Category: pyrazoles-derivatives

Kudo, Noriaki published the artcileA versatile method for Suzuki cross-coupling reactions of nitrogen heterocycles, Category: pyrazoles-derivatives, the publication is Angewandte Chemie, International Edition (2006), 45(8), 1282-1284, database is CAplus and MEDLINE.

A wide-ranging study of Suzuki reactions which use nitrogen-containing heterocycles was described. This method was highly versatile (a single procedure was used for all substrates, including boronate esters and trifluoroborates), compatible with a variety of unprotected functionalities (e.g., NH₂– and OH-substituted substrates), and efficient even with inactivated aryl chlorides.

Angewandte Chemie, International Edition published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C3H5BN2O2, Category: pyrazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Kudo, Noriaki published the artcileA versatile method for Suzuki cross-coupling reactions of nitrogen heterocycles, Application of (1-Isobutyl-1H-pyrazol-5-yl)boronic acid, the publication is Angewandte Chemie, International Edition (2006), 45(8), 1282-1284, database is CAplus and MEDLINE.

A wide-ranging study of Suzuki reactions which use nitrogen-containing heterocycles was described. This method was highly versatile (a single procedure was used for all substrates, including boronate esters and trifluoroborates), compatible with a variety of unprotected functionalities (e.g., NH₂– and OH-substituted substrates), and efficient even with inactivated aryl chlorides.

Angewandte Chemie, International Edition published new progress about 847818-64-8. 847818-64-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Pyrazole,Boronic Acids,Boronic acid and ester, name is (1-Isobutyl-1H-pyrazol-5-yl)boronic acid, and the molecular formula is C7H13BN2O2, Application of (1-Isobutyl-1H-pyrazol-5-yl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Chumakov, Yu. M. published the artcileCrystal structure of bis(4-benzoyl-3-methyl-1-phenyl-4,5-dihydro-1H-pyrazol-5-onato)-(ethanol)-dioxourane(VI) ethanol solvate, Recommanded Product: 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, the publication is Journal of Structural Chemistry (2014), 55(6), 1116-1119, database is CAplus.

The crystal structure of bis(4-benzoyl-3-methyl-1-phenyl-4,5-dihydro-1H-pyrazol-5-onato)-(EtOH)-dioxourane(VI) EtOH solvate [UO₂L₂(EtOH)]·EtOH (I), where HL is 4-benzoyl-3-methyl-1-phenyl-4,5-dihydro-1H-pyrazol-5-one, is determined The asym. part on the unit cell of the crystal structure of I contains the complex of uranyl ion with two bidentately coordinated L^– ions and coordinated mol. of EtOH. In the outer coordination sphere of the central atom, the solvated EtOH mol. is located. The coordination polyhedron of the U atom in complex I is a pentagonal bipyramid. Its equatorial plane is composed of O atoms of HL and EtOH. In the axial positions of the metal coordination polyhedron the O atoms are located. In the crystal, the complexes of the studied compound are linked together via H bonds of the outer-sphere EtOH mol. in chains along the [100] direction. Between the chains in the crystal, the van der Waals interaction occurs.

Journal of Structural Chemistry published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C17H14N2O2, Recommanded Product: 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Pettinari, Riccardo published the artcileCytotoxicity of Ruthenium-Arene Complexes Containing β-Ketoamine Ligands, Product Details of C17H14N2O2, the publication is Organometallics (2013), 32(1), 309-316, database is CAplus.

New ruthenium(II) arene derivatives (arene = p-cymene, benzene, hexamethylbenzene) containing β-ketoamine ligands L’ (HL’ in general; in detail, HL^ph,ph = (4Z)-3-methyl-4-((phenylamino)(phenyl)methylene)-1-phenyl-1H-pyrazol-5(4H)-one, HL^naph,ph = (4Z)-3-methyl-4-((phenyamino)(naphthalen-2-yl)methylene)-1-phenyl-1H-pyrazol-5(4H)-one, HL^et,ph = (4Z)-3-methyl-4-(1-(phenylamino)propylidene)-1-phenyl-1H-pyrazol-5(4H)-one) have been synthesized and characterized by spectroscopy (IR, ESI-MS, ¹H and ¹³C NMR) and elemental anal. The ligands in the anionic form coordinate ruthenium in a chelating κ²N,O-bidentate fashion, affording 1:1 derivatives of the formula [Ru(arene)(L’)Cl]. Further reaction of [Ru(p-cymene)(L’)Cl] with AgPF₆ or PTA (PTA = 1,3,5-triaza-7-phosphaadamantane) in methanol affords [Ru(p-cymene)(L’)(CH₃OH)][PF₆] and [Ru(p-cymene)(L’)(PTA)]Cl, resp. The solid-state structures of the ligand HL^et,ph and complexes [Ru(p-cymene)(L^ph,ph)Cl], [Ru(p-cymene)(L^naph,ph)Cl], and [Ru(p-cymene)(L^et,ph)Cl] have been determined by single-crystal x-ray diffraction. The antitumor activity of both the ligands and complexes has been evaluated against the human ovarian carcinoma cell line A2780 and its cisplatin-resistant equivalent A2780R, some of the complexes showing significant cytotoxicity toward the cisplatin-resistant cell line.

Organometallics published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C17H14N2O2, Product Details of C17H14N2O2.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Duncton, Matthew A. J. published the artcileArylphthalazines. Part 2: 1-(Isoquinolin-5-yl)-4-arylamino phthalazines as potent inhibitors of VEGF receptors I and II, Recommanded Product: 1H-Pyrazole-4-boronic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2006), 16(6), 1579-1581, database is CAplus and MEDLINE.

A novel class of 1-(isoquinolin-5-yl)-4-arylamino-phthalazines is described as inhibitors of vascular endothelial growth factor receptor II (VEGFR-2). Many compounds display VEGFR-2 inhibitory activity with an IC₅₀ as low as 0.017 μM in an HTRF enzymic assay. The compounds also inhibit VEGFR-1, a related tyrosine kinase.

Bioorganic & Medicinal Chemistry Letters published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C3H5BN2O2, Recommanded Product: 1H-Pyrazole-4-boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Wrzeciono, U. published the artcileAzoles. Part 2: furyl and 5-nitrofuryl derivatives of 1-chlorophenyl-3-methylpyrazolones(5), Computed Properties of 14580-22-4, the publication is Pharmazie (1978), 33(5), 264-6, database is CAplus and MEDLINE.

Condensation of the furfurals I (R = H, Me) with the pyrazolones II (R¹ = 2-, 3-, 4-Cl) gave III (R, R¹ as above, R²R³ = bond), which were readily reduced by NaBH₄ to III (R² = R³ = H), having bactericidal activity against Staphylococcus aureus at 39-1250 mg/mL.

Pharmazie published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C7H16ClNO2, Computed Properties of 14580-22-4.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Li, Shasha published the artcileMerging Late-Stage Diversification with Solid-Phase Peptide Synthesis Enabled by High-Throughput On-Resin Reaction Screening, Safety of 1-(3-Chlorophenyl)pyrazole-4-boronic acid, the publication is ACS Catalysis (2022), 12(5), 3201-3210, database is CAplus.

An integrated workflow is described that combines micromole-scale high-throughput experimentation (HTE) reaction screening and solid-phase peptide synthesis (SPPS) to enable rapid synthetic method development for on-resin peptide diversification. Using this new approach, we have identified several sets of robust Suzuki-Miyaura coupling conditions with complementary scope that collectively display broad coverage with respect to both resin-bound peptide substrates containing aryl halide side chains and (hetero)arylboronic acid coupling partners. We have also demonstrated the utility of this integrated SPPS/chem. diversification method by synthesizing a multidimensional library of diverse peptides in high yields.

ACS Catalysis published new progress about 1072945-88-0. 1072945-88-0 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is 1-(3-Chlorophenyl)pyrazole-4-boronic acid, and the molecular formula is C9H8BClN2O2, Safety of 1-(3-Chlorophenyl)pyrazole-4-boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Belyy, Alexander Yu. published the artcileA New Simple Procedure for the Synthesis of Heptamethyl Cyclohepta-1,3,5-triene-1,2,3,4,5,6,7-heptacarboxylate, COA of Formula: C4H6N2, the publication is Synlett (2018), 29(9), 1157-1160, database is CAplus.

A new and simple procedure for the synthesis of heptamethyl cyclohepta-1,3,5-triene-1,2,3,4,5,6,7-heptacarboxylate in a 51% yield was presented. An optimization of the reaction conditions was performed and a convenient protocol for the isolation of the reaction product was developed. The structure of the key electrophilic intermediate was determined by means of NMR spectroscopy and a plausible reaction mechanism was proposed.

Synlett published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C4H6N2, COA of Formula: C4H6N2.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Bercean, Vasile-Nicolae published the artcileNew azo compounds derived from 1H-5-amino-4-ethoxycarbonyl-3-methyl-pyrazole and 3-mono- or 1,3-disubstituted pyrazol-5-ones, Synthetic Route of 23286-70-6, the publication is Revista de Chimie (Bucharest, Romania) (2010), 61(4), 364-367, database is CAplus.

Pyrazole-derived azo compounds were designed, and the synthesis of the target compounds was achieved by a coupling reaction of 3-amino-5-methyl-1H-pyrazole-4-carboxylic acid Et ester (I) with pyrazolone derivatives The products thus obtained were confirmed by MS, IR, UV-VIS, ¹H-NMR, and ¹³C-NMR, and existed in multiple tautomeric forms.

Revista de Chimie (Bucharest, Romania) published new progress about 23286-70-6. 23286-70-6 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Amine,Ester, name is Ethyl 5-amino-3-methyl-1H-pyrazole-4-carboxylate, and the molecular formula is C7H11N3O2, Synthetic Route of 23286-70-6.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Bercean, Vasile-Nicolae published the artcileAzo compounds derived from 1H-5-amino-4-ethoxycarbonyl-3-methyl-pyrazole and phenols or phenolic derivatives and possibilities of their cyclization to pyrazolo[5,1-c]benzo[1,2-e][1,2,4]triazines, Computed Properties of 23286-70-6, the publication is Revista de Chimie (Bucharest, Romania) (2011), 62(2), 154-157, database is CAplus.

The coupling reaction of 1H-4-ethoxycarbonyl-3-methylpyrazol-5-yldiazonium chloride with phenols and phenolic derivatives led to 1H-5-arylazo-4-ethoxycarbonyl-3-methylpyrazoles. Cyclization of one of the latter compounds, [1H-4-ethoxycarbonyl-5-(4,6-dimethoxy-2-hydroxyphenylazo)-3-methylpyrazole] gave the corresponding pyrazolo[5,1-c]benzo[1,2-e][1,2,4]triazine.

Revista de Chimie (Bucharest, Romania) published new progress about 23286-70-6. 23286-70-6 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Amine,Ester, name is Ethyl 5-amino-3-methyl-1H-pyrazole-4-carboxylate, and the molecular formula is C7H11N3O2, Computed Properties of 23286-70-6.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics