Category: 67-51-6

An article Effect of benzoic acid substituents and additional functional groups of ancillary ligands in modulating the nuclearity and aggregation behavior of transition metal carboxylates WOS:000454151300036 published article about SECONDARY BUILDING UNITS; X-RAY STRUCTURES; CRYSTAL-STRUCTURE; PADDLE-WHEEL; MAGNETIC-PROPERTIES; SPECTRAL CHARACTERIZATION; COMPLEXES; COPPER(II); 1,10-PHENANTHROLINE; SOLIDS in [Rajakannu, Palanisamy; Kaleeswaran, Dhananjayan; Banerjee, Subarna; Murugavel, Ramaswamy] Indian Inst Technol, Dept Chem, Bombay 400017, Maharashtra, India; [Butcher, Ray J.] Howard Univ, Dept Chem, Washington, DC 20059 USA in 2019.0, Cited 68.0. HPLC of Formula: C5H8N2. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6

Structural modulation of transition metal carboxylates has been studied by employing different auxiliary ligands in the reactions of metal acetates with substituted benzoic acids. A series of neutral transition metal benzoates [Cu(tbba)(2)(imH)(2)] (1), [Cu(tipba)(2)(2,4,6-collidine)(2)] (2), [Co(tbba)(2) (dmpH)(2)] (3), [Co(tipba)(2)(imH)(2)] (4), [M (tmba)(2)(pymeH)(2)] (M = Cu (5), Co (6) and Zn (7)), [Zn(tmba)(2)(pydmeH(2))] (8), [Cu-2(tmba)(2)(pydmeH(2))(2)] [(tmba)(2)(tmbaH)(2)] (9) and [Zn-2(dmp)(2) (tbba)(2)(dmpH)(2)] (10) have been isolated as products from the reaction between the respective metal acetates and substituted benzoic acids (acids used: 4-tert-butylbenzoic acid (tbbaH), 2,4,6-triisopropylbenzoic acid (tipbaH), 2,4,6-trimethylbenzoic acid (tmbaH)) and N-donor auxiliary ligands (imidazole (imH), 3,5-dimethylpyrazole (dmpH), 2,4,6-collidine, 2-pyridinemethanol (pymeH), and pyridine-2,6-dimethanol (pydmeH(2))). The new complexes have been characterized by both analytical and spectroscopic methods. The molecular structures of 1-10 have further been established by single crystal X-ray diffraction studies. The complexes 1-8 are mononuclear, while compounds 9 and 10 have been found to be dinuclear due to the role of benzoic acid in 9 and pyrazolate anion as bridging ligand in 10. The geometry around the metal ion is square-planar in 1 and 2, tetrahedral in 3, 4 and 10, octahedral in 5-7 and 9 and trigonal-bipyramidal in 8. Complexes with ligands that contain additional functional groups such as > NH and -OH are involved in hydrogen bonding interactions. These weak interactions lead to the formation of 1-D linear polymers or 2-D sheets.

HPLC of Formula: C5H8N2. About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Rajakannu, P; Kaleeswaran, D; Banerjee, S; Butcher, RJ; Murugavel, R or concate me.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

In 2021.0 CHEMISTRYSELECT published article about NUCLEOPHILIC REACTIONS; TERTIARY-AMINES; CATALYSTS; OPTIMIZATION; AMMONIOLYSIS; AMINOLYSIS; ALKYLATION; ALCOHOLS; MODEL in [Shirshin, Konstantin K.; Esipovich, Anton L.; Kazantsev, Oleg A.; Rumyantsev, Misha; Korotaev, Mikhail S.; Rogozhin, Anton E.] Nizhnii Novgorod State Tech Univ, 24 Ulitsa Minina Minin St, Nizhnii Novgorod, Russia in 2021.0, Cited 54.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6. Name: 3,5-Dimethyl-1H-pyrazole

Comparison of various organic compounds such as glycols, amines and alkanolamines as organocatalysts in amidation of fatty acid methyl esters with 3-(dimethylamino)-1-propylamine was made for the first time. It was experimentally detected that catalysts containing OH-groups (alcohols, glycols, glycerol and aminoalcohols) influence the reaction rate. Moreover, catalytic effect is depending on the catalysts geometry significantly. 1,5-diols (e. g. diethylene glycol and diethanolamine) were found to accelerate the reaction more than other OH-groups containing additives. It was supposed, that this catalytic effect is caused by specific associative interactions between reactants and 1,5-diols, what was confirmed by quantum mechanics calculations. Catalysts concentration effects on the reaction rate were also investigated.

Name: 3,5-Dimethyl-1H-pyrazole. About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Shirshin, KK; Esipovich, AL; Kazantsev, OA; Rumyantsev, M; Korotaev, MS; Rogozhin, AE or concate me.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Formula: C5H8N2. In 2020.0 J MATER CHEM B published article about DRUG-DELIVERY; ANTICANCER DRUG; ACID; LIPOSOME; VULGARIS; EFFICACY; PROBE in [Du, Peifang; Long, Shuo; Wen, Nachuan; Wang, Yirong; Liu, Yanfei] Cent South Univ, Coll Chem & Chem Engn, Dept Pharmaceut Engn, Changsha 410083, Hunan, Peoples R China; [Yan, Jianhua; Xiong, Hongjie; Cai, Shundong; Liu, Zhenbao] Cent South Univ, Xiangya Sch Pharmaceut Sci, 172 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China; [Peng, Dongming] Hunan Univ Chinese Med, Sch Pharm, Dept Med Chem, Changsha 410208, Hunan, Peoples R China; [Liu, Zhenbao] Cent South Univ, Mol Imaging Res Ctr, Changsha 410008, Hunan, Peoples R China in 2020.0, Cited 52.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6.

A berberine 9-O-pyrazole alkyl derivative, a chemical compound (called B3) previously synthesized by our group, shows anti-cancer activity. However, B3 lacks targeting cytotoxicity to cancer cells, leading to obvious toxic side effects on normal cells. To solve this problem, here, we prepared a drug delivery system, namely, AS1411-GO/B3 for tumor targeting, in which nano-graphene oxide (GO) sheets were employed as the drug carrier, and the aptamer AS1411 was conjugated onto GO for tumor targeting. GO also had a photothermal effect, which helped the release of B3 from GO as well as the thermal cytotoxicity to cells. We found that the release of B3 could respond to acid conditions, indicating that the tumor intracellular environment could promote the release of B3, thus allowing it to perform chemotherapy effects. This system could also release B3 in response to photothermal heating, moreover, combined photothermal therapy and chemotherapy to improve the anticancer activity was achieved. This AS1411-GO/B3 platform with chemo-photothermal synergetic therapy provides a very promising treatment for tumors.

Formula: C5H8N2. About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Du, PF; Yan, JH; Long, S; Xiong, HJ; Wen, NC; Cai, SD; Wang, YR; Peng, DM; Liu, ZB; Liu, YF or concate me.

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Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Application In Synthesis of 3,5-Dimethyl-1H-pyrazole. Authors Yuan, Y; Xu, RJ; Zhao, HK in ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD published article about in [Yuan, Yang; Zhao, Hongkun] Yangzhou Univ, Coll Chem & Chem Engn, Yangzhou 225002, Jiangsu, Peoples R China; [Xu, Renjie] Yangzhou Univ, Guangling Coll, Yangzhou 225009, Jiangsu, Peoples R China in 2019.0, Cited 1.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6

Errors were discovered regarding the published equation coefficients of Yao and co-workers (2017) for mathematically describing the solubility of 3,5-dimethylpyrazole in nine organic solvents using the NRTL model. Larger differences were found between our back-calculated data and those reported in the authors’ published paper. The equation parameters were re-regressed based on the reported solubility data. (C) 2018 Elsevier Ltd.

Application In Synthesis of 3,5-Dimethyl-1H-pyrazole. About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Yuan, Y; Xu, RJ; Zhao, HK or concate me.

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Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

An article Synthesis and Cyclizations of N-(Thieno[2,3-b]pyridin-3-yl)cyanoacetamides WOS:000511196800006 published article about HETEROCYCLIC SYNTHESIS; ESTIMATE SOLUBILITY; CYANOACETIC ACID; DRUG DISCOVERY; DERIVATIVES; PERMEABILITY; INHIBITORS; CHEMISTRY in [Chigorina, E. A.] Kurchatov Inst, Inst Chem Reagents & High Pur Chem Subst, Natl Res Ctr, Moscow, Russia; [Bespalov, A. V.; Dotsenko, V. V.] Kuban State Univ, Krasnodar, Russia; [Dotsenko, V. V.] North Caucasian Fed Univ, Stavropol, Russia in 2019.0, Cited 46.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6. HPLC of Formula: C5H8N2

3-Aminothieno[2,3-b]pyridine-2-carboxylic acid esters readily reacted with 3,5-dimethyl-1-(cyanoacetyl)-1H-pyrazole to give previously unknown N-(thieno[2,3-b]pyridin-3-yl)cyanoacetamides. Reactions of the latter with 2-(arylmethylidene)malononitriles were nonselective, and mixtures of different heterocyclization products were generally formed. The cyclization of ethyl 4,6-dimethyl-3-[(cyanoacetyl)amino]thieno[2,3-b]pyridine-2-carboxylate afforded 2,4-dihydroxy-7,9-dimethylthieno[2,3-b : 4,5-b’]dipyridine-3-carbonitrile whose tautomeric equilibrium was studied by DFT quantum chemical calculations. In silico analysis of biological activity of the synthesized compounds was performed.

About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Chigorina, EA; Bespalov, AV; Dotsenko, VV or concate me.. HPLC of Formula: C5H8N2

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

An article Slow magnetic relaxation in penta-coordinate cobalt(II) field-induced single-ion magnets (SIMs) with easy-axis magnetic anisotropy WOS:000563083800029 published article about STATE PERTURBATION-THEORY; MOLECULE MAGNET; ZERO-FIELD; DONOR LIGANDS; NI-II; COMPLEXES; VALENCE; COPPER(II); EFFICIENT; BEHAVIOR in [Massoud, Salah S.; Perez, Zoe E.; Courson, Jessica R.] Univ Louisiana Lafayette, Dept Chem, POB 94370, Lafayette, LA 70504 USA; [Massoud, Salah S.] Alexandria Univ, Fac Sci, Dept Chem, Alexandria, Egypt; [Fischer, Roland C.] Graz Univ Technol, Inst Anorgan Chem, A-8010 Graz, Austria; [Mautner, Franz A.] Graz Univ Technol, Inst Phys & Theoret Chem, A-8010 Graz, Austria; [Vanco, Jan; Cajan, Michal; Travnicek, Zdenek] Palacky Univ Olomouc, Reg Ctr Adv Technol & Mat, Div Biol Act Complexes & Mol Magnets, Slechtitelu 27, CZ-78371 Olomouc, Czech Republic in 2020.0, Cited 99.0. Category: pyrazoles-derivatives. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6

Two penta-coordinate complexes of the general formula [Co(L-n)(NCS)]ClO4, where L-1= {bis[(3,5-dimethyl-1H-pyrazol-1-yl)ethyl]-[(3,4-dimethoxypyridin-2-yl)methyl]}amine and L-2= {bis[(3,5-dimethyl-1H-pyrazol-1-yl)ethyl]-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]}amine, have been synthesized and thoroughly characterized. Each of the cobalt(ii) atoms is penta-coordinated in the {CoN5} donor set with a distorted square-pyramidal geometry in [Co(L-1)(NCS)]ClO4 center dot MeOH (1), while the vicinity of the central atom can be described as a distorted trigonal-bipyramidal geometry in [Co(L-2)(NCS)]ClO4(2) as revealed using the SHAPE analysis. Differences in interatomic parameters among the cobalt(ii) and donor atoms in 1 and 2 have definite impact on the magnetic features of both compounds. The complexes show an easy-axis magnetic anisotropy (D = -38.5 cm(-1) for 1 and D= -8.5 for 2), and both complexes reveal a large rhombicity with E/D = 0.21 for 1 and E/D = 0.29 for 2. The ZFS parameters (g, D and E) were also calculated using CASSCF/NEVPT2 methods and they are in good agreement with those determined from experimental data. A frequency dependent out-of-phase susceptibility has been observed in external magnetic field (B-dc= 0.1 T) revealing the following parameters of slow relaxation of magnetization for 1: energy of the spin reversal barrier, U-eff = 16.0 cm(-1)(U-eff/kB = 23.0 K) and the relaxation time, tau(0)= 1.28 x 10(-6)s. In the case of complex 2, no maxima of frequency dependent out-of-phase susceptibility have been observed and thus, the value of U-eff= 17 cm(-1) has been estimated using the expression U-eff = vertical bar D vertical bar x (S-2- 1/4). It has been demonstrated that the degree of substitution and the type of substituents on the pyridyl moieties of the tripodal ligands (L-1 and L-2) used in these penta-coordinate cobalt(ii) complexes have significant impact on structural and magnetic features.

About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Massoud, SS; Perez, ZE; Courson, JR; Fischer, RC; Mautner, FA; Vanco, J; Cajan, M; Travnicek, Z or concate me.. Category: pyrazoles-derivatives

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Product Details of 67-51-6. Authors Hassanzadeh, C; Rudra, S; Bommireddy, A; Hawkins, WG; Wang-Gillam, A; Fields, RC; Cai, B; Park, J; Green, O; Roach, M; Henke, L; Kim, H in ELSEVIER INC published article about in [Hassanzadeh, Comron; Rudra, Soumon; Cai, Bin; Park, Justin; Green, Olga; Henke, Lauren; Kim, Hyun] Washington Univ, Sch Med, Dept Radiat Oncol, St Louis, MO USA; [Hassanzadeh, Comron; Rudra, Soumon; Hawkins, William G.; Wang-Gillam, Andrea; Fields, Ryan C.; Cai, Bin; Park, Justin; Green, Olga; Henke, Lauren; Kim, Hyun] Alvin J Siteman Comprehens Canc Ctr, St Louis, MO USA; [Bommireddy, Ani] St Louis Univ, Sch Med, St Louis, MO USA; [Hawkins, William G.; Fields, Ryan C.] Washington Univ, Sch Med, Dept Surg, St Louis, MO 63110 USA; [Wang-Gillam, Andrea] Washington Univ, Sch Med, Dept Med Oncol, St Louis, MO USA; [Roach, Michael] Canc Ctr Hawaii, Honolulu, HI USA in 2021.0, Cited 25.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6

Purpose: Patients with inoperable pancreatic adenocarcinoma have limited options, with traditional chemoradiation providing modest clinical benefit and an otherwise poor prognosis. Stereotactic body radiation therapy for pancreatic cancer is limited by proximity to organs-at-risk (OAR). However, stereotactic magnetic resonance-guided adaptive radiation therapy (SMART) has shown promise in delivering ablative doses safely. We sought to demonstrate the benefits of SMART using a 5-fraction approach with daily on-table adaptation. Methods and Materials: Patients with locally advanced, nonmetastatic pancreatic adenocarcinoma were treated with 50 Gy in 5 fractions (biologically effective dose(10) 100 Gy) with a prescribed goal of 95% planning target volume coverage by 95% of prescription, prioritizing hard OAR constraints. Daily online adaptation was performed using magnetic resonance-guidance and on-table reoptimization. Patient outcomes, treatment factors, and daily adaptation were evaluated. Results: Forty-four patients were treated with SMART at our institution from 2014 to 2019. Median follow-up from date of diagnosis was 16 months (range, 6.7-51.6). Late toxicity was limited to 2 (4.6%) grade 3 (gastrointestinal ulcers) and 3 (6.8%) grade 2 toxicities (duodenal perforation, antral ulcer, and gastric bleed). Tumor abutted OARs in 35 patients (79.5%) and tumor invaded OARs in 5 patients (11.1%). Reoptimization was performed for 93% of all fractions. Median overall survival was 15.7 months (95% confidence interval, 10.2-21.2), while 1-year and 2-year overall survival rates were 68.2% and 37.9%, respectively. One-year local control was 84.3%. Conclusions: This is the first reported experience using 50 Gy in 5 fractions for inoperable pancreatic cancer. SMART allows this ablative dose with promising outcomes while minimizing toxicity. Additional prospective trials evaluating efficacy and safety are warranted. (C) 2020 The Author(s). Published by Elsevier Inc. on behalf of American Society for Radiation Oncology.

Product Details of 67-51-6. About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Hassanzadeh, C; Rudra, S; Bommireddy, A; Hawkins, WG; Wang-Gillam, A; Fields, RC; Cai, B; Park, J; Green, O; Roach, M; Henke, L; Kim, H or concate me.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

An article Nickel(II) complexes with tripodal NNN ligands as homogenous and supported catalysts for ethylene oligomerization WOS:000456751700004 published article about BRANCHED POLYETHYLENE; FUNCTIONALIZED POLYOLEFINS; ALKYLALUMINUM COCATALYST; METAL-COMPLEXES; NITROGEN DONOR; AMINE LIGANDS; POLYMERIZATION; ALUMINUM; NMR; TEMPERATURE in [Tuskaev, Vladislav A.; Zubkevich, Sergei V.; Gagieva, Svetlana Ch.; Bulychev, Boris M.] Moscow MV Lomonosov State Univ, Chem Dept, Leninskie Gory 11, Moscow 119991, Russia; [Tuskaev, Vladislav A.; Kononova, Elena G.; Khrustalev, Victor N.; Zarubin, Dmitry N.] Russian Acad Sci, AN Nesmeyanov Inst Organoelement Cpds, Vavilov Str 28, Moscow 119991, Russia; [Saracheno, Daniele] Dimitri Mendeleev Univ Chem Technol Russia, Higher Coll Chem Russia, Miusskaya Sq 9, Moscow 125047, Russia; [Dorovatovskii, Pavel V.; Khrustalev, Victor N.] Natl Res Ctr, Kurchatov Inst, Moscow, Russia; [Khrustalev, Victor N.] Peoples Friendship Univ Russia RUDN, Moscow, Russia; [Kissin, Yury V.] Rutgers State Univ, Dept Chem & Chem Biol, 123 Bevier Rd, Piscataway, NJ 08854 USA in 2019.0, Cited 73.0. Recommanded Product: 3,5-Dimethyl-1H-pyrazole. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6

Four new coordination compounds of nickel (II) with derivatives of N,N-bis(pyrazol-1-ylmethyl)propylamine were synthesized; their composition and structure were confirmed with IR-spectroscopy and elemental analysis. The structures of products 13 and 15 were unambiguously established in an X-ray diffraction study. Compounds 13 and 15 crystallize in the orthorhombic space groups Pna2(1) and P2(1)2(1)2(1) correspondingly and represent a monomeric octahedral nickel complexes, that are typical for tridentate scorpion-type ligands. New method for immobilization of nickel complexes with derivatives of N,N-bis(pyrazol-1-ylmethyl)propylamine on silica gel modified with aminopropyl groups was proposed. The EXAFS/XANES analysis indicated that Ni atom in the supported complexes adopt almost octahedral geometry, being partly surrounded by nitrogen atoms from organic ligand and partly grafted to silica surface through silanol groups, with Br- in outer coordination sphere. Both the original and the supported complexes, when activated with Et2AlCl or Et3Al2Cl3, catalyze ethylene oligomerization with the predominant formation of butene isomers. Generally, the immobilized complexes show higher activity and better selectivity towards 1-butene formation.

Recommanded Product: 3,5-Dimethyl-1H-pyrazole. About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Tuskaev, VA; Zubkevich, SV; Saracheno, D; Gagieva, SC; Dorovatovskii, PV; Kononova, EG; Khrustalev, VN; Zarubin, DN; Bulychev, BM; Kissin, YV or concate me.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

An article Energetically favorable anti-electrostatic hydrogen bonded cationic clusters in Ni(II) 3,5-dimethylpyrazole complexes: Anticancer evaluation and theoretical studies WOS:000473377900014 published article about SUPRAMOLECULAR ASSOCIATION; COORDINATION-COMPLEXES; NICKEL(II) COMPLEXES; CYTOTOXIC ACTIVITIES; MOLECULAR-STRUCTURE; CRYSTAL-STRUCTURE; BLISTER BEETLES; PROTEIN-BINDING; PI INTERACTIONS; CU(II) in [Gogoi, Anshuman; Dutta, Debajit; Nath, Hiren; Guha, Ankur K.; Bhattacharyya, Manjit K.] Cotton Univ, Dept Chem, Gauhati 781001, Assam, India; [Verma, Akalesh K.] Cotton Univ, Dept Zool, Cell & Biochem Technol Lab, Gauhati 781001, Assam, India; [Frontera, Antonio] Univ Illes Balears, Dept Quim, Crta Valldemossa Km 7-7, Palma De Mallorca 07122, Baleares, Spain in 2019.0, Cited 94.0. Quality Control of 3,5-Dimethyl-1H-pyrazole. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6

Two new Ni(II) coordination complexes of pyrazole and acetato ligands, involving nitrate and chloride counter anions, viz. [Ni(Hdmpz)(2)(CH3COO)(H2O)(3)]NO3 center dot 2H(2)O (1) and [Ni(Hdmpz)(2)(CH3COO)(H2O)(3)]Cl (2) (where Hdmpz = 3,5-dimethylpyrazole), have been synthesized in purely aqueous medium at room temperature. The complexes have been characterized by elemental analysis, FT-IR, electronic spectroscopy, PXRD, TGA and single crystal X-ray diffraction. The H-bonds established between the isostructural cationic [Ni(Hdmpz)(2)(CH3COO)(H2O)(3)](+) moieties of both complexes can be classified as anti-electrostatic H-bonds (AEHBs) and these have been studied using DFT calculations. Remarkably, in one case these AEHBs exhibit favorable interaction energies, thus indicating that the attractive nature of the H-bonds is able to compensate the pure electrostatic repulsion. The analyses of the cell viability results for the DL cell line show a significant concentration dependent decrease by compounds 1 and 2 with a negligible cytotoxic effect observed against normal cells (PBMC) in comparison to the cancer cells (DL). The cytotoxic activity of these compounds in DL cells occurs via apoptosis. Molecular docking and SAR analysis reveal that the compounds possess high binding affinities against most common cancer target proteins. (C) 2019 Elsevier Ltd. All rights reserved.

Quality Control of 3,5-Dimethyl-1H-pyrazole. About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Gogoi, A; Dutta, D; Verma, AK; Nath, H; Frontera, A; Guha, AK; Bhattacharyya, MK or concate me.

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Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

An article Iridium(III) Complexes Bearing a Formal Tetradentate Coordination Chelate: Structural Properties and Phosphorescence Fine-Tuned by Ancillaries WOS:000506719300055 published article about CYCLOMETALATED IR(III) COMPLEXES; C-H ACTIVATION; PHOTOPHYSICAL PROPERTIES; LIGANDS; RHODIUM; DESIGN; BIDENTATE; PYRAZOLE; HYDRIDE in [Yuan, Yi; Lee, Chun-Sing; Chi, Yun] City Univ Hong Kong, Dept Mat Sci & Engn, Dept Chem, Hong Kong, Peoples R China; [Yuan, Yi; Lee, Chun-Sing] City Univ Hong Kong, Ctr Super Diamond & Adv Films COSDAF, Hong Kong, Peoples R China; [Gnanasekaran, Premkumar; Chen, Yu-Wen; Chi, Yun] Natl Tsing Hua Univ, Dept Chem, Hsinchu 30013, Taiwan; [Gnanasekaran, Premkumar; Chen, Yu-Wen; Chi, Yun] Natl Tsing Hua Univ, Frontier Res Ctr Fundamental & Appl Sci Matters, Hsinchu 30013, Taiwan; [Lee, Gene-Hsiang] Natl Taiwan Univ, Instrumentat Ctr, Taipei 10617, Taiwan; [Ni, Shao-Fei] Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Guangdong, Peoples R China in 2020.0, Cited 53.0. Safety of 3,5-Dimethyl-1H-pyrazole. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6

Synthesis of the multidentate coordinated chelate N3C-H-2, composed of a linked functional pyridyl pyrazole fragment plus a peripheral phenyl and pyridyl unit, was obtained using a multistep protocol. Preparation of Ir(III) metal complexes bearing a N3C chelate in the tridentate (kappa(3)), tetradentate (kappa(4)), and pentadentate (kappa(5)) modes was executed en route from two nonemissive dimer intermediates [Ir(kappa(3)-N3CH)Cl-2](2) (1) and [Ir(kappa(4)-N3C)Cl](2) (2). Next, a series of mononuclear Ir(III) complexes with the formulas [Ir(kappa(4)-N3C)Cl(py)] (3), [Ir(kappa(4)-N3C)Cl(dmap)] (4), [Ir(kappa(4)-N3C)-Cl(mpzH)] (5), and [Ir(kappa(4)-N3C)Cl(dmpzH)] (6), as well as diiridium complexes [Ir-2(kappa(5)-N3C)-(mpz)(2)(CO)(H)(2)] (7) and [Ir-2(kappa(5)-N3C)-(dmpz)(2)(CO)(H)(2)] (8), were obtained upon treatment of dimer 2 with pyridine (py), 4-dimethylaminopyridine (dmap), 4-methylpyrazole (mpzH), and 3,5-dimethylpyrazole (dmpzH), respectively. These Ir(III) metal complexes were identified using spectroscopic methods and by X-ray crystallographic analysis of representative derivatives 3, 5, and 7. Their photophysical and electrochemical properties were investigated and confirmed by the theoretical simulations. Notably, green-emitting organic light-emitting diode (OLED) on the basis of Ir(III) complex 7 gives a maximum external quantum efficiency up to 25.1%. This result sheds light on the enormous potential of this tetradentate coordinated chelate in the development of highly efficient iridium complexes for OLED applications.

Safety of 3,5-Dimethyl-1H-pyrazole. About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Yuan, Y; Gnanasekaran, P; Chen, YW; Lee, GH; Ni, SF; Lee, CS; Chi, Y or concate me.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics