Category: 330792-70-6

Synthetic Route of 330792-70-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 330792-70-6, name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a stirred solution of 5-amino-3-(4-phenoxyphenyl)- 1H-pyrazole- 4-carbonitrile (20 g, 1.0 eq) and Cs2CO3 (70.7 g, 3.0 eq) in 300 mL dry DMF at 60°C was added (S)-tert-butyl 3-(tosyloxy)piperidine-1-carboxylate (31 g, 1.2 eq) slowly. After addition was completed, the reaction mixture was stirred at 60 °C for 40 hours. Water was added and the mixture was extracted with EtOAc. The organic extract was washed with water and brine, dried with anhydrous Na2SO4, and purified by flash chromatography to give compound 7 as a white solid (8.8 g, 27percent). ?H NMR (400 MHz, CDC13) oe 7.85-7.88 (m, 2H), 7.33-7.37 (m, 2H), 7.09-7.14 (m, 1H), 7.03-7.06 (m, 4H), 4.52 (brs, 2H), 4.19-4.29 (m, 1H), 4.01-4.18 (m, 1H), 3.80-3.89 (m, 1H), 3.02-3.19 (m, 1H), 2.81 (t, J = 12.8 Hz, 1H), 2.20-2.31 (m, 1H), 2.07-2.18 (m, 1H),1.83-1.92 (m, 1H), 1.76-1.81 (m, 1H), 1.44 (s, 9H).

The synthetic route of 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile has been constantly updated, and we look forward to future research findings.

Related Products of 330792-70-6, A common heterocyclic compound, 330792-70-6, name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, molecular formula is C16H12N4O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[0179] To a solution of (E)-N-(3-(3-(dimethylamino)acryloyl)phenyl)acetamide (46 mg, 0.2mmol) in HOAc (5 mL) was added 5-amino-3-(4-phenoxyphenyl)-IH-pyrazole- 4-carbonitrile(55 mg, 0.2 mmol). The mixture was stirred at 118 DC for 4 hr. Then the reaction mixture wasconcentrated to a residue and partitioned between ethyl acetate (100 mL) and brine (100 mL).Organic layer was separated, washed with brine (2×100 mL), dried over sodium sulfate andconcentrated to afford 80 mg (90percent) of N-(3-(3-cyano-2-(4-phenoxyphenyl)pyrazolo[l,5-a]pyrimidin-7-yl)phenyl)acetamide as a colorless oil. MS (ESI) m/e [M+ It 446.

The synthetic route of 330792-70-6 has been constantly updated, and we look forward to future research findings.

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 330792-70-6, Name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile. In a document, author is Jilloju, Parameshwara Chary, introducing its new discovery. Product Details of 330792-70-6.

Four-component, one-pot synthesis of (E)-N-benzylidene-3-(benzylthio)-5-(3,5-dimethyl-1H-pyrazol-1-yl)-4H-1,2,4-triazol-4-amines and their DNA binding and molecular docking studies

An efficient four-component strategy has been developed for the synthesis of a novel series of (E)-N-benzylidene-3-(benzylthio)-5-(3,5-dimethyl-1H-pyrazol-1-yl)-4H-1,2,4-triazol-4-amines in good yields. The method is effective for the synthesis of benzylidene aralkyl/allyl/propargyl thio pyrazolyl-1,2,4-triazol-4-amines in a one-pot operation. This method is operationally simple, metal-free, and works under reflux conditions with diverse substrates. Among all the synthesized compounds 5a, b, c, h, j , and n were shown good results in silico studies. 5n is showing good results in both DNA binding and molecular docking studies. (C) 2020 Elsevier B.V. All rights reserved.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 330792-70-6 help many people in the next few years. Product Details of 330792-70-6.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 330792-70-6, Name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, molecular formula is , belongs to pyrazoles-derivatives compound. In a document, author is Ismail, Magda M. F., Quality Control of 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile.

Synthesis of new arylazopyrazoles as apoptosis inducers: Candidates to inhibit proliferation of MCF-7 cells

New 4-arylazo-3,5-diamino-1H-pyrazole derivatives substituted in the 4-aryl ring with the acetyl moiety were designed and synthesized. The antiproliferative activity of the novel arylazopyrazoles was examined against the MCF-7 cell line. Among all target compounds,8b(IC(50)3.0 mu M) and8f(IC(50)4.0 mu M) displayed higher cytotoxicity as compared with the reference standard imatinib (IC(50)7.0 mu M). Further studies to explore the mechanism of action were performed on the most active hit of our library,8b, via anti-CDK2 kinase activity. It demonstrated good inhibitory effects for CDK2 (IC(50)0.24 mu M) with 62.5% inhibition, compared with imatinib. The cell cycle analysis in the MCF-7 cell line revealed apoptosis induction by8band cell cycle arrest at the S phase. Docking in the CDK2 active site and pharmacophore modeling confirmed the affinity of8bto the CDK2 active site. Absorption, distribution, metabolism, and excretion studies revealed that our target compounds are orally bioavailable, with no permeation through the blood-brain barrier.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 330792-70-6, in my other articles. Quality Control of 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Synthetic Route of 330792-70-6, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 330792-70-6, Name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, SMILES is N#CC1=C(N)NN=C1C2=CC=C(OC3=CC=CC=C3)C=C2, belongs to pyrazoles-derivatives compound. In a article, author is Teng, Qiaoqiao, introduce new discover of the category.

Evaluating the electronic properties of ditopic and hetero-ditopic ligands derived from benzimidazole and pyrazole by C-13 NMR spectroscopy

Huynh’s electronic parameter (HEP) was applied to distinguish the electronic properties of benzimidazole and pyrazole donors in (NN)-N-boolean AND ditopic and (NN)-N-boolean AND’ hetero-ditopic, dinucleating ligands by C-13 NMR spectroscopy of their dipalladium complexes bearing terminal Pr-i(2)-bimy reporter ligands. The C-13(carbene) NMR resonances of the Pr-i(2)-bimy ligand (HEPs) indicate stronger donation of the symmetrical dibenzimidazole compared to that of the dipyrazole with a Delta HEP value of 1.5(4) ppm. Based on this benchmark value, the effect of spacer groups on the electron donation of the mixed benzimidazole-pyrazole ligands was investigated for the first time. The donicity gap between the benzimidazole and pyrazole donors increases with alkylene spacers, but shrinks with the 1,4-phenylene linker, suggesting electronic communication between the two different heterocycles via pi-electron conjugation. Furthermore, these complex probes could also be used to catalyze the direct arylation of pentafluorobenzene, which showed that the unsymmetrically bridged, dinuclear complexes with alkylene linkers are more reactive. (C) 2020 Elsevier B.V. All rights reserved.

Synthetic Route of 330792-70-6, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 330792-70-6 is helpful to your research.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Application of 330792-70-6, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 330792-70-6, Name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, SMILES is N#CC1=C(N)NN=C1C2=CC=C(OC3=CC=CC=C3)C=C2, belongs to pyrazoles-derivatives compound. In a article, author is Mohamed, Magda F., introduce new discover of the category.

Attacking the mitochondria of colorectal carcinoma by novel 2-cyanoacrylamides linked to ethyl 1,3-diphenylpyrazole-4-carboxylates moiety as a new trend for chemotherapy

