Category: 27258-33-9

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 27258-33-9, name is 1-Methyl-1H-pyrazole-5-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 27258-33-9

General procedure: To the solution of 45.0 g aldehyde 10 (0.363 mol) in 225 cm3 pyridine, 45.4 g malonic acid (0.436 mol) and 0.900 g piperidine (10.9 mmol) were added. The resulting mixture was heated at 70 C for 3 days. The solvent was removed in vacuo, and the residue was triturated with H2O. The precipitate was filtered to give the product 11

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 27258-33-9.

Synthetic Route of 27258-33-9,Some common heterocyclic compound, 27258-33-9, name is 1-Methyl-1H-pyrazole-5-carbaldehyde, molecular formula is C5H6N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 4; Influence of the ligand Using the optimal conditions [Example 2] which leads to 85-87% ee with the ligand sd499, a ligand screening with a variety of N,O-ligands was carried out. The results are given in the following table. The best results were obtained with the ligands sd311b (91% ee) and commercially available (S)-2-piperidinyl-1,1,2-triphenylethanol at 5 mol% scale. As the latter one is known to be a somewhat slower ligand than the paracyclophane-based ligands and the derivatives of sd499, we repeated the experiment with 10 mol% of (S)-2-piperidinyl-1,1,2-triphenylethanol. This experiment gave 93% ee. The ligand is available in both enantiomeric forms.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-1H-pyrazole-5-carbaldehyde, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 27258-33-9, name is 1-Methyl-1H-pyrazole-5-carbaldehyde, A new synthetic method of this compound is introduced below., name: 1-Methyl-1H-pyrazole-5-carbaldehyde

B); With ligand (S)-2-piperidinyl-1,1,2-triphenylethanol and diethylzinc at -10 C In a 20 ml vial 50 mg (0.21 mmol) 2-aminoethyl-dithienyl-borinate and 9.3 mg (0.025mmol) of ligand (S)-2-piperidinyl-1,1,2-triphenylethanol (10 mol%) is placed. The vial is closed and flushed with argon. Dry toluene (2 mL) is added and the vial is placed in a cooling bath of -10 C. Diethylzinc (0.7 mL, 0.7 mmol, 2M solution in toluene) and 25 mul (0.25 mmol) 2-methyl-2H-pyrazole-3-carbaldehyde is added and the reaction mixture is stirred for at least 12 h at -10 C. Work-up is conducted as described in Example 2a affording the title compound (24 mg, 51%) in 70% ee.

The synthetic route of 27258-33-9 has been constantly updated, and we look forward to future research findings.

Application of 27258-33-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 27258-33-9, name is 1-Methyl-1H-pyrazole-5-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows.

To 2-methylpyrazole-3-carbaldehyde (55 mg, 0.50 mmol), benzyl 2-aminoacetate tosylate (186 mg, 0.550 mmol), acetic acid (1 mL), and dichloromethane (1.5 mL) were added, followed by stirring at room temperature. Sodium triacetoxyborohydride (159 mg, 0.750 mmol) was added thereto, followed by stirring at room temperature overnight. The reaction liquid was diluted with dichloromethane, and saturated aqueous sodium hydrogen carbonate was added thereto. After extraction with dichloromethane, the organic layer was washed with water and saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure

The chemical industry reduces the impact on the environment during synthesis 1-Methyl-1H-pyrazole-5-carbaldehyde. I believe this compound will play a more active role in future production and life.

Adding a certain compound to certain chemical reactions, such as: 27258-33-9, name is 1-Methyl-1H-pyrazole-5-carbaldehyde, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 27258-33-9, SDS of cas: 27258-33-9

Example 4; Influence of the ligand Using the optimal conditions [Example 2] which leads to 85-87% ee with the ligand sd499, a ligand screening with a variety of N,O-ligands was carried out. The results are given in the following table. The best results were obtained with the ligands sd311b (91% ee) and commercially available (S)-2-piperidinyl-1,1,2-triphenylethanol at 5 mol% scale. As the latter one is known to be a somewhat slower ligand than the paracyclophane-based ligands and the derivatives of sd499, we repeated the experiment with 10 mol% of (S)-2-piperidinyl-1,1,2-triphenylethanol. This experiment gave 93% ee. The ligand is available in both enantiomeric forms.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methyl-1H-pyrazole-5-carbaldehyde, and friends who are interested can also refer to it.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 27258-33-9, name is 1-Methyl-1H-pyrazole-5-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 27258-33-9

(ii) (1-Methyl-1 H-pyrazol-5-yl)methanol was prepared as follows (c.f. Bioorg. Med. Chem., 2001 , 9, 961-982): A stirred solution of 1-methyl-1 H-pyrazole-5- carbaldehyde (5.2 g, 47 mmol) in ethanol (50 ml) at 5C was treated with sodium borohydride (893 mg, 23. 5mmol). The reaction mixture was stirred at 5C for 30 minutes, hydrochloric acid (5N, 10 ml) was added and the organic solvent was evaporated. The residue was partitioned between ethyl acetate and water. The layers were separated and the aqueous solution was saturated with sodium chloride and re-extracted with ethyl acetate. The combined organic extracts were washed with brine, then dried and evaporated to afford (1-methyl-1 H-pyrazol-5-yl)methanol which was used in the next step.

According to the analysis of related databases, 27258-33-9, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 27258-33-9 as follows. category: pyrazoles-derivatives

Example 4; Influence of the ligand Using the optimal conditions [Example 2] which leads to 85-87% ee with the ligand sd499, a ligand screening with a variety of N,O-ligands was carried out. The results are given in the following table. The best results were obtained with the ligands sd311b (91% ee) and commercially available (S)-2-piperidinyl-1,1,2-triphenylethanol at 5 mol% scale. As the latter one is known to be a somewhat slower ligand than the paracyclophane-based ligands and the derivatives of sd499, we repeated the experiment with 10 mol% of (S)-2-piperidinyl-1,1,2-triphenylethanol. This experiment gave 93% ee. The ligand is available in both enantiomeric forms.

According to the analysis of related databases, 27258-33-9, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 27258-33-9, name is 1-Methyl-1H-pyrazole-5-carbaldehyde, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 27258-33-9, 27258-33-9

General procedure: Method B [34]: The reaction mixture of aldehyde (4 mmol), acetone (116 mg, 2 mmol) and K2CO3 (1.1 g, 4 mmol) in the mixed solvent of toluene-ethanol-water (10 mL 4.0 mL 2.0 mL) was stirred at 70 C for 12 h. After cooling down to room temperature, the solvent was evaporated in vacuo. The resulting residue was partitioned between dichloromethane and water. The aqueous phase was further extracted with dichloromethane twice. The combined organic extracts were rinsed with brine and dried over anhydrous magnesium sulfate. The organic solvent was removed under vacuum to give a residue, which was purified by preparativeTLC (5% methanol in dichloromethane) or column chromatography(2% methanol in dichloromethane).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-pyrazole-5-carbaldehyde, other downstream synthetic routes, hurry up and to see.

27258-33-9, Name is 1-Methyl-1H-pyrazole-5-carbaldehyde, 27258-33-9, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

A mixture of 1-methyl-1H-pyrazole-5-carbaldehyde (5.0 g, 45.4 mmol), N-iodosuccinimide(15.3 g, 68.1 mmol), and TFA (50 mL) was stirred at room temperature for 1.5 h. H20 (50mL) was added, and the precipitate was filtered, rinsed with H20 (100 mL), and dried toafford the title compound (9.03 g, 84%).?H NMR (500 MHz, CDC13) oe ppm 4.19 (s, 3H), 7.58 (s, 1H), 9.80 (s, 1H)

Statistics shows that 1-Methyl-1H-pyrazole-5-carbaldehyde is playing an increasingly important role. we look forward to future research findings about 27258-33-9.

A common compound: 27258-33-9, name is 1-Methyl-1H-pyrazole-5-carbaldehyde, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 27258-33-9

Production Example 16 N-[(1-methyl-1H-pyrazol-5-yl)methyl]-4-(trifluoromethyl)aniline Acetic acid (0.87 mL) was added to a chloroform (10 mL) solution that contained 1-methyl-1H-pyrazol-5-carbaldehyde (1.00 g) and 4-aminobenzotrifluoride (1.76 g) at a room temperature, and the obtained solution was then stirred for 10 minutes. Thereafter, sodium triacetoxyborohydride (2.89 g) was added to the reaction solution, and the obtained mixture was then stirred for 5.5 hours. Thereafter, a saturated sodium hydrogencarbonate aqueous solution was added to the reaction solution, and the obtained mixture was then extracted with chloroform. The organic layer was dried over anhydrous sodium sulfate, and was then concentrated under a reduced pressure. The obtained solid was washed with diisopropyl ether, so as to obtain the title compound (1.88 g) in the form of a light yellow solid. 1H NMR (600 MHz, CHLOROFORM-d) delta ppm 3.87 (s, 3H) 4.08-4.17 (m, 1H) 4.35 (s, 2H) 6.21 (d, J=1.83 Hz, 1H) 6.67 (d, J=8.71 Hz, 2H) 7.42 (d, J=1.83 Hz, 1H) 7.44 (d, J=8.71 Hz, 2H); MS (ESI pos.) m/z: 256 [M+H]+

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 27258-33-9, other downstream synthetic routes, hurry up and to see.