Category: 1453-58-3

Reference of 1453-58-3, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 1453-58-3, Name is 3-Methylpyrazole, SMILES is CC1=NNC=C1, belongs to pyrazoles-derivatives compound. In a article, author is Saberi, Farveh, introduce new discover of the category.

Insight into 6-aminopenicillanic acid structure and study of the quantum mechanical calculations of the acid-base site on gamma-Fe2O3@SiO2 core-shell nanocomposites and as efficient catalysts in multicomponent reactions

Grafting 6-aminopenicillanic acid (6-APA) onto superparamagnetic gamma-Fe2O3@SiO2 nanocomposites led to the production of 6-APA/gamma-Fe2O3@SiO2 as a novel heterogeneous nanocatalyst. Protonation and deprotonation of 6-APA/gamma-Fe2O3@SiO2 nanocomposites were investigated using quantum mechanical calculations. The behaviour of bifunctionality on this catalyst was examined and the results showed that it acts as an acid-base bifunctional system, and the reaction proceeds very well under mild and ambient conditions. The deprotonation of the COOH group is easier than the NH and NH2 groups with respect to the energy data and the results of the molecular electrostatic potential (MEP) analyses. In the presence of the nanocomposite, the protonation of the NH2 group is more favourable than the NH group. It was characterized by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive spectroscopy (EDS), vibrating sample magnetometery (VSM), thermo-gravimetric analysis (TGA), and Fourier transform infrared spectroscopy (FT-IR). This reaction is not only kinetically stable but is also a spontaneous reaction and thermodynamically favored. The superparamagnetic nanocomposite was used in the preparation of 1,4-dihydropyrano[2,3-c]pyrazole derivatives under a one-pot multicomponent reaction. The nanocomposite was recyclable for at least 10 cycles without any loss in the activity.

Reference of 1453-58-3, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 1453-58-3 is helpful to your research.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 1453-58-3, Name is 3-Methylpyrazole, molecular formula is C4H6N2, belongs to pyrazoles-derivatives compound. In a document, author is Zheng, You-Guang, introduce the new discover, Category: pyrazoles-derivatives.

Design, synthesis, biological activity evaluation of 3-(4-phenyl-1H-imidazol-2-yl)-1H-pyrazole derivatives as potent JAK 2/3 and aurora A/B kinases multi-targeted inhibitors

In this study, a series of 3-(4-phenyl-1H-imidazol-2-yl)-1H-pyrazole derivatives were designed, synthesized, and evaluated for their biological activities. Upon performing kinase assays, most of the compounds exhibited potent inhibition against JAK2/3 and Aurora A/B with the IC50 values ranging from 0.008 to 2.52 mu M. Among these derivatives, compound 10e expressed the most moderate inhibiting activities against all the four kinases with the IC50 values of 0.166 mu M (JAK2), 0.057 mM (JAK3), 0.939 mM (Aurora A), and 0.583 mu M (Aurora B), respectively. Moreover, most of the derived compounds exhibited potent cytotoxicity against human chronic myeloid leukemia cells K562 and human colon cancer cells HCT116, while compound 10e expressed antiproliferative activities against K562 (IC50 =6.726 mu M). According to western blot analysis, compound 10e down-regulated the phosphorylation of STAT3, STAT5, Aurora A, and Aurora B in a dose-dependent manner in K562 and HCT116 cells. Cell cycle analysis revealed that compound 10e inhibited the proliferation of cells by inducing cell cycle arrest in the G2 phase. The molecular modeling suggested that compound 10e could maintain a binding mode similar to the binding mode of AT9832, a common JAK 2/3 and Aurora A/B kinases multi-target kinase inhibitor. Therefore, compound 10e might be a potential agent for cancer therapy deserving further research. (C) 2020 Elsevier Masson SAS. All rights reserved.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 1453-58-3. Category: pyrazoles-derivatives.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 1453-58-3, Name is 3-Methylpyrazole, SMILES is CC1=NNC=C1, in an article , author is Sofan, Mamdouh A., once mentioned of 1453-58-3, Computed Properties of C4H6N2.

One-Step Dyeing and Antimicrobial Finishing of PET Fabric with Novel 4-Arylazopyrazolone Disperse Dyes

Azopyrazole disperse dyes 8-12 could be synthesized either by condensing ethyl 3-hydroxy-2-aryldiazenyl butenoates 3-7 with S-methyl hydrazine carbodithioate 1 or by coupling the parent pyrazole 2 with diazotized aniline, p-substituted anilines and/or 4-aminoantipyrine. These dyes were applied to polyester fabrics using a high-temperature dyeing method at 120 degrees C and displayed yellow to orange hues. Raman spectra of the dyed samples undoubtedly excluded ring dyeing and were found to agree with the proposed structures. The synthesized disperse dyes were found to possess very good dyeing properties, as indicated by color strength measurements, and all of them except dye 12 had a color strength (K/S) value ranging from 19-23. The dyed fabrics exhibited excellent fastness to washing and dry and wet rubbing as well as light fastness, which varied from moderate to very good. The antimicrobial activities of the synthesized pyrazoles 2 and 8-12 as well as the dyed fabric samples against Escherichia coli and Staphylococcus aureus were measured, and the results showed very good activity.

Interested yet? Read on for other articles about 1453-58-3, you can contact me at any time and look forward to more communication. Computed Properties of C4H6N2.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1453-58-3, Name is 3-Methylpyrazole, molecular formula is C4H6N2. In an article, author is Fu, Qing,once mentioned of 1453-58-3, Product Details of 1453-58-3.

Synthesis and herbicidal activity of new pyrazole ketone derivatives

A series of pyrazole derivatives was designed according to prodrug strategy. These compounds were synthesized via eight steps and their structures were confirmed by(1)H NMR spectroscopy and MS. The preliminary herbicidal bioassay results indicated that the title pyrazole ketone compounds exhibited low herbicidal activity against six weeds at 150 g/ha, which is weaker than that of the commercial HPPD herbicide topramezone. The docking results showed that the binding mode of the key intermediate (3-(2-(2-fluorophenoxy)ethoxy)-2-methyl-4-(methylsulfonyl)phenyl)(5-hydroxy-1,3-dimethyl-1H-pyrazol-4-yl)methanone is the same as the reported inhibitor DAS689 in the complex.

Interested yet? Keep reading other articles of 1453-58-3, you can contact me at any time and look forward to more communication. Product Details of 1453-58-3.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Application of 1453-58-3, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 1453-58-3, Name is 3-Methylpyrazole, SMILES is CC1=NNC=C1, belongs to pyrazoles-derivatives compound. In a article, author is Hossain, Sayed Muktar, introduce new discover of the category.

A nano-molar level fluorogenic and oxidation state-selective chromogenic dual reversible chemosensor for multiple targets, Cu2+/S(2-)and Fe3+/F(-)ions

A pyridine-pyrazole-pyrene-based chemosensor,L, has been developed and fully characterized by all the possible techniques (ESI-MS, NMR, CHN, IRetc.). It has been found that the probe,L, selectively recognizes Cu(2+)ion and Fe(3+)ion fluorogenically and chromogenically, respectively, among a wide range of competitive metal ions. It has been demonstrated that the probe is not only metal ion-selective but also oxidation state-selective for Fe(3+)ions. The metal complexes (Cu and Fe) of the ligand were synthesized and characterized using different spectroscopic techniques and they were also characterised X-ray structurally as well, which confirm the stoichiometry (L : M = 2 : 1). The sensitivities for the fluorogenic sensing of Cu(2+)ions and chromogenic sensing of Fe(3+)have been found to be as low as nano molar level detection (69 nM and 27 nM, respectively). Further studies reveal that the Cu(II)L(2)complex can act as a turn-off fluorescent chemosensor for S(2-)ions and Fe(III)L(2)can act as a reversible turn-off colorimetric chemosensor for F(-)ions over other anions.

Application of 1453-58-3, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 1453-58-3 is helpful to your research.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , SDS of cas: 1453-58-3, 1453-58-3, Name is 3-Methylpyrazole, molecular formula is C4H6N2, belongs to pyrazoles-derivatives compound. In a document, author is Jilloju, Parameshwara Chary, introduce the new discover.

An Efficient One-Pot Synthesis of 6-Phenyl-3-(1H-Pyrazol-1-yl)-[1,2,4]Triazolo[3,4-b][1,3,4]Thiadiazole Derivatives and Their Antimicrobial Evaluation and Molecular Docking Studies

An efficient rapid synthesis of a new class of diversely functionalized 6-phenyl-3-(1H-pyrazol-1-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives (4a-q) is described via a facile one-pot, three-component cascade reaction with high yields. It is a multi-functional cyclization reaction to form two new heterocycles. The structures of newly formed compounds were confirmed by using spectral and analytical studies. Simple reaction conditions, the good isolated yield of the product, and no column chromatographic purification are attractive features of the present protocol. Further, the newly synthesized compounds were screened for anti-microbial activity and molecular docking interactions.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 1453-58-3. SDS of cas: 1453-58-3.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1453-58-3, name is 3-Methylpyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 1453-58-3

General procedure: The N-nucleophile (1.47 mmol), CuI (Sigma-Aldrich, 99.999percent purity, 0.147 mmol), MnF2 (Sigma-Aldrich, 98percent purity, 0.441 mmol), KOH (2.94 mmol), the aryl halide (2.21 mmol), trans-1,2-diaminocyclohexane (0.294 mmol) and water (0.75 mL) were added to a reaction vial and a screw cap was fitted to it. The reaction mixture was stirred under air in a closed system at 60C for 24 h. After cooling to room temperature, the mixture was diluted with dichloromethane and filtered through a pad of Celite. The combined organic extracts were dried with anhydrous Na2SO4 and the solvent was removed under reduced pressure. The crude product was purified by silica-gel column chromatography to afford the N-arylated product. The identity and purity of known products was confirmed by 1H and 13C NMR spectroscopic analysis.

The synthetic route of 1453-58-3 has been constantly updated, and we look forward to future research findings.

Application of 1453-58-3,Some common heterocyclic compound, 1453-58-3, name is 3-Methylpyrazole, molecular formula is C4H6N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(a) 1-Benzenesulfonyl-3-methylpyrazole. A mixture of 3-methylpyrazole (5 g, 60.9 mmol), benzenesulfonyl chloride (8.55 mL, 67 mmol) and triethylamine (9.3 mL, 67 mmol) in acetonitrile was heated at reflux for 2 h, allowed to cool and concentrated. EtOAc (300 mL) was added and the solution was filtered and concentrated to provide a solid residue which was crystallised from EtOAc to give the title compound as an off-white powder (Yield:7.92 g, 58 percent).1H-NMR (DMSO-d6): delta 8.35 (d, 1 H), 7.97-7.94 (m, 2H), 7.78 (tt, 1 H), 7.66 (t, 2H),6.43 (d, 1 H), 2.17 (s, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Methylpyrazole, its application will become more common.

1453-58-3,Some common heterocyclic compound, 1453-58-3, name is 3-Methylpyrazole, molecular formula is C4H6N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

After 3-methyl-1-pyrazole (2.0 g, 24.3 mmol) was dissolved in acetonitrile (25 mL), tert-butyl dicarbonate (6.5 g, 29.8 mmol) and 4-dimethylaminopyridine (0.31 g, 2.49 mmol) were added thereto at 0¡ãC, and the mixture was slowly warmed to room temperature and then stirred for 2 hours. Ethyl acetate (50 mL) was added to the reaction material, and the result was washed with a 1N aqueous hydrochloric acid solution (50 mL), a saturated aqueous sodium hydrogen carbonate solution (50 mL) and salted water (50 mL), dried with anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was purified using silica gel column chromatography (ethyl acetate/normal-hexane=1/4) to give tert-butyl 3-methyl-1H-pyrazole-1-carboxylate (4.13 g, 93percent). 1H-NMR (300 MHz, CDCl3) delta 1.64 (s, 9H), 2.34 (s, 3H), 6.17 (s, 1H), 7.96 (s, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Methylpyrazole, its application will become more common.

1453-58-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1453-58-3, name is 3-Methylpyrazole, This compound has unique chemical properties. The synthetic route is as follows.

Sodium hydride (30 mg, 1.25 mmol) was added to a solution of 3-methylpyrazole (88 mg, 1.07 mmol) in dry THF (5 cm3) under an atmosphere of argon. A solution of 7-tert-butyl-2-chloro-1-azaxanthone (280 mg, 0.97 mmol) in dry THF (5 cm3) was then added to the reaction mixture, which was stirred at 65 ¡ãC for 16 h. The reaction mixture was allowed to cool to room temperature before water (~10 cm3) was added to the reaction mixture. The precipitate was collected via centrifugation and the resultant solid triturated with a minimum volume of Et2O. The solvent was decanted to yield the title compound as a white solid (290 mg, 0.87 mmol, 90percent). deltaH (CDCI3, 400 MHz) 1.39 (9H, s, tBu), 2.37 (1H, s, Me), 6.31 (1H, d, J 2.8, H2′), 7.51 (1H, d, J 8.8, H10), 7.80 (1H, dd, J 8.8; 2.8, H9), 7.99 (1H, d, J 8.4, H2), 8.27 (1H, d, J 2.8, H7), 8.51 (1H, d, J 2.8, H 1′, 8.72 (1H, d, J 8.4, H3). deltac (CDCI3, 100 MHz) 14.2 (Me), 31.6 (C14), 35.1 (C13), 109.7 (C2), 110.1 (C2′), 113.9 (C4), 118.1 (C10), 121.4 (C6), 122.7 (C7), 129.0 (C1′), 133.4 (C9), 140.1 (C3), 148.3 (C8), 153.7 (C11), 153.9 (C12), 154.0 (C3′), 160.0 (C1), 177.0 (C5). m/z (ES+) 688.9 (100percent, 2M + H), 334.3 (50percent, M + H). HRMS (ES+) 334.1551; C20H20O2N3 requires 334.1550, [M + H]+.

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