A novel set of 2-cyanoacrylamides linked to ethyl 1,3-diphenylpyrazole-4-carboxylates moiety were synthesized and elucidated by different spectroscopic tools. In vitro cytotoxic assay was carried out against different cell lines (Hct(116), A(549), MDA-MB231, and HFB4). Ethyl 5-(2-cyano-3-(furan-2-yl)acrylamido)-1,3-diphenylpyrazole-4-carboxylate 5 achieved the potent cytotoxic effect toward all tested cancer cell lines especially colon cancer (HCT116) with IC50 value (30.6 mu g/ml) relative to the lead compound 3 and the standard positive control 5-FU. Additionally, it exhibited less toxic effect toward the normal human melanocytes (HFB4) cell line. Compound 5 was theoretically investigated and compared for its binding affinity to a model of protein markers relative to the lead compound 3 using two different molecular docking programs. More investigations were performed in an attempt to find out the molecular mechanism of this novel compound inside colon cancer cells, as real time PCR analysis, Elisa assay, flow cytometry, and morphological characterizations using TEM and SEM tools. Herein, we showed that compound 5 interferes with the intrinsic pathway of apoptosis at the mitochondrial level in response to an apoptogenic stimulus as cytochrome c, caspase-9 and caspases-3 which were triggered by our novel compound 5. All molecular investigations proved that intrinsic apoptotic pathway of colorectal carcinoma was strongly initiated by the effect of compound 5 through upregulation of mitochondrial apoptosis related genes as (Caspase-3, caspase-9, BAX, P-53, and cytochrome-c) and down-regulated anti-apoptotic proteins (BCL2, MMP1, CDK4, and VEGFR). Further studies proved cell cycle arrest of HCT116 cell lines at G2/M phase after treatment. In addition, our data revealed that our novel efficiently damage the genomic DNA of colorectal cells involving P-53 dependent mechanism using DPA assay. Sever morphological and ultrastructural changes were detected in colorectal cells treated by compound 5 compared to control using both scanning electron microscopy (SEM) and transmission electron microscopy (TEM).

Application of 330792-70-6, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 330792-70-6.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Related Products of 330792-70-6, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 330792-70-6, Name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, SMILES is N#CC1=C(N)NN=C1C2=CC=C(OC3=CC=CC=C3)C=C2, belongs to pyrazoles-derivatives compound. In a article, author is Shadap, Lathewdeipor, introduce new discover of the category.

Synthesis and biological evaluation of some new class of benzothiazole-pyrazole ligands containing arene ruthenium, rhodium and iridium complexes

Metal complexes 1-9 have been synthesized by reacting the benzothiazole-pyrazole derivative ligands (L1, L2 and L3) with the metal precursors of ruthenium (Ru), rhodium (Rh) and iridium (Ir). The complexes have been isolated as cationic mononuclear N boolean AND N chelating metal complexes having the general formula as [(arene)M(kappa(2)((N boolean AND N))-L)Cl]PF6 where L = L1, L2 and L3, M = Ru, Rh and Ir, arene = p-cymene, Cp*. Structural studies revealed the mode of binding of the ligands to the metal centers is through the nitrogen atom of the benzothiazole ring and the pyrazole nitrogen atom forming a five-membered ring. All these complexes were characterized by various spectroscopic techniques as well as by XRD analysis. These complexes, as well as the ligands, have been investigated for antibacterial and antioxidant activity studies where only a few of the complexes exhibited antibacterial activity against Gram-positive bacterial strains, i.e., Staphylococcus aureus and Bacillus thuringiensis with complex 6 showing the highest bacterial inhibition toward Staphylococcus aureus and complexes 3, 4 and 6 showing the highest inhibition toward Bacillus thuringiensis. While for the antioxidant activity study, all the compounds showed profound antioxidant potency with complexes 6 and 9 showing more the 50% DRSA activity with reference to ascorbic acid (100%) taken as a reference. The antioxidant activity of the complexes is more pronounced as compared to their respective ligands alone.

Related Products of 330792-70-6, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 330792-70-6.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 330792-70-6, Name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, SMILES is N#CC1=C(N)NN=C1C2=CC=C(OC3=CC=CC=C3)C=C2, in an article , author is Salotra, R., once mentioned of 330792-70-6, SDS of cas: 330792-70-6.

A Convenient One-Pot Synthesis of Chalcones and Their Derivatives and Their Antimicrobial Activity

A series of chalcones were synthesized by base-catalyzed Clasien-Schmidt condensation of substituted benzaldehydes and substituted acetophenones at room temperature. The addition of hydrazine hydrate and hydroxylamine hydrochloride across the double bond of the obtained chalcones gave pyrazole and isoxazole derivatives, respectively. All the synthesized compounds were characterized by 1H and 13C NMR and FT-IR spectroscopy and screened for their in vitro antimicrobial activity against two bacterial strains, Pseudomonas aeruginosa and Pseudomonas oryzihabitans using Ciprofloxacin as standard drug. 1-(2- Methoxyphenyl)3-phenylprop- 2- en-1-one and 1-(4-chlorophenyl)- 3-phenylprop- 2- en-1-one showed significant activity against both bacterial strains and hence proved to be potent antimicrobial agents.

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Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 330792-70-6, Name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, molecular formula is C16H12N4O, belongs to pyrazoles-derivatives compound, is a common compound. In a patnet, author is Qi, Hong-Liang, once mentioned the new application about 330792-70-6, Quality Control of 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile.

A robust Co(II)-organic framework for photocatalytic dye degradation and treatment effect on the neonatal sepsis

A stable Co(II)-based metal-organic framework (MOF) was constructed by applying a dual ligand strategy. The ultra-stable Co(II) MOF, [Co(H(3)tpb)(Hbtc)](n) (1), was obtained by hydrothermal reaction of a novel trimer pyrazole ligand H(3)tpb and a classic carboxylic ligand H(3)btc (H(3)tpb = 1,3,5-tris (pyrazolyl) benzene, H(3)btc = 1,3,5-benzoic acid). In addition, complex 1 shows photocatalytic activity for the degradation of the dyes methylene blue (MB) and methyl orange (MO) under UV light. About 83.8% MB and 75.3% MO could be removed within 150 min. Serial experiments were performed to evaluate the biological activity of this compound in neonatal sepsis and explore its related mechanism. The results of the ELISA showed that the compound could reduce the releasing of the inflammatory cytokines in a dose-dependent manner. Besides, the compound could also reduce the relative expression levels of the gram-positive bacterial virulence. Simulations based on the molecular docking found that the complex could form multiple hydrogen bonds with several residues in the domain pocket. [GRAPHICS] .

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 330792-70-6. The above is the message from the blog manager. Quality Control of 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Let¡¯s face it, organic chemistry can seem difficult to learn, Category: pyrazoles-derivatives, Especially from a beginner¡¯s point of view. Like 330792-70-6, Name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, molecular formula is C9H15NO2, belongs to catalyst-ligand compound. In a document, author is Kausar, Nabeela, introducing its new discovery.

Celebrex derivatives: Synthesis, alpha-glucosidase inhibition, crystal structures and molecular docking studies

Celebrex (1), commonly used as an anti-inflammatory drug, was functionalized (compounds 2-9) to identify new alpha-glucosidase inhibitors. Initially, all the synthesized derivatives were evaluated for anti-inflammatory activity but none was found to be active. Subsequently a random biological screening was carried out. Interestingly many of them were found to be potent alpha-glucosidase inhibitors in vitro. All the structures of synthesized derivatives were deduced through H-1 NMR, FAB-MS, HR-MS, FT-IR analysis. The single-crystal X-ray structures of compounds 1, and 5 further confirmed the assigned structures. Compounds exhibited a potent alpha-glucosidase inhibitory activity (IC50 = 92.32 +/- 1.530-445.20 +/- 1.04 mu M) against tested standard acarbose (IC50 = 875.75 +/- 2.08 mu M), except compounds 2 and 4, which appeared as inactive. Among them, compound 9 (IC50 = 92.32 +/- 1.530 mu M) was the most potent inhibitor of alpha-glucosidase enzyme. Molecular docking studies revealed that compounds 6, and 9 interacted with the key amino acid residues of alpha-glucosidase via H-bonding, and pi-pi stacking interactions. alpha-Glucosidase is a key target for the anti-diabetic drug development, and its inhibitors are known to exert anti hyperglycemic effect and help in lowering of post-prandial blood glucose levels.

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Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics