Category: pyrazoles-derivatives

An article Iridium(III) Complexes Bearing a Formal Tetradentate Coordination Chelate: Structural Properties and Phosphorescence Fine-Tuned by Ancillaries WOS:000506719300055 published article about CYCLOMETALATED IR(III) COMPLEXES; C-H ACTIVATION; PHOTOPHYSICAL PROPERTIES; LIGANDS; RHODIUM; DESIGN; BIDENTATE; PYRAZOLE; HYDRIDE in [Yuan, Yi; Lee, Chun-Sing; Chi, Yun] City Univ Hong Kong, Dept Mat Sci & Engn, Dept Chem, Hong Kong, Peoples R China; [Yuan, Yi; Lee, Chun-Sing] City Univ Hong Kong, Ctr Super Diamond & Adv Films COSDAF, Hong Kong, Peoples R China; [Gnanasekaran, Premkumar; Chen, Yu-Wen; Chi, Yun] Natl Tsing Hua Univ, Dept Chem, Hsinchu 30013, Taiwan; [Gnanasekaran, Premkumar; Chen, Yu-Wen; Chi, Yun] Natl Tsing Hua Univ, Frontier Res Ctr Fundamental & Appl Sci Matters, Hsinchu 30013, Taiwan; [Lee, Gene-Hsiang] Natl Taiwan Univ, Instrumentat Ctr, Taipei 10617, Taiwan; [Ni, Shao-Fei] Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Guangdong, Peoples R China in 2020.0, Cited 53.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6. HPLC of Formula: C5H8N2

Synthesis of the multidentate coordinated chelate N3C-H-2, composed of a linked functional pyridyl pyrazole fragment plus a peripheral phenyl and pyridyl unit, was obtained using a multistep protocol. Preparation of Ir(III) metal complexes bearing a N3C chelate in the tridentate (kappa(3)), tetradentate (kappa(4)), and pentadentate (kappa(5)) modes was executed en route from two nonemissive dimer intermediates [Ir(kappa(3)-N3CH)Cl-2](2) (1) and [Ir(kappa(4)-N3C)Cl](2) (2). Next, a series of mononuclear Ir(III) complexes with the formulas [Ir(kappa(4)-N3C)Cl(py)] (3), [Ir(kappa(4)-N3C)Cl(dmap)] (4), [Ir(kappa(4)-N3C)-Cl(mpzH)] (5), and [Ir(kappa(4)-N3C)Cl(dmpzH)] (6), as well as diiridium complexes [Ir-2(kappa(5)-N3C)-(mpz)(2)(CO)(H)(2)] (7) and [Ir-2(kappa(5)-N3C)-(dmpz)(2)(CO)(H)(2)] (8), were obtained upon treatment of dimer 2 with pyridine (py), 4-dimethylaminopyridine (dmap), 4-methylpyrazole (mpzH), and 3,5-dimethylpyrazole (dmpzH), respectively. These Ir(III) metal complexes were identified using spectroscopic methods and by X-ray crystallographic analysis of representative derivatives 3, 5, and 7. Their photophysical and electrochemical properties were investigated and confirmed by the theoretical simulations. Notably, green-emitting organic light-emitting diode (OLED) on the basis of Ir(III) complex 7 gives a maximum external quantum efficiency up to 25.1%. This result sheds light on the enormous potential of this tetradentate coordinated chelate in the development of highly efficient iridium complexes for OLED applications.

HPLC of Formula: C5H8N2. Welcome to talk about 67-51-6, If you have any questions, you can contact Yuan, Y; Gnanasekaran, P; Chen, YW; Lee, GH; Ni, SF; Lee, CS; Chi, Y or send Email.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Formula: C5H8N2. In 2020.0 J ORG CHEM published article about 2+2 PHOTOCYCLOADDITION REACTIONS; PHOTOREDOX CATALYSIS; BRONSTED ACID; THIOXANTHONE; ALKYLATION; ELECTRON; ACTIVATION; AMINATION; THIOUREA in [Lyu, Jiyuan; Claraz, Aurelie; Masson, Geraldine] Univ Paris Saclay, UPR2301, CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France; [Lyu, Jiyuan; Allain, Clemence] Univ Paris Saclay, ENS Paris Saclay, PPSM, CNRS, F-91190 Gif Sur Yvette, France; [Vitale, Maxime R.] PSL Univ, Sorbonne Univ, CNRS, Lab Biomol,LBM,Dept Chim,Ecole Normale Super, F-75005 Paris, France in 2020.0, Cited 70.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6.

Chiral phosphoric acid based organocatalysis and visible-light photocatalysis have both emerged as promising technologies for the sustainable production of fine chemicals. In this context, we have envisioned the design and the synthesis of a new class of chimeric catalytic entities that would feature both catalytic capabilities. Given their multitask nature, such catalysts would be particularly attractive for the development of new catalytic transformations, tandem processes in particular. Toward this goal, several BINOL-based chiral phosphoric acid backbones presenting one or two visible-light-sensitive thioxanthone moieties have been prepared and studied. The utility of these new photoactive chiral organocatalysts is then demonstrated in the enantioselective tandem three-component electrophilic amination of enecarbamates. Of note, the C-1-symmetric organo/photocatalyst has shown a better catalytic activity than those presenting a C-2 symmetry.

Bye, fridends, I hope you can learn more about C5H8N2, If you have any questions, you can browse other blog as well. See you lster.. Formula: C5H8N2

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article Squaramide-catalyzed asymmetric Mannich reactions between 3-fluorooxindoles and pyrazolinone ketimines published in 2019. COA of Formula: C11H12N2O, Reprint Addresses Du, DM (corresponding author), Beijing Inst Technol, Sch Chem & Chem Engn, 5 South Zhongguancun St, Beijing 100081, Peoples R China.. The CAS is 86-92-0. Through research, I have a further understanding and discovery of 3-Methyl-1-p-tolyl-5-pyrazolone

An enantioselective Mannich reaction between 3-fluorooxindoles and pyrazolinone ketimines has been developed for the construction of amino-pyrazolone-oxindoles containing stereogenic C-F units. Based on this new protocol that allows for the generation of two adjacent tetrasubstituted stereocenters, a variety of structurally diverse fluorinated amino-pyrazolone-oxindoles were obtained in good to excellent yields with excellent diastereoselectivities and enantioselectivities (up to 98% yield, >20 : 1 dr and >99% ee). What’s more, good yield and high stereoselectivities were obtained in the gram-scale reaction.

COA of Formula: C11H12N2O. Bye, fridends, I hope you can learn more about C11H12N2O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Zhang, Yong; Nie, Long-Jun; Luo, Liang; Mao, Jia-Xin; Liu, Jin-Xiang; Xu, Guo-Hai; Chen, Deliang; Luo, Hai-Qing; Tetrahedron; vol. 76; 7; (2020);,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

An article The First Example of Palladium(II)-Catalyzed Oxidative C-N Cross Coupling of 2H-Imidazole 1-Oxide with Azoles WOS:000485299000017 published article about DIRECT FUNCTIONALIZATION; OXIDES; BOND; DERIVATIVES; ARYLATION; RADICALS; LITHIUM; AZINES in [Akulov, Alexey A.; Varaksin, Mikhail V.; Charushin, Valery N.; Chupakhin, Oleg N.] Ural Fed Univ, 19 Mira St, Ekaterinburg 620002, Russia; [Varaksin, Mikhail V.; Charushin, Valery N.; Chupakhin, Oleg N.] Russian Acad Sci, Ural Branch, Postovsky Inst Organ Synth, 22 S Kovalevskoi,20 Akad Skaya St, Ekaterinburg 620990, Russia in 2019.0, Cited 28.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6. Formula: C5H8N2

We report the first example of the direct nucleophilic C-H functionalization of cyclic aldonitrone, a derivative of 2H-imidazole 1-oxide, with 1H-imidazole and 3,5-dimethylpyrazole rings using oxidative C-N cross-coupling reactions in the presence of palladium(II) catalyst. The obtained new bisheterocyclic N-oxides may be of interest as molecules with potential biological activity and as functional organic materials.

Welcome to talk about 67-51-6, If you have any questions, you can contact Akulov, AA; Varaksin, MV; Charushin, VN; Chupakhin, ON or send Email.. Formula: C5H8N2

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Hamid, A; Roy, RK in [Hamid, Aabid; Roy, Ram Kinkar] Birla Inst Technol & Sci, Dept Chem, Pilani 333031, Rajasthan, India published Correlation between Equilibrium Constant and Stabilization Energy: A Combined Approach Based on Chemical Thermodynamics, Statistical Thermodynamics, and Density Functional Reactivity Theory in 2020.0, Cited 28.0. Recommanded Product: 67-51-6. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6.

In the present work, an attempt is made to establish the correlation between equilibrium constant and stabilization energy [Delta E-SE(AB)] generated from density functional reactivity theory (DFRT). The reactions chosen here are of type A + B (sic) AB (i.e., adduct formation type) between an electron acceptor, A, and an electron donor, B. The representative acceptors are methyltrioxorhenium (MTO) and substituted benzaldehydes whereas donors are 26 mono- and bidentate ligands (having N-donors) and semicarbazide. The trends of experimentally generated equilibrium constant (K) values match with those of Delta E-SE(AB) in most of the cases, both in gas phase as well as in solvent. Justification of this reliable correlation is provided analytically using the expressions of standard Gibbs free energy of reaction (i.e., Delta(r)G(theta)) and the stabilization energy expression generated by DFRT. A further analytical explanation (albeit not very rigorous) is provided through statistical thermodynamics showing how equilibrium constant (K) is related to Delta E-SE(AB) for reactions of the type A + B (sic) AB, where either A or B is a common species.

Recommanded Product: 67-51-6. Welcome to talk about 67-51-6, If you have any questions, you can contact Hamid, A; Roy, RK or send Email.

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Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

COA of Formula: C12H12N2O3. Recently I am researching about CLINICAL-PRACTICE; SURVIVAL; MULTICENTER; ANTITUMOR; SAFETY; SITE; SEX, Saw an article supported by the BayerBayer AG; Amgen MerckAmgenMerck & Company; RocheRoche Holding. Published in DOVE MEDICAL PRESS LTD in ALBANY ,Authors: Novakova-Jiresova, A; Kopeckova, K; Boublikova, L; Chloupkov, R; Melichar, B; Petruzelka, L; Finek, J; Fiala, O; Grell, P; Batko, S; Linke, Z; Kiss, I; Prausov, J; Buchler, T. The CAS is 83-10-3. Through research, I have a further understanding and discovery of 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid

Purpose: Regorafenib is an oral multikinase inhibitor approved for the therapy of previously treated metastatic colorectal carcinoma (mCRC). The aim of the present study was to analyze the outcomes of treatment with regorafenib in real-world clinical practice based on data from a national registry. Methods: The CORECT registry, the Czech non-interventional database of patients with mCRC treated with targeted agents, searched for patients with metastatic CRC treated with regorafenib. In total, 555 evaluable patients were identified. Results: The median age at diagnosis was 61.7 years. All patients had disease progression on or after previous systemic treatment. Most patients were treated with an initial dose of 160 mg daily (n = 463; 83.6%). The median duration of treatment was 2.7 months (range 0.023.4 months). By the data cut-off date, 472 patients (85%) had completed treatment with regorafenib and were evaluable for treatment response evaluation. Partial response was reported in 13 patients (2.8%) and disease stabilization in 130 patients (27.5%). Median progression-free survival (PFS) and overall survival (OS) were 3.5 months (95% confidence interval [CI] 3.2-3.7 months) and 9.3 months (95% CI 8.3-10.3 months), respectively. The 6-month OS rate was 67.7% (95% CI 63.4-72.1%). Multivariable analysis showed that female gender, longer interval from diagnosis of metastatic disease, MO stage at diagnosis, and Eastern Cooperative Oncology Group performance status (ECOG PS) 0 were associated with longer PFS, while higher body-mass index (BMI), longer interval from diagnosis of metastatic disease, and ECOG PS of 0 were associated with longer OS. Conclusion: OS of patients treated with regorafenib in the real-world clinical practice in this cohort exceeded that reported in randomized trials. Regorafenib is a safe and active treatment option for a subgroup of patients with mCRC who are progressing after other systemic therapies and maintain good performance status.

Welcome to talk about 83-10-3, If you have any questions, you can contact Novakova-Jiresova, A; Kopeckova, K; Boublikova, L; Chloupkov, R; Melichar, B; Petruzelka, L; Finek, J; Fiala, O; Grell, P; Batko, S; Linke, Z; Kiss, I; Prausov, J; Buchler, T or send Email.. COA of Formula: C12H12N2O3

Reference:
Patent; Shanghai Pharmaceutical Industry Institute; China Pharmaceutical Industry Zongyuan; Li Jianqi; Huang Daowei; Wang Wenya; Zhang Zhiguo; Jiang Ling; (45 pag.)CN107286140; (2017); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Authors Ma, YY; Shi, YQ; Yang, F; Wu, YS; Wu, YJ in PERGAMON-ELSEVIER SCIENCE LTD published article about C-H AMINATION; CARBON-NITROGEN BONDS; 1-NAPHTHYLAMINE DERIVATIVES; 8-AMINOQUINOLINE AMIDES; C5-H PHOSPHONATION; ARYL HALIDES; ACTIVATION; QUINOLINES; STRATEGY; SCOPE in [Ma, Yueyue; Shi, Yaqi; Yang, Fan; Wu, Yangjie] Zhengzhou Univ, Key Lab Appl Chem Henan Univ, Henan Key Lab Chem Biol & Organ, Coll Chem & Mol Engn, Zhengzhou 450052, Henan, Peoples R China; [Wu, Yusheng] TetranovBiophann LLC, Zhengzhou 450001, Henan, Peoples R China; [Wu, Yusheng] Collaborat Innovat Ctr New Drug Res & Safety Eval, Zhengzhou 450001, Henan, Peoples R China in 2019, Cited 35. COA of Formula: C5H8N2. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6

A practical and efficient protocol for Ag/Ru-cocatalyzed regioselective C-H amination of 8-hydroxyquinoline esters with pyrazoles was developed, This reaction proceeded smoothly via a photoredox-mediated direct C-H/N-H oxidative coupling process. The remarkable features of this reaction include the wide substrate scope, mild reaction conditions and high regioselectivity at the C4 site of the quinolinyl moiety. (C) 2019 Elsevier Ltd. All rights reserved.

Welcome to talk about 67-51-6, If you have any questions, you can contact Ma, YY; Shi, YQ; Yang, F; Wu, YS; Wu, YJ or send Email.. COA of Formula: C5H8N2

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

An article Supramolecular association in Cu(II) and Co(II) coordination complexes of 3,5-dimethylpyrazole: Experimental and theoretical studies WOS:000447787500019 published article about METAL-ORGANIC FRAMEWORKS; X-RAY STRUCTURES; CRYSTAL-STRUCTURE; BONDING INTERACTIONS; CATALYTIC-ACTIVITIES; ALUMINUM TRIHALIDES; CHALCOGEN BOND; SOLID-STATE; TRIEL BONDS; LIGANDS in [Gogoi, Anshuman; Nashre-ul-Islam, Swah Mohd.; Bhattacharyya, Manjit K.] Cotton Univ, Dept Chem, Gauhati 781001, Assam, India; [Frontera, Antonio] Univ Illes Balears, Dept Quim, Crta Valldemossa Km 7-7, Palma De Mallorca 07122, Baleares, Spain in 2019.0, Cited 75.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6. Safety of 3,5-Dimethyl-1H-pyrazole

Two coordination complexes of Cu(II) and Co(II) involving 3,5-dimethylpyrazole viz. { [Cu(mu-O,O’-SO4) (Hdmpz)(2)(H2O)]center dot 2H(2)O}(n) (1) and [Co(Hdmpz)(4)(H2O)(2)Cl-2 (2) (where Hdmpz = 3,5-dimethylpyrazole) have been synthesized in purely aqueous medium at room temperature. Crystal structure of complex 1 consists of a polymeric chain of distorted square pyramidal Cu(II) centers bridged by bidentate sulfato ligands. The polymeric chain in 1 has been stabilized by N-H center dot center dot center dot O and C-H center dot center dot center dot pi interactions. Particularly relevant is the polymeric chain in 1, since in addition to the afore mentioned non-covalent contacts, unprecedented chalcogen bonding interactions involving the sigma-hole at the tetrahedral sulfur atom are observed and characterized using theoretical calculations. To our knowledge, sigma-hole chalcogen bonding interactions involving tetrahedral sulfur atom have not been previously reported in the literature. The lattice water molecules self assembles the polymeric chains of 1 into a 3D supramolecular architecture via C-H center dot center dot center dot O hydrogen bonding interactions. The cationic units in the crystal structure of 2 self assembles via O-H center dot center dot center dot Cl, N-H center dot center dot center dot Cl and C-H center dot center dot center dot Cl weak hydrogen bonding interactions into a 2D supramolecular architecture induced by chloride anions in the lattice. PXRD patterns of 1 and 2 demonstrate good phase purity of the complexes. In addition, the thermal behaviour of the complexes has also been investigated.

Welcome to talk about 67-51-6, If you have any questions, you can contact Gogoi, A; Nashre-ul-Islam, SM; Frontera, A; Bhattacharyya, MK or send Email.. Safety of 3,5-Dimethyl-1H-pyrazole

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Name: 3,5-Dimethyl-1H-pyrazole. Authors Sharma, T; Kumar, R; Sahoo, SC; Sindhu, J; Singh, J; Singh, B; Mehta, SK; Umar, A; Saini, TS; Kumar, V; Kataria, R in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Sharma, Tulika; Singh, Joginder] Maharishi Markandeshwar Deemed Univ, Dept Chem, Ambala 133207, Haryana, India; [Kumar, Rakesh; Sahoo, Subash Chandra; Mehta, Surinder Kumar; Kataria, Ramesh] Panjab Univ, Dept Chem, Chandigarh 160014, India; [Kumar, Rakesh; Sahoo, Subash Chandra; Mehta, Surinder Kumar; Kataria, Ramesh] Panjab Univ, Ctr Adv Studies Chem, Chandigarh 160014, India; [Kumar, Rakesh] Govt Coll Barwala 134118, Dept Chem, Panchkula, Haryana, India; [Sindhu, Jayant] CCS Haryana Agr Univ, Dept Chem, COBS&H, Hisar 125004, Haryana, India; [Singh, Bijender] Cent Univ Haryana, Dept Biotechnol, Mahendergarh 123031, Haryana, India; [Umar, Ahmad] Najran Univ, Dept Chem, Fac Sci & Arts, Najran 11001, Saudi Arabia; [Umar, Ahmad] Najran Univ, Promising Ctr Sensors & Elect Devices PCSED, Najran 11001, Saudi Arabia; [Saini, Tej Singh] Govt Coll Jind, Dept Chem, Jind 126102, Haryana, India; [Kumar, Vinod] Cent Univ Haryana, Dept Chem, Mahendergarh 123031, Haryana, India in 2021.0, Cited 42.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6

Some new compounds, 2-(3,5-dimethyl-1H-pyrazol-1-yl)-4-substituted acetophenone oximes [4a-4f; here, 4-substituent = H (a), Br (b), Me (c), Cl(d), NO2 (e), F (f)] were synthesized by the reaction of 2-(3,5-d imethyl-1H-pyrazol-1 -yl)-1 -arylethano nes with hydroxylamine hydrochloride. These compounds were characterized by analyzing their IR, H-1, C-13 NMR and mass spectral data. Compounds 4a-4f were further converted into their silver complexes (4g-4l) and chemical structures of which were established on the basis of their X-ray crystallographic data. The antibacterial and DNA photocleavage activity studies were carried out for all the synthesized compounds 4a-4l, and it has been found that compound 4l displayed an excellent level of antibacterial and DNA photocleavage activity. Among the series, Ag-complexes (4g-4l) displayed excellent antibacterial activity against four bacterial strains using Ciprofloxacin as a standard drug. In DNA photocleavage study, it has been observed that compounds 4a, 4e, 4f degraded both forms of DNA, whereas their Ag-complexes degraded DNA completely even at a very low concentration. The intermolecular interactions present in 4g and 4h were described by decomposing Hirshfeld surfaces into 2D fingerprint plots. It was observed that non-polar interactions contribute dominantly in overall intermolecular interactions exit in crystals of both the compounds. (C) 2020 Elsevier Ltd. All rights reserved.

Welcome to talk about 67-51-6, If you have any questions, you can contact Sharma, T; Kumar, R; Sahoo, SC; Sindhu, J; Singh, J; Singh, B; Mehta, SK; Umar, A; Saini, TS; Kumar, V; Kataria, R or send Email.. Name: 3,5-Dimethyl-1H-pyrazole

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

An article 4-[(3,5-Dimethyl-1H-pyrazol-1-yl)methyl]-4-methyl-2-phenyl-4,5-dihydrooxazole WOS:000488250800004 published article about DERIVATIVES SYNTHESIS; PYRAZOLE in [Hajib, Sara] Sidi Mohamed Ben Abdellah Univ, Fac Sci Dhar Mahraz, Ctr Doctoral Studies Sci & Technol, Doctoral Training Bioact Mol Hlth & Biotechnol, Fes 30000, Morocco; [Alami, Anouar; Faraj, Hassane] Sidi Mohammed Ben Abdellah Univ, Fac Sci Dhar El Mahraz, Organ Chem Lab LCO, Fes 30000, Morocco; [Aouine, Younas] Ibn Zohr Univ, Fac Sci, Organ Chem Lab LCO, PB 8106, Cite Dakhla 80060, Agadir, Morocco in 2019.0, Cited 15.0. Name: 3,5-Dimethyl-1H-pyrazole. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6

The compound, 4-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]-4-methyl-2-phenyl-4,5-dihydrooxazole 2 was prepared in high yield, through nucleophilic substitution reaction of the O-tosyl oxazoline derivative 1, by heating in dimethyl sulfoxide (DMSO) and in presence of KOH as base. The structure of the synthesized compound was established on the basis of NMR spectroscopy (H-1, C-13), MS data and elemental analysis.

Welcome to talk about 67-51-6, If you have any questions, you can contact Hajib, S; Alami, A; Faraj, H; Aouine, Y or send Email.. Name: 3,5-Dimethyl-1H-pyrazole

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics