Category: 930-36-9

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 930-36-9, name is 1-Methylpyrazole, A new synthetic method of this compound is introduced below., SDS of cas: 930-36-9

A solution of POCl3 (2.61 mL, 28 mmol) in DMF (2.16 mL, 28 mmol)was stirred at 8 C for 2 h, and the resultant viscous solution waswarmed to 80 C. To this solution was added N-methylpyrazole (1 g,12 mmol), and it was stirred at 80 C for 1 h, at 100 C for 3 h, and at115 C for 1 h. The solution was then cooled to room temperature andquenched by addition of 60 mL of ice-cold water. The reaction mixturewas stirred for 24 h and then neutralized to pH 7 using 1 N NaOH andextracted with chloroform (3¡Á30 mL). The combined organic layerwas washed with brine (30 mL) and dried over MgSO4. After filtration, the filtrate was concentrated in vacuo. The residue was purified bycolumn chromatography to afford 5 (0.68 g, 50%), Rf=0.2 Hex/EA7:3. 1H NMR (400 MHz, CDCl3) delta 9.80 (s, 1H), 7.91 (s, 1H), 7.89 (s, 1H),3.93 (s, 3H). MS (ESI) m/z 110.8 [M+H]+. HRMS calcd for C5H6N2O[M+H]+ 111.0558, found 111.0556.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 930-36-9, name is 1-Methylpyrazole, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 1-Methylpyrazole

To a mixture of 1-methyl-1H-pyrazole (16.4 g, 0.2 mol, 1.0 eq) in dry THF (150 mL) was added n-BuLi (2.5 M in hexane, 96 mL, 0.24 mol, 1.2 eq) at -78 C. under nitrogen atmosphere. The mixture was stirred at -78 C. for 1 h. Then DMF (30.8 mL, 0.4 mol, 2.0 eq) was added dropwise and the mixture was stirred for 1 h. TLC analysis of the reaction mixture showed full conversion to the desired product. The reaction was quenched with a saturated aqueous solution of NH4Cl and extracted with EA (3¡Á500 mL). The organic layer was washed with brine and water, dried over Na2SO4 and concentrated under vacuum. The residue was purified by column chromatography on a silica gel to give compound OI-5a (12.7 g, 58%).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 930-36-9.

Some common heterocyclic compound, 930-36-9, name is 1-Methylpyrazole, molecular formula is C4H6N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C4H6N2

A mixture of phosphoryl chloride (467 gm, 3.045 moles) and DMF was stirred for 1 hour at 0-5 C. The reaction is exothermic so temperature should be below 5 C. To this slowly added 1-methyl-1H-pyrazole (50 gm, 0.6090 moles) and stirred for 30 min at 0-5 C. Then slowly raised the temperature from 20-30 C. to 60-70 C. and stirred for 10-15 hours. Progress of the reaction was monitored by HPLC. The reaction mixture was cooled to 0-5 C., to this added ethyl acetate (250 ml), DM water (1 L) and aqueous ammonia solution (350 ml, pH-6 to 7). The reaction mixture was stirred for 1 hour at 20-30 C. The inorganic salt obtained was filtered off, washed with ethyl acetate (250 ml). The filtrate was transferred in to a separating funnel. The reaction mixture was allowed to settle. The organic layer was separated and aqueous layer was extracted with ethyl acetate (250 ml). The entire organic layer was transferred to the reaction vessel, stirred for 10-15 min and separated the final aqueous layer and organic layer. The combined organic layer having 1-methyl-1H-pyrazole-4-carbaldehyde and ethyl acetate was used as such for Step 2 without any purification or isolation at this step.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 930-36-9, its application will become more common.

These common heterocyclic compound, 930-36-9, name is 1-Methylpyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 930-36-9

Adding 5.92 g (20 mmol) of FeBr3 to a solution of 8.2 g (100 mmol) of 1-methylpyrazole dissolved in 100 mL of methyl tert-butyl ether at 0 ;Under stirring, 32 g (200 mmol) of Br2 was added dropwise.Stir at room temperature,The end of the reaction was followed by TLC.After confirming the reaction,Filter the system,The filtrate is poured into the water.Use Na2S2O3 solution in sequence,Water washing,Liquid separation.The obtained organic phase was dried over anhydrous magnesium sulfate.The solvent was evaporated under reduced pressure,Got 14.5g(yield: 90.5%, purity 98%)5-bromo-1-methylpyrazole.

The synthetic route of 1-Methylpyrazole has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 930-36-9, name is 1-Methylpyrazole, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 1-Methylpyrazole

General procedure: To a stirred mixture of pyrazole (200 mmol) and the appropriate acid anhydride (350 mmol, 1.75 equiv), concd H2SO4(0.2 mL) was added, and the resulting mixture was stirred under a nitrogen atmosphere in an oil bath until the pyrazole was consumed. For low boiling components, this mixture was heated at reflux. Reaction conditions (temperature and time) are given in Table 2. When the reaction was complete, volatile compounds were removed under reduced pressure and the residue was poured onto 100 mL crushed ice. The reaction mixture was neutralized under vigorous stirring by the addition of 20% aqueous NaOH or (in the case of fluorinated ketones) solid KHCO3 to adjust pH to 7-8. The ketone was extracted with CH2Cl2(3 ¡Á 50 mL) and the combined organic phases were washed with brine (50 mL), dried over MgSO4, and evaporated under reduced pressure. The resulting crude ketone was purified by either distillation or recrystallization from the appropriate solvent.

According to the analysis of related databases, 930-36-9, the application of this compound in the production field has become more and more popular.