Category: 852227-86-2

Reference of 852227-86-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 852227-86-2 as follows.

Example 42 3-Bromo-5-(3-cyano-2-methyl-5-oxo-7-propyl-1,4,5,6,7,8-hexahydro-quinolin-4-yl)-2-(2,5-dimethyl-2H-pyrazol-3-ylmethoxy)-N,N-dimethyl-benzenesulfonamide A mixture of the compound described in example 41a (153 mg), potassium carbonate (125 mg), and 5-chloromethyl-1,3-dimethyl-1H-pyrazole (55 mg) in DMF (1.4 ml) was heated at 60 C. for 3 h. The mixture was diluted with 1N hydrochloric acid and extracted with ethyl acetate. The organic layer was dried (MgSO4), filtered and concentrated in vacuo. The residue was purified by preparative HPLC (Method B), then purified by chromatography on aluminum oxide using ethyl acetate as eluent.Yield: 51 mg. MS-ESI: [M+H]+=616.2/618.2; anal. HPLC: Rt=18.40 min. (method 2)

According to the analysis of related databases, 852227-86-2, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 852227-86-2, name is 5-(Chloromethyl)-1,3-dimethyl-1H-pyrazole, A new synthetic method of this compound is introduced below., Computed Properties of C6H9ClN2

A solution of 7d (58 mg, 0.20 mmol, 1.0 equiv) in anhydrous DMF (0.8 mL) was treated with 60% sodium hydride (18 mg, 0.44 mmol, 2.2 equiv). After stirring at room temperature for 5 min, 5-(chloromethyl)-l,3-dimethyl-lH-pyrazole (63 mg, 0.42 mmol, 2.1 equiv) was introduced. Then the mixture was stirred at room temperature for 2 hours. The reaction was quenched with saturated aqueous NaHCO3. The resulting solution was extracted with ethyl acetate. The combined extracts were washed once with brine, dried over Na2SO4, filtered and concentrated in vacuo. The residue was purified by prep-TLC (ethyl acetate/dichloromethane/ methanol 10/10/1, 2 runs) to afford compound 30 (50 mg, 50%) as a white solid. MS 505 (MH)+, 503 (M-H)”. Purity 99% (HPLC).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Related Products of 852227-86-2, These common heterocyclic compound, 852227-86-2, name is 5-(Chloromethyl)-1,3-dimethyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a stirred suspension of10(30 mg, 0.07 mmol) and potassium carbonate (20 mg, 0.15 mmol) in DMF (500 muL) was added 2-bromoacetamide (15 mg, 0.11 mmol) and the mixture heated to 80 C for 1 h. The reaction mixture was concentrated to dryness and 4 MHCl/dioxane (1 mL) added. After concentrating to dryness, the residue was purified by prepHPLC(high pH) to afford the title compound(8 mg, 30%) as a white powder.

Statistics shows that 5-(Chloromethyl)-1,3-dimethyl-1H-pyrazole is playing an increasingly important role. we look forward to future research findings about 852227-86-2.

852227-86-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 852227-86-2 name is 5-(Chloromethyl)-1,3-dimethyl-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of 3-[(1 -methylpyrazol-4-yl)methyl]-2,4-dioxo-N-[1 – (trideuteriomethyl)cyclopropyl]- 1H -quinazoline-6-sulfonamide (100 mg, 0.25 mmol), 5- (chloromethyl)-1 ,3-dimethyl- 1H -pyrazole (37 mg, 0.25 mmol), potassium carbonate (70 mg, 0.51 mmol) and potassium iodide (42 mg, 0.25 mmol) in DMF (2 mL) was heated with agitation in the microwave at 80 C for 30 minutes. The solvent was removed in vacuo and the residue purified by prep HPLC (high pH) to give the desired product (68 mg, 0.136 mmol, 53%) as a white powder

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-(Chloromethyl)-1,3-dimethyl-1H-pyrazole, and friends who are interested can also refer to it.