Category: pyrazoles-derivatives

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 149739-65-1 as follows. Application In Synthesis of 3-(3-Bromophenyl)-1H-pyrazole

Into 300 ml round-bottomed flask, 7.00 g (31.4 mmol) compound 3, 3.30 g (34.5 mmol) sodium tert-butoxide , and 100 ml DMF were placed. Thereto, 2.15 ml (34.5 mmol) of iodomethane was added dropwise and the mixture was stirred for 24 hours at room temperature. Elimination of the raw materials and generation of a new compound were confirmed by thin layer chromatography (TLC). The reaction solution was concentrated and separated three times with toluene/water to recover the organic phase. The organic phase was dried over magnesium sulfate, concentrated, and purified by silica gel column chromatography (developing solvent:toluene: heptane: ethyl acetