Category: 27412-71-1

Elfahham, Hassan A. published the artcileThe reactions of nitrile imines with amino- and oxo-substituted azoles, Name: 5-Phenyl-1H-pyrazol-3(2H)-one, the main research area is azole reaction nitrile imine hydrazonyl halide; pyrazole cyclization hydrazonyl chloride; pyrazolopyrazole; pyrazolotriazole; azatricycloundecanone; adamantanone oxime rearrangement.

The behavior of several amino and hydroxy azoles toward nitrile imines and hydrazonyl halides is reported. Thus, the pyrazoles I (R = Ph, R1 = H2N, OH) reacted with PhCCl:NNHPh to give the pyrazolopyrazole II. I (R = Me, R1 = OH) under identical conditions gave the pyrazolotriazole III. I (R = Ph, R1 = NH2) reacted with MeCOCCl:NNHPh to give the pyrazoloimidazole IV.

Chemistry Letters published new progress about Cycloaddition reaction. 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Name: 5-Phenyl-1H-pyrazol-3(2H)-one.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Elfahham, H. A. published the artcileSynthesis of heterocycles through the reactions of nitrilimines with amino and oxo diazoles, Safety of 5-Phenyl-1H-pyrazol-3(2H)-one, the main research area is pyrazoletriazole; pyrazolopyrazine; pyrazoloimidazole; nitrilimine cyclocondensation diazole; pyrazole amino hydroxy cyclocondensation nitrilimine.

Fused azoles such as pyrazolo[5,1-c][1,2,4]triazoles, pyrazolo[3,4-b]pyrazine and pyrazolo[1,5-a]imidazole have been prepared from the reactions of nitrilimines , produced from hydrazidoyl halides I (R = Cl, Me, MeO), or II (R1 = NO2, Me), with amino- and oxo-azoles. In some cases acyclic products are formed.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about Cyclocondensation reaction. 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Safety of 5-Phenyl-1H-pyrazol-3(2H)-one.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Schreiner, Ella published the artcileConsecutive Three-Component Synthesis of 2,6-Disubstituted Pyrimid-4(3H)-ones and 1,5-Disubstituted 3-Hydroxypyrazoles Initiated by Copper(I)-Catalyzed Carboxylation of Terminal Alkynes, Recommanded Product: 5-Phenyl-1H-pyrazol-3(2H)-one, the main research area is pyrimidone hydroxypyrazole preparation green chem; terminal alkyne carboxylation copper catalyst methylation Michael addition cyclocondensation.

A copper(I)-catalyzed carboxylation of terminal alkynes followed trapping of the carboxylate with Me iodide provides a straightforward access to 3-substituted Me propiolates that can be reacted in the same reaction vessel in a consecutive fashion to give 2,6-disubstituted pyrimid-4(3H)-ones I (R1 = Ph, 4-MeOC6H4, 4-MeC6H4, etc.; R2 = Me, Ph, 4-H2NC6H4, etc.) and 1,5-disubstituted 3-hydroxypyrazoles II (R1 = Ph, 4-MeOC6H4, etc.; R2 = H, Me, Bn, etc.) in moderate to good yields. The Cu(I)-catalyzed carboxylation with carbon dioxide as C1 source therefore provides an environmentally benign entry to three-carbon building blocks in heterocyclic synthesis.

Advanced Synthesis & Catalysis published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Recommanded Product: 5-Phenyl-1H-pyrazol-3(2H)-one.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Pal, Sarbani published the artcileHigh speed synthesis of pyrazolones using microwave-assisted neat reaction technology, Related Products of pyrazoles-derivatives, the main research area is keto ester cyclization hydrazine microwave; pyrazolone preparation reaction acrylate; spiro cyclohexane pyrazolone preparation.

A high speed, solvent-free, and practical synthesis of pyrazolones under microwave irradiation was described. This greener synthetic methodol. involves the reaction of β-keto ester with substituted or unsubstituted hydrazine and provides a simple and straightforward one-pot approach for the synthesis of a variety of pyrazolone derivatives with high regioselectivity. These pyrazolones can exist in different tautomeric forms in solution and the aryl ring of 2-aryl pyrazol-3-ones remain twisted with respect to the pyrazole plane in the crystal state. Mechanism of the reaction accounting the regioselectivity was proposed. One of the pyrazolones obtained via this process was utilized to prepare a spiro-cyclohexanone derivative of potential biol. significance.

Journal of the Brazilian Chemical Society published new progress about Hydrazines Role: RCT (Reactant), RACT (Reactant or Reagent). 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Related Products of pyrazoles-derivatives.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Zheng, Zhaoyan published the artcileTautomerism-Dependent Ring Construction of N-Heterocyclic Compounds from the Reactions of 1-Alkynyl Fischer Carbene Complexes and Substituted Pyrazolinones, Safety of 5-Phenyl-1H-pyrazol-3(2H)-one, the main research area is pyrazolone fused preparation alkynyl Fischer carbene complex.

Four types of N-heterocyclic ring systems were successfully constructed from the reactions of 1-alkynyl Fischer carbene complexes (OC)5M:C(OEt)CCPh (I, M = Cr, W) and substituted pyrazolinones. Reactions of I with 3-methyl-, 3-propyl-, 3,4-dimethyl-, 3,4-trimethylene-, or 3,4-tetramethylene-2-pyrazolin-5-one generated three kinds of Fischer aminocarbene complexes, and reactions of I with 3-phenyl-2-pyrazolin-5-one and its tautomer 3-phenyl-3-pyrazolin-5-one, gave Fischer alkoxycarbene complexes as the major products and aminocarbene complexes as the minor products. Multiple tautomerism of pyrazolinones is attributed to the versatile formation of N-heterocyclic Fischer carbene complexes. Oxidative demetalation of the complexes with pyridine N-oxide or m-chloroperoxybenzoic acid efficiently afforded organic carbonyl products, and thus, strongly fluorescent syn-mixed-bimanes were prepared The present findings constitute an alternative new method to synthesize mixed bimanes and other novel N-heterocyclic compounds

Journal of Organic Chemistry published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Safety of 5-Phenyl-1H-pyrazol-3(2H)-one.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Morozov, Oleg S. published the artcileHydrohydrazination of Arylalkynes Catalyzed by an Expanded Ring N-Heterocyclic Carbene (er-NHC) Gold Complex Under Solvent-Free Conditions, COA of Formula: C9H8N2O, the main research area is aryldiazepinylidene gold carbene complex preparation mol crystal structure; diastereoselective hydroamination aryl alkyne hydrazine aryldiazepinylidene gold complex catalyst; hydrazone stereoselective preparation green chem solvent free; aryl alkyne hydrazine hydrohydrazination gold carbene catalyst; expanded ring nitrogen heterocyclic carbene gold complex catalyst.

The gold carbene complex [(THD-Dipp)AuOTf], containing the strongly electron donating, sterically bulky 1,3-bis(2,6-diisopropylphenyl)hexahydro-2H-1,3-diazepine-2-ylidene ligand, was an effective catalyst for the stereoselective hydroamination of aryl alkynes with tosylhydrazine and tert-Bu carbazate under solvent-free conditions to give (E)-tosyl and Boc hydrazones. The structure of (THD-Dipp)AuOTf was determined by X-ray crystallog.

Advanced Synthesis & Catalysis published new progress about Addition reaction, stereoselective (hydrohydrazination). 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, COA of Formula: C9H8N2O.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Belmar, J. published the artcileSynthesis and tautomerism of new 1-n-alkyl-5-pyrazolone derivatives, Related Products of pyrazoles-derivatives, the main research area is pyrazolone alkylation acylation nitrosation tautomerism.

3-Phenyl-5-pyrazolone (1) is selectively alkylene at position 1 in 40% yield. The alkylated compound (2) is acylated (3) in 60% yield and nitrosated (4) in 80% yield. According to the spectroscopic data a N-H or O-H structure can be proposed for 1 in DMSO. The proton may be at N-2 or on the oxygen at C-5, resp. The alkylated compound 2 exists as 5-pyrazolone in chloroform with a CH2 at C-4. In DMSO, 2 is a 5-hydroxypyrazole. For compound 3 in chloroform the structure corresponds to 4-acyl-5-hydroxypyrazole. For compound 4 in chlorolform there is one tautomer with a 4-nitroso-5-hydroxypyrazole structure while in DMSO the same 4-nitroso-5-hydroxypyrazole (92%) and a 4-nitroso-5-pyrazolone (8%) tautomer can be found.

Boletin de la Sociedad Chilena de Quimica published new progress about Acylation (of 1-alkyl-3-phenyl-5-pyrazolone). 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Related Products of pyrazoles-derivatives.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Songsichan, T. published the artcileThiocyanation of Pyrazoles Using KSCN/K2S2O8 Combination, COA of Formula: C9H8N2O, the main research area is pyrazole potassium thiocyanate persulfate promoter regioselective thiocyanation green chem; thiocyanatopyrazole preparation.

A convenient and practical thiocyanation of pyrazoles employed a combination of KSCN and K2S2O8 in DMSO (DMSO) was reported. The salient features of the present reaction included environmentally benign reagents, solvents and simple operation. The reaction showed wide functional group tolerance and gave moderate to excellent yields.

SynOpen published new progress about Cyanation, thiocyanation (regioselective). 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, COA of Formula: C9H8N2O.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Huang, Zhen-Zhong published the artcileA convenient oxidation of 5-substituted pyrazol-3(2H)-ones into methyl 2-alkynoates using poly[4-(diacetoxyiodo)styrene], Category: pyrazoles-derivatives, the main research area is pyrazolone polyacetoxyiodostyrene oxidation ring cleavage; alkynoate preparation; alkyne carboxylate preparation.

An operationally simple oxidation of 5-substituted pyrazol-3(2H)-ones to the corresponding Me 2-alkynoates in good yields with a mediated poly[4-(diacetoxyiodo)styrene] system in methanol and acetonitrile at room temperature was carried out. The polymeric reagent can be regenerated and reused as an environmentally benign reagent.

Journal of the Chinese Chemical Society (Taipei, Taiwan) published new progress about Alkynes Role: SPN (Synthetic Preparation), PREP (Preparation). 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Category: pyrazoles-derivatives.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Bhandari, Shashikant V. published the artcileDesign, synthesis and pharmacological screening of novel nitric oxide donors containing 1,5-diarylpyrazolin-3-one as nontoxic NSAIDs, Name: 5-Phenyl-1H-pyrazol-3(2H)-one, the main research area is diarylpyrazolinone preparation; ethyl acetoacetate diethylmalonate benzoyl chloride condensation cyclocondensation nucleophilic substitution; NSAID inflammation antiinflammatory pain analgesic structure activity vasorelaxant; prostaglandin synthase COX2 inhibitor mol simulation acute ulcerogenicity histopathol.

Various substituted 1,5-diarylpyrazol-3-one derivatives were synthesized and screened for analgesic, anti-inflammatory activities, ulcerogenic potential and for their ability to release nitric oxide. Most compounds exhibited significant analgesic and anti-inflammatory activities. It was interesting to note that out of ten compounds, I (R = H) (59.64%) was found to have anti-inflammatory activity greater than the standard drug Indomethacin (57.89%), whereas II (R = 2-OMe) (57.89%) was found to be equipotent to that of standard, Indomethacin. The pharmacol. studies suggested that the presence of 4-nitro and 2-methoxy on Ph ring at C5 of pyrazole has a significant anti-inflammatory activity and 4-chloro substitution on same Ph ring was found to have decreased activity. However only a Ph substituted derivative was found to have most potent activity. I (R = H) containing plane Ph at C5 of pyrazole was found to have significant analgesic activity (56.86%) in acetic acid induced writhing model. I and II (R = 4-Cl) having 4-chloro substituted Ph ring showed least analgesic activity (10.78%) and (6.86%) resp. The compounds also showed significantly reduced GI-ulcerogenicity and gastroprotective results in histopathol. studies i.e. they were found to be causing no mucosal injury. All the synthesized compounds were found to exhibit significant nitric oxide releasing activity, in both in vitro and in vivo models. Mol. docking studies served to be an important tool for the study of binding of compounds with that of a COX-2 enzyme. The results of the docking studies were found to endorse the result of exptl. work. Thus, the rationale used to design the NCEs was found to produce the promising results as anticipated. Therefore it can be said that the strategy employed can serve as an important tool in future for the design and development of novel therapeutic agents of various categories too.

European Journal of Medicinal Chemistry published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Name: 5-Phenyl-1H-pyrazol-3(2H)-one.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics