Category: 5334-40-7

Related Products of 5334-40-7, The chemical industry reduces the impact on the environment during synthesis 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, I believe this compound will play a more active role in future production and life.

SOCI2 (4.62 mL, 63.66 mmol) was added dropwise over 5 min approximately to a solution of 4-Nitro-lH-pyrazole-3-carboxylic acid (5.00 g, 31.83 mmol) in MeOH (50 mL) at 0 C. The resulting clear solution was stirred at 0 C for 30 min, followed by rt for 16 h. Solvent was evaporated under reduced pressure to obtain 5.4 of intermediate 487 (99% yield, white solid).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Nitro-1H-pyrazole-3-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Application of 5334-40-7, These common heterocyclic compound, 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4-(octahydrocyclopentane[c]pyrrolylmethyl)-phenyl-1,2-diamine (4.0 g, 17.32 mmol), 4-nitro-1H-pyrazole-3-carboxylic acid (2.47 g) , 17.32mmol), EDC ¡¤ HCl (4.98g, 19.05mmol) and HOBt (3.4g, 19.05mmol) was dissolved in dry DMF (25mL) are stirred at room temperature overnight. The solvent was removed under reduced pressure, was added glacial acetic acid (40 mL), heated to reflux for 3h, the solvent was removed under reduced pressure, purified through the column, and then washed with methanol, methanol-insoluble product as a yellow solid that is, to give a yellow solid (0.90 g, 23.94percent).

Statistics shows that 4-Nitro-1H-pyrazole-3-carboxylic acid is playing an increasingly important role. we look forward to future research findings about 5334-40-7.

Application of 5334-40-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5334-40-7 name is 4-Nitro-1H-pyrazole-3-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 4-nitro-3-pyrazolecarboxylic acid (3.14 g,20.0 mmol) in MeOH (50 mL) was slowly added thionyl chloride(7.3 mL, 0.1 mol) at 0 C. After the completion of the addition, thetemperature of the reaction mixture increased to 70 C and stirredfor 5 h. Methanol was removed in vacuo, and the resulting residuewas poured into ice water and extracted with EtOAc. The organiclayer was washed with 10% NaHCO3 solution, brine and dried overNa2SO4. The resulting reaction mixture concentrated in vacuo toafford 1 as a white solid (3.37 g, 99%). 1H NMR (400 MHz, DMSO-d6)delta 8.93 (s, 1H), 3.89 (s, 3H); 13C NMR (100 MHz, DMSO-d6)delta 161.4,138.0, 133.7, 132.0, 53.3.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Nitro-1H-pyrazole-3-carboxylic acid, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5334-40-7, Formula: C4H3N3O4

To a solution of 4-nitro-1H-pyrazole-3-carboxylic acid (1.00 g, 6.37 mmol) in DMF (20 mL) were added K2C03 (1.93 g, 14.01 mmol) and iodomethane (1.99 g, 14.01 mmol), and the mixture was stirred at rt overnight under nitrogen. Water (50 mL) was added and the mixture was extracted with EtOAc (3 x 60 mL). The combined organic layers were washed with brine (25 mL), dried over anhydrous Na2SO4 and concentrated. The residue was purified by silica gel chromatography eluting with petroleum ether EtOAc (8: ito 1:2) to afford methyl 1- methyl-4-nitro- 1H-pyrazole-3-carboxylate.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Application of 5334-40-7,Some common heterocyclic compound, 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, molecular formula is C4H3N3O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A) Methyl 1-methyl-4-nitro-1H-pyrazole-5-carboxylate To a suspension of 4-nitro-1H-pyrazole-3-carboxylic acid (37 g) and potassium carbonate (97.6 g) in DMF (600 mL), dimethyl sulfate (71.2 g) was added dropwise under ice cooling, and the mixture was stirred at room temperature for 16 hours. The reaction mixture was poured to water, followed by extraction with ethyl acetate. The extract was dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/petroleum ether) to obtain the title compound (8.62 g). 1H NMR (400 MHz, CDCl3) delta 4.02 (3H, s), 4.03 (3H, s), 8.01 (1H, s).

The synthetic route of 5334-40-7 has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, molecular formula is C4H3N3O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C4H3N3O4

4-(morpholinomethyl)-phenyl-1,2-diamine (2.3 g, 11.1 mmol), 4-nitro-1H-pyrazole-3-carboxylic acid (1.57 g, 10 mmol), EDC¡¤HCl (2.13 g, 11.1 mmol) and HOBt (1.5 g, 11.1 mmol) were dissolved in anhydrous DMF (25 mL). The solvent was removed under reduced pressure, was added glacial acetic acid (40 mL), heated to reflux for 3 hours, the solvent was removed under reduced pressure, and purified by column (CH2Cl2 / CH3OH (V / V) = 20/1), and then washed with methanol (30mL) to give a solid (0.9g, 27percent).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5334-40-7, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, A new synthetic method of this compound is introduced below., Safety of 4-Nitro-1H-pyrazole-3-carboxylic acid

A solution of 4-nitro-lH-pyrazole-3-carboxylic acid (1.0 g, 6.4 mmol) in dichloromethane (20 ml) was treated with thionyl chloride (1.4 ml, 19 mmol) and a drop of DMF at ambient temperature. The reaction mixture is stirred at 40¡ãC overnight whereupon another equivalent of thionyl chloride (0.46 ml, 6.4 mmol) was added and stirring was continued at 40¡ãC for another 24h. All volatiles were removed and the acid chloride was suspended in dichloromethane (6 ml) and cooled to 0¡ãC. Triethylamine (4.44 ml, 31.8 mmol) and dimethylamin (4.14 ml, 2M solution in THF) were added. The reaction mixture was allowed to warm-up to ambient temperature and stirring was continued for 3h. The reaction mixture was partitioned between potassium hydrogen sulfate (20 ml, 10percent aqueous solution) and ethyl acetate (40 ml) and extracted. The organic phase was washed with water and brine, dried and the solvent was evaporated. The crude product was triturated with diethylether, sucked off and dried to yield a light brown solid (0.35 g, 30 percent).MS: M = 185.1 (M+H)+

The synthetic route of 5334-40-7 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 5334-40-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Complex NiL2*4H2O was synthesized in the reaction on the warm ethanolic solutions of Ni(CH3COO)2 and 4-nitro-3-pyrazolecarboxylic acid ligand (L) mixed in molar ratio 1:2. After 6 h, the microcrystalline product was filtered off and washed with ethanol.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Nitro-1H-pyrazole-3-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, A new synthetic method of this compound is introduced below., HPLC of Formula: C4H3N3O4

Preparation of the Resin (ii):30 g of Rink resin (PolymerLab; 0.99 mmol/g) is swollen in 150 ml of DMF. After stirring for 10 minutes, the DMF is filtered off and replaced with 150 ml of a solution of piperidine in DMF (50/50, v/v). The mixture is stirred for 1 hour and then filtered. The resin is washed successively with five times 150 ml of DMF, twice 150 ml of methanol and three times 150 ml of DMF. Next, a solution of 14.1 g of 4-nitro-3-pyrazolecarboxylic acid (90 mmol, 3 eq.) and 13.8 g of HOBt (90 mmol, 3 eq.) in 150 ml of DMF is added to the resin, immediately followed by 13.8 ml of DIC (90 mmol; 3 eq.). The mixture is stirred for 16 hours at room temperature. The solution is filtered and the resin is washed successively with five times 150 ml of DMF, twice 150 ml of methanol, three times 150 ml of DMF and then with 150 ml of a 1 M SnCl2 solution (33 g in 150 ml). The mixture is stirred at room temperature for 24 hours and is then filtered, and the resin is washed with five times 150 ml of DMF, twice 150 ml of methanol, three times 150 ml of DCM and twice 150 ml of ethyl ether. After drying under vacuum, 31 g of intermediate resin (ii) are isolated.

The synthetic route of 5334-40-7 has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 4-Nitro-1H-pyrazole-3-carboxylic acid

Step 1. 4-Nitro-lH-pyrazole-3-carboxylic acid ethyl ester; Thionyl chloride (2.90 ml, 39.8 mmol) was slowly added to a mixture of 4-nitro-3- pyrazolecarboxylic acid (5.68 g, 36.2 mmol) in EtOH (100 ml) at ambient temperature and the mixture stirred for 48 hours. The mixture was reduced in vacuo and dried through azeotrope with toluene to afford 4-nitro-lH-pyrazole-3- carboxylic acid ethyl ester as a white solid (6.42 g, 96%). (1H NMR (400 MHz, DMSO-d6) delta 14.4 (s, IH), 9.0 (s, IH), 4.4 (q, 2H), 1.3 (t, 3H)).

The synthetic route of 4-Nitro-1H-pyrazole-3-carboxylic acid has been constantly updated, and we look forward to future research findings.