Category: 345637-71-0

Reference of 345637-71-0, A common heterocyclic compound, 345637-71-0, name is 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid, molecular formula is C7H7F3N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step A: Preparation of 5-methyl-3-(trifluoromethyl)-lH-pyrazole-l -acetyl chloride A mixture of 5-methyl-3-(trifluoromethyl)-lH-pyrazole-l -acetic acid (5.2 g, 25 mmol) in dichloromethane (70 mL) and N,N-dimethylformamide (2 drops) was cooled to 0 C and oxalyl chloride (4.76 g, 37.5 mmol) in dichloromethane (10 mL) was added dropwise. The reaction mixture was stirred at room temperature for 16 h, and then concentrated under reduced pressure to give the title compound as a slightly yellowish solid (5.64 g). H NMR (CDC13): delta 6.38 (s, 1H), 5.27 (s, 2H), 2.31 (s, 3H).

The synthetic route of 345637-71-0 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 345637-71-0, name is 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid

Example 1 : This example illustrates the preparation of 3-chloro-2-hydroxy-N-(3-{1-[2-(5- methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-phenyl)-benzamide (Compound No. I. U.003) a) Preparation of 1-[4-(3-amino-phenyl)-piperidin-1-y l]-2-(5-methyl-3-trifluoromethyl- pyrazol-1 -yl)-ethanoneTo a solution of (5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetic acid (0.49 g, 2.35 mmol) in DMF (10 ml_) is added triethylamine (0.65 ml_, 4.7 mmol), followed by 1-hydroxy-7- benzotriazole (0.32 g, 2.35 mmol) and 1-Ethyl-3-(3-dimethyllaminopropyl)carbodiimide hydrochloride (0.45 g, 2.35 mmol). After stirring 15 min at RT, 3-Piperidin-4-yl-phenylamine hydrochloride (0.50 g, 2.35 mmol) is added to the reaction mixture. After stirring overnight at RT, solvent is evaporated and the resulting yellow oil is dissolved in ethylacetate (20 ml_), washed with saturated aqueous sodium bicarbonate solution (20 ml_), and brine (20 ml_). The organic layer is dried over sodium sulfate, filtered, and evaporated under reduced pressure to give 1-[4-(3-amino-phenyl)-piperidin-1-y l]-2-(5-methyl-3-trifluoromethyl-py razol- 1-yl)-ethanone as a crude mixture of good enough purity for the next step (0.86 g, quantitative). 1 H-NMR (400 MHz, MeOD): delta =1.52-1.63 (m, 1 H), 1.64-1.73 (m, 1 H), 1.80-1.93 (m, 2H), 2.33 (s, 3H), 2.68-2.81 (m, 2H), 2.99 (s, 2H), 3.21-3.27 (m, 1 H), 4.02-4.09 (m, 1 H), 4.55-4.62 (m, 1 H), 5.12-5.28 (q, 2H), 6.41 (s, 1 H), 6.55-6.60 (m, 1 H), 6.61-6.62 (m, 1 H), 7.00-7.07 (t, 1 H), 7.99 (s, 1 H). MS: m/z = 367 (M+1).

The synthetic route of 345637-71-0 has been constantly updated, and we look forward to future research findings.