CO2)10(Hmpo)8] (15), where 5-R-3-pyrazolone [R = Me (Hmpo), Et (Hepo), CF3 (Hfpo), Ph (Hppo)]. Variable-temperature bulk magnetization measurements were performed for each type of complex. The [NiII4NaI4] clusters show intramol. antiferromagnetic coupling and a spin ground state of S = 0. [NiII5NaI4] also display antiferromagnetic superexchange, leading to an S = 1 spin ground state. The mol. with nuclearity [NiII5Li16], in contrast, exhibits ferromagnetic interactions, resulting in the presence of low energy states with high multiplicity, and a spin ground state S > 1. The [NiII8M12] and [NiII8] clusters have the same topol. of spin carriers, which display predominantly antiferromagnetic interactions to yield a diamagnetic ground state. The coupling within these octanuclear NiII clusters is rationalized in terms of the nature of the Ni-O-Ni angles within the core.

Chemistry – A European Journal published new progress about Antiferromagnetic exchange. 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Synthetic Route of 27412-71-1.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Kottha, Thirumalaswamy S. published the artcileA Bioisosteric and Scaffold Hopping Approach for the Design and Synthesis of Double Ring Replacement Analogues of 4-Aryl-4H-Chromenes and in silico Tubulin Inhibitor Studies, Recommanded Product: 5-Phenyl-1H-pyrazol-3(2H)-one, the main research area is aryl chromene bioisosteric analog preparation green chem tubulin inhibitor.

An eco-friendly reaction protocol was developed for the synthesis of heterocyclic hybrid scaffolds through bioisosteric replacement and scaffold hopping approach. The isosteric analogs of salicylaldehyde were designed, identified/synthesized and employed in a three component reaction to afford bioisosteric analogs of 4-aryl-4H-chromenes. Thus central core swapping of benzene-pyridine/pyrazole ring on 4-aryl-4H-chromenes was achieved under simple one-pot reaction conditions and easy work-up. Docking studies show that almost all the compounds possess good binding affinities at the colchicine binding site of tubulin.

ChemistrySelect published new progress about Gastrointestinal absorption. 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Recommanded Product: 5-Phenyl-1H-pyrazol-3(2H)-one.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Wu, Fan published the artcileNickel-Catalyzed C-O Cross-Coupling Reaction at Low Catalytic Loading with Weak Base Participation, Formula: C9H8N2O, the main research area is diaryl ether preparation nickel catalyst coupling base.

Herein, the authors report a nickel-catalyzed cross-coupling reaction for the synthesis of diaryl ethers. The desired products are achieved by coupling heterocyclic alcs. with aryl bromides bearing strong electron withdrawing nitro group under the catalyst system of NiCl2(PPh3)2 and weak base KHCO3. This mild reaction exhibits a broad functional group tolerance. 5-(3, 4-Dichlorophenyl)-1-(4-nitrophenyl)-1H-pyrazol-3-ol as an important intermediate is suitable for further structural modification of MALT1 inhibitor MI-2.

European Journal of Organic Chemistry published new progress about Aromatic ethers Role: SPN (Synthetic Preparation), PREP (Preparation). 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Formula: C9H8N2O.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Burja, Bojan published the artcileA simple approach to pyrazol-3-ones via diazenes, Quality Control of 27412-71-1, the main research area is arylpropenoic acid oxalyl chloride activation methyl carbazate amidation; hydrazide arylpropenoic acid preparation oxidation zirconium tetrachloride cyclization; nitrogen protected arylpyrazolone preparation deprotection; arylpyrazolone preparation.

An efficient entry into pyrazol-3-ones is described starting from propenoic acids that were first transformed into the corresponding hydrazides. Oxidation of the hydrazides gave the diazenes and the latter cyclized to pyrazol-3-ones on treatment with ZrCl4. The methoxycarbonyl protection of the N-1 of the pyrazolone derivatives was easily removed under mild reaction conditions.

Tetrahedron published new progress about Amidation. 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Quality Control of 27412-71-1.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Aromi, Guillem published the artcileNovel topologies in NiII cluster chemistry: incorporation of alkaline-earth metals in the new [NiII6MgII2] and [NiII8MII] (M = Sr, Ba) cages, Name: 5-Phenyl-1H-pyrazol-3(2H)-one, the main research area is nickel alk earth pivalato pyrazolinone polynuclear complex preparation structure; crystal structure nickel alk earth pivalato pyrazolinone polynuclear complex; magnetic property nickel alk earth pivalato pyrazolinone polynuclear complex.

The reaction of [Ni2(H2O)(piv)4(Hpiv)4] (1) (Hpiv = pivalic acid) with Hppo (3-phenylpyrazolin-5-one) in the presence of a base of an alk.-earth metal (MII = MgII, SrII or BaII) led to three different NiII clusters whose structures are controlled by the nature of MII. The formulas of the new heteronuclear cages are [Ni6Mg2(OH)2(ppo)4(piv)10(Hppo)4(MeOH)2] (2), [Ni8Sr(OH)2(ppo)6(piv)10(Hppo)5(Hpiv)2(MeCN)] (3) and [Ni8Ba(OH)2(ppo)6(piv)10(Hppo)5.3(Hpiv)0.7(MeCN)2] (4). Magnetic measurements indicate that the spin ground state of 2 consists of two independent S = 3 units, while the presence of two noninteracting S = 2 fragments in the mol. is postulated for compounds 3 and 4.

Dalton Transactions published new progress about Antiferromagnetic exchange. 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Name: 5-Phenyl-1H-pyrazol-3(2H)-one.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 27412-71-1, name is 5-Phenyl-1H-pyrazol-3(2H)-one belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 27412-71-1

Synthesis of 5-Phenyl-1H-pyrazol-3-yl 1-(2,2,2-trifluoroacetyl)indoline-5-sulfonate (8) and 5-phenyl-1H-pyrazol-3-yl indoline-5-sulfonate (9). Added anhydrous potassium carbonate (1.6 g, 12.5 mM) to a cold solution of 5-phenyl-1H-pyrazol-3(2H)-one (7,1 g, 6.25 mM) and (1-(2,2,2-trifluoroacetyl)indolin-5-ylsulfonyl chloride (2.0 g, 6.39 mM) in DMF and stirred the reaction mixture for 2 h at room temperature. After completion of the reaction was confirmed by TLC, the reaction mixture was mixed with ice cold water and extracted with ethyl acetate. Organic layer was dehydrated with anhydrous sodium sulfate and evaporated under reduced pressure. The crude solid was subjected to column chromatography to separate 8 and 9.

The synthetic route of 27412-71-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Subramanian, Santhosh; Sharma, Vinay K.; Yun, Jieun; Jung, Sang-Hun; Bulletin of the Korean Chemical Society; vol. 35; 10; (2014); p. 2922 – 2928;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics