Category: pyrazoles-derivatives

Application of 288-13-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 288-13-1, name is 1H-Pyrazole, This compound has unique chemical properties. The synthetic route is as follows.

4-Iodopyrazole (20) [0159] A flask equipped with a nitrogen inlet, an addition funnel, a thermowell, and a mechanical stirrer was charged with pyrazole (1, 450 g, 6.62 mol) and tetrahydrofuran (THF, 5 L) at ambient temperature. The mixture was then cooled to 10 C. and N-iodosuccinimide (NIS, 1490 g, 6.62 mol, 1.0 equiv) was added to the mixture in portions as a solid at approximately 10 C. The resulting reaction mixture was then stirred at ambient temperature for 1 hour (longer reaction times may be necessary depending on ambient temperature). The mixture was then filtered and the THF was removed under reduced pressure. The residue was suspended in ethyl acetate (6 L) and insoluble materials were filtered. The dark filtrate was sequentially washed with saturated aqueous sodium thiosulfate solution (2¡Á3 L) (organic layer lightens to a pale yellow), water (2¡Á3 L), and brine (2 L). The resulting organic layer was then dried over sodium sulfate, filtered, and concentrated under reduced pressure to afford 4-iodopyrazole (1138 g, 1284.1 g theoretical, 88.6%) as a white to pale yellow solid after being dried in a vacuum oven at approximately 30 C. overnight. 1H NMR (400 MHz, DMSO-d6) delta 13.17 (bs, 1H), 7.93 (bs, 1H), 7.55 (bs, 1H) ppm; C3H31N2 (MW, 193.97), LCMS (EI) m/e 195 (M++H).

The chemical industry reduces the impact on the environment during synthesis 1H-Pyrazole. I believe this compound will play a more active role in future production and life.

Electric Literature of 84547-84-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 84547-84-2 name is 4-Bromo-1-methyl-1H-pyrazole-5-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Compound 22 (20 g) was dissolved in 100 mL of concentrated sulfuric acid.33 mL of concentrated nitric acid was slowly added dropwise in an ice water bath.After reacting for 16 h at room temperature, TLC showed a large amount of substrate remaining.After heating to 50 ¡ã C for 16 h, the substrate substantially disappeared.After cooling, the reaction solution was slowly added dropwise to 1 L of ice water.Extract with ethyl acetate and wash the organic phase several times with water until pH = 7.After concentration, column chromatography gave yellowSolid 23 (15 g).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-1-methyl-1H-pyrazole-5-carboxylic acid, and friends who are interested can also refer to it.

Related Products of 10250-64-3,Some common heterocyclic compound, 10250-64-3, name is 1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid, molecular formula is C11H10N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 2. 1 -Methyl-3 -phenyl-N- [( 1 -pyridin-3 -ylcyclohexyl)methyl] – 1 H-pyrazole-5 – carboxamide; A solution of DMC in DCM (1.2 mL, 0.1 M, 1.2 eq.) is added to a solution of 2- methyl-5-phenyl-2H-pyrazole-3-carboxylic acid (20 mg, 0.1 mmol, 1.0 equ.), (1 -pyridin-3 -yl- cyclohexyl)-methylamine (19 mg, 0.1 mmol, 1.0 eq.) and TEA (33 muL, 0.24 mmol, 2. 4 eq.) in DCM (1.0 mL) at RT. After standing overnight at RT, the reaction mixture is purified by PTLC (EtOAc/etaexanes/TEA 50/50/1) to give the title compound. LC/MS (M+l) = 375.16; RT = 1.38 min. *IC50.

The synthetic route of 10250-64-3 has been constantly updated, and we look forward to future research findings.

Related Products of 132712-71-1, A common heterocyclic compound, 132712-71-1, name is 3-Methyl-1H-pyrazol-5-ol, molecular formula is C4H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Dichloromethane (10 mL) was taken in a round-bottomed flask,into which 1.0 equivalent (1 mmol) of triethylamine and pyrazolonewere poured. The mixture was stirred for 2 min without heating. To this mixture, 1.0 equivalent of corresponding presynthesized benzylidene from malononitrile was added. Then the mixture was agitated for 25-30 min. The reaction was observed by TLC. The desired products appeared as precipitates. The precipitates were washed with water to remove the unreacted pyrazolone to obtain pure products. Melting points were recordedfor crystalline substances.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Electric Literature of 1203705-55-8, These common heterocyclic compound, 1203705-55-8, name is 3-Bromo-1H-pyrazol-5-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Methyl 2-(2-bromo-7-hydroxy-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)acetate To a solution of 3-bromo-1H-pyrazol-5-amine (0.2 g, 1.235 mmol) and dimethyl 2-acetylsuccinate (0.697 g, 3.70 mmol) in xylene (10 mL) was added p-toluenesulfonic acid monohydrate (2 mg, 10.51 mumol). The reaction mixture was heated at reflux under a Dean-Stark trap for 8 h. The solid was filtered and washed with hexanes to afford the title compound (0.201 g, 54.2%). 1H NMR (400 MHz, MeOD) delta 2.37 (3H, s), 3.65 (2H, s), 3.71 (3H, s), 6.20 (1H, s).

Statistics shows that 3-Bromo-1H-pyrazol-5-amine is playing an increasingly important role. we look forward to future research findings about 1203705-55-8.

51516-67-7, name is 5-Amino-1-(4-chlorophenyl)-1H-pyrazole-4-carbonitrile, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 51516-67-7

General procedure: To a stirred solution of the intermediate compounds 1a-1d (1 mmol) and triethylamine (2 mmol) in DMF (12 mL) medium, a mixture of EDCI (1 mmol) and HOBt (1mmol) was added and the reaction mixture was stirred at room temperature for 30 min, then a mixture of compounds 2a-2d (1 mmol) and DMF (5 mL) was added, the reaction was stirred at room temperature. And the reaction progress was monitored by TLC. After completion of the reaction, the product was added into chloroform, then extracted from chloroform with water, and washed successively with 0.2 mol/L hydrochloric acid, water,2 mol/L sodium hydroxide, water, saturated sodium chloride, then dried, concentrated and purified by preparative thin layer chromatography (PE:EA = 8:1) followed by recrystallization from ethanol.

The synthetic route of 51516-67-7 has been constantly updated, and we look forward to future research findings.

1260243-04-6, name is Ethyl 5-amino-1H-pyrazole-4-carboxylate, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: pyrazoles-derivatives

To 5-amino-1H-pyrazole-4-carboxylic acid ethyl ester (250 mg, 1.61 mmol) in DCM (10 mL) was added di-tert-butyl dicarbonate (352 mg, 1.61 mmol) and diisopropylethylamine (702 mu, 521 mg, 4.03 mmol) and the reaction stirred at rt overnight. Reaction mixture was diluted with DCM, water added, separated, washed with brine, dried (MgSC ), filtered and concentrated in vacuo. Flash chromatography afforded 1-tert-butyl 4-ethyl 3-aminopyrazole-1,4-dicarboxylate as a white solid (122 mg, 30percent yield). [MH]+ = 256.2

The synthetic route of 1260243-04-6 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 2075-46-9,Some common heterocyclic compound, 2075-46-9, name is 4-Nitro-1H-pyrazole, molecular formula is C3H3N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4-Nitro-1H-pyrazole 12 (10.0 g, 88.4 mmol) was taken in CH3CN (100 mL) in a 250 mL round bottom flask under N2. To it were sequentially added iodomethane (18.8 g, 132.0 mmol) and K2C03 (30.5 g, 221.0 mmol). The reaction mixture was heated at 100C for 1 6h. The reaction mixture was then poured into ice water (100 g) and extracted with EtOAc (3 x 100 mL). The combined organic layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude was further washed with n-pentane to afford 15 as a light yellow solid (10.8 g, 96% yield). ?H NMR (400 MHz, CDC13): 88.11 (s, 1H), 8.05 (s, 1H), 3.96 (s, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Nitro-1H-pyrazole, its application will become more common.

Related Products of 285984-25-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 285984-25-0, name is 3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-amine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a solution of CDI (91 mg, 0.56 mmol) in DCM (1.0 mL) was added Intermediate A1 (129 mg, 0.563 mmol) and the reaction mixture maintained at RT for 2 hr. A portion of this solution (500 pL, 0.28 mmol) was added to a solution of Intermediate B16 (80 mg, 0.19 mmol) in THF (2.0 mL) and the reaction mixture kept at RT for 3 hr and then quenched with the addition of MeOH (2.0 mL). The resulting mixture was evaporated in vacuo and the residue was purified by flash column chromatography (Si02, 12 g, 0-100% [10% MeOH in EtOAc] in isohexane, gradient elution) to afford methyl 5-((4-((4-(3-(3-(ierf-butyl)-1-(p-tolyl)-1 H-pyrazol- 5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)-1 /-/-indazole-3-carboxylate as a pale tan solid (77 mg, 57 %); Rl 2.50 min (Method 2, acidic); m/z 680 (M-H)”, (ES”).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-amine, other downstream synthetic routes, hurry up and to see.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 37687-24-4, name is Diethyl 3,5-pyrazoledicarboxylate, A new synthetic method of this compound is introduced below., HPLC of Formula: C9H12N2O4

2-fluorobenzyl bromide (2.0 ml, 16.58 mmol) was added to a mixture of diethyl 3,5-pyrazoledicarboxylate (3.01 g, 14.18 mmol), Cs2CO3 (5.57 g, 17.1 mmol), and acetonitrile (140 ml) under N2. Heated to 60 C. for two hours and then cooled to room temperature. Filtered and concentrated the reaction solution. Added water (~200 mL) to the resulting residue and extracted with EtOAc. Washed organics with water and brine. Dried organics over sodium sulfate and filtered and concentrated. Obtained diethyl 1-(2-fluorobenzyl)-1H-pyrazole-3,5-dicarboxylate (light-yellow oil) in quantitative yield.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.