Category: 152120-54-2

Related Products of 152120-54-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 152120-54-2 as follows.

Compound 48 (200 mg), N,N?-bis(tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine (11) (420 mg) and diisopropylethylamine (0.12 mL) were dissolved in THF (4 mL). The mixture was stirred at room temperature for 12 h and then evaporated in vacuo. The residue was purified with silica gel chromatography (5% CHCl3/MeOH) to give tert-butyl {(E)-({4-[2-(2-acetamido-5-{2-[4-(methylsulfonyl)phenyl]ethyl}-1,3-thiazol-4-yl)ethyl]phenyl}amino)[(tert-butoxycarbonyl)amino]methylene}carbamate (307 mg, 99%). tert-Butyl {(E)-({4-[2-(2-acetamido-5-{2-[4-(methylsulfonyl)phenyl]ethyl}-1,3-thiazol-4-yl)ethyl]phenyl}amino)[(tert-butoxycarbonyl)amino]methylene}carbamate (228 mg) was dissolved in 4 M HCl/ dioxane (5 mL). The mixture was stirred at room temperature overnight and then evaporated in vacuo. The residue was triturated with AcOEt to give 49 (183 mg, 106%) as a white solid. 1H NMR (DMSO-d6) delta 2.16 (3H, s), 2.67 (4H, br s), 2.82-2.94 (4H, m), 3.14 (3H, s), 7.12 (2H, d, J = 8.4 Hz), 7.20 (2H, d, J = 8.4 Hz), 7.43 (2H, d, J = 8.4 Hz), 7.82 (2H, d, J = 8.4 Hz), 9.87 (1H, s), 11.97 (1H, s); FAB MS m/e (M+H)+ 486; HRMS calcd for C23H28N5O3S2 (M+H)+: 486.1634, found: 486.1633.

According to the analysis of related databases, 152120-54-2, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 152120-54-2, name is tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate, A new synthetic method of this compound is introduced below., Safety of tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate

To a solution of compound 14 (40 mg, 1 eq) in 2 ml anhydrous DCM, TEA (40 muIota, 4 eq) was added. The solution was cooled down to 0 C and N, N’-Di-Boc-1 H-pyrazole-1-carboxamidine (42 mg, 2 eq) added. The reaction mixture was allowed to warm up to room temperature and kept stirring overnight. After completion, the reaction was quenched with water, extracted with ethyl acetate. The organic phase was washed with brine, dried over Na2S04, concentrated and purified by flash chromatography to give the desired product. Crude product, 40 mg (72%).1H NMR (500 MHz, CD3OD) delta 8.55 (s, 1 H, Triazole-H5), 8.06 (d, J = 8.3 Hz, 2H, Ar-H), 7.92 (d, J = 8.3 Hz, 2H), 6.00 (d, J = 2.3 Hz, 1 H, H-3), 5.58 (d, J = 1.5 Hz, 1 H, H-7), 5.56 – 5.52 (m, 1 H, H-8), 5.31 (dd, J = 14.8, 2.4 Hz, 1 H, H-9), 5.02 (dd, J = 10.2, 2.3 Hz, 1 H, H-4), 4.74 (dd, J = 14.8, 9.0 Hz, 1 H, H-9′), 4.53 (dd, J = 10.2, 1.5 Hz, 1 H, H-6), 4.27 (t, J = 10.2 Hz, 1 H, H-5), 3.91 , 3.80 (2 x s, 3H, COOCH3), 2.12, 1 .94, 1.85 (3 x s, 3 x 3H, 3 x COCH3), 1 .51 , 1 .46 (2 x s, 2 x 9H, 2 x Boc).13C NMR (125 MHz, CD3OD) delta 173.57, 171 .77, 171.41 , 168.07, 164.32, 163.39, 158.01 (C=0), 153.82 (C=N), 147.64 (Triazole-C4), 124.50 (Triazole-C5), 145.61 (C-2), 136.34, 131.27, 131.27, 126.55 (Ar-C), 11 1.83 (C-3), 84.84, 80.57 (>Boc-C(CH3)3), 78.89 (C-6), 74.00 (C-8), 69.87 (C-7), 53.07, 52.74 (COOCH3), 51.27 (C-9), 50.84 (C- 4), 47.90 (C-5), 28.59, 28.26 (‘Betaomicronomicron-0(OmicronEta3)3), 22.77, 20.86, 20.65 (COCH3). HR-MS (ESI) calcd. for C37H49N7NaOi4 [M+Na]+, 838.3235; found 838.3226.

The synthetic route of 152120-54-2 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 152120-54-2, name is tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate, A new synthetic method of this compound is introduced below., Safety of tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate

Step 1 : 3-{[{[(ferf-butoxy)carbonyl]amino}({[(ferf-butoxy)carbonyl]imino})methyl]amino} propanoic acid (INT- 16) beta-alanine (1 .0 mmol) and A/,/V-di-(Boc)-1 H-pyrazole-1 -carboxamide (1 .0 mmol) are suspended in pyridine (2.0 mL) and stirred at 25 C for 2 days. The homogenous reaction is treated with 1 N NaOH and extracted into ethyl acetate. The aqueous layer is acidified (pH 3) with 1 N HCI and then extracted into ethyl acetate. The combined organic layers are washed with brine, dried over sodium sulfate, filtered and concentrated under reduced pressure to provide 3-{[{[(ferf-butoxy)carbonyl]amino}({[(ferf- butoxy)carbonyl]imino})methyl]amino}propanoic acid (INT-16).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.