Category: pyrazoles-derivatives

In 1967,Micheel, Fritz; Dammert, Walter published 《Condensation products from trimethyl fluorotrimesate and α-amino-β-hydroxy compounds》.Chemische Berichte published the findings.Related Products of 15366-34-4 The information in the text is summarized as follows:

N-[6-carboxy-2,4-bis(methoxycarbonyl)phenyl]-DL-serinolactone (I) was treated with CH2N2 to form a pyrazoline which was converted to the corresponding cyclopropane derivative by elimination of N. The structures of the pyrazoline and cyclopropane derivatives were confirmed by degradation and synthesis. Condensates of DL-threonine and β-phenyl-DL-serine with methyl fluorotrimesate formed ester lactones, which on treatment with CH2N2 formed Me N-[2,4,6-(trimethoxycarbonyl)phenyl]-α-aminocrotonate and Me N-[2,4,6 (trimethoxycarbonyl)phenyl]-α-aminocinnamate, resp. In the experimental materials used by the author, we found Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Related Products of 15366-34-4)

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Related Products of 15366-34-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Name: 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazoleIn 2018 ,《A robust iron catalyst for the selective hydrogenation of substituted (iso)quinolones》 was published in Chemical Science. The article was written by Sahoo, Basudev; Kreyenschulte, Carsten; Agostini, Giovanni; Lund, Henrik; Bachmann, Stephan; Scalone, Michelangelo; Junge, Kathrin; Beller, Matthias. The article contains the following contents:

By applying N-doped carbon modified iron-based catalysts, the controlled hydrogenation of N-heteroarenes, especially (iso)quinolines, is achieved. The catalysts are prepared by pyrolysis of a carbon-impregnated composite, obtained from iron(II) acetate and N-aryliminopyridines. As demonstrated by TEM, XRD, XPS and Raman spectroscopy, the synthesized material is composed of Fe(0), Fe3C and FeNx in a N-doped carbon matrix. The decent catalytic activity of this robust and easily recyclable Fe-material allowed for the selective hydrogenation of various (iso)quinoline derivatives, even in the presence of reducible functional groups, such as nitriles, halogens, esters and amides. For a proof-of-concept, this nanostructured catalyst was implemented in the multistep synthesis of natural products and pharmaceutical lead compounds as well as modification of photoluminescent materials. As such this methodol. constitutes the first heterogeneous iron-catalyzed hydrogenation of substituted (iso)quinolines with synthetic importance. After reading the article, we found that the author used 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 847818-74-0Name: 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole)

1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 847818-74-0) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, antipyretic, neuroleptic, anticonvulsant, antiarrhythmic, sedative, muscle relaxant, monoamine oxidase inhibitory, anti-inflammatory, antidiabetic and antibacterial activities. Name: 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Formula: C4H3F3N2In 2020 ,《Pyrazole-Enaminones as Promising Prototypes for the Development of Analgesic Drugs》 appeared in ChemistrySelect. The author of the article were Moraes, Paulo A.; Brum, Evelyne S.; Brusco, Indiara; Marangoni, Mario A.; Lobo, Marcio M.; Camargo, Adriano F.; Nogara, Pablo A.; Bonacorso, Helio G.; Martins, Marcos A. P.; Da Rocha, Joao Batista T.; Oliveira, Sara M.; Zanatta, Nilo. The article conveys some information:

This study reports the chemo- and regioselective synthesis, at good yields, of (E)-4-(amino)-1,1,1-trifluoro-5-(4,5-alkyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)pent-3-en-2-ones (pyrazole-enaminones), from the of N-alkylation reaction of trifluoromethyl pyrazoles with 5-bromo enaminones. The obtained compounds were tested as potential analgesics in a screening test involving mice. Three of these compounds significantly reduced the spontaneous nociception induced by the application of capsaicin, which is an algogenic substance. Compound I presented satisfactory antinociceptive activity compared to celecoxib, a drug used as a pos. control, without promoting locomotor changes in the mice. Moreover, mol. modeling simulations showed that compound I interacts with the cyclooxygenase enzyme at the same binding site as celecoxib. Together, present data suggest that compound I is a promising prototype for the development of new analgesic drugs. After reading the article, we found that the author used 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Formula: C4H3F3N2)

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Formula: C4H3F3N2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 2015,Cheema, Hammad; Islam, Ashraful; Han, Liyuan; El-Shafei, Ahmed published 《Monodentate pyrazole as a replacement of labile NCS for Ru (II) photosensitizers: Minimum electron injection free energy for dye-sensitized solar cells》.Dyes and Pigments published the findings.Computed Properties of C4H3F3N2 The information in the text is summarized as follows:

A mono-dentate ligand of 3-(trifluoromethyl) pyrazole, instead of the labile isothiocyanate ligand for Ru (II) photosensitizers, was developed. This mol. modulation resulted in a new structure motif (HD-11) with 50 nm red shift in the low energy metal-to-ligand charge transfer (MLCT) absorption peak. However, electrochem. measurements revealed that both ground and excited state oxidation potentials were stabilized, this is attributed to the presence of strong electron withdrawing group CF3 tethered to pyrazole, which resulted in more free energy for dye regeneration, but less driving force for electron injection into the conduction band of TiO2. Hence HD-11, resulted in lower Jsc of 12.89 mA cm-2 compared to 17.07 mA cm-2 of N719 under similar conditions. Addnl., Voc of HD-11 was lower than N719, owing to decreased eTiO2 life time of 0.674 ms compared to 8.8 ms of N719 for injected electrons as found by impedance measurements. In addition to this study using 3-(Trifluoromethyl)-1H-pyrazole, there are many other studies that have used 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Computed Properties of C4H3F3N2) was used in this study.

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Computed Properties of C4H3F3N2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 1973,Akrem, A. A.; Kvasyuk, E. I.; Mikhailopulo, I. A. published 《Unusual reaction of 3-(methoxycarbonyl)-Δ2-pyrazoline with lead tetraacetate》.Tetrahedron Letters published the findings.Name: Methyl 1H-pyrazole-3-carboxylate The information in the text is summarized as follows:

The title reaction gave 70% 3-(methoxycarbonyl)-1-[1-(methoxycarbonyl)-cyclopropyl]pyrazole (I) and 14% 3-(methoxycarbonyl)-1-[3-(methoxycarbonyl)pyrazol-1-yl]-2-pyrazoline (II). NMR, ir, and uv spectral data for I, II, 3-(methoxycarbonyl)pyrazole, and 7-acetyl-3-(methoxycarbonyl)-2-pyrazoline were determined The experimental process involved the reaction of Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Name: Methyl 1H-pyrazole-3-carboxylate)

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Name: Methyl 1H-pyrazole-3-carboxylate

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Formula: C5H6N2O2In 1985 ,《N,N’-Linked biazoles. Part 5. Synthesis of pyrazolyl dimers by the reaction of 3-methoxycarbonyl-2-pyrazoline with lead tetraacetate》 appeared in Heterocycles. The author of the article were De Mendoza, Javier; Rosario Gonzalez-Muniz, M.; Rosario Martin, M.. The article conveys some information:

Depending on the reaction conditions, the title oxidation gave all products earlier reported and several new ones, e.g. I-III. In the experiment, the researchers used Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Formula: C5H6N2O2)

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Formula: C5H6N2O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 2019,Chemical Science included an article by Chong, Eugene; Qu, Bo; Zhang, Yongda; Cannone, Zachary P.; Leung, Joyce C.; Tcyrulnikov, Sergei; Nguyen, Khoa D.; Haddad, Nizar; Biswas, Soumik; Hou, Xiaowen; Kaczanowska, Katarzyna; Chwalba, Michal; Tracz, Andrzej; Czarnocki, Stefan; Song, Jinhua J.; Kozlowski, Marisa C.; Senanayake, Chris H.. Application In Synthesis of 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole. The article was titled 《A versatile catalyst system for enantioselective synthesis of 2-substituted 1,4-benzodioxanes》. The information in the text is summarized as follows:

The synthesis of enantiomerically enriched 1,4-benzodioxanes containing alkyl, aryl, heteroaryl and/or carbonyl substituents at the 2-position was reported. The starting 1,4-benzodioxines were readily synthesized via ring closing metathesis using an efficient nitro-Grela catalyst at ppm levels. Excellent enantioselectivities of up to 99:1 er were obtained by using the versatile catalyst system [Ir(cod)Cl]2/BIDIME-dimer in the asym. hydrogenation of 2-substituted 1,4-benzodioxines. Furthermore, DFT calculations revealed that the selectivity of the process was controlled by the protonation step; and coordinating groups on the substrate may alter the interaction with the catalyst, resulting in a change in the facial selectivity. In the experiment, the researchers used many compounds, for example, 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 847818-74-0Application In Synthesis of 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole)

1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 847818-74-0) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, antidiabetic and antibacterial activities. Application In Synthesis of 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 2018,ACS Catalysis included an article by Boit, Timothy B.; Weires, Nicholas A.; Kim, Junyong; Garg, Neil K.. Recommanded Product: 847818-74-0. The article was titled 《Nickel-Catalyzed Suzuki-Miyaura Coupling of Aliphatic Amides》. The information in the text is summarized as follows:

Authors report the Ni-catalyzed Suzuki-Miyaura coupling of aliphatic amide derivatives Prior studies have shown that aliphatic amide derivatives can undergo Ni-catalyzed carbon-heteroatom bond formation but that Ni-mediated C-C bond formation using aliphatic amide derivatives has remained difficult. The coupling disclosed herein is tolerant of considerable variation with respect to both the amide-based substrate and the boronate coupling partner and proceeds in the presence of heterocycles and epimerizable stereocenters. Moreover, a gram-scale Suzuki-Miyaura coupling/Fischer indolization sequence demonstrates the ease with which unique polyheterocyclic scaffolds can be constructed, particularly by taking advantage of the enolizable ketone functionality present in the cross-coupled product. The methodol. provides an efficient means to form C-C bonds from aliphatic amide derivatives using nonprecious-metal catalysis and offers a general platform for the heteroarylation of aliphatic acyl electrophiles. In addition to this study using 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, there are many other studies that have used 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 847818-74-0Recommanded Product: 847818-74-0) was used in this study.

1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 847818-74-0) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, monoamine oxidase inhibitory, anti-inflammatory, antipyretic, neuroleptic, anticonvulsant, antiarrhythmic, sedative, muscle relaxant, antidiabetic and antibacterial activities. Recommanded Product: 847818-74-0

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Yi, Rong-Nan; Wu, Zhi-Lin; Ouyang, Wen-Tao; Wang, Wei-Fan; He, Wei-Min published their research in Tetrahedron Letters on August 3 ,2021. The article was titled 《Green synthesis of 4-organylselanyl-1H-pyrazoles through electrochemical cross-dehydrogenative coupling of 1H-pyrazoles and diorganyl diselenides》.Formula: C4H6N2 The article contains the following contents:

An atom-economical and efficient method for synthesizing 4-organylselanyl-1H-pyrazoles through electrochem. cross-dehydrogenation coupling of N-unsubstituted pyrazoles with diorganyl diselenides under chem. oxidant-free and mild conditions was developed. This reaction not only shows good functional-group tolerance but also has high scalability. The experimental part of the paper was very detailed, including the reaction process of 1-Methylpyrazole(cas: 930-36-9Formula: C4H6N2)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Formula: C4H6N2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

de Araujo, Marcos Lopes; Correia, Gilvan Aguiar; Carvalho, Wagner Alves; Shul’pina, Lidia Sergeevna; Kozlov, Yuriy Nikitovich; Shul’pin, Georgiy Borisovich; Mandelli, Dalmo published their research in Catalysis Today on December 1 ,2021. The article was titled 《The effect of additives (pyrazine, pyrazole and their derivatives) in the oxidation of 2-butanol with FeCl3-H2O2 in aqueous solutions》.Reference of 1-Methylpyrazole The article contains the following contents:

In the present paper we described the oxidation of 2-butanol as a representative of secondary aliphatic alcs. The oxidizing system FeCl3-H2O2 was used. A kinetic study of the oxidation reaction has been carried out. Different substituted pyrazines and pyrazoles, namely 2-pyrazinecarboxylic acid (PCA), 5-methyl-2-pyrazinecarboxylic acid (5MPCA), 2-methylpyrazine (2MPZINE), 3-(trifluoromethyl)pyrazole (3TFMPZOLE), 3-methylpyrazole (3MPZOLE) and 1-methylpyrazole (1MPZOLE) were added as cooperating ligands in aqueous solutions DFT based calculations were also used in order to evaluate the different results obtained. Addition of PCA, 5MPCA and 3TFMPZOLE led to a better reaction performance, while the other ligands led to lower accumulation of products than the reaction without additives. Performed DFT studies suggested that the metal-ligand π-backbonding might be responsible for the reaction activity increase, while ligands more strongly bonded to Fe make it more difficult the access to the metal, leading to lower yields. After reading the article, we found that the author used 1-Methylpyrazole(cas: 930-36-9Reference of 1-Methylpyrazole)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Reference of 1-Methylpyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics