Category: pyrazoles-derivatives

Li, Fang published the artcileMetal-ion controlled solid-state reactivity and photoluminescence in two isomorphous coordination polymers, Quality Control of 19959-71-8, the publication is Inorganic Chemistry Frontiers (2014), 1(2), 172-177, database is CAplus.

Reactions of [M(NH₃)₂]OH (M = Ag and Cu) and 4-(1H-pyrazol-4-yl)pyridine (Hpypz), using p-xylene (C₈H₁₀) as the template, gave isomorphous two-dimensional porous metal azolate frameworks [Ag₂(pypz)₂]·0.5C₈H₁₀ (MAF-36(Ag), 1·g) and [Cu₂(pypz)₂]·0.5C₈H₁₀ (MAF-36(Cu), 2·g). Powder and single-crystal x-ray diffraction studies showed that, upon guest removal, 1·g transformed into a three-dimensional nonporous framework [Ag₆(pypz)₆] (1‘), while 2·g can retain its porous two-dimensional structure. Depending on the metal ion, framework flexibility/rigidity, and/or porosity, 1·g and 2·g, as well as their guest-free derivatives, showed distinctly different photoluminescence and guest-responsive behaviors.

Inorganic Chemistry Frontiers published new progress about 19959-71-8. 19959-71-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Pyridine, name is 4-(1H-Pyrazol-4-yl)pyridine, and the molecular formula is C8H7N3, Quality Control of 19959-71-8.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Wu, Jing published the artcileElectronic and steric effects of substituents in series of Zn²⁺ asymmetrical bis-Schiff-base ligands complexes on catalytic ring-opening copolymerization of CHO and MA, SDS of cas: 4551-69-3, the publication is Journal of Organometallic Chemistry (2014), 302-311, database is CAplus.

Based on the half-unit Schiff-base ligand HL and series of asym. bis-Schiff-base ligand H₂Lⁿ (n = 1-6) in situ synthesized from the reaction of 1-phenyl-3-methyl-4-benzoyl-5-pyrazolone (PMBP), o-phenylenediamine, and/or different salicylaldehyde derivatives, complexes [Zn(L)₂] (1) and series of [Zn(Lⁿ)] (n = 1-6, 2-7) are obtained, resp. Complex 1 proves to be inactive, resulting from its saturated octahedral coordination environment around the central Zn²⁺ ion, while in complexes 2-7, the unsaturated coordination environment for the catalytic active centers (Zn²⁺ ions) permits the monomer insertion for the effective bulk or solution copolymerization of CHO (cyclohexene oxide) and MA (maleic anhydride). As to the electron and steric effect in complexes 2-7 on the catalytic behaviors, the copolymerization results show that the introduction of withdrawing -Br substituent para to the phenoxide group endows higher reactive activity, while the bulkiness effect of the encumbering substituent (-Br, -OMe or tert-butyl) ortho to the phenoxide groups is in favor of the chain growth of the copolymers. Moreover, all the bulk copolymerizations in 2-7/DMAP (4-(dimethylamino)pyridine) systems afford poly(ester-co-ether)s, while lower catalyst and co-catalyst concentration for 3/DMAP system is helpful for the formation of perfectly alternating polyester in solution Of the three co-catalysts, DMAP is found to be the most efficient, while an excess thereof is detrimental for the chain growth of the copolymers.

Journal of Organometallic Chemistry published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C17H14N2O2, SDS of cas: 4551-69-3.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Zhu, Luqun published the artcileA trinuclear [Zn₃(L)₂(OAc)₂] complex based on the asymmetrical bis-Schiff-base ligand H₂L for ring-opening copolymerization of CHO and MA, Application of 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, the publication is Inorganic Chemistry Communications (2013), 182-185, database is CAplus.

Based on asym. bis-Schiff-base ligand H₂L from o-vanillin and the half-unit Schiff-base precursor HL synthesized from 1-phenyl-3-methyl-4-benzoyl-5-pyrazolone (PMBP) and o-phenylenediamine, a trinuclear [Zn₃(L)₂(OAc)₂] (1) is obtained. In complex 1, the unsaturated five and four-coordinate coordination environment for the catalytic active centers (Zn²⁺ ions) permits the monomer insertion for the effective bulk or solution copolymerization of CHO (cyclohexene oxide) and MA (maleic anhydride) in the presence of co-catalyst of DMAP (4-(dimethylamino)pyridine), TPP (triphenylphosphine) or n-Bu₄NBr. All the bulk copolymerizations afford poly(ester-co-ether)s, while some of the solution copolymerizations produce perfectly alternating polyester copolymers. Of the three co-catalysts, DMAP is found to be the most efficient, while an excess thereof is detrimental for chain growth of the copolymers.

Inorganic Chemistry Communications published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C12H16N2O2, Application of 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Pan, Fu-de published the artcileDetermination of total amount of rare earth elements in tea by arsenazo III-spectrophotometry coupled with extraction with PMBP, Name: 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, the publication is Lihua Jianyan, Huaxue Fence (2016), 52(1), 93-95, database is CAplus.

In the work, the sample was subjected to mixed acid digestion, the test solution was purified by combined masking, extraction, and back extraction methods, and the content of rare earth elements was determined by arsenazo III-spectrophotometry. The results of the method were accurate and reliable. Spectrophotometry had the advantages of simplicity, fastness, low cost, etc., and had the significance of popularization and application.

Lihua Jianyan, Huaxue Fence published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C17H14N2O2, Name: 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Liu, Chen-Fei published the artcileIridium(III)-Catalyzed Tandem Annulation Synthesis of Pyrazolo[1,2-α]cinnolines from Pyrazolones and Sulfoxonium Ylides, Application In Synthesis of 4551-69-3, the publication is Journal of Organic Chemistry (2019), 84(1), 409-416, database is CAplus and MEDLINE.

A highly efficient iridium-catalyzed cascade annulation of pyrazolones and sulfoxonium ylides to access various pyrazolo[1,2-α]cinnoline derivatives has been achieved. This novel approach expanded the application scope of coupling partners to ylides. The control experiments were performed to give insight into the mechanism of this reaction.

Journal of Organic Chemistry published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C17H14N2O2, Application In Synthesis of 4551-69-3.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Ma, Jingyi published the artcileSynthesis, physicochemical and antimicrobial properties of cardanol-derived quaternary ammonium compounds (QACs) with heterocyclic polar head, Application of 1-Methylpyrazole, the publication is Journal of Molecular Liquids (2019), 111669, database is CAplus.

As new biomass derived raw material, cardanol has attracted the attention of numerous academic and industrial groups due to its renewability and unique structural features. In this work, seven cardanol-derived quaternary ammonium compounds (QACs) were synthesized with their physicochem. properties and antimicrobial ability evaluated. The surface tension was measured in aqueous medium by the platinum ring method, 2b has the optimal surface activities, which is considerably better than commercialized QAC product cetyltrimethylammonium bromide. Both broth dilution method and agar dilution method were used to obtain the MIC and MBC values of the targeted QACs. 1a, 1b, 2b inhibit the tested bacterial at a concentration of 32μg/mL. SEM (SEM) results intuitively showed that the QACs could interact with the bacterial cell membrane, for disrupting the integrity of the membrane. Meanwhile, it was found that the antimicrobial activity depended not only on the alkyl chain length, but also on the CMC value. To sum, seven cardanol-derived QACs were synthesized easily, which showed excellent surface activities and antimicrobial activity, as a promising alternative to the existing fossil fuel derived cationic surfactants and antiseptics.

Journal of Molecular Liquids published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C4H6N2, Application of 1-Methylpyrazole.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Wang, Yingjun published the artcileSynthesis of Neutral Brilliant Yellow 3GL, Computed Properties of 14580-22-4, the publication is Pige Huagong (2002), 19(4), 23-27, database is CAplus.

The neutral brilliant yellow 3GL was synthesized by condensing 2,4-diaminobenzenesulfonic acid with cyanuric chloride, condensing with aniline, diazotizing, and then coupling with 3- methyl-1-(2-chlorophenyl)-5(4H)-pyrazolone (I). The intermediate (I) was also synthesized from 2-chloroaniline by diazotization, reduction, hydrolysis, condensation with Et acetoacetate, and self-cyclization.

Pige Huagong published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C4H5NS2, Computed Properties of 14580-22-4.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Sakai, Holt A. published the artcileCross-Electrophile Coupling of Unactivated Alkyl Chlorides, Recommanded Product: 4-Chloro-1-methyl-1H-pyrazolo[3,4-b]pyridine, the publication is Journal of the American Chemical Society (2020), 142(27), 11691-11697, database is CAplus and MEDLINE.

Overcoming intrinsic limitations of C(sp³)-Cl bond activation, the development of a novel organosilane reagent Si(TMS)₃(N)R¹R² (R¹ = adamantyl, tert-Bu, i-Pr, n-Bu; R² = H) that can participate in chlorine atom abstraction under mild photocatalytic conditions were reported. In particular, the application of this mechanism to a dual nickel/photoredox catalytic protocol that enables the first cross-electrophile coupling of unactivated alkyl chlorides R³Cl (R³ = cyclohexyl, oxan-4-yl, 4-cyanobutyl, etc.) and aryl chlorides R⁴Cl (R⁴ = pyridin-4-yl, quinolin-3-yl, 2-(methylsulfanyl)pyrimidin-5-yl, etc.) was described. Employing these low-toxicity, abundant, and com. available organochloride building blocks, this methodol. allows access to a broad array of highly functionalized C(sp₂)-C(sp₃) coupled adducts, e.g., I including numerous drug analogs.

Journal of the American Chemical Society published new progress about 1268520-92-8. 1268520-92-8 belongs to pyrazoles-derivatives, auxiliary class Other Aromatic Heterocyclic,Chloride, name is 4-Chloro-1-methyl-1H-pyrazolo[3,4-b]pyridine, and the molecular formula is C7H6ClN3, Recommanded Product: 4-Chloro-1-methyl-1H-pyrazolo[3,4-b]pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Toutov, Anton A. published the artcileSilylation of C-H bonds in aromatic heterocycles by an Earth-abundant metal catalyst, Product Details of C4H6N2, the publication is Nature (London, United Kingdom) (2015), 518(7537), 80-84, database is CAplus and MEDLINE.

Heteroaromatic compounds containing C-Si (C-Si) bonds are of great interest in the fields of organic electronics and photonics, drug discovery, nuclear medicine and complex mol. synthesis, because these compounds have very useful physicochem. properties. Many of the methods now used to construct heteroaromatic C-Si bonds involve stoichiometric reactions between heteroaryl organometallic species and Si electrophiles or direct, transition-metal-catalyzed intermol. C-H (C-H) silylation using Rh or Ir complexes in the presence of excess H acceptors. Both approaches are useful, but their limitations include functional group incompatibility, narrow scope of application, high cost and low availability of the catalysts, and unproven scalability. For this reason, a new and general catalytic approach to heteroaromatic C-Si bond construction that avoids such limitations is highly desirable. Here the authors report an example of cross-dehydrogenative heteroaromatic C-H functionalization catalyzed by an Earth-abundant alkali metal species. Readily available and inexpensive K tert-butoxide catalyzes the direct silylation of aromatic heterocycles with hydrosilanes, furnishing heteroarylsilanes in a single step. The silylation proceeds under mild conditions, in the absence of H acceptors, ligands or additives, and is scalable to >100 g under optionally solvent-free conditions. Substrate classes that are difficult to activate with precious metal catalysts are silylated in good yield and with excellent regioselectivity. The derived heteroarylsilane products readily engage in versatile transformations enabling new synthetic strategies for heteroaromatic elaboration, and are useful in their own right in pharmaceutical and materials science applications.

Nature (London, United Kingdom) published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C6H10N2, Product Details of C4H6N2.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Avinesh, P. published the artcileFacile Synthesis of Fully Decorated Imidazo[4,5-b] and Imidazo[4,5-c] Pyridines in Aqueous DMF via C-H Activation under Microwave Irradiation, HPLC of Formula: 1190875-39-8, the publication is ChemistrySelect (2016), 1(10), 2265-2270, database is CAplus.

Catalytic C-H bond activation of heteroarenes has gained tremendous potential in recent years due to their environmentally and economically benign nature. In this paper, the regioisomeric synthesis of fully decorated imidazopyridines, e.g., I employing a C-H activation protocol with a wide range of aryl/hetero aryl/alkyl boronic acids, e.g., II in aqueous DMF is reported. The use of inexpensive copper catalyst and bathophenanthroline as ligand were found to be instrumental in driving these reactions to completion. This optimized protocol was further extended to alkyl/aryl/heteroaryl potassium organo trifluoroborates such as potassium trifluoro(4-methoxyphenyl)boranuide, potassium trifluoro[4-(trifluoromethyl)phenyl]boranuide, potassium trifluoro(3,4,5-trimethylphenyl)boranuide, etc. A wide range of diversely substituted imidazo pyridine analogs which are known for their potential therapeutic applications have been synthesized using this highly efficient and atom economical protocol.

ChemistrySelect published new progress about 1190875-39-8. 1190875-39-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Piperidine,Boronic acid and ester,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (1-(1-(tert-Butoxycarbonyl)piperidin-4-yl)-1H-pyrazol-4-yl)boronic acid, and the molecular formula is C13H22BN3O4, HPLC of Formula: 1190875-39-8.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics