Category: 67-51-6

Application In Synthesis of 3,5-Dimethyl-1H-pyrazole. In 2020.0 ACTA CRYSTALLOGR E published article about COMPLEXES; CU(II); WELL in [Vynohradov, Oleksandr S.; Pavlenko, Vadim A.; Naumova, Dina D.; Partsevska, Sofiia, V] Taras Shevchenko Natl Univ Kyiv, Dept Chem, Volodymyrska Str 64-13, UA-01601 Kiev, Ukraine; [Shova, Sergiu] Poni Petru Inst Macromol Chem, Voda 41A, Iasi 700487, Romania; [Safarmamadov, Safarmamad M.] Tajik Natl Univ, Dept Chem, 17 Rudaki Ave, Dushanbe 734025, Tajikistan in 2020.0, Cited 22.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6.

In the title bicyclic trinuclear pyrazolate aminoalcohol complex, [Cu-3(C5H7N2)(2)-(C6H14NO3)(2)]Br-2 center dot 1.5H(2)O, the central Cu atom lies on a center of symmetry and is involved in the formation of two five-membered rings. It has a coordination number of 4, is in a distorted tetrahedral environment and is connected by the bridging oxygen atoms of the deprotonated OH groups of different aminoalcohol groups, and by the N atoms of deprotonated dimethylpyrazole ligands. The peripheral Cu atom is in a trigonal-bipyramidal coordination environment formed by the nitrogen atom of the deprotonated bridging dimethylpyrazole unit, the bridging oxygen atom of the deprotonated OH group, two oxygen atoms of the protonated hydroxy groups and the nitrogen atom of triethanolamine. One of the C atoms and the Br- anion were found to be disordered over two positions with occupancy factors of 0.808 (9):0.192 (9) and 0.922 (3):0.078 (3), respectively.

Application In Synthesis of 3,5-Dimethyl-1H-pyrazole. About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Vynohradov, OS; Pavlenko, VA; Naumova, DD; Partsevska, SV; Shova, S; Safarmamadov, SM or concate me.

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Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

In 2020.0 RUSS J ORG CHEM+ published article about ACID; CATALYST; OXIDE in [Hassani, H.; Jahani, Z.] Payame Noor Univ, Dept Chem, Tehran 193954697, Iran in 2020.0, Cited 32.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6. Quality Control of 3,5-Dimethyl-1H-pyrazole

Pyrazoles and hydrazones, as two significant kinds of potentially bioactive compounds, were produced with good to excellent yields by condensation of beta-dicarbonyl compounds with hydrazines in aqueous media in the presence of Fe3O4@CeO2 nanocomposite as an efficient heterogeneous nanocatalyst. The magnetic nanocatalyst can readily be separated using an external magnet and reused at least six times without significant loss in activity. The products were characterized by IR and H-1 and(13)C NMR spectra.

Quality Control of 3,5-Dimethyl-1H-pyrazole. Welcome to talk about 67-51-6, If you have any questions, you can contact Hassani, H; Jahani, Z or send Email.

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Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Authors Vafaee, A; Davoodnia, A; Nakhaei, A; Yadegarian, S; Nejatianfar, M in MAIK NAUKA/INTERPERIODICA/SPRINGER published article about in [Vafaee, A.; Davoodnia, A.] Islamic Azad Univ, Dept Chem, Mashhad Branch, Mashhad 9175687119, Razavi Khorasan, Iran; [Davoodnia, A.; Nakhaei, A.] Islamic Azad Univ, Young Researchers & Elite Club, Mashhad Branch, Mashhad 9175687119, Razavi Khorasan, Iran; [Nejatianfar, M.] Ferdowsi Univ Mashhad, Dept Chem, Fac Sci, Mashhad 9177948974, Razavi Khorasan, Iran in 2021.0, Cited 33.0. Computed Properties of C5H8N2. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6

Two novel room-temperature disulfonic acid functionalized ionic liquids derived from 3,5-dimethyl-1H-pyrazole consisting of chloride and trichlorostannate anions, 3,5-dimethyl-1,2-disulfonic acid-1H-pyrazolium chloride and 3,5-dimethyl-1,2-disulfonic acid-1H-pyrazolium trichlorostannate, have been synthesized, characterized and evaluated for their catalytic efficiency in the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones by the one-pot, three-components reaction of phthalhydrazide, an aromatic aldehyde and malononitrile or ethyl cyanoacetate under solvent-free conditions. The results have demonstrated high catalytic activity of these novel ionic liquids containing acidic SO3H groups in producing high yields of the desired products in short reaction time. The ionic liquids can be used at least four times without any noticeable decrease in catalytic activity.

Computed Properties of C5H8N2. Welcome to talk about 67-51-6, If you have any questions, you can contact Vafaee, A; Davoodnia, A; Nakhaei, A; Yadegarian, S; Nejatianfar, M or send Email.

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Pyrazole – Wikipedia,
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Computed Properties of C5H8N2. I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Potential 2,4-dimethyl-1H-pyrrole-3-carboxamide bearing benzimidazole template: Design, synthesis, in vitro anticancer and in silico ADME study published in 2020.0, Reprint Addresses Jagtap, SV (corresponding author), Savitribai Phule Pune Univ, Baburaoji Gholap Coll, Dept Chem, Pune 411017, Maharashtra, India.. The CAS is 67-51-6. Through research, I have a further understanding and discovery of 3,5-Dimethyl-1H-pyrazole.

A new series of 2,4-dimethyl-1H-pyrrole-3-carboxamide derivatives bearing benzimidazole moiety was synthesized through a molecular hybridization approach and evaluated for in vitro anticancer activity by NCI-60 on leukemia, melanoma, lung, colon, CNS, ovarian, renal, prostate and breast cancer cell lines at a single dose (10 mu M). Among all the synthesized conjugates, some derivatives showed more or less good activity even at such a small dose, while, compound 5-(1H-benzo[d]imidazol-2-yl) N (1-cyclohexylethyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (80 displayed significant antiproliferative activity specifically against MDA-MB human cancer cell lines. Compound 8f showed promising activity against MDA-MB-435 cell line of melanoma (Growth inhibition: 62.46%) and MDA-MB-468 cell line of breast (Growth inhibition: 40.24%). Computational ADME study qualified its significant physicochemical, pharmacokinetic and drug-likeness properties with good predicted oral bioavailability. Thus this new hybrid molecules would be useful for further anticancer drug development.

Computed Properties of C5H8N2. About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Basal, NK; Sonawane, RB; Jagtap, SV or concate me.

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Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

In 2019.0 CRYST GROWTH DES published article about BOND; COMPLEXES in [Verma, Ashish; Tomar, Kapil; Bharadwaj, Parimal K.] Indian Inst Technol Kanpur, Dept Chem, Kanpur 208016, Uttar Pradesh, India in 2019.0, Cited 36.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6. Recommanded Product: 67-51-6

A novel bispyrazole-based expanded cryptand was synthesized via Schiff base condensation reaction having an internal cavity of 160 angstrom(3) with a hydrophobic nature. The cryptand features electron-rich multiple pyrazole rings for enhanced weak noncovalent interactions with the guest molecules. The host-guest capabilities of the cryptand were investigated for encapsulation of the most inactive halogen bond donor molecules (having small sigma-hole size), namely, CH2Cl2, CHCl3, CCl4, C2HCl3, C2H4Cl2, and C2H4Br2. Analysis of crystal structures clearly revealed that halogen bonding (C-Cl/Br center dot center dot center dot pi (pyrazole)) and hydrogen bonding (C-H center dot center dot center dot pi(pyrazole)) interactions played a key role in stabilizing the halogenated guests inside the hydrophobic cavity of cryptand. At the same time, the cage is efficiently able to exclude hydrophilic solvent molecules, like, water and methanol, suggesting the hydrophobic nature of the cavity. Due to the comparably large sigma-hole in C2H4Br2, it showed the strongest halogen bonding interaction with the host cryptand, while weakest interaction was found for the CH2Cl2 guest which has the smallest size sigma-hole. Furthermore, the cryptand is able to adjust its central cavity according to the size of the guest. The biggest cavity size was found for the C2H4Br2 guest, while smallest size was found for the CH2Cl2 guest molecule. This study sheds more light on the interaction of halogenated solvents via halogen and hydrogen bonding, which is critical in understanding and controlling chemical reactions where solvent effects play an important role.

Welcome to talk about 67-51-6, If you have any questions, you can contact Verma, A; Tomar, K; Bharadwaj, PK or send Email.. Recommanded Product: 67-51-6

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Recently I am researching about DRUG DISCOVERY; CARDIOVASCULAR SAFETY; BIOLOGICAL-ACTIVITIES; LIBRARIES; BIOAVAILABILITY; COMBINATORIAL; PREDICTION, Saw an article supported by the Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-Brasil (CAPES)Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [001]; FAP-UNIVALI. COA of Formula: C5H8N2. Published in SPRINGER BIRKHAUSER in NEW YORK ,Authors: Macarini, AF; Sobrinho, TUC; Rizzi, GW; Correa, R. The CAS is 67-51-6. Through research, I have a further understanding and discovery of 3,5-Dimethyl-1H-pyrazole

In the process of research and development of new drugs, in silico analyzes are widely used. They address the pharmacokinetics of the molecules in study and can predict the binding mode and affinity, using a docking software. This approach can optimize the development of new drugs, reducing costs, time, and resources. In this study, a library of 300 pyrazole-chalcone derivatives were designed, the in silico ADMET (absorption, distribution, metabolism, excretion, and toxicity) properties were evaluated, and a structure-based virtual screening was performed using AutoDock Vina. The docking results exhibited that the derivatives binding mode at the COX-2 active site is similar to celecoxib, the reference drug, and presented similar binding energy. Six compounds were synthetized and tested for in vitro inhibition of the COX-1 and COX-2 isoenzymes and the selectivity index (SI) was calculated. The compound 2a11 showed the best activity for COX-2 (IC50COX-2=0.73M) whereas the control, celecoxib, resulted IC50COX-2=0.88M. All the other compounds synthetized presented better potency for COX-2 inhibition than the control. Compound 2a23 exhibited the higher SI, of 280.17 (IC50COX-1=210.13M/ IC50COX-2=0.75M), while celecoxib was 246.88 (IC50COX-1=217.26M/ IC50COX-2=0.88M). These results corroborate with a possible anti-inflammatory activity and COX-2 selectivity of the new compounds synthetized.

Welcome to talk about 67-51-6, If you have any questions, you can contact Macarini, AF; Sobrinho, TUC; Rizzi, GW; Correa, R or send Email.. COA of Formula: C5H8N2

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Safety of 3,5-Dimethyl-1H-pyrazole. Liu, J; Ren, ZH; Fan, L; Wei, JY; Tang, XM; Xu, XR; Yang, DC in [Liu, Jie; Ren, Zhenghong; Fan, Li; Wei, Jianyong; Yang, Dacheng] Southwest Univ, Sch Chem & Chem Engn, Inst Bioorgan & Med Chem, Key Lab Appl Chem Chongqing Municipal, Chongqing 400715, Peoples R China; [Tang, Xuemei] Southwest Univ, Sch Life Sci, Chongqing 400715, Peoples R China; [Xu, Xingran] Southwest Univ, Coll Pharmaceut Sci, Chongqing 400715, Peoples R China published Design, synthesis, biological evaluation, structure-activity relationship, and toxicity of clinafloxacin-azole conjugates as novel antitubercular agents in 2019.0, Cited 44.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6.

Based on the advantages of azole molecules and fluoroquinolone drugs, we designed and synthesized 34 clinafloxacin- azole conjugates using fragment-based drug design and drug combination principles. The in vitro activities of the synthesized conjugates against Mycobacterium tuberculosis (H37Rv), Hela cell as well as Gram-positive and Gram-negative bacteria were assayed. The bioassay results revealed that most of the target molecules had anti-tuberculosis (anti-TB) activity, of which 14 compounds had very strong anti-TB activity [minimum inhibitory concentration (MIC) < 2 mu M]. In addition, the compounds with strong activity towards H37Rv had weak activity towards Gram-negative and Gram-positive bacteria, showing obvious selectivity towards H37Rv. Predicted toxicity data indicated that 27 molecules were less toxic or equivalent to that of the original drug (clinafloxacin). Especially, it is demonstrated that compound TM2l exhibited the strongest anti-TB activity (MIC = 0.29 mu M), low antibacterial activity, negligible toxicity, and good drug-likeness values, which can be considered as an ideal lead molecule for future optimization. Welcome to talk about 67-51-6, If you have any questions, you can contact Liu, J; Ren, ZH; Fan, L; Wei, JY; Tang, XM; Xu, XR; Yang, DC or send Email.. Safety of 3,5-Dimethyl-1H-pyrazole

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Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

An article VOLATILE PROFILE OF GREEN COFFEE BEANS FROM COFFEA ARABICA L. PLANTS GROWN AT DIFFERENT ALTITUDES IN ETHIOPIA WOS:000496971800002 published article about BIOCHEMICAL-COMPOSITION; ROASTING DEGREE; QUALITY; COMPOUND; AROMA; IDENTIFICATION; FINGERPRINT; COMPONENTS; ODORANTS; CAFFEINE in [Tsegay, Girmay; Redi-Abshiro, Mesfin; Chandravanshi, Bhagwan Singh; Ele, Estifanos; Mohammed, Ahmed M.] Addis Ababa Univ, Coll Nat Sci, Dept Chem, POB 1176, Addis Ababa, Ethiopia; [Tsegay, Girmay] Ethiopian Inst Agr Res, Agr Qual Res Lab, POB 2003, Addis Ababa, Ethiopia; [Mamo, Hassen] Addis Ababa Univ, Coll Nat Sci, Dept Microbial Cellular & Mol Biol, POB 1176, Addis Ababa, Ethiopia in 2019.0, Cited 38.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6. Product Details of 67-51-6

This study was aimed to identify volatile compounds of 31 green coffee bean samples and evalute their correlation with altitude of the coffee plants grown in two zones (Gedeo and Jimma) in Ethiopia. A total of 81 different compounds were detected. The contents of dominant volatile compounds in green coffee beans were in the range: trans-linalooloxide (3.24-19.13%), linalool (1.56-21.76%), 2-methoxy-4-vinylphenol (2.34-15.08%) and cis-linalooloxide (1.03-13.27%). In addition, benzene acetaldehyde (0.45-10.97%), 2-heptanol (0.67-8.49%), alpha-terpineol (0.64-6.52%), phenylethyl alcohol (0.44-4.98%) and furfural (0.92-5.3%) were the next dominant compounds. The volatile compounds identified in the green coffee beans are groups of alcohols, aldehydes, ketones, pyrazines, pyridines, and furans. The volatile compounds in green coffee beans showed either weak positive or weak negative correlation with the altitude of coffee plants indicating that variation in altitude of the coffee plants does not significantly influence the volative compounds of green coffee beans.

Welcome to talk about 67-51-6, If you have any questions, you can contact Tsegay, G; Redi-Abshiro, M; Chandravanshi, BS; Ele, E; Mohammed, AM; Mamo, H or send Email.. Product Details of 67-51-6

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Formula: C5H8N2. In 2021.0 ACS OMEGA published article about ANTIBACTERIAL; ANTIFUNGAL; COMPLEXES; SERIES; ACID in [Glukhacheva, Vera S.; Il’yasov, Sergey G.; Kazantsev, Igor, V; Shestakova, Elena O.; Il’yasov, Dmitri S.] Russian Acad Sci IPCET SB RAS, Inst Problems Chem & Energet Technol, Siberian Branch, Biisk 659322, Russia; [Eltsov, Ilia, V; Nefedov, Andrey A.] Novosibirsk State Univ, Novosibirsk 630090, Russia; [Nefedov, Andrey A.; Gatilov, Yuri, V] Russian Acad Sci NIOCh SB RAS, Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, Novosibirsk 630090, Russia in 2021.0, Cited 40.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6.

A new approach is suggested herein for the synthesis of pyrazole derivatives by reacting 4-nitrosemicarbazide with acetylacetone. Additional studies were done on the reaction of acetylacetone with semicarbazide and its derivatives (4-aminosemicarbazide, methylsemicarbazide, and dimethylsemicarbazide). The study on the reaction with acetylacetone resulted in monocyclic 3,5-dimethyl-N-nitropyrazole-1-carboxamide, monocyclic 5-hydroxy-3,5-dimethyl-2-pyrazoline, and bicyclic bis(3,5-dimethylpyrazole-1-carbonyl)hydrazine, and conditions for the formation of acetone semicarbazone were identified. The structures of the resultant compounds were validated by physicochemical analytical methods, including X-ray diffraction. The computer-aided screening in the PASS prediction software discovered a high biological activity of the newly obtained compounds.

Formula: C5H8N2. Welcome to talk about 67-51-6, If you have any questions, you can contact Glukhacheva, VS; Il’yasov, SG; Kazantsev, IV; Shestakova, EO; Il’yasov, DS; Eltsov, IV; Nefedov, AA; Gatilov, YV or send Email.

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Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

HPLC of Formula: C5H8N2. I found the field of Chemistry very interesting. Saw the article Self-assembly of a nonanuclear Ni-II cluster via atmospheric CO2 fixation: synthesis, structure, collision-induced dissociation mass spectrometry and magnetic property published in 2020, Reprint Addresses Sun, D (corresponding author), Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China.; Sun, D (corresponding author), Shandong Univ, State Key Lab Crystal Mat, Jinan 250100, Peoples R China.; Sheng, K (corresponding author), Shandong Jiaotong Univ, Sch Aeronaut, Jinan 250037, Peoples R China.; Jagodic, M (corresponding author), Inst Math Phys & Mech, Jadranska 19, Ljubljana 1000, Slovenia.. The CAS is 67-51-6. Through research, I have a further understanding and discovery of 3,5-Dimethyl-1H-pyrazole.

A novel nonanuclear nickel(ii) cluster identified as [Ni-9(OH)(6)(CO3)(2)(ba)(8)(Hdmpz)(6)(DMF)(2)]center dot EtOH center dot 2DMF (SD/Ni9a, Hba = benzoic acid, Hdmpz = 3,5-dimethyl-1H-pyrazole) is successfully constructed from mixed ligands. The single-crystal X-ray diffraction (SCXRD) structural analysis confirms the composition and reveals the drum-like inner core structure surrounded by ba(-)and DMF. Six Hdmpz ligands in their neutral form further sandwich the drum up and down, and is hydrogen bonded with two carbonate anions that are derived from the atmospheric CO2 with the help of Et3N. Electrospray ionization mass spectrometry (ESI-MS) reveals that the SD/Ni9a maintains an intact core in the solution with a slight exchange of outer ligands. Detailed collision-induced dissociation (CID) experiments reveal the collision energy (CE)-promoted ligand loss and exchange between ba(-) and Hdmpz. Furthermore, the magnetic study shows that there is no interaction between the Ni centers at room temperature, whereas the ferromagnetic coupling between the Ni centers is found with an S = 3 spin ground state of the cluster at low temperature. Moreover, the UV-vis spectrum and the photocurrent response measurements show its good optical properties with an indirect bandgap of about 2.35 eV and fast current response upon visible light irradiation.

HPLC of Formula: C5H8N2. Bye, fridends, I hope you can learn more about C5H8N2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics