Category: pyrazoles-derivatives

Li, You published the artcileA one-pot synthesis of omarigliptin and its analogues through stabilized beta-amino ketone intermediate, SDS of cas: 1280210-80-1, the main research area is omarigliptin analog preparation beta amino ketone stabilization reductive amination.

A unique stabilization condition for beta-amino ketone has been described. With the above beta-amino ketone as an unprecedented intermediate, omarigliptin could be prepared in a highly efficient one-pot procedure with good yield. Also with this intermediate, some analogs of omarigliptin were readily prepared for the first time.

Synthetic Communications published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1280210-80-1 belongs to class pyrazoles-derivatives, name is 2-(Methylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole benzenesulfonate, and the molecular formula is C12H15N3O5S2, SDS of cas: 1280210-80-1.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Jung, Jae-Chul published the artcileSynthesis of 3-substituted and 3,4-disubstituted pyrazolin-5-ones, Application In Synthesis of 27412-71-1, the main research area is acetoacetate acid chloride acylation; malonate acid chloride acylation; hydroxybutenoate preparation hydrazine cyclocondensation; alkylidenemalonate preparation hydrazine cyclocondensation; pyrazolinone preparation.

The synthesis of 3-substituted and 3,4-disubstituted pyrazolin-5-ones from acylated Et acetoacetates and di-Et malonates is described. The reaction of acylated Et acetoacetates and di-Et acetylmalonate with hydrazine (98%) gave 3-substituted pyrazolin-5-ones and malonyldihydrazide, resp., following a deacetylation-condensation sequence. The reaction of Et 2-acetyl-3-hydroxy-2-butenoate (I; R = Me) and di-Et 2-(1-hydroxyethylidene)malonate (I; R = EtO) with hydrazine monohydrochloride yielded Et 3,5-dimethyl-1H-pyrazole-4-carboxylate (II) and 4-ethoxycarbonyl-3-methylpyrazolin-5-one (III), resp., following a dehydration-cyclocondensation sequence, in high yields.

Tetrahedron published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Application In Synthesis of 27412-71-1.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Bhandari, Shashikant V. published the artcileDesign, synthesis and pharmacological screening of novel nitric oxide donors containing 1,5-diarylpyrazolin-3-one as nontoxic NSAIDs, Name: 5-Phenyl-1H-pyrazol-3(2H)-one, the main research area is diarylpyrazolinone preparation; ethyl acetoacetate diethylmalonate benzoyl chloride condensation cyclocondensation nucleophilic substitution; NSAID inflammation antiinflammatory pain analgesic structure activity vasorelaxant; prostaglandin synthase COX2 inhibitor mol simulation acute ulcerogenicity histopathol.

Various substituted 1,5-diarylpyrazol-3-one derivatives were synthesized and screened for analgesic, anti-inflammatory activities, ulcerogenic potential and for their ability to release nitric oxide. Most compounds exhibited significant analgesic and anti-inflammatory activities. It was interesting to note that out of ten compounds, I (R = H) (59.64%) was found to have anti-inflammatory activity greater than the standard drug Indomethacin (57.89%), whereas II (R = 2-OMe) (57.89%) was found to be equipotent to that of standard, Indomethacin. The pharmacol. studies suggested that the presence of 4-nitro and 2-methoxy on Ph ring at C5 of pyrazole has a significant anti-inflammatory activity and 4-chloro substitution on same Ph ring was found to have decreased activity. However only a Ph substituted derivative was found to have most potent activity. I (R = H) containing plane Ph at C5 of pyrazole was found to have significant analgesic activity (56.86%) in acetic acid induced writhing model. I and II (R = 4-Cl) having 4-chloro substituted Ph ring showed least analgesic activity (10.78%) and (6.86%) resp. The compounds also showed significantly reduced GI-ulcerogenicity and gastroprotective results in histopathol. studies i.e. they were found to be causing no mucosal injury. All the synthesized compounds were found to exhibit significant nitric oxide releasing activity, in both in vitro and in vivo models. Mol. docking studies served to be an important tool for the study of binding of compounds with that of a COX-2 enzyme. The results of the docking studies were found to endorse the result of exptl. work. Thus, the rationale used to design the NCEs was found to produce the promising results as anticipated. Therefore it can be said that the strategy employed can serve as an important tool in future for the design and development of novel therapeutic agents of various categories too.

European Journal of Medicinal Chemistry published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Name: 5-Phenyl-1H-pyrazol-3(2H)-one.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Huang, Zhen-Zhong published the artcileA convenient oxidation of 5-substituted pyrazol-3(2H)-ones into methyl 2-alkynoates using poly[4-(diacetoxyiodo)styrene], Category: pyrazoles-derivatives, the main research area is pyrazolone polyacetoxyiodostyrene oxidation ring cleavage; alkynoate preparation; alkyne carboxylate preparation.

An operationally simple oxidation of 5-substituted pyrazol-3(2H)-ones to the corresponding Me 2-alkynoates in good yields with a mediated poly[4-(diacetoxyiodo)styrene] system in methanol and acetonitrile at room temperature was carried out. The polymeric reagent can be regenerated and reused as an environmentally benign reagent.

Journal of the Chinese Chemical Society (Taipei, Taiwan) published new progress about Alkynes Role: SPN (Synthetic Preparation), PREP (Preparation). 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Category: pyrazoles-derivatives.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Anka-Lufford, Lukiana L. published the artcileNickel-Catalyzed Cross-Electrophile Coupling with Organic Reductants in Non-Amide Solvents, SDS of cas: 116228-41-2, the main research area is nickel catalyst cross electrophilic coupling aryl alkyl halide; cross-coupling; green chemistry; heterocycles; homogeneous catalysis; nickel.

Cross-electrophile coupling of aryl halides with alkyl halides has thus far been primarily conducted with stoichiometric metallic reductants in amide solvents. This report demonstrates that the use of tetrakis(dimethylamino)ethylene (TDAE) as an organic reductant enables the use of non-amide solvents, such as acetonitrile or propylene oxide, for the coupling of benzyl chlorides and alkyl iodides with aryl halides. Furthermore, these conditions work for several electron-poor heterocycles that are easily reduced by manganese. Finally, the authors demonstrate that TDAE addition can be used as a control element to ‘hold’ a reaction without diminishing yield or catalyst activity.

Chemistry – A European Journal published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 116228-41-2 belongs to class pyrazoles-derivatives, name is 4-Bromo-1-tosyl-1H-pyrazole, and the molecular formula is C10H9BrN2O2S, SDS of cas: 116228-41-2.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Si, Wei-Jie published the artcileDesign, synthesis, antifungal activity and 3D-QSAR study of novel pyrazole carboxamide and niacinamide derivatives containing benzimidazole moiety, Synthetic Route of 769132-77-6, the main research area is pyrazole carboxamide niacinamide benzimidazole preparation antifungal; quant structure activity relationship.

A series of novel pyrazole carboxamide I (R1 = H, Cl, Me; R2 = Me, CF3), II (R1 = H, Cl, Me; R2 = Me, i-Bu) and niacinamide derivatives III (R1 = H, Cl, Me; R2 = H, Cl, SH) containing a benzimidazole moiety were designed and synthesized as antifungal candidate agents. The structure of compound I (R1 = H; R2 = Me) was confirmed by single crystal X-ray diffraction anal. The antifungal activities of the target compounds were evaluated in vitro against four phytopathogenic fungi (namely Botrytis cinerea, Rhizoctonia solani, Fusarium graminearum and Alternaria solani) by the mycelium growth inhibition method. The bioassay results indicated that some of the compounds exhibited good antifungal activity against B. cinerea at 100 μg ML-1 compared to other three fungi. In order to better explore the structure-activity relationship (SAR), the EC50 values of target compounds against B. cinerea were measured and assessed. Subsequently, a 3D quant. structure-activity relationship (3D-QSAR) study was carried out using the comparative mol. field anal. (CoMFA) technique based on the inhibitory activities of tested compounds against B. cinerea. Mol. modeling results revealed fine predictive ability with cross-validated q2 and non-cross-validated r2 values of 0.578 and 0.850, resp.

New Journal of Chemistry published new progress about Fungal plant disease. 769132-77-6 belongs to class pyrazoles-derivatives, name is 3-Isobutyl-1-methyl-1H-pyrazole-5-carboxylic acid, and the molecular formula is C9H14N2O2, Synthetic Route of 769132-77-6.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Uzoukwu, B. A. published the artcileSpectroscopic studies of Th(IV), La(III) and Pb(II) complexes of 4-trifluoroacetyl and 4-trichloroacetyl derivatives of 3-methyl-1-phenylpyrazol-5-one, Product Details of C12H9F3N2O2, the main research area is acetylpyrazolone lanthanum thorium lead complex preparation; lanthanum acetylpyrazolone complex preparation; thorium acetylpyrazolone complex preparation; lead acetylpyrazolone complex preparation.

Th(IV), La(III) and Pb(II) complexes of 4-trifluoroacetyl and 4-trichloroacetyl derivatives of 3-methyl-1-phenylpyrazol-5-one were synthesized and characterized by elemental, UV, IR,1H and 13C NMR spectral studies. Spectral analyses show that the complexes are dehydrated and have the general mol. formula MLn where M(n) = Th(4),La(3) and Pb(2). The analyses further showed that the CO-M bond of metal-trifluoroacetylpyrazolonate complexes are weaker than the metal-trichloroacetylpyrazolonate complexes.

Journal of the National Science Council of Sri Lanka published new progress about. 1691-93-6 belongs to class pyrazoles-derivatives, name is 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, and the molecular formula is C12H9F3N2O2, Product Details of C12H9F3N2O2.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Aromi, Guillem published the artcileNovel topologies in NiII cluster chemistry: incorporation of alkaline-earth metals in the new [NiII6MgII2] and [NiII8MII] (M = Sr, Ba) cages, Name: 5-Phenyl-1H-pyrazol-3(2H)-one, the main research area is nickel alk earth pivalato pyrazolinone polynuclear complex preparation structure; crystal structure nickel alk earth pivalato pyrazolinone polynuclear complex; magnetic property nickel alk earth pivalato pyrazolinone polynuclear complex.

The reaction of [Ni2(H2O)(piv)4(Hpiv)4] (1) (Hpiv = pivalic acid) with Hppo (3-phenylpyrazolin-5-one) in the presence of a base of an alk.-earth metal (MII = MgII, SrII or BaII) led to three different NiII clusters whose structures are controlled by the nature of MII. The formulas of the new heteronuclear cages are [Ni6Mg2(OH)2(ppo)4(piv)10(Hppo)4(MeOH)2] (2), [Ni8Sr(OH)2(ppo)6(piv)10(Hppo)5(Hpiv)2(MeCN)] (3) and [Ni8Ba(OH)2(ppo)6(piv)10(Hppo)5.3(Hpiv)0.7(MeCN)2] (4). Magnetic measurements indicate that the spin ground state of 2 consists of two independent S = 3 units, while the presence of two noninteracting S = 2 fragments in the mol. is postulated for compounds 3 and 4.

Dalton Transactions published new progress about Antiferromagnetic exchange. 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Name: 5-Phenyl-1H-pyrazol-3(2H)-one.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Burja, Bojan published the artcileA simple approach to pyrazol-3-ones via diazenes, Quality Control of 27412-71-1, the main research area is arylpropenoic acid oxalyl chloride activation methyl carbazate amidation; hydrazide arylpropenoic acid preparation oxidation zirconium tetrachloride cyclization; nitrogen protected arylpyrazolone preparation deprotection; arylpyrazolone preparation.

An efficient entry into pyrazol-3-ones is described starting from propenoic acids that were first transformed into the corresponding hydrazides. Oxidation of the hydrazides gave the diazenes and the latter cyclized to pyrazol-3-ones on treatment with ZrCl4. The methoxycarbonyl protection of the N-1 of the pyrazolone derivatives was easily removed under mild reaction conditions.

Tetrahedron published new progress about Amidation. 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Quality Control of 27412-71-1.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Sita, N. Mahalakshmi published the artcileEquilibrium studies of lanthanide(III) complexes of 1-phenyl-3-methyl-4-benzoyl pyrazolone-5 (PMBP) and 1-phenyl-3-methyl-trifluoroacetyl-pyrazolone-5 (PMTFP), COA of Formula: C12H9F3N2O2, the main research area is rare earth complex PMBP PMTFP stability; pyrazolone benzoyl fluoroacetyl lanthanide complex stability.

The stability constants of [Ln(PMBP)3.NO3] and [Ln(PMTFP)3] complexes have been determined by the potentiometric method and the values obtained practically agree for the whole series of lanthanides for both types of complexes. The “”gadolinium break”” is also evident. Under the same exptl. conditions, the competitive coordination reaction of the ligands with Ca2+ and Na+ have been carried out whose ionic radii are almost the same but their charges are different. The IR spectral studies show that in the PMBP and PMTFP complexes, the ligands are similarly coordinated by the carbonyl oxygen groups. The multiplet pattern of NMR spectra which partially disappears on coordination of the ligands shows a more rigid structure for PMBP than for PMTFP complexes.

Indian Journal of Chemistry, Section A: Inorganic, Bio-inorganic, Physical, Theoretical & Analytical Chemistry published new progress about IR spectra. 1691-93-6 belongs to class pyrazoles-derivatives, name is 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, and the molecular formula is C12H9F3N2O2, COA of Formula: C12H9F3N2O2.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics