Category: 28466-26-4

Application of 28466-26-4, These common heterocyclic compound, 28466-26-4, name is 4-Aminopyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: N,N-Diisopropylethylamine (3.0-4.0 eq) was added to 8-methoxyquinoline-3-carboxylic acid (1.0 eq) in solvent (dichloromethane, tetrahydrofuran,or N,N-dimethylformamide, 0.05 to 0.2 M) at room temperature. Then, 1-((dimethylamino)(dimethyliminio)methyl)-1H-[1,2,3]triazolo[4,5-b]pyridine 3-oxide hexafluorophosphate(V)(1.0-1.5 eq) was added and the reaction mixture was stirred for five minutes. Then, amine (1.0 – 2.0 eq) was added and the reaction mixture was stirred for one to sixteen hours. 10% Aqueous citric acid was added and the reaction mixture was extracted with dichloromethane, washed with saturated sodium bicarbonate, dried over magnesium sulfate, filtered,and concentrated. The resulting residue was purified by RP HPLC or silica gel chromatography to give the quinoline-3-carboxamide (1%-95% yield).

The synthetic route of 28466-26-4 has been constantly updated, and we look forward to future research findings.

Related Products of 28466-26-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 28466-26-4 name is 4-Aminopyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A mixture of the appropriate aminopyrazole 1 (0.01 mol), NaN3 (0.78 g, 0.012 mol), andtriethyl orthoformate (1.60 ml, 0.015 mol) or triethylorthoacetate (1.74 ml, 0.015 mol) in glacial acetic acid(10 ml) was stirred for 3-4 h at 90. The reaction mixturewas cooled and poured into ice water (50 ml). In the case ofcompounds 2a-c, 4b, the precipitate that formed wasfiltered off, washed with water, and recrystallized from EtOH. In the case of compounds 2d, 3a, 4a,c, the aqueouslayer was extracted with ethyl acetate (3¡Á15 ml), and theorganic layer was dried over anhydrous Na2SO4. Thesolvent was removed at reduced pressure, and the solidresidue was recrystallized from EtOH.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Aminopyrazole, and friends who are interested can also refer to it.

28466-26-4, Name is 4-Aminopyrazole, 28466-26-4, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

46 mg (0.53 mmol) of 4-amino-1H-pyrazole were dissolved in 2.4 ml of DMF and stirred with 21 mg (0.5 mmol) of sodium hydride (60% in paraffin) at 23 C. for 30 minutes. 100 mg (0.18 mmol) of 5-[4-chloro-3-(trifluoromethyl)benzyl]-2-(methylsulphonyl)-6-(trifluoromethyl)pyrimidin-4(3H)-one (Example 39A, purity 77%) were then added, and the mixture was stirred at 120 C. for 30 minutes. The mixture was then purified directly by preparative HPLC [column: Chromatorex C18 10 mum, 250¡Á30 mm; flow rate: 50 ml/min; run time: 35 min; detection: 210 nm; injection after 3 min of run time; mobile phase A: acetonitrile, mobile phase B: water; gradient: 10% A (5.00 min)?80% A (25.00 min)?95% A (25.50-30.00 min)?10% A (30.50-35.00 min)]. The product-containing fractions were combined and concentrated. The residue was re-purified by preparative thin-layer chromatography (silica gel, mobile phase dichloromethane/methanol 20:1). This gave 41 mg (53% of theory) of the title compound.

Statistics shows that 4-Aminopyrazole is playing an increasingly important role. we look forward to future research findings about 28466-26-4.

These common heterocyclic compound, 28466-26-4, name is 4-Aminopyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 28466-26-4

Example No. 121Preparation of (8-Methoxy-3H-pyrazolo [3 , 4-c] quinolin-4-yl) – (lH-pyrazol-4-yl) -amine4-chloro-8-methoxy-2- (4-methoxybenzyl) -2H-pyrazolo [3,4- c]quinoline (0.16 mmol) and lH-pyrazol-4 -amine (2 eq.,0.3 mmol) were suspended in MeOH (dry, 3mL) in a microwave vial (2-5mL) , HC1 in dioxane (4M, 3 drops) was added. The reaction mixture was irradiated in a microwave reactor for 5 min at 140C. The reaction mixture was evaporated and used without further purification. The residue was dissolved in TFA (3mL) . The reaction mixture was irradiated in a microwave reactor for 5 min at 140C. The reaction mixture was concentrated and purified by semi-preparative HPLC-MS and freeze dried from water/t-BuOH 4/1. exact mass: 280.1224 g/molHPLC-MS: analytical method Brt: 1.54 min – found mass: 281.1 (m/z+H)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 28466-26-4.

Adding a certain compound to certain chemical reactions, such as: 28466-26-4, name is 4-Aminopyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 28466-26-4, 28466-26-4

To a solution of sodium 2-(1-((lr,4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)acetate (Intermediate 4, 100 mg, 0.278 mmol) and 1H-pyrazol-4-amine (50.0 mg, 0.602 mmol ) in DMF (1.2 mL) were added PyBrOP (217 mg, 0.417 mmol) and DIPEA (0.144 mL, 0.835 mmol) and was stirred at room temperature overnight. The DMF was removed under reduced pressure and the residue was purified by flash column chromatography and by reverse phase HPLC to provide the product as the TFA salt.This material was dissolved in 10% MeOH in CH2C12 and passed through a 500mg column of SILICYCLE SPE-R66030B-03P Carbonate (SiliaBond acid scavenger solid phase extraction cartridge) to remove the TFA to provide the title compound (37.0 mg, 33% yield) as a white solid. MS (ESI): mass calcd. for C21H22N80, 402.19; m/z found, 403.2 [M+H]t ?HNMR (400IVIHz, CD3OD) = 8.55 (s, 1H), 7.92 (br s, 1H), 7.65 (br s, 1H), 7.48 (d, J3.5 Hz, 1H), 6.83(d, J3.5 Hz, 1H), 4.59 (br s, 1H), 4.26-4.20 (m, 1H), 2.63 -2.43 (m, 4H), 2.17-2.00 (m, 6H),1.44 (q, J= 11.8 Hz, 2H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Aminopyrazole, other downstream synthetic routes, hurry up and to see.

A common compound: 28466-26-4, name is 4-Aminopyrazole, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 28466-26-4

10054] A 250-mE 3-neck flask was charged with 1H-pyra- zol-4-amine (5 g, 60.2 mmol) and dichioromethane (50 mE). The resulting suspension was cooled to 5 C. and triethylamine (9.13 g, 90.0 mmol) was added, followed by acetic anhydride (7.37 g, 72.2 mmol) at <20 C. The reaction was stirred at room temperature for 18 hours, at which point thin layer chromatography [Eluent: ethyl acetate] analysis indicated that the reaction was incomplete. Additional triethylamine (4.57 g, 45.0 mmol) and acetic anhydride (3.70 g, 36.0 mmol) were added and the reaction was heated at 30 C. for an additional 3 hours to give a dark solution, at which point thin layer chromatography analysis indicated that only a trace of starting material remained. The reaction mixture was purified by flash column chromatography using ethyl acetate as eluent. The fractions containing pure product were combined and concentrated to dryness to afford an off-white solid. The solid was dried under vacuum at room temperature for 18 hours (5.55 g, 55%): ?H NMR (400 MHz, DMSO-d5) oe 10.30 (s, 1H), 8.39 (d, J=0.7 Hz, 1H), 7.83 (d, J=0.7 Hz, 1H), 2.60 (s, 3H), 2.03 (s, 3H); ElMS mlz 167 ([M]j. In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 28466-26-4, other downstream synthetic routes, hurry up and to see.