Category: 1572-10-7

Reference of 1572-10-7, The chemical industry reduces the impact on the environment during synthesis 1572-10-7, name is 3-Amino-5-phenylpyrazole, I believe this compound will play a more active role in future production and life.

General procedure: The general method was described for the synthesis of D1. Compound C1 (150 mg, 0.393 mmol) was dissolved in ethanol (2 mL),followed by addition of 5-phenyl-1H-pyrazol-3-amine (62.63 mg, 0.393 mmol) and triethylamine (119.43 mg, 1.18 mmol). The mixture was stirred at room temperature for 5 h. The resultant mixture was purified by column chromatography to give D1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Amino-5-phenylpyrazole, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Wang, Shuai; Shen, Dandan; Zhao, Lijie; Yuan, Xiaohan; Cheng, Jialing; Yu, Bin; Zheng, Yichao; Liu, Hongmin; Chinese Chemical Letters; vol. 31; 2; (2020); p. 418 – 422;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1572-10-7, name is 3-Amino-5-phenylpyrazole, A new synthetic method of this compound is introduced below., HPLC of Formula: C9H9N3

Compounds8a-e(4.12 g, 20mmol) were dissolved in 30 mL of ethanol followed by the addition of 3-amino-5-phenylpyrazole(3.18 g, 20mmol) and three-four drops ofHCl. Then the reaction mixture was refluxed at ethanol temperature for 2 h. The reaction mixture was allowed to cool to room temperature, and the precipitated product was collected by vacuum filtration and washed with ethanol (3mL) thenrecrystallizedfrom ethanol to afford pure compounds9a-eas yellow solids in good yields.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Kamal, Ahmed; Faazil, Shaikh; Hussaini, S.M. Ali; Ramaiah, M. Janaki; Balakrishna; Patel, Nibedita; Pushpavalli; Pal-Bhadra, Manika; Bioorganic and Medicinal Chemistry Letters; vol. 26; 8; (2016); p. 2077 – 2083;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1572-10-7, name is 3-Amino-5-phenylpyrazole, A new synthetic method of this compound is introduced below., SDS of cas: 1572-10-7

General procedure: The compound tetronic acid (15) (80 mg, 0.8 mmol) was dissolved in 4 mL of ethanol, followed by addition of terphenyl aldehyde 13a (221.2 mg, 0.8 mmol) and 3-amino-5-phenyl pyrazole 14a (127.2 mg, 0.8 mmol). The reaction mixture was refluxed in ethanol at 78 C for an hour. Then reaction suspension was cooled to room temperature, and the precipitated product was collected by vacuum filtration and washed with ethanol (3 mL), then recrystallized from ethanol to afford pure compound 8a as a white solid, 340 mg in 85% yield. Mp: 273-274 C; 1H NMR (300 MHz, DMSO-d6): delta 4.80 (s, 2H), 5.25 (s, 1H ), 6.89-6.99 (m, 1H), 7.19-7.35 (m, 7H), 7.42-7.52 (m, 4H), 7.65 (dd, 4H, J = 8.8, 11.7 Hz), 8.05 (s, 1H), 10.19 (s, 1H ), 12.56 (s, 1H); 13C NMR (300 MHz, DMSO-d6): delta 30.5, 64.8, 94.4, 99.8, 111.1, 111.3, 113.2, 121.3, 125.4, 126.1, 126.7, 126.9, 127.1, 127.2, 127.3, 128.3, 128.7, 128.8, 132.7, 137, 137.2, 138.8, 139.3, 145.8, 152.7, 157.7, 172.2; MS (ESI): 500 [M+H]+; HRMS (ESI) calcd for C32H23O2N3F [M+H]+ 500.1712; found: 500.1738.

The synthetic route of 1572-10-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kamal, Ahmed; Tamboli, Jaki R.; Lakshma Nayak; Adil; Vishnuvardhan; Ramakrishna; Bioorganic and Medicinal Chemistry; vol. 22; 9; (2014); p. 2714 – 2723;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1572-10-7, name is 3-Amino-5-phenylpyrazole, A new synthetic method of this compound is introduced below., Formula: C9H9N3

General procedure: A mixture of appropriate aniline, p-toluidine, p-anisidine, 3-amino-5-phenylpyrazole or 3-aminol,2,4-triazole (5 mmol) and azido compound 20 (1.78 g, 5 mmol) in dry dioxane (20 mL) was refluxed for 4 h. The resulting solid, so formed, was collected and recrystallized gave 21a-d, respectively.

The synthetic route of 1572-10-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Abdelriheem, Nadia Abdelhamed; Ahmad, Sayed Abdel-Kader; Abdelhamid, Abdou Osman; Molecules; vol. 20; 1; (2015); p. 822 – 838;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Related Products of 1572-10-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1572-10-7 as follows.

General procedure: An oven dried 25 mL RB flaskwas charged with chalcone (1.0 mmol), 3-aminopyrazole (1.2 mmol), KOH (0.1mmol) and DMF (5 mL). The resulting solution was stirred at 110 C for 20 min.On completion, the reaction mass was allowed to cool to ambient temperature,diluted with water (20 mL) and extracted into ethyl acetate (2 20 mL). The combined organic layers were dried overanhydrous Na2SO4, and organic solvent was evaporated on arotatory evaporator. The crude residue was purified by column chromatography(silica gel 60-120 mesh, eluent 20% EtOAc/hexanes).

According to the analysis of related databases, 1572-10-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Kaswan, Pinku; Pericherla, Kasiviswanadharaju; Purohit, Deepshikha; Kumar, Anil; Tetrahedron Letters; vol. 56; 3; (2015); p. 549 – 553;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthetic Route of 1572-10-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1572-10-7 name is 3-Amino-5-phenylpyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: The compound tetronic acid (15) (80 mg, 0.8 mmol) was dissolved in 4 mL of ethanol, followed by addition of terphenyl aldehyde 13a (221.2 mg, 0.8 mmol) and 3-amino-5-phenyl pyrazole 14a (127.2 mg, 0.8 mmol). The reaction mixture was refluxed in ethanol at 78 C for an hour. Then reaction suspension was cooled to room temperature, and the precipitated product was collected by vacuum filtration and washed with ethanol (3 mL), then recrystallized from ethanol to afford pure compound 8a as a white solid, 340 mg in 85% yield. Mp: 273-274 C; 1H NMR (300 MHz, DMSO-d6): delta 4.80 (s, 2H), 5.25 (s, 1H ), 6.89-6.99 (m, 1H), 7.19-7.35 (m, 7H), 7.42-7.52 (m, 4H), 7.65 (dd, 4H, J = 8.8, 11.7 Hz), 8.05 (s, 1H), 10.19 (s, 1H ), 12.56 (s, 1H); 13C NMR (300 MHz, DMSO-d6): delta 30.5, 64.8, 94.4, 99.8, 111.1, 111.3, 113.2, 121.3, 125.4, 126.1, 126.7, 126.9, 127.1, 127.2, 127.3, 128.3, 128.7, 128.8, 132.7, 137, 137.2, 138.8, 139.3, 145.8, 152.7, 157.7, 172.2; MS (ESI): 500 [M+H]+; HRMS (ESI) calcd for C32H23O2N3F [M+H]+ 500.1712; found: 500.1738.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Amino-5-phenylpyrazole, and friends who are interested can also refer to it.

Synthetic Route of 1572-10-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1572-10-7, name is 3-Amino-5-phenylpyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: An oven dried 25 mL RB flaskwas charged with chalcone (1.0 mmol), 3-aminopyrazole (1.2 mmol), KOH (0.1mmol) and DMF (5 mL). The resulting solution was stirred at 110 C for 20 min.On completion, the reaction mass was allowed to cool to ambient temperature,diluted with water (20 mL) and extracted into ethyl acetate (2 20 mL). The combined organic layers were dried overanhydrous Na2SO4, and organic solvent was evaporated on arotatory evaporator. The crude residue was purified by column chromatography(silica gel 60-120 mesh, eluent 20% EtOAc/hexanes).

The synthetic route of 3-Amino-5-phenylpyrazole has been constantly updated, and we look forward to future research findings.

Related Products of 1572-10-7,Some common heterocyclic compound, 1572-10-7, name is 3-Amino-5-phenylpyrazole, molecular formula is C9H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The compound tetronic acid (15) (80 mg, 0.8 mmol) was dissolved in 4 mL of ethanol, followed by addition of terphenyl aldehyde 13a (221.2 mg, 0.8 mmol) and 3-amino-5-phenyl pyrazole 14a (127.2 mg, 0.8 mmol). The reaction mixture was refluxed in ethanol at 78 C for an hour. Then reaction suspension was cooled to room temperature, and the precipitated product was collected by vacuum filtration and washed with ethanol (3 mL), then recrystallized from ethanol to afford pure compound 8a as a white solid, 340 mg in 85% yield. Mp: 273-274 C; 1H NMR (300 MHz, DMSO-d6): delta 4.80 (s, 2H), 5.25 (s, 1H ), 6.89-6.99 (m, 1H), 7.19-7.35 (m, 7H), 7.42-7.52 (m, 4H), 7.65 (dd, 4H, J = 8.8, 11.7 Hz), 8.05 (s, 1H), 10.19 (s, 1H ), 12.56 (s, 1H); 13C NMR (300 MHz, DMSO-d6): delta 30.5, 64.8, 94.4, 99.8, 111.1, 111.3, 113.2, 121.3, 125.4, 126.1, 126.7, 126.9, 127.1, 127.2, 127.3, 128.3, 128.7, 128.8, 132.7, 137, 137.2, 138.8, 139.3, 145.8, 152.7, 157.7, 172.2; MS (ESI): 500 [M+H]+; HRMS (ESI) calcd for C32H23O2N3F [M+H]+ 500.1712; found: 500.1738.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Amino-5-phenylpyrazole, its application will become more common.

Application of 1572-10-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1572-10-7, name is 3-Amino-5-phenylpyrazole, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A solution of beta-bromovinyl aldehyde 1 (1.0 mmol), aminopyrazole 2 (1.0 mmol), Pd(OAc)2 (5mol%), PPh3 (10 mol%) and K2CO3(1.2 mmol) in DMF (1.0 mL) was irradiated in a closed vessel in a Synthos 3000 microwave reactor at 700 Watt (120 oC and 14 bar) for 20 minutes. After completion of the reaction, the reaction mixture was treated with water (30 mL) and then extracted with ethylacetate (30 x 3 mL). The organic portion was washed with water, dried over anhydrous sodium sulfate and the solvent was removed in vacuo to obtain a crude product which on silica gel column chromatographic purification using EtOAc/hexane as the eluent afforded compounds 3a-l.

The chemical industry reduces the impact on the environment during synthesis 3-Amino-5-phenylpyrazole. I believe this compound will play a more active role in future production and life.

Electric Literature of 1572-10-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1572-10-7, name is 3-Amino-5-phenylpyrazole, This compound has unique chemical properties. The synthetic route is as follows.

3-Amino-5-phenyl pyrazole (477 mg) and ethyl 2-N,N-dimethylaminomethylene acetoacetate (556 mg) were dissolved in ethanol (10 ml) and stirred at 70C for 1.5 hours. The reaction mixture was added conc. hydrochloric acid (1 mg), and was stirred for additional 1 hour. The mixture was cooled to room temperature and concentrated under reduced pressure. Ethanol (10 ml) and 5 N aqueous sodium hydroxide solution (3 ml) were added to the residues and then stirred at 70C for 1 hour. After cooling to room temperature, water and ethyl acetate were added to the mixture. 2 N hydrochloric acid was added to the aqueous phase until it became acidic, and precipitated crystals were collected and washed with water and n-hexane to give 3f (463 mg, Y.: 61%) as yellow crystals.1H NMR: d 3.2 (3H, s), 7.4 (1H, s), 7.5 (3H, m), 8.1 (2H, d), 8.9 (1H, s), 13.6 (1H, brs); MS (m/z): 252 (M-H)-.

The chemical industry reduces the impact on the environment during synthesis 3-Amino-5-phenylpyrazole. I believe this compound will play a more active role in future production and life.