Category: pyrazoles-derivatives

Category: pyrazoles-derivativesOn November 15, 2019 ,《Synthesis, physicochemical and antimicrobial properties of cardanol-derived quaternary ammonium compounds (QACs) with heterocyclic polar head》 appeared in Journal of Molecular Liquids. The author of the article were Ma, Jingyi; Liu, Na; Huang, Mengen; Wang, Limin; Han, Jianwei; Qian, Hui; Che, Fei. The article conveys some information:

As new biomass derived raw material, cardanol has attracted the attention of numerous academic and industrial groups due to its renewability and unique structural features. In this work, seven cardanol-derived quaternary ammonium compounds (QACs) were synthesized with their physicochem. properties and antimicrobial ability evaluated. The surface tension was measured in aqueous medium by the platinum ring method, 2b has the optimal surface activities, which is considerably better than commercialized QAC product cetyltrimethylammonium bromide. Both broth dilution method and agar dilution method were used to obtain the MIC and MBC values of the targeted QACs. 1a, 1b, 2b inhibit the tested bacterial at a concentration of 32μg/mL. SEM (SEM) results intuitively showed that the QACs could interact with the bacterial cell membrane, for disrupting the integrity of the membrane. Meanwhile, it was found that the antimicrobial activity depended not only on the alkyl chain length, but also on the CMC value. To sum, seven cardanol-derived QACs were synthesized easily, which showed excellent surface activities and antimicrobial activity, as a promising alternative to the existing fossil fuel derived cationic surfactants and antiseptics. The experimental part of the paper was very detailed, including the reaction process of 1-Methylpyrazole(cas: 930-36-9Category: pyrazoles-derivatives)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Category: pyrazoles-derivatives

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

《Synthesis and solid-state structure of thermally stable linear bi-pyrazoles》 was written by Maspero, Angelo; Cernuto, Giuseppe; Galli, Simona; Palmisano, Giovanni; Tollari, Stefano; Masciocchi, Norberto. Electric Literature of C9H7N3O2 And the article was included in Solid State Sciences on August 31 ,2013. The article conveys some information:

The long and rigid bi-pyrazolyl-based ligands 2,6-bis[4-(1H-pyrazol-4-yl)phenyl]pyrrolo[3,4-f]isoindole-1,3,5,7(2H,6H)-tetrone, , and 2,5-bis[4-(1H-pyrazol-4-yl)phenyl]thiazolo[5,4-d]thiazole, were isolated in pure form, with satisfying yields, as very insoluble polycrystalline materials. Their thermal behavior was studied by coupling thermal analyses and variable-temperature x-ray powder diffraction measurements. Their crystal structures were unraveled from powder diffraction data by a rather unconventional structure determination approach, without the a priori knowledge of the unit cell parameters. Inline with shorter analogs, successfully employed in the formation of porous MOFs with intriguing functional properties, 2,6-bis[4-(1H-pyrazol-4-yl)phenyl]pyrrolo[3,4-f]isoindole-1,3,5,7(2H,6H)-tetrone and 2,5-bis[4-(1H-pyrazol-4-yl)phenyl]thiazolo[5,4-d]thiazole are promising to construct higher-porosity materials, potentially capable of hosting nano-sized guests.4-(4-Nitrophenyl)-1H-pyrazole(cas: 114474-26-9Electric Literature of C9H7N3O2) was used in this study.

4-(4-Nitrophenyl)-1H-pyrazole(cas: 114474-26-9) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, antipyretic, neuroleptic, anticonvulsant, antiarrhythmic, sedative, muscle relaxant, monoamine oxidase inhibitory, anti-inflammatory, antidiabetic and antibacterial activities. Electric Literature of C9H7N3O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Formula: C5H6N2O2In 1976 ,《Modified nucleosides. V. Synthesis of pyrazole nucleosides》 appeared in Zhurnal Obshchei Khimii. The author of the article were Akhrem, A. A.; Garbuz, N. I.; Kvasyuk, E. I.; Mikhailopulo, I. A.. The article conveys some information:

Pyrazole nucleosides I, II (R = Ac, R1 = OEt) were obtained in 52 and 26% yields by treatment of Et acetoxymethylpyrazolecarboxylate with α-D-glucopyranose pentaacetate. Subsequent aminolysis yielded 90% I, II (R = H, R1 = NH2). Analogously obtained were 71 and 11% III, IV (R = Bz, R1 = Ac, R2 = OEt) which were treated with NH3 to give 90% III, IV (R = R1 = H, R2 = NH2). Similar results were obtained by glucosylation of Me pyrazolecarboxylate and by ribosylation of Et 4-acetoxymethyl-3-pyrazolecarboxylate. The experimental part of the paper was very detailed, including the reaction process of Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Formula: C5H6N2O2)

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Formula: C5H6N2O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

《Correction to “”Modular, Step-Efficient Palladium-Catalyzed Cross-Coupling Strategy To Access C6-Heteroaryl 2-Aminopurine Ribonucleosides”” [Erratum to document cited in CA167:176274]》 was written by Buchanan, Helena S.; Pauff, Steven M.; Kosmidis, Tilemachos D.; Taladriz-Sender, Andrea; Rutherford, Olivia I.; Hatit, Marine Z. C.; Fenner, Sabine; Watson, Allan J. B.; Burley, Glenn A.. Related Products of 847818-74-0This research focused ontriazole isoxazole isonitrile nucleoside preparation cycloaddition erratum; aminopurine nucleoside chloroguanosine Suzuki Miyaura chloroguanosine heteroarylaminopurine Sonogashira coupling; palladium catalyzed coupling heteroaryl aminopurine nucleoside cycloaddition isonitrile isoxazole; erratum. The article conveys some information:

The following statement was inadvertently omitted from the Acknowledgments section of the manuscript: “”This work was supported by an EPSRC-GSK industrial CASE studentship for H.S.B. In the experiment, the researchers used many compounds, for example, 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 847818-74-0Related Products of 847818-74-0)

1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 847818-74-0) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, monoamine oxidase inhibitory, anti-inflammatory, antipyretic, neuroleptic, anticonvulsant, antiarrhythmic, sedative, muscle relaxant, antidiabetic and antibacterial activities. Related Products of 847818-74-0

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Computed Properties of C5H6N2O2In 2004 ,《Synthesis and luminescence properties of lanthanide(III) chelates with polyacid derivatives of thienyl-substituted terpyridine analogues》 was published in Journal of Luminescence. The article was written by Yuan, Jingli; Tan, Mingqian; Wang, Guilan. The article contains the following contents:

Two new polyacid derivative ligands of thienyl-substituted terpyridine analogs, N,N,N1,N1-[4′-(2”’-thienyl)-2,2′:6′,2”-terpyridine-6,6”-diyl]bis(methylenenitrilo) tetrakis(acetic acid) (TTTA) and N,N,N1,N1-[2,6-bis(3′-aminomethyl-1′-pyrazolyl)-4-(2”-thienyl)pyridine]tetrakis(acetic acid) (BTTA), were synthesized, and the luminescence properties of their Eu3+ and Tb3+ chelates were studied. The Eu3+chelates of the two ligands are strongly luminescent having luminescence quantum yields of 0.150 (TTTA-Eu3+) and 0.114 (BTTA-Eu3+), and lifetimes of 1.284 ms (TTTA-Eu3+) and 1.352 ms (BTTA-Eu3+), whereas their Tb3+ chelates are weakly luminescent. The TTTA-Eu3+ chelate was used for streptavidin (SA) labeling, and the labeled SA was used for time-resolved fluoroimmunoassay of insulin in human sera. The method gives the detection limits of 33 pg ml-1. In the part of experimental materials, we found many familiar compounds, such as Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Computed Properties of C5H6N2O2)

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Computed Properties of C5H6N2O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The author of 《Infrared spectra of pyrazoles. I. Monoalkyl-substituted pyrazoles》 were Zerbi, Giuseppe; Alberti, Carlo. And the article was published in Spectrochimica Acta in 1962. Recommanded Product: 52096-24-9 The author mentioned the following in the article:

The compounds studied were pyrazole, 3-alkyl-, 4-alkyl-, and N-alkylpyrazole, where the substituents were Me, Et, Pr, Bu, and amyl. The spectral region was 2-15 μ. Observed bands can be used to recognize the pyrazole structure and the position of the substituent. Most of the observed bands were assigned. In addition to this study using 1-Butyl-1H-pyrazole, there are many other studies that have used 1-Butyl-1H-pyrazole(cas: 52096-24-9Recommanded Product: 52096-24-9) was used in this study.

1-Butyl-1H-pyrazole(cas: 52096-24-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Recommanded Product: 52096-24-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Molander, Gary A.; Argintaru, O. Andreea; Aron, Ioana; Dreher, Spencer D. published their research in Organic Letters on December 17 ,2010. The article was titled 《Nickel-Catalyzed Cross-Coupling of Potassium Aryl- and Heteroaryltrifluoroborates with Unactivated Alkyl Halides》.Related Products of 1258323-45-3 The article contains the following contents:

A method for the cross-coupling of alkyl electrophiles with various potassium aryl- and heteroaryltrifluoroborates has been developed. Nearly stoichiometric amounts of organoboron species could be employed to cross-couple a large variety of challenging heteroaryl nucleophiles. Several functional groups were tolerated on both the electrophilic and the nucleophilic partners. Chemoselective reactivity of C(sp3)-Br bonds in the presence of C(sp2)-Br bonds was achieved. In the experiment, the researchers used many compounds, for example, Potassium trifluoro(1-methyl-1H-pyrazol-5-yl)borate(cas: 1258323-45-3Related Products of 1258323-45-3)

Potassium trifluoro(1-methyl-1H-pyrazol-5-yl)borate(cas: 1258323-45-3) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Related Products of 1258323-45-3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Product Details of 930-36-9On November 30, 2022 ,《Machine learning-assisted non-target analysis of a highly complex mixture of possible toxic unsymmetrical dimethylhydrazine transformation products with chromatography-mass spectrometry》 appeared in Chemosphere. The author of the article were Sholokhova, Anastasia Yu.; Grinevich, Oksana I.; Matyushin, Dmitriy D.; Buryak, Aleksey K.. The article conveys some information:

Unsym. dimethylhydrazine (UDMH) is a toxic and environmentally hostile compound that was massively introduced to the environment during previous decades due to its use in the space and rocket industry. The compound forms multiple transformation products, and many of them are as dangerous as UDMH or even more dangerous. The danger includes, but is not limited to, acute toxicity, chronic health hazards, carcinogenicity, and environmental damage. UDMH transformation products are poorly investigated. In this work, the mixture formed by long storage of the waste that contained UDMH was studied. Even a preliminary screening of such a mixture is a complex task. It consists of dozens of compounds, and most of them are missing in chem. and spectral databases. The complete preparative separation of such a mixture is very laborious. We applied several methods of gas chromatog.-mass spectrometry and liquid chromatog.-mass spectrometry, and several machine learning and chemoinformatics methods to make a preliminary but informative screening of the mixture Machine learning allowed predicting retention indexes and mass spectra of candidate structures. The combination of various ion sources and a comparison of the observed with the predicted spectra and retention was used to propose confident structures for 24 compounds It was demonstrated that neither high-resolution mass spectrometry nor mass spectral library matching is enough to elucidate the structures of unknown UDMH transformation products. At the same time, the use of machine learning and a combination of methods significantly improves the identification power. Finally, machine learning was applied to estimate the acute toxicity of the discovered compounds It was shown that many of them are comparable to or even more toxic than UDMH itself. Such an extremely wide and still underestimated variety of easily formed derivatives of UDMH can lead to a significant underestimation of the potential hazard of this compound The experimental part of the paper was very detailed, including the reaction process of 1-Methylpyrazole(cas: 930-36-9Product Details of 930-36-9)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Product Details of 930-36-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Safety of 3-(Trifluoromethyl)-1H-pyrazoleIn 2010 ,《First Application of an Efficient and Versatile Ligand for Copper-Catalyzed Cross-Coupling Reactions of Vinyl Halides with N-Heterocycles and Phenols》 appeared in Organic Letters. The author of the article were Kabir, M. Shahjahan; Lorenz, Michael; Namjoshi, Ojas A.; Cook, James M.. The article conveys some information:

2-Pyridin-2-yl-1H-benzoimidazole (I) is presented as a new, efficient, and versatile bidentate N-donor ligand suitable for the copper-catalyzed formation of vinyl C-N and C-O bonds. This inexpensive and easily prepared ligand facilitates copper-catalyzed cross-coupling reactions of alkenyl bromides and iodides with N-heterocycles and phenols to afford the desired cross-coupled products in good to excellent yields with full retention of stereochem. This method is particularly noteworthy given its efficiency, i.e., mild reaction conditions, low catalyst loading, simplicity, versatility, and exceptional level of functional group tolerance. The results came from multiple reactions, including the reaction of 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Safety of 3-(Trifluoromethyl)-1H-pyrazole)

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Safety of 3-(Trifluoromethyl)-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Recommanded Product: 20154-03-4In 2015 ,《Design, synthesis and herbicidal evaluation of novel 4-(1H-pyrazol-1-yl)pyrimidine derivatives》 appeared in Pest Management Science. The author of the article were Ma, Hong-Ju; Zhang, Jian-Hua; Xia, Xiang-Dong; Kang, Jing; Li, Jian-Hong. The article conveys some information:

A series of novel pyrazolylpyrimidine derivatives I (R1 = H, CH3; R2 = OCH2CH3, SCH3, SO2CH3, N(CH3)2, etc.; R3 = H, CH3; R4 = CF3; X = H, Cl) were designed and synthesized. The herbicidal activities of 30 pyrazolylpyrimidine derivatives were assessed. Nine compounds caused good herbicidal activity for Pennisetum alopecuroides L. Among them, I (R1 = H; R2 = NHCH2CH3; R3 = CH3; R4 = CF3; X = H) exhibited the strongest inhibitory activity against the root growth of P. alopecuroides, with an IC50 of 1.90 mg L-1. Compound I (R1 = CH3; R2 = prop-2-yn-1-yloxy; R3 = CH3; R4 = CF3; X = H) produced the highest inhibition of chlorophyll level in seedlings of P. alopecuroides (IC50 = 3.14 mg L-1). The structure-activity relationship indicated that the alkynyloxy group at the 6-position on the pyrimidine ring played a very important role for bleaching activities. When the alkynyloxy group was replaced by alkoxy, amino, alkylthio and alkylsulfonyl groups, the bleaching activities of the compounds were diminished. However, the compounds substituted by an amino at the 6-position of the pyrimidine ring exhibited excellent inhibition activities against weed root growth. In addition to this study using 3-(Trifluoromethyl)-1H-pyrazole, there are many other studies that have used 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Recommanded Product: 20154-03-4) was used in this study.

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Recommanded Product: 20154-03-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics