Category: pyrazoles-derivatives

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 330792-70-6, Name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, molecular formula is , belongs to pyrazoles-derivatives compound. In a document, author is Ismail, Magda M. F., Quality Control of 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile.

Synthesis of new arylazopyrazoles as apoptosis inducers: Candidates to inhibit proliferation of MCF-7 cells

New 4-arylazo-3,5-diamino-1H-pyrazole derivatives substituted in the 4-aryl ring with the acetyl moiety were designed and synthesized. The antiproliferative activity of the novel arylazopyrazoles was examined against the MCF-7 cell line. Among all target compounds,8b(IC(50)3.0 mu M) and8f(IC(50)4.0 mu M) displayed higher cytotoxicity as compared with the reference standard imatinib (IC(50)7.0 mu M). Further studies to explore the mechanism of action were performed on the most active hit of our library,8b, via anti-CDK2 kinase activity. It demonstrated good inhibitory effects for CDK2 (IC(50)0.24 mu M) with 62.5% inhibition, compared with imatinib. The cell cycle analysis in the MCF-7 cell line revealed apoptosis induction by8band cell cycle arrest at the S phase. Docking in the CDK2 active site and pharmacophore modeling confirmed the affinity of8bto the CDK2 active site. Absorption, distribution, metabolism, and excretion studies revealed that our target compounds are orally bioavailable, with no permeation through the blood-brain barrier.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 330792-70-6, in my other articles. Quality Control of 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

In an article, author is Delancey, Evan, once mentioned the application of 67-51-6, Product Details of 67-51-6, Name is 3,5-Dimethyl-1H-pyrazole, molecular formula is C5H8N2, molecular weight is 96.13, MDL number is MFCD00005243, category is pyrazoles-derivatives. Now introduce a scientific discovery about this category.

Synthesis of 4,4 ‘-(4-Formyl-1H-pyrazole-1,3-diyl)dibenzoic Acid Derivatives as Narrow Spectrum Antibiotics for the Potential Treatment of Acinetobacter Baumannii Infections

Acinetobacter baumannii has emerged as one of the most lethal drug-resistant bacteria in recent years. We report the synthesis and antimicrobial studies of 25 new pyrazole-derived hydrazones. Some of these molecules are potent and specific inhibitors of A. baumannii strains with a minimum inhibitory concentration (MIC) value as low as 0.78 mu g/mL. These compounds are non-toxic to mammalian cell lines in in vitro studies. Furthermore, one of the potent molecules has been studied for possible in vivo toxicity in the mouse model and found to be non-toxic based on the effect on 14 physiological blood markers of organ injury.

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Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Electric Literature of 1985-46-2, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 1985-46-2, Name is N2,N2-Dimethyl-1,3,5-triazine-2,4,6-triamine, SMILES is NC1=NC(N)=NC(N(C)C)=N1, belongs to pyrazoles-derivatives compound. In a article, author is Gumus, Mehmet, introduce new discover of the category.

Enamines and Dimethylamino Imines as Building Blocks in Heterocyclic Synthesis: Reactions of DMF-DMA Reagent with Different Functional Groups

N,N-Dimethylformamide dimethyl acetal (DMF-DMA) reagent can react with different functional groups of organic compounds. Enamines and dimethylamino imines are obtained, when the DMF-DMA reagent is reacted with methylene, methyl and amino groups. These products are formed in the intermediate step in the synthesis of many hetero rings. These compounds are especially used as a starting material in the synthesis of heterostructures such as pyrimidine, pyridine, pyrazole, etc. Therefore, DMF-DMA has been particularly prominent as a reagent in targeted synthesis and designs of many heterocyclic compounds. Herein, the reactions of DMF-DMA reagent with different functional groups are categorized in four classes (methylene, methyl, amino, other groups) and the reactions of obtained enamine and dimethylamino imine compounds are investigated in detail such as nucleophilic addition, intramolecular cyclization or condensation reactions. The synthesis and continuation reactions of the enamine and dimethylamino imine compounds are also examined in terms of experimental conditions and reagents used.

Electric Literature of 1985-46-2, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 1985-46-2.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Electric Literature of 4233-33-4, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 4233-33-4, Name is 4-Phenyl-3H-1,2,4-triazole-3,5(4H)-dione, SMILES is O=C1N=NC(=O)N1C1=CC=CC=C1, belongs to pyrazoles-derivatives compound. In a article, author is Khaleghi Abbasabadi, Masoud, introduce new discover of the category.

Sulfonic acid-functionalized Fe3O4-supported magnetized graphene oxide quantum dots: A novel organic-inorganic nanocomposite as an efficient and recyclable nanocatalyst for the synthesis of dihydropyrano[2,3-c]pyrazole and 4H-chromene derivatives

In this research, the main emphasis has been focused on the preparation of a novel Fe3O4-supported propane-1-sulfonic acid-grafted graphene oxide quantum dots (Fe3O4@GOQD-O-(propane-1-sulfonic acid)) that it was readily synthesized via a five-step procedure as a hitherto unreported magnetic nanocatalyst. This newly prepared Fe3O4@GOQD-O-(propane-1-sulfonic acid) nanocomposite was structurally well-established by different analytical techniques including Fourier transform infrared (FT-IR), X-ray diffraction (XRD), energy-dispersive X-ray (EDX), thermal gravimetric analysis (TGA), field emission gun-scanning electron microscope (FESEM), high-resolution transmission electron microscopy (HRTEM) and vibrating sample magnetometer (VSM) analyses. The high catalytic performance of this nanocomposite was exhibited in one-pot synthesis of dihydropyrano[2,3-c]pyrazole and 4H-chromene derivatives under mild conditions. Low reaction times, excellent yields of the products, benignity of the catalyst, easy reaction work-up and magnetic recyclability of the catalyst are the main advantages of the present protocol. Also, our research indicated that the Fe3O4@GOQD-O-(propane-1-sulfonic acid) could be reused up to five times without considerable loss of catalytic activity.

Electric Literature of 4233-33-4, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 4233-33-4.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 2075-46-9, Name is 4-Nitro-1H-pyrazole, SMILES is C1=N[NH]C=C1[N+]([O-])=O, in an article , author is Puri, Sachin, once mentioned of 2075-46-9, SDS of cas: 2075-46-9.

Monocarboxylate transporter 1 and 4 inhibitors as potential therapeutics for treating solid tumours: A review with structure-activity relationship insights

Development of multidrug resistance (MDR) is one of the major causes leading to failure of cancer chemotherapy and radiotherapy. Monocarboxylate transporters (MCTs) MCT1 and MCT4, which are overexpressed in solid tumours, play a very important role in cancer cell survival and proliferation. These lactate transporters work complimentarily to drive lactate shuttle in tumour cells, which results in maintenance of H+ ion (pH) balance necessary for their survival. Inhibition of these transmembrane proteins has been demonstrated as a novel strategy to treat drug resistant solid cancers. Presently, only a few small molecule MCT1 inhibitors such as AZD3965 and AR-C155858 are known with clinical potential. Even lesser mention of MCT4 inhibitors, which include molecules having scaffolds such as pyrazole and indazole, is available in the literature. Current overview presents the status of recent developments undertaken in identification of efficacious MCT1 and/or MCT4 inhibitors as a potential anticancer therapy overcoming MDR. Further, detailed structure-activity relationships for different classes of compounds has been proposed to streamline the understandings learnt from ongoing research work. Through this review, we aim to highlight the importance of these excellent targets and facilitate future development of selective, potent and safe MCT1 and/or MCT4 inhibitors as promising chemotherapy for drug resistant cancer. (C) 2020 Elsevier Masson SAS. All rights reserved.

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Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

176969-34-9, Name is 3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid, molecular formula is C6H6F2N2O2, Product Details of 176969-34-9, belongs to pyrazoles-derivatives compound, is a common compound. In a patnet, author is Khanagwal, Jyoti, once mentioned the new application about 176969-34-9.

Synthesis and photoluminescence analysis of europium(III) complexes with pyrazole acid and nitrogen containing auxiliary ligands

Four red photoluminescent europium(III) complexes have been synthesized by using fluorinated carboxylate ligand, 1-(4-methoxyphenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid as main ligand and bathophenanthroline, 1,10-phenanthroline and 2,2-bipyridyl as auxiliary ligands, through solution precipitation approach. The complexes possess an optimum thermal stability, which is sufficient for organic light emitting diodes fabrication. Under ultraviolet excitation, the complexes display an intense emission peak of europium ion, which makes them a promising red color emitter in display devices. Internal quantum efficiency, color coordinates, Judd-Ofelt parameters, and energy transfer mechanism have been explored. The investigated antimicrobial and antioxidant activity suggest that the synthesized complexes are potent antimicrobial and antioxidant agents.

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Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Quality Control of Phenylbutazone, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 50-33-9, Name is Phenylbutazone, molecular formula is C19H20N2O2. In an article, author is Li, Dongying,once mentioned of 50-33-9.

K2CO3-Promoted Pyrazoles Synthesis from 1,3-Dipolar Cycloaddition ofN-Tosylhydrazones with Acetylene Gas

1,3-Dipolar cycloaddition ofN-tosylhydrazones with acetylene gas on balloon was investigated. Bases and solvents were screened and K(2)CO(3)was verified to be an efficient base to promote this process. DMSO gave the better result in the reaction ofN-tosylhydrazones derived from aldehyde, and NMP was a better suitable solvent in the reaction of ketoneN-tosylhydrazones. And a series of pyrazoles were provided in mediate to good yields. This process was easy to handle and suitable to the industrial application.

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Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 83-07-8, Name is 4-Aminoantipyrine, SMILES is O=C1N(C2=CC=CC=C2)N(C)C(C)=C1N, belongs to pyrazoles-derivatives compound. In a document, author is Ghoneim, Amira A., introduce the new discover, Application In Synthesis of 4-Aminoantipyrine.

Design and Synthesis of Heterocyclic Compounds from 1,4-Diacetylbenzene with Expected Antimicrobial Activity

IN this present work, synthesized a novel derivatives of his-chalcones via condensation of 1,4-diacetylbenzene with different aldehydes in basic media. The reaction of chalcone derivatives 3a,b with thioglycolic acid gave compounds -1a,b. That was reacted with ethyl cyanoacetate in presence of ammonium acetate to give the corresponding cyanopyridine derivatives Sa,b. Furthermore, bis-chalcone 3a,b was cyclization to pyrazole analogs by using 2,4-dinitrophenythydrazine to give compounds 7a,b in good yields. All products were characterized by IR spectrum, CNMR, and elemental analysis. The new compounds have been screened as anti -bacterial activity

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 83-07-8 is helpful to your research. Application In Synthesis of 4-Aminoantipyrine.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

In an article, author is Kumar, M. Rajesh, once mentioned the application of 67-51-6, Category: pyrazoles-derivatives, Name is 3,5-Dimethyl-1H-pyrazole, molecular formula is C5H8N2, molecular weight is 96.13, MDL number is MFCD00005243, category is pyrazoles-derivatives. Now introduce a scientific discovery about this category.

p-TSA center dot H2O mediated one-pot, multi-component synthesis of isatin derived imidazoles as dual-purpose drugs against inflammation and cancer

A novel one-pot multicomponent reaction was performed to synthesize different imidazole and benzotriazole (BTA) isatin-based medicinally important compounds using (p-TSA center dot H2O) as an economical and operative acid catalyst. The yield of the products was found to be up to a maximum of 92% when using this catalyst. Antioxidant, anti-breast cancer and anti-inflammatory activities of these 13 isatin-based derivatives (named as 5a-m) were assessed. The inhibitory effects of these compounds were tested in vitro against cyclooxygenase-2 (COX-2, an enzyme responsible for inflammation) and phosphoinositide-3 kinase (PI3K, a key enzyme in breast cancer). Among the 13 isatin-based Imidazole derivatives, five compounds (5a, 5d, 5f, 5 k and 5l) were found to exhibit anti-inflammatory as well as anti-cancer activity, which was validated using HRBC stabilization assay (to show anti-inflammatory activity) and cytotoxicity in MCF-7 (breast cancer cell line) to provide proof for anticancer property of the compounds. The molecular interactions between the two enzymes were probed using molecular docking. Structure-Activity Relationship (SAR) and ADMET prediction results were also useful to screen the most effective imidazole derivatives and to establish them as putative COX-2 inhibitors/anti-inflammatory drugs. These selected compounds which showed appreciable activity against COX-2 and PI3K are promising drug candidates for the treatment of breast cancer and inflammation which is often associated with breast cancer pathophysiology.

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Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Related Products of 83-07-8, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 83-07-8, Name is 4-Aminoantipyrine, SMILES is O=C1N(C2=CC=CC=C2)N(C)C(C)=C1N, belongs to pyrazoles-derivatives compound. In a article, author is Kommera, Rajkumar, introduce new discover of the category.

RuCl3 Catalyzed Reaction of Chromones with Bestmann-Ohira Reagent for the Construction of 2-Hydroxybenzoyl-1H-pyrazolylphosphonates and Dihydrochromeno[3,2-c]pyrazolylphosphonates

A novel and efficient method has been developed for the synthesis of 2-hydroxybenzoyl-1H-pyrazolylphosphonates and dihydrochromeno[3,2-c]pyrazolylphosphonates by the reaction of 3-formylchromones/3-halo-4H-chromenones with Bestmann-Ohira Reagent (BOR) in the presence of RuCl(3)catalyst. The reactions proceeded through decarbonylation, debromination, intramolecular cyclization andN-methylation to provide the new heterocyclic compounds in one-pot with the formation of C-C and C-N bonds. The structure assignment of compound3 fwas confirmed by X-ray analysis.

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Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics