Category: 930-36-9

Petzold, Daniel published the artcilePhotocatalytic Oxidative Bromination of Electron-Rich Arenes and Heteroarenes by Anthraquinone, Category: pyrazoles-derivatives, the publication is Advanced Synthesis & Catalysis (2018), 360(4), 626-630, database is CAplus.

The estimated excited oxidation potential of sodium anthraquinone-2-sulfonate (SAS) increases from 1.8 V to ∼2.3 V vs. SCE by protonation with Bronsted acids. This increased photooxidation power of protonated anthraquinone was used for the regio-selective oxidative bromination of electron rich (hetero)arenes and drugs in good yield. The mild reaction conditions are compatible with many functional groups, such as double and triple bonds, ketones, amides and amines, hydroxyl groups, carboxylic acids and carbamates. Mechanistic studies indicate the photooxidation of the arene followed by nucleophilic bromide addition as the likely pathway.

Advanced Synthesis & Catalysis published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C4H6N2, Category: pyrazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Kim, Og Soon published the artcileSynthesis of Fluorescent Indazoles by Palladium-Catalyzed Benzannulation of Pyrazoles with Alkynes, HPLC of Formula: 930-36-9, the publication is Organic Letters (2017), 19(6), 1450-1453, database is CAplus and MEDLINE.

Pentasubstituted indazoles such as I (R = H, Me, t-Bu, MeO, EtO₂C, F, Cl) were prepared in 34-84% yields by oxidative benzannulation reactions of pyrazoles such as 1-methylpyrazole with sym. internal alkynes such as 4-(4-RC₆H₄CC)C₆H₄R (R = H, Me, t-Bu, MeO, EtO₂C, F, Cl) in the presence of Pd(OAc)₂ and Cu(OAc)₂ in 1,4-dioxane or by benzannulation of substituted 4-bromopyrazoles with sym. internal alkynes in the presence of Pd(OAc)₂, t-Bu₃P•HBF₄, K₂CO₃, and pivalic acid in toluene; unsym. internal alkynes gave mixtures of regioisomers. 1,2-Disubstituted imidazoles also underwent oxidative benzannulation with diphenylacetylene in the presence of Pd(OAc)₂ and Cu(OAc)₂ in 1,4-dioxane to yield tetraphenylbenzimidazoles in 41-50% yields. The fluorescence and optical bandgaps of I (R = H, t-Bu, MeO, EtO₂C, F, Cl) were determined The structure of I (R = H) was determined by X-ray crystallog.

Organic Letters published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C4H6N2, HPLC of Formula: 930-36-9.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Wang, Zhaogai published the artcileConcentrating sulphur-containing flavour from Toona sinensis shoots using corn oil with and without aqueous dispersion, Recommanded Product: 1-Methylpyrazole, the publication is International Journal of Food Science and Technology (2022), 57(3), 1644-1653, database is CAplus.

Toona sinensis (TS) shoot is a seasonal and quick deteriorating vegetable with unique alliaceous flavor. In this study, corn oil was used to concentration the sulfur-containing compounds responsible for the unique TS flavor with and without aq dispersion. The level of sulfur-containing compounds in TS shoots was 0.32μg g-1 and concentratio to 2.34μg g-1 in the corn oil with aq dispersion. The sulfur-containing compounds, trans-2-Mercapto-3,4-dimethyl-2,3-dihydrothiophene and (E,Z)-Di-1-propenyldisulfide, were identified in the corn oil, while they were not detected in the oil without aq dispersion. Based on sensory and electronic nose anal., the aroma of corn oil with aq medium extraction had stronger alliaceous aroma than TS shoots and the extraction corn oil without aq dispersion. With aq dispersion assistance, the sulfur-containing aroma compounds in TS shoots were effectively concentration in corn oil. The flavor-enriched oil could serve as a flavor ingredient to deliver TS shoots aroma for different food applications.

International Journal of Food Science and Technology published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C8H8O3, Recommanded Product: 1-Methylpyrazole.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Margrey, Kaila A. published the artcilePredictive Model for Site-Selective Aryl and Heteroaryl C-H Functionalization via Organic Photoredox Catalysis, Quality Control of 930-36-9, the publication is Journal of the American Chemical Society (2017), 139(32), 11288-11299, database is CAplus and MEDLINE.

Direct C-H functionalization of aromatic compounds is a useful synthetic strategy that has garnered much attention because of its application to pharmaceuticals, agrochems., and late-stage functionalization reactions on complex mols. On the basis of previous methods disclosed by our lab, we sought to develop a predictive model for site selectivity and extend this aryl functionalization chem. to a selected set of heteroaromatic systems commonly used in the pharmaceutical industry. Using electron d. calculations, we were able to predict the site selectivity of direct C-H functionalization in a number of heterocycles and identify general trends observed across heterocycle classes.

Journal of the American Chemical Society published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C4H6N2, Quality Control of 930-36-9.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Doba, Takahiro published the artcileHomocoupling-free iron-catalyzed twofold C-H activation/cross-couplings of aromatics via transient connection of reactants, HPLC of Formula: 930-36-9, the publication is Nature Catalysis (2019), 2(5), 400-406, database is CAplus.

Herein, an efficient strategy was developed for the synthesis of biaryls and (aryl)alkenamides Ar(R)C=C(R¹)C(O)NHAr¹ [R = Me; R¹ = Me; RR¹ = (CH₂)₄; Ar = 3,4-Cl₂C₆H₃, 5-Ph-2-thienyl, benzothiophen-2-yl, etc.; Ar¹ = 8-quinolyl] via iron-catalyzed twofold C-H activation/cross-coupling of arenes with alkenyl/aryl carboxamides. A transient connection of two reactants by an anionic group appended to one reactant helped to achieve this goal under mildly oxidative iron-catalyzed conditions, through the formation of a productive heteroleptic R¹-M-R² intermediate. An N-(quinolin-8-yl)amide anion was utilized for the temporary connection and cross-coupled a stoichiometric mixture of aromatics in high yield without any trace of homocoupling products. A short-step synthesis of several donor/acceptor thiophene compounds and carbon/sulfur-bridged flat conjugated systems illustrated the utility of this method to streamline organic synthesis.

Nature Catalysis published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C4H6N2, HPLC of Formula: 930-36-9.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Zhou, Jun published the artcilePhosphine-free ruthenium complexes supported by a pincer ligand bearing 1,2-dihydropyrimidine for Oppenauer-type oxidation of secondary alcohols, HPLC of Formula: 930-36-9, the publication is Journal of Organometallic Chemistry (2022), 122323, database is CAplus.

Treatment of the (diethylaminomethyl-picolyl)pyrazolium (A3) with NaOH in dichloromethane affords the pincer ligand (L) bearing a 1,2-dihydropyrimidine unit. Reaction of [RuCl₂(DMSO)₄] and the ligand (L) affords the complex [RuCl₂(L)(DMSO)] (Ru1). Removal of the chlorides from Ru1 with either NaBF₄ or KPF₆ in CH₃CN produces the complexes [Ru(L)(CH₃CN)₃](BF₄)₂ (Ru2) and [Ru(L)(CH₃CN)₃](PF₆)₂ (Ru3), resp. Ru2 has been characterized with X-ray crystallog. All of the new ruthenium complexes (Ru1-Ru3) are catalytically active in the Oppenauer-type oxidation of secondary alcs. Among them, the complex Ru1 is the most active. Steric effects were observed from the outcome of substituted acetophenones.

Journal of Organometallic Chemistry published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C3H8N2S, HPLC of Formula: 930-36-9.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Wang, Tengfei published the artcileHydroxyl-functionalized pyrazolium ionic liquids to catalyze chemical fixation of CO₂: Further benign reaction condition for the single-component catalyst, Synthetic Route of 930-36-9, the publication is Journal of Molecular Liquids (2019), 111479, database is CAplus.

Lots of ionic liquids have been utilized as catalyst for the coupling reaction of carbon dioxide with epoxides; however, catalyzed conditions could not be regarded as benign, especially when no co-catalyst and/or organic solvent is involved. A series of hydroxyl-functionalized pyrazolium ionic liquids are firstly synthesized. They would efficiently catalyze the cycloaddition of carbon dioxide and propylene oxide under 110°C and 1.0 MPa carbon dioxide initial pressure with 1 mol% catalyst during 4 h resulting in the product yield of 91.2%. The catalytic condition is greatly refined as compared with other single-component ionic liquids with simple anion. Simultaneously, the effect of reaction temperature, amount of catalyst, carbon dioxide initial pressure, and reaction time is explored along with the reusability of catalyst. For most of epoxides with terminal substituted group, HEEPzBr presents acceptable catalytic activity. The difference of HEMPzBr, HEEPzBr, and HPEPzBr is also explored by the d. functional theory calculations

Journal of Molecular Liquids published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C9H9BrO2, Synthetic Route of 930-36-9.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Guo, Jun-ling published the artcileOne-step synthesis and thermal behavior of 1-methyl-3,4,5-trinitropyrazole, Product Details of C4H6N2, the publication is Hanneng Cailiao (2015), 23(3), 304-306, database is CAplus.

1-Methyl-3, 4 ,5-trinitropyrazole (MTNP) as an insensitive energetic compound was one-step synthesized with 1-methylpyrazole via direct nitration using mixture of nitric acid and fuming sulfuric acid for the first time. The structure of MTNP was characterized by IR, NMR, elemental anal., and mass spectrum. The reaction conditions were optimized as following: reaction temperature 90 °C, reaction time 6 h , molar ratio of HNO₃ and fuming sulfuric acid 1 : 8. At this condition, the yield of MTNP can reach up to 15.2%. Thermal behavior of MTNP was studied by DSC. Results show that its decomposition temperature is 272.0 °C, indicating a good heat stability.

Hanneng Cailiao published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C4H6N2, Product Details of C4H6N2.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Ma, Jingyi published the artcileSynthesis, physicochemical and antimicrobial properties of cardanol-derived quaternary ammonium compounds (QACs) with heterocyclic polar head, Application of 1-Methylpyrazole, the publication is Journal of Molecular Liquids (2019), 111669, database is CAplus.

As new biomass derived raw material, cardanol has attracted the attention of numerous academic and industrial groups due to its renewability and unique structural features. In this work, seven cardanol-derived quaternary ammonium compounds (QACs) were synthesized with their physicochem. properties and antimicrobial ability evaluated. The surface tension was measured in aqueous medium by the platinum ring method, 2b has the optimal surface activities, which is considerably better than commercialized QAC product cetyltrimethylammonium bromide. Both broth dilution method and agar dilution method were used to obtain the MIC and MBC values of the targeted QACs. 1a, 1b, 2b inhibit the tested bacterial at a concentration of 32μg/mL. SEM (SEM) results intuitively showed that the QACs could interact with the bacterial cell membrane, for disrupting the integrity of the membrane. Meanwhile, it was found that the antimicrobial activity depended not only on the alkyl chain length, but also on the CMC value. To sum, seven cardanol-derived QACs were synthesized easily, which showed excellent surface activities and antimicrobial activity, as a promising alternative to the existing fossil fuel derived cationic surfactants and antiseptics.

Journal of Molecular Liquids published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C4H6N2, Application of 1-Methylpyrazole.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Toutov, Anton A. published the artcileSilylation of C-H bonds in aromatic heterocycles by an Earth-abundant metal catalyst, Product Details of C4H6N2, the publication is Nature (London, United Kingdom) (2015), 518(7537), 80-84, database is CAplus and MEDLINE.

Heteroaromatic compounds containing C-Si (C-Si) bonds are of great interest in the fields of organic electronics and photonics, drug discovery, nuclear medicine and complex mol. synthesis, because these compounds have very useful physicochem. properties. Many of the methods now used to construct heteroaromatic C-Si bonds involve stoichiometric reactions between heteroaryl organometallic species and Si electrophiles or direct, transition-metal-catalyzed intermol. C-H (C-H) silylation using Rh or Ir complexes in the presence of excess H acceptors. Both approaches are useful, but their limitations include functional group incompatibility, narrow scope of application, high cost and low availability of the catalysts, and unproven scalability. For this reason, a new and general catalytic approach to heteroaromatic C-Si bond construction that avoids such limitations is highly desirable. Here the authors report an example of cross-dehydrogenative heteroaromatic C-H functionalization catalyzed by an Earth-abundant alkali metal species. Readily available and inexpensive K tert-butoxide catalyzes the direct silylation of aromatic heterocycles with hydrosilanes, furnishing heteroarylsilanes in a single step. The silylation proceeds under mild conditions, in the absence of H acceptors, ligands or additives, and is scalable to >100 g under optionally solvent-free conditions. Substrate classes that are difficult to activate with precious metal catalysts are silylated in good yield and with excellent regioselectivity. The derived heteroarylsilane products readily engage in versatile transformations enabling new synthetic strategies for heteroaromatic elaboration, and are useful in their own right in pharmaceutical and materials science applications.

Nature (London, United Kingdom) published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C6H10N2, Product Details of C4H6N2.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics