Category: pyrazoles-derivatives

Synthetic Route of 139756-02-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 139756-02-8, name is 4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

2) 1-methyl-3-propyl-4 – (2-propoxy benzamido- ) pyrazole-5-carboxamide preparation: heating 7.5mmol2-propoxy benzoyl chloride is dissolved in a 50 mu L methylene chloride, by adding 0.07g4-dimethyl aminopyridine, 0.5 ml triethylamine, stirring slowly dripping 6.8mmol4-amino-1-methyl-3-n-propyl -1H-pyrazole-5-carboxamide, microwave heating 100 C reaction 5 minutes, after the reaction of the organic solvent is removed by reduced pressure distillation, a small amount of ethanol re-crystallization, drying after filtration, a kind of white obtained 1-methyl-3-propyl-4 – (2-propoxy benzamido- ) pyrazole-5-carboxamide, the yield is 80-84%;

The synthetic route of 4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide has been constantly updated, and we look forward to future research findings.

Application of 35100-92-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35100-92-6, name is 1,5-Dimethyl-1H-pyrazol-3-amine, This compound has unique chemical properties. The synthetic route is as follows.

Combine c/s-4-[(4-bromo- I -methyi-1H-benzimidazoi-6-vi)oxyj cyciohexanamine(25.70 g, 79.27 rnrnol), 1.5-dimethyi-1H-pyrazol-3-arnine (9.08 g, 1.0 eq), potassiumcarbonate (28.48 g, 2.6 eq), 2-(dicyclohexvlphosphino)3,6-dimethoxy-2?,4?,6?- tisopropyi- 1,1 ?-biphenyl (8.60 g, 0,20 eq), tris(dibenzylideneacetone)dipailadium(0) (3.63 g, 0.050 eq), and acetic acid (0.14 rnL) in tert-butyl alcohol (250 mL). Heat at reflux overnight. Concentrate the reaction mixture in vacuo. Add DCM and water;separate the layers. Dry the organics over anhydrous magnesium sulfate, filter, and concentrate in vacuo. Triturate from EtOAc and hexanes to give a tan solid. Subject the tan solid to normal phase chromatography, eluting with hexanes, then 5% MeOFI in DCM, then 20% 2M amrnoniated MeOH in DCM, to give the title compound as a tan solid (21,71 g, 77%). MS (ES) m/z = 355 (M-t-H).

The chemical industry reduces the impact on the environment during synthesis 1,5-Dimethyl-1H-pyrazol-3-amine. I believe this compound will play a more active role in future production and life.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 31728-75-3, name is 1,5-Dimethyl-1H-pyrazole-4-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., Formula: C6H8N2O2

The 1,5-Dimethyl-1H-pyrazole-4-carboxylic acid [3-(3-hydroxymethylene-2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide was prepared from 3-nitrobenzoyl chloride using the following multiple step procedure: Step 1: 1,5-Dimethyl-1H-pyrazole-4-carboxylic acid [3-(2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide.; A dry flask was charged with 1,5-Dimethyl-1H-pyrazole-4-carboxylic acid (0.144 g, 1.03 mmol) and thionyl chloride (5 mL) and allowed to stir at 79 C. for 3 h. The thionyl chloride was then removed by concentration in vacuo. The crude acid chloride was cooled to room temperature, and then dissolved in THF (101 mL). 6-(3-Amino-benzoyl)-1,3-dihydro-indol-2-one (as prepared in Example 40, 0.260 g, 1.03 mmol) was added to the THF solution of the acid chloride, and the mixture was allowed to reflux overnight. The reaction mixture was then allowed to cool to room temperature and filtered. The solid residue was washed with 0 C. THF and collected to afford the 1,5-Dimethyl-1H-pyrazole-4-carboxylic acid [3-(2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide as a solid (0.177 g, 0.47 mmol, 46%).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 31728-75-3.

Electric Literature of 1904-31-0,Some common heterocyclic compound, 1904-31-0, name is 1-Methyl-1H-pyrazol-3-amine, molecular formula is C4H7N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Preparation of 2-[4-(2,3-difluoro-phenoxy)-2-oxo-2H-pyridin-1-yl]-4-methyl-pentanoic acid (1-methyl-1H-pyrazol-3-yl)-amide: A solution of 2-[4-(2,3-difluoro-phenoxy)-2-oxo-2H-pyridin-1-yl]-4-methyl-pentanoic acid (100 mg, 0.3 mmol) in N,N-dimethylformamide (2 mL) at 25¡ã C. was treated with N,N-diisopropyethylamine (0.15 mL, 0.9 mmol), O-(7-azabenzotriazol-1-yl)-N,N,N’N’-tetramethyluronium hexafluorophosphate (HATU) (171 mg, 0.45 mmol) and 1-methyl-1H-pyrazol-3-ylamine (32 mg, 0.33 mmol). The reaction was stirred at 25¡ã C. overnight. At this time, the reaction was diluted with ethyl acetate (30 mL) and was washed with a saturated aqueous ammonium chloride solution (20 mL), a saturated aqueous sodium bicarbonate solution (20 mL) and a saturated aqueous sodium chloride solution (20 mL), dried over anhydrous sodium sulfate, filtered, rinsed and concentrated in vacuo. Silica gel column chromatography (100percent ethyl acetate) afforded 2-[4-(2,3-difluoro-phenoxy)-2-oxo-2H-pyridin-1-yl]-4-methyl-pentanoic acid (1-methyl-1H-pyrazol-3-yl)-amide (95 mg, 76percent) as a white solid; ES+-HRMS m/e calcd for C21H22N4O3F2 [M+H+]417.1733, found 417.1733; 1H NMR (400 MHz, DMSO-d6) delta ppm 10.96 (s, 1H), 7.83 (d, J=7.9 Hz, 1H), 7.55 (d, J=2.0 Hz, 1H), 7.40-7.49 (m, 1H), 7.23-7.37 (m, 2H), 6.38 (d, J=2.0 Hz, 1H), 6.22 (dd, J=7.9, 2.8 Hz, 1H), 5.74 (dd, J=11.6, 4.9 Hz, 1H), 5.55 (d, J=2.8 Hz, 1H), 3.74 (s, 3H), 1.97-2.07 (m, 1H), 1.77 (ddd, J=14.2, 9.6, 4.9 Hz, 1H), 1.23-1.37 (m, 1H), 0.88 (d, J=6.6 Hz, 3H), 0.85 (d, J=6.6 Hz, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-1H-pyrazol-3-amine, its application will become more common.

Synthetic Route of 111493-52-8,Some common heterocyclic compound, 111493-52-8, name is 5-Chloro-1-methyl-1H-pyrazole-4-carbonitrile, molecular formula is C5H4ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 4: 5-(5-chloro- l -methyl-lH-pyrazole-4-yl)-2H-tetrazole The above product, 5-chloro- l -methyl- lH-pyrazole-4-carbonitrile ( 13.0 gm, 0.092 moles), was dissolved in DMF (40 ml), followed by addition of ammonium chloride (9.9 gm, 0.184 moles) and sodium azide (12.0 gm, 0.184 moles) and stirred at 100- 140C for 10- 16 hours. The progress of the reaction was monitored by HPLC. The reaction mixture was cooled at 0- 5C and quenched with aqueous HC1 (78.0 ml) and stirred for 30-60 min at 0-5C. The solid material obtained was filtered, washed with cold DM water (40 ml) and dried at 60-65C to yield the product, 5-(5-chloro-l -methyl- lH-pyrazole-4-yl)-2H-tetrazole Dry wt : 16.2 gm Yield . : 1 .25 w/w (96%) HPLC purity : 99.26% MP : 215-219C

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Chloro-1-methyl-1H-pyrazole-4-carbonitrile, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 360056-45-7, name is Methyl 4-amino-1H-pyrazole-3-carboxylate, A new synthetic method of this compound is introduced below., name: Methyl 4-amino-1H-pyrazole-3-carboxylate

2A. 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid 2,6-dichlorobenzoyl chloride (8.2 g; 39.05 mmol) was added cautiously to a solution of 4-amino-1H-pyrazole-3-carboxylic acid methyl ester (prepared in a manner analogous to 165B) (5 g; 35.5 mmol) and triethylamine (5.95 ml; 42.6 mmol) in dioxan (50 ml) then stirred at room temperature for 5 hours. The reaction mixture was filtered and the filtrate treated with methanol (50 ml) and 2M sodium hydroxide solution (100 ml), heated at 50 C. for 4 hours, and then evaporated. 100 ml of water was added to the residue then acidified with concentrated hydrochloric acid. The solid was collected by filtration, washed with water (100 ml) and sucked dry to give 10.05 g of 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid as a pale violet solid.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 92525-10-5, name is 3-Iodo-1-methyl-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Formula: C4H5IN2

A suspension of tert-butyl (3S)-3-methyl-5-oxo-piperazine-1 -carboxylate (see Example 73, step b) (280 mg, 1.31 mmol) and 3-iodo-1-methyl-1 H-pyrazole (326 mg, 1.57 mmol) in dioxane (10 ml) was prepared and argon was bubbled for 10 minutes. K3P04 (610 mg, 2.87 mmo), copper (I) iodide (25 mg, 131 pmol) and N,N’-dimethylethylenediamine (28.1 muIota, 261 pmol) were added. The mixture was heated to 120 C for 20 h. The mixture was filtered, the soiids washed twice with ethyl acetate and the filtrate was evaporated. The residue was purified by flash chromatography (EtOAc in heptane 20% to 100%) to afford the title compound (287 mg, 75%) as a light yellow solid. (1042) MS (ESI, m/z): 295.2 [(M+H)+].

The synthetic route of 92525-10-5 has been constantly updated, and we look forward to future research findings.

Related Products of 6715-84-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6715-84-0, name is Methyl 4-Nitro-1H-pyrazole-1-acetate, This compound has unique chemical properties. The synthetic route is as follows.

A clear, pale yellow solution of methyl 2-(4-nitro-1H-pyrazol-1-yl)acetate (0.250 g, 1.35 mmol) in EtOH (27.0 ml) was degassed with argon for 10 min. Then 10% Pd-C (0.072 g, 0.068 mmol) was added. The reaction was degassed with hydrogen from a balloon for several minutes and then the reaction was stirred vigorously under a hydrogen atmosphere. After 3 h, the reaction was stopped. The vessel was purged with argon/vacuum three times. Then Celite was added. After 10 min, the reaction was filtered through a plug of Celite, rinsing with EtOH, to give a clear, colorless filtrate. The filtrate was concentrated to give methyl 2-(4-amino-1H-pyrazol-1-yl)acetate (0.204 g, 97 % yield) as a clear, orange oil. The material was used in the next step without further purification. MS(ESI) m/z: 156.1 (M+H)+.

The chemical industry reduces the impact on the environment during synthesis Methyl 4-Nitro-1H-pyrazole-1-acetate. I believe this compound will play a more active role in future production and life.

52222-73-8, name is 4-(Trifluoromethyl)-1H-pyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C4H3F3N2

55 mg of 2-[3-(ethylsulphonyl)-6-fluoropyridin-2-yl]-1-methyl-5-(trifluoromethyl)-1H-benzimidazole (0.14 mmol) were dissolved in 2 ml of acetonitrile. 29 mg (0.21 mmol) of 4-(trifluoromethyl)-1H-pyrazole and 59 mg (0.42 mmol) of potassium carbonate were added and stirred for 3 h at room temperature. The mixture was filtered, concentrated and purified by column chromatography with a cyclohexane/ethyl acetate gradient as mobile phase. log P (neutral): 4.16; MH+: 504; 1H-NMR (400 MHz, D6-DMSO) delta ppm: 9.38 (s, 1H), 8.712 (d, 1H), 8.46 (s, 1H), 8.42 (d, 1H), 8.16 (s, 1H), 7.98 (d, 1H), 7.70 (dd, 1H), 3.906 (q, 2H), 3.90 (s, 3H), 1.24 (t, 3H).

The synthetic route of 52222-73-8 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 35344-95-7,Some common heterocyclic compound, 35344-95-7, name is 1H-Pyrazole-4-carbaldehyde, molecular formula is C4H4N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a stirring solution of 6bromonicotinaldehyde (1.25 g, 6.72 mmol) in DMF (10 mL) was added K2CO3 (2.32 g, 16.80 mmol) and 4methyl1Himidazole (0.55 g, 6.72 mmol). The resulting mixture was heated at 100 ¡ãC for 1 h then cooled to ambient temperature. The reaction was poured into ice water (30 mL) and extracted with ethyl acetate (2 x 75 mL). The combined organic layers were washed with brine (50 mL), dried over sodium sulfate and evaporated under reduced pressure. The residue was purified by flash chromatography (Redisep40 g, 0100percent EtOAc/nHexane)) to obtain Intermediate 20 (0.50 g, 39.70percent) as light brown solid.1H NMR (300 MHz, DMSOd6) G ppm 2.50 (s, 3 H), 7.76 (s, 1 H), 7.95 (dd, J = 6.00, 1.20 Hz, 1 H), 8.39 (dd, J = 6.60, 1.80 Hz, 1 H), 8.55 (d, 1.20 Hz, 1 H), 8.99 (s, 1 H), 10.08 (s, 1 H), LCMS:(MethodH) retention time :1.03 min, [M+1]: 188.0.

The synthetic route of 35344-95-7 has been constantly updated, and we look forward to future research findings.