Category: 930-36-9

Yi, Rong-Nan published the artcileGreen synthesis of 4-organylselanyl-1H-pyrazoles through electrochemical cross-dehydrogenative coupling of 1H-pyrazoles and diorganyl diselenides, Application In Synthesis of 930-36-9, the publication is Tetrahedron Letters (2021), 153257, database is CAplus.

An atom-economical and efficient method for synthesizing 4-organylselanyl-1H-pyrazoles through electrochem. cross-dehydrogenation coupling of N-unsubstituted pyrazoles with diorganyl diselenides under chem. oxidant-free and mild conditions was developed. This reaction not only shows good functional-group tolerance but also has high scalability.

Tetrahedron Letters published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C15H20O6, Application In Synthesis of 930-36-9.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Fillion, Joseph J. published the artcilePhase Transitions, Decomposition Temperatures, Viscosities, and Densities of Phosphonium, Ammonium, and Imidazolium Ionic Liquids with Aprotic Heterocyclic Anions, HPLC of Formula: 930-36-9, the publication is Journal of Chemical & Engineering Data (2016), 61(8), 2897-2914, database is CAplus.

Ionic liquids (ILs) with aprotic heterocyclic anions (AHAs) have been developed primarily for CO₂ capture applications. However, they have also been considered for cofluid CO₂/IL vapor compression refrigeration cycles and for various electrochem. applications. In all of these cases, reducing the viscosity of the IL is of primary importance. Therefore, the focus of this work is tuning the cation to produce AHA ILs with both low viscosities and low m.ps. Toward this goal we have synthesized 40 AHA ILs paired with phosphonium, ammonium and imidazolium cations, as well as a number of ILs with the bis(trifluoromethylsulfonyl)imide anion to use for comparison. The azolide anions investigated were 2-cyanopyrrolide, 4-nitropyrazolide, various substituted imidazolides, 1,2,3-triazolide, and tetrazolide. M.ps., glass transition temperatures, and decomposition temperatures were measured for all ILs. Viscosities and densities were measured from 278.15 to 343.15 K and 283.15 to 353.15 K, resp., for all ILs except those with high m.ps. or excessively high viscosities. Shortening the alkyl chains on tetra-alkylphosphonium and tetra-alkylammonium cations reduces viscosity, but eventually results in unacceptably higher m.ps. For equivalent alkyl chain lengths and anions, ammoniums have higher m.ps. and lower decomposition temperatures than phosphoniums. The introduction of an ether chain on a phosphonium cation lowers viscosity but reduces thermal stability. Di- and trialkylimidazolium with sufficiently low m.ps. have relatively high viscosities.

Journal of Chemical & Engineering Data published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C4H6N2, HPLC of Formula: 930-36-9.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Hara, Naofumi published the artcileC2-Selective silylation of pyridines by a rhodium-aluminum complex, Product Details of C4H6N2, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(48), 5957-5960, database is CAplus and MEDLINE.

We have developed a C2-selective dehydrogenative mono-silylation of a variety of pyridines using a Rh-Al complex [(R₂PCH₂N-1,2-C₆H₄NMe-1,2-C₆H₄NCH₂PR₂)AlClRhCl(L)]_n (R = Ph, ⁱPr; n = 1, L = nbd; n = 2, L void). Both the site- and mono-selectivity are controlled via the pyridine coordination to the Lewis-acidic Al center prior to the activation of the pyridine C(2)-H bond at the proximal Rh center. A reaction mechanism is proposed based on several mechanistic studies, including the isolation of a (2-pyridyl)silylrhodium intermediate.

Chemical Communications (Cambridge, United Kingdom) published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C4H6N2, Product Details of C4H6N2.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Popov, Mark S. published the artcileGas Chromatography-Mass Spectrometry Quantification of 1,1-Dimethylhydrazine Transformation Products in Aqueous Solutions: Accelerated Water Sample Preparation, HPLC of Formula: 930-36-9, the publication is Molecules (2021), 26(19), 5743, database is CAplus and MEDLINE.

The use of highly toxic rocket fuel based on 1,1-dimethylhydrazine (UDMH) in many types of carrier rockets poses a threat to environment and human health associated with an ingress of UDMH into wastewater and natural reservoirs and its transformation with the formation of numerous toxic nitrogen-containing products. Their GC-MS quantification in aqueous samples requires matrix change and is challenging due to high polarity of analytes. To overcome this problem, accelerated water sample preparation (AWASP) based on the complete removal of water with anhydrous sodium sulfate and transferring analytes into dichloromethane was used. Twenty-nine UDMH transformation products including both the acyclic and heterocyclic compounds of various classes were chosen as target analytes. AWASP ensured attaining near quant. extraction of 23 compounds with sample preparation procedure duration of no more than 5 min. Combination of AWASP with gas chromatog.-mass spectrometry and using pyridine-d5 as an internal standard allowed for developing the rapid, simple, and low-cost method for simultaneous quantification of UDMH transformation products with detection limits of 1-5 μg L^-1 and linear concentration range covering 4 orders of magnitude. The method has been validated and successfully tested in the anal. of aqueous solutions of rocket fuel subjected to oxidation with atm. oxygen, as well as pyrolytic gasification in supercritical water modeling wastewater from carrier rockets launch sites.

Molecules published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C4H6N2, HPLC of Formula: 930-36-9.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Lee, Liang Wei published the artcileModulation of the volatile and non-volatile profiles of coffee fermented with Yarrowia lipolytica: II. Roasted coffee, Recommanded Product: 1-Methylpyrazole, the publication is LWT–Food Science and Technology (2017), 32-42, database is CAplus.

The fermentation of green coffee beans by Yarrowia lipolytica led to significant changes in the volatile and non-volatile profiles of green coffees (Part I). Therefore, the objective of this continuation study was to evaluate the effects of fermentation after roasting by characterizing the volatile profiles of coffees at three different roast levels and non-volatile profiles of coffee where the effects of fermentation on volatiles were most prominent (light roast). Y. lipolytica fermentation led to significant changes in the volatile profiles of roasted coffees which arose from both the modification of aroma precursors and the retention of volatile profile changes observed in green fermented coffees. The levels of 4-vinylguaiacol and 4-vinylphenol were 1.2-fold and 1.6-fold higher in light roasted fermented coffees resp. and could be explained by the higher levels detected in green fermented coffees before roasting. The levels of γ-butyrolactone were 5 times higher in light roasted fermented coffees than unfermented coffees. The increase in sulfur compounds levels and decrease in ketones levels were attributed to changes in the concentrations of aroma precursors like sugars and amino acids. Thus, this study highlighted the potential of utilizing yeast fermentation of green coffee beans for coffee aroma modulation.

LWT–Food Science and Technology published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C4H6N2, Recommanded Product: 1-Methylpyrazole.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Aravindakshan, Aghil Soorya published the artcileAnalysis of bio-active compounds present in the leaves and stem of Trichosanthes roxb. using GC-MS technique with respect to its anti-inflammatory action, Recommanded Product: 1-Methylpyrazole, the publication is International Journal of Pharmacy and Pharmaceutical Sciences (2021), 13(2), 7-13, database is CAplus.

Structural elucidation studies on Trichosanthes lobata Et acetate and methanol extracts of leaf and stem parts through Gas Chromatog.-Mass Spectrometry (GC-MS) technique with respect to anti-inflammatory potential. Extracts obtained with shade dried and powd. samples in successive solvent extraction using Et acetate and methanol by Soxhlet apparatus and subjected to GC-MS anal. and interpreted for its anti-inflammatory compounds The study revealed that the extraction solvent used was able to recover compound of classes such as organic acid esters and conjugated alkaloids in larger quantities than other classes of compounds and they varied with leaf and stem and also with the polarity of solvents used. In total compounds identified, GC-MS profile of the Et Acetate leaf extract of T. lobata contained 41 compounds, stem extract contained 45 compounds which have reported bioassays in PubChem. Whereas GC-MS profile of methanol leaf extract of T. lobata contained 66 compounds and stem extract contained 46 compounds having bioassay reports in PubChem. A large number of phytochem. peaks with good area percentage were found in methanolic extract We were also able to find out potent anti-inflammatory compounds including Octanoic acid, Dodecanoic acid, Octadecane, Enoic acid, Hexanoic acid, Quinazolin-8-one, Ilicic acid, Pentadecanoic acid, Oxaspiro, Benzeneacetic acid, etc. from the extracts T. lobata contains phytocompounds against inflammation which may serve as a new drug lead of natural products origin in future and make it employable in modern pharmacol. practices.

International Journal of Pharmacy and Pharmaceutical Sciences published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C4H6N2, Recommanded Product: 1-Methylpyrazole.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Kajita, Harutake published the artcileA Oxidative Bromination of (Hetero)Arenes in the TMSBr/DMSO System: A Non-Aqueous Procedure Facilitates Synthetic Strategies, Formula: C4H6N2, the publication is ChemistrySelect (2017), 2(3), 1117-1121, database is CAplus.

An oxidative bromination protocol for aromatic compounds using trimethylsilyl bromide (TMSBr) and DMSO has been developed. This mild bromination system tolerates a wide variety of functionalities including amide, aldehyde, ester and acetal groups. Arylbromides and heteroarylbromides are produced in up to 95 % yield at 25°. Arenes bearing electron-donating groups are selectively brominated at the para position unless it is blocked. The highlight of this protocol consists in its non-aqueous conditions, which are fruitful particularly in the context of integrated synthetic systems. The utility of this method was demonstrated with three examples, in either of which the bromination was followed by another reaction: a “click” triazole formation, a Suzuki-Miyaura cross-coupling, or an aldehyde formation via lithium-bromine exchange, without the isolation of the bromide intermediate in any case. It is particularly remarkable for this non-aqueous protocol to allow lithiation reactions to sequentially follow the bromination.

ChemistrySelect published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C4H6N2, Formula: C4H6N2.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Song, Song published the artcileEfficient and Practical Oxidative Bromination and Iodination of Arenes and Heteroarenes with DMSO and Hydrogen Halide: A Mild Protocol for Late-Stage Functionalization, COA of Formula: C4H6N2, the publication is Organic Letters (2015), 17(12), 2886-2889, database is CAplus and MEDLINE.

An efficient and practical system for inexpensive bromination and iodination of arenes as well as heteroarenes by using readily available DMSO (DMSO) and HX (X = Br, I) reagents is reported. This mild oxidative system demonstrates a versatile protocol for the synthesis of aryl halides. HX (X = Br, I) are employed as halogenating reagents when combined with DMSO which participates in the present chem. as a mild and inexpensive oxidant. This oxidative system is amenable to late-stage bromination of natural products. The kilogram-scale experiment (>95% yield) shows great potential for industrial application.

Organic Letters published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C3H5BN2O2, COA of Formula: C4H6N2.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Fuse, Shinichiro published the artcileDesign, synthesis, and evaluation of indeno[2,1-c]pyrazolones for use as inhibitors against hypoxia-inducible factor (HIF)-1 transcriptional activity, Application of 1-Methylpyrazole, the publication is Bioorganic & Medicinal Chemistry (2020), 28(1), 115207, database is CAplus and MEDLINE.

In this study, indeno[2,1-c]pyrazolones, compounds I [Y = C, N; R¹ = H, Me; R² = H, Me, Ph, etc] were designed as readily available synthetic inhibitors of HIF-1 transcriptional activity. Nine compounds were synthesized in 4-5 steps from com. available starting materials. In evaluations of the ability to inhibit the hypoxia-induced transcriptional activity of HIF-1, compound I [Y = C, R¹ = H, R² = 4-MeC₆H₄] showed a higher level compared with that of known inhibitor, YC-1. The compound I [Y = C, R¹ = H, R² = 4-MeC₆H₄] suppressed HIF-1α protein accumulation without affecting the levels of HIF-1α mRNA.

Bioorganic & Medicinal Chemistry published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C4H6N2, Application of 1-Methylpyrazole.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Hayashi, Hiroki published the artcileSynthesis of difluoroglycine derivatives from amines, difluorocarbene, and CO₂: computational design, scope, and applications, Application of 1-Methylpyrazole, the publication is Chemistry – A European Journal (2021), 27(39), 10040-10047, database is CAplus and MEDLINE.

A three-component reaction (3CR) for the synthesis of difluoroglycine derivatives has been achieved by using amines, difluorocarbene (generated in situ), and the abundant, inexpensive, and nontoxic C₁ source CO₂. Various tert-amines and pyridine, (iso)quinoline, imidazole, thiazole, and pyrazole derivatives were incorporated, and the corresponding products were isolated in solid form without purification by column chromatog. on silica gel. Detailed reaction profiles of the 3CR were obtained from computational anal. using DFT calculations, and the results critically suggest that simple ammonia is not applicable to this reaction. In addition, as strongly supported by computational predictions, a new reagent that can generate difluorocarbene at 0°C without any additives was discovered. Finally, radical substitution reactions of the obtained difluoroglycine derivatives under photoredox conditions, as well as a synthetic application as an N-heterocyclic carbene ligand are shown.

Chemistry – A European Journal published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C4H6N2, Application of 1-Methylpyrazole.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics