Category: 82560-12-1

Adding a certain compound to certain chemical reactions, such as: 82560-12-1, name is 3-Amino-5-tert-butylpyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 82560-12-1, 82560-12-1

To a mixture of Intermediate 7a (1.50 g, 4.46 mmol), 5-tert-butyl-2H- pyrazol-3-ylamine (620 mg, 4.46 mmol), copper (I) iodide (42 mg, 0.22 mmol) and K2CO3 (1.29 g, 9.37 mmol) was added to toluene (4.6 mL; previously degassed by using a stream of Argon). (R,R)-(-)-N,N’-Dimethyl- 1 ,2-cyclohexanediamine (141 L, 0.89 mmol) was then added and the reaction mixture was heated at 140 C for 2.5 h under microwave irradiation. The crude reaction mixture was poured into water and extracted with EtOAc (x 3). The combined organic layers were washed with brine, dried (MgSO4) and concentrated in vacuo. The resultant residue was purified by FCC, using a gradient of 0-100% EtOAc in cyclohexane, to give the title compound (1.14 g, 73%). LCMS (Method 4): Rt 2.34 min, m/z 348 [MH+].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Amino-5-tert-butylpyrazole, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 82560-12-1, name is 3-Amino-5-tert-butylpyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 82560-12-1, 82560-12-1

To a mixture of Intermediate 7a (1.50 g, 4.46 mmol), 5-tert-butyl-2H- pyrazol-3-ylamine (620 mg, 4.46 mmol), copper (I) iodide (42 mg, 0.22 mmol) and K2CO3 (1.29 g, 9.37 mmol) was added to toluene (4.6 mL; previously degassed by using a stream of Argon). (R,R)-(-)-N,N’-Dimethyl- 1 ,2-cyclohexanediamine (141 L, 0.89 mmol) was then added and the reaction mixture was heated at 140 C for 2.5 h under microwave irradiation. The crude reaction mixture was poured into water and extracted with EtOAc (x 3). The combined organic layers were washed with brine, dried (MgSO4) and concentrated in vacuo. The resultant residue was purified by FCC, using a gradient of 0-100% EtOAc in cyclohexane, to give the title compound (1.14 g, 73%). LCMS (Method 4): Rt 2.34 min, m/z 348 [MH+].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Amino-5-tert-butylpyrazole, other downstream synthetic routes, hurry up and to see.

82560-12-1, name is 3-Amino-5-tert-butylpyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 82560-12-1

c. 2-[5-(5-Amino-3-tert-butyl-pyrazol-1-yl)-2-chloro-phenyl]-ethanol (Intermediate Rc) A suspension of Intermediate Rb (236 mg, 0.835 mmol), 3-tert-butyl-1H-pyrazole-5-amine (Fluorochem, 122 mg, 0.88 mmol), copper(I) iodide (8.00 mg, 0.04 mmol), trans-N,N’-dimethylcyclohexane-1,2-diamine (23.8 mg, 0.17 mmol) and K2CO3 (242 mg, 1.75 mmol) in degassed toluene (1 mL) was stirred at 100 C. under Ar for 3 h, and then heated to 150 C. for 5 h using microwave irradiation. The cooled solution was partitioned between EtOAc (10 mL), water (5 mL) and concentrated aqueous ammonia (5 mL). The aqueous layer was extracted with EtOAc (10 mL), then the combined organics washed with water (10 mL), brine (10 mL), dried (Na2SO4), filtered and concentrated in vacuo to leave a oil (305 mg). FCC, using 20-45% EtOAc in cyclohexane, gave the title compound as an opaque sticky gum (129 mg, 53%). LCMS (Method 3): Rt 2.80 min, m/z 294 [MH+].

Statistics shows that 82560-12-1 is playing an increasingly important role. we look forward to future research findings about 3-Amino-5-tert-butylpyrazole.

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 82560-12-1 name is 3-Amino-5-tert-butylpyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 82560-12-1

3-(Tert-butyl)-lH-pyrazol-5-amine (0.32 g, 2.30 mmol) was treated with a solution of Intermediate 61b (1.04 g, 2.60 mmol) in toluene (4 mL) then potassium carbonate (0.68 g, 4.90 mmol), (IS, 2S)-N,N’-bis-methyl-l,2-cyclohexane-diamine (0.07 g, 0.47 mmol) and copper (I) iodide (0.022 g, 0.11 mmol) were added. The mixture was degassed then heated at 150 C for 1 h using microwave irradiation. Another portion of copper (I) iodide (0.022 g, 0.11 mmol) was added and the reaction mixture heated at 150 C for a further 1 h using microwave irradiation. The mixture was diluted with EtOAc and water and the phases separated. The aqueous layer was then extracted with EtOAc (2 x ). The combined organic layers were washed with brine, dried (Na2S04), filtered and evaporated in vacuo. The organic layer was evaporated in vacuo. The residue was purified by FCC, using 0-15% EtOAc in DCM, to give the title compound (0.14 g, 15%). LCMS (Method 3): Rt 3.87 min, m/z 418 [MH+].

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Amino-5-tert-butylpyrazole, and friends who are interested can also refer to it.

82560-12-1, Name is 3-Amino-5-tert-butylpyrazole, 82560-12-1, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

3-(tert-butyl)-lH-pyrazole-5-amine (1.00 g, 7.18 mmol), 3-bromo-5- hydroxypyridine (1.14 g, 6.53 mmol), copper (I) iodide (62.0 mg, 0.33 mmol), K2CO3 (1.90 g, 13.7 mmol) and trans-N, N’-dimethylcyclohexane- l ,2-diamine (186 mg, 1.31 mmol), were weighed in a 20 mL microwave vial fitted with a stirrer bar and sealed with a crimped septum. The vial was then evacuated and purged with N2, and anhydrous toluene (10 mL) added. The resulting mixture vacuum degassed and purged with N2, and then heated at 100C for 24 h. The resulting dark suspension was diluted with EtOAc and filtered through Celite, washed with EtOAc and the filtrates concentrated in vacuo. The resulting residue was purified by FCC, eluting with 0-8% MeOH/DCM, to afford the title compound (1.15 g, 76%). LCMS (Method 3): t 2.31 min, m/z 233.2 [MH+]. NMR (300 MHz, CDC13): 1.32 (9H, s), 3.49 (1H, s), 5.55 (1H, s), 7.37 (1H, t, J = 2.3 Hz), 8.04 (1H, d, J = 2.5 Hz), 8.27 (1H, d, J = 2.1 Hz).

Statistics shows that 3-Amino-5-tert-butylpyrazole is playing an increasingly important role. we look forward to future research findings about 82560-12-1.