Category: 17827-61-1

Wijnberger, C.; Habraken, Clarisse L. published the artcile< Pyrazoles. VI. Electron-releasing capacity of the pyrazole ring>, Application In Synthesis of 17827-61-1, the main research area is pyrazoles electron releasing capacity.

Uv and 1H N.M.R. spectral data and C : O frequencies of some methylpyrazoles containing in the 3-, 4- or 5-position, a formyl-, acetyl- or ethoxycarbonyl group are reported. These data confirm earlier conclusions that, in particular, the 4-pyrazolyl group acts as an electron releasing group. The syntheses of a number of formyl-, acetyl- and ethoxycarbonyl pyrazoles are described. In addition, some 4-dicyanovinyl- and 4-tricvanovinylpyrazoles were investigated.

Journal of Heterocyclic Chemistry published new progress about 17827-61-1. 17827-61-1 belongs to class pyrazoles-derivatives, and the molecular formula is C6H8N2O2, Application In Synthesis of 17827-61-1.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Jeon, Dong Ju; Lee, Jung No; Kim, Hyoung Rae; Ryu, Eung K. published the artcile< The synthesis of a new pyrazolylimidazolinone via 1,3-dipolar cycloaddition reaction of N-methyl sydnone with methyl propiolate>, Product Details of C6H8N2O2, the main research area is pyrazolylimidazolinone preparation dipolar cycloaddition methylsydnone.

The preparation of 1-methyl-3-[4-methyl-4-(1-methylethyl)-5-oxo-1H-imidazol-2-yl]-1H-pyrazole-4-carboxylic acid starting from N-methylsydnone and Me propiolate via a 1,3-dipolar cycloaddition reaction was reported.

Bulletin of the Korean Chemical Society published new progress about 1,3-Dipolar cycloaddition reaction. 17827-61-1 belongs to class pyrazoles-derivatives, and the molecular formula is C6H8N2O2, Product Details of C6H8N2O2.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Wijnberger, C.; Habraken, Clarisse L. published the artcile< Pyrazoles. VI. Electron-releasing capacity of the pyrazole ring>, Application In Synthesis of 17827-61-1, the main research area is pyrazoles electron releasing capacity.

Uv and 1H N.M.R. spectral data and C : O frequencies of some methylpyrazoles containing in the 3-, 4- or 5-position, a formyl-, acetyl- or ethoxycarbonyl group are reported. These data confirm earlier conclusions that, in particular, the 4-pyrazolyl group acts as an electron releasing group. The syntheses of a number of formyl-, acetyl- and ethoxycarbonyl pyrazoles are described. In addition, some 4-dicyanovinyl- and 4-tricvanovinylpyrazoles were investigated.

Journal of Heterocyclic Chemistry published new progress about 17827-61-1. 17827-61-1 belongs to class pyrazoles-derivatives, and the molecular formula is C6H8N2O2, Application In Synthesis of 17827-61-1.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Jeon, Dong Ju; Lee, Jung No; Kim, Hyoung Rae; Ryu, Eung K. published the artcile< The synthesis of a new pyrazolylimidazolinone via 1,3-dipolar cycloaddition reaction of N-methyl sydnone with methyl propiolate>, Product Details of C6H8N2O2, the main research area is pyrazolylimidazolinone preparation dipolar cycloaddition methylsydnone.

The preparation of 1-methyl-3-[4-methyl-4-(1-methylethyl)-5-oxo-1H-imidazol-2-yl]-1H-pyrazole-4-carboxylic acid starting from N-methylsydnone and Me propiolate via a 1,3-dipolar cycloaddition reaction was reported.

Bulletin of the Korean Chemical Society published new progress about 1,3-Dipolar cycloaddition reaction. 17827-61-1 belongs to class pyrazoles-derivatives, and the molecular formula is C6H8N2O2, Product Details of C6H8N2O2.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Schantl, J. G. published the artcile< Product class 19: azomethine imines>, Reference of 17827-61-1, the main research area is review azomethine imine preparation organic synthesis.

A review. Methods for preparing azomethine imines and their application to organic synthesis.

Science of Synthesis published new progress about Imines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (azomethine). 17827-61-1 belongs to class pyrazoles-derivatives, and the molecular formula is C6H8N2O2, Reference of 17827-61-1.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Witiak, Donald T.; Lu, Matthias C. published the artcile< Product ratio analysis of the reaction of methyl cis- and trans-β-(acetylthio)acrylates with diazomethane>, Recommanded Product: Methyl 1-Methylpyrazole-3-carboxylate, the main research area is pyrazoles from acetylthioacrylates diazomethanation; acetylthioacrylates diazomethanation pyrazoles from; diazomethanation acetylthioacrylates pyrazoles from.

The relative yield of Me cis-β-(methylmercapto)acrylate 1-methyl-5-carbomethoxypyrazole 3-carbomethoxypyrazole and 1-methyl-3-carbomethoxypyrazole when Me cis- or trans-β-(acetylthio)acrylate undergoes reaction with excess CH2N2 in ether, was determined by means of gas-liquid partition chromatog. The analysis shows product formation to be dependent upon the stereochemistry of the starting Me β-(acetylthio)acrylate. Competing reaction pathways are proposed to account for the different yields of products. 25 references.

Journal of Organic Chemistry published new progress about 17827-61-1. 17827-61-1 belongs to class pyrazoles-derivatives, and the molecular formula is C6H8N2O2, Recommanded Product: Methyl 1-Methylpyrazole-3-carboxylate.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Saakyan, A. A. published the artcile< Esterification of pyrazole-3- and 4-carboxylic acids>, COA of Formula: C6H8N2O2, the main research area is pyrazole carboxylic acid methanol esterification acid catalyst; ester pyrazole preparation substituent effect.

The esterification of pyrazole-3- and 4-carboxylic acids with MeOH was described.

Russian Journal of General Chemistry published new progress about Carboxylic acids Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (heteroaryl). 17827-61-1 belongs to class pyrazoles-derivatives, and the molecular formula is C6H8N2O2, COA of Formula: C6H8N2O2.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Broom, N. J. P.; Elder, J. S.; Hannan, P. C. T.; Pons, J. E.; O’Hanlon, P. J.; Walker, G.; Wilson, J.; Woodall, P. published the artcile< The chemistry of pseudomonic acid. Part 14. Synthesis and in vivo biological activity of heterocycle-substituted oxazole derivatives>, Electric Literature of 17827-61-1, the main research area is pseudomonic acid heterocycle oxazole derivative preparation; bactericide heterocycle oxazole derivative preparation.

Semisynthetic analogs of pseudomonic acid A were prepd containing a heterocycle-substituted oxazole. Derivatives in which the heterocycle was thiophene, furan, pyridine, or isoxazole showed good antibacterial potency and were further evaluated in vivo. Both pharmacokinetic parameters and oral activity against an exptl. i.p. sepsis were superior to results obtained from previously described pseudomonic acid A derivatives

Journal of Antibiotics published new progress about 17827-61-1. 17827-61-1 belongs to class pyrazoles-derivatives, and the molecular formula is C6H8N2O2, Electric Literature of 17827-61-1.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Auwers, K. v.; Breyhan, Th. published the artcile< Further observations on alkylation and acylation of pyrazoles>, COA of Formula: C6H8N2O2, the main research area is .

3(5)- Methyl-5(3)-chloropyrazole with MeBr (8 hrs. at 100) gives 100% of the 1,3-di-Me derivative; CH2N2 gives largely the 1,3-di-Me derivative with some of the 1,5-isomer; the Na salt with Mel gives 100% of the 1,5-isomer. 3(5)- Phenylpyrazole (I) with MeBr (1 day at 100°) gives principally 1-methyl-3-phenylpyrazole, with some of the 5-Ph isomer; the Na salt with MeI yields 100% of the 5-Ph isomer. Excess ClCO2Me gives 1-carbomethoxy-3-phenylpyrazole (II), m. 76°. The Na derivative of BzCH:CHOH and MeO2CNHNH2 in dilute Et4OH give a nearly quant. yield of the carbomethoxyhydrazone of benzoylacetaldehyde, m. 152°; POCl3 in CHCl3 yields the 5-Ph isomer of II, m. 63-4°, with some II. I and SO2Cl2 give 4-chloro-5(3)- phenylpyrazole (III), b11 193°, m. 102°. 1-Methyl-4- chloro-3-phenylpyrazole (IV), pale brown, b9 163-5°; 5-Ph isomer (V), b12 153-6°. III and MeI with Na give about equal quantities of IV and V; Me2SO, in NaOH also give a mixture of the 2 isomers; MeBr gives essentially IV; CH2N2 reacts only slightly with III. II and SO2Cl2 give the 4-Cl derivative (VI), m. 89-90°; the 5-Ph isomer, m. 113-15°. III and ClCO2Me give VI. 3(5)-Methyl-5(3)-phenylpyrazole and MeBr (8 hrs. at 100°) give principally 1,5- dimethyl-3-phenylpyrazole, with some of the isomer; the Na salt with MeI gives the same products. 1-Carbomethoxy-3-phenyl-5-methylpyrazole, m. 74-5°; it is unchanged after heating with MeBr at 100° for 1 day; 4-Cl derivative, m. 107°. The carbomethoxyhydrazone of benzoylacetone, pale yellow, m. 121-2°; POCl3 gives 1-carbomethoxy-3-methyl-5-phenylpyrazole, m. 58-9°; 4-Cl derivative, m. 97°. Me pyrazole-3(5)-carboxylate, m. 139-40°; both MeBr and CH2N2 give principally Me 1-methylpyrazole-5-carboxylate, b9 73°, with a little of the 1,3-isomer, bg 120°. Me 5(3)-methylpyrazole-3(5)-carboxylate and CH2N2 give principally the 1,3-di-Me derivative, with some 1,5-isomer; the Et ester behaved similarly; there was no reaction with MeBr; MeI gives the almost pure 1,5-di- Me derivative; the Na salt with MeI gives principally the 1,3- isomer; EtI gives the 1-ethyl-5-methyl derivative; the salt with AcCl in C6H6 yields the 1-Ac derivative, m. 68.5-9.5°, and with ClCO2Me in Et2O the 1-MeO2C derivative Me 3(5)-phenylpyrazole-5(3)-carboxylate does not react with MeBr; with Mel it yields Me 1-methyl-3-phenylpyrazole 5-carboxylate; the Na salt and Mel in C6H6 give the same compound; the free ester or the Na salt and ClCO2Me yield a N-carbomethoxy derivative, m. 95°; the Et ester also does not react with EtBr; the Na salt and EtI give Et 1-ethyl-3- phenylpyrazole-5-carboxylate; the Na salt does not react with AcCl. 3(5)-Phenylpyrazole-5(3)-carboxylic acid (VII) and ClCO22Me give a N-carbomethoxy derivative, m. 126- 6.5°; with Cl the CO2Me group is split off. The 4-Cl derivative of VII m. 258-61°; it does not yield a CO2Me derivative

Journal fuer Praktische Chemie (Leipzig) published new progress about Acylation. 17827-61-1 belongs to class pyrazoles-derivatives, and the molecular formula is C6H8N2O2, COA of Formula: C6H8N2O2.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Perrocheau, Jacques; Carrie, Robert; Fleury, Jean-Pierre published the artcile< Thermal and photochemical evolution of triazolines obtained by addition of diazo compounds to methyl esters of oximino-malonodinitriles, oximino-cyanoacetates and oximino-malonates>, HPLC of Formula: 17827-61-1, the main research area is thermolysis triazoline; photolysis triazoline; triazoline thermolysis photolysis; aziridine.

Thermolysis of 1,2,3-triazolines I [R = Ts, COC6H4Z-4, Ac; R1 = H, Me, Ph, (MeO)2CH] leads to the corresponding aziridines only when X = Y = CO2Me, and then with a very low yield. However, photolysis or evolution in the presence of trifluoroacetic acid gives good results when carried out at sufficiently low temperature The thermolysis study of I shows a new route to 1,2,3-triazoline decomposition that has not yet been mentioned in the literature. The easy elimination of the p-toluenesulfonate or benzoate group explains this particular behavior.

Canadian Journal of Chemistry published new progress about Photolysis. 17827-61-1 belongs to class pyrazoles-derivatives, and the molecular formula is C6H8N2O2, HPLC of Formula: 17827-61-1.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics