Category: 632365-54-9

Related Products of 632365-54-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 632365-54-9 as follows.

A suspension of methyl 5-amino-1H-pyrazole-3-carboxylate (1.00 g, 7.086 mmol) and 1-(3,4-dimethoxyphenyl)-4,4,4-trifluorobutane-1,3-dione (2.153 g, 7.794 mmol) in ACETIC ACID (10 ml, 174.682 mmol) was heated to reflux (at 100 C.) for 5 hours. The mixture was cooled at room temperature, water was added and the precipitate collected by filtration, washed with water and dried under vacuum to give J1 as a green solid, 2.33 g (86% yield).

According to the analysis of related databases, 632365-54-9, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 632365-54-9, name is Methyl 5-amino-1H-pyrazole-3-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 632365-54-9, COA of Formula: C5H7N3O2

Compound 260.3. Methyl 5-iodo-lH-pyrazole-3-carboxylate. Into a 100-mL three neck round-bottom flask, which was purged and maintained with an inert atmosphere of nitrogen, was placed a solution of methyl-5-amino-lH-pyrazole-3-carboxylate (compound 260.2, 1.0 g, 7.1 mmol) in a carefully prepared solution of sulfuric acid (15 mL) into water (30 mL)(Caution: addition of sulfuric acid to water is exothermic). The solution was cooled to 0 C, then a solution of NaN02 (0.53 g, 7.7 mmol) in water (5 mL) was added drop-wise. The resulting mixture was stirred for 2 h at 0 C, then a solution of KI (1.4 g, 8.4 mmol) in water (5 mL) was added drop-wise at 0 C. The resulting mixture was stirred overnight at room temperature, then the pH of the mixture was carefully adjusted to 7 with aqueous sodium bicarbonate (sat.). The mixture was extracted with ethyl acetate (3 x 50 mL) and the combined organic extracts were washed with brine (3 x 50 mL), dried (Na2S04), filtered and concentrated under reduced pressure. The residue was purified by a silica gel chromatography with ethyl acetate/petroleum ether (1 :5) as eluent to obtain the title compound as a yellow solid (0.6 g, 30%).

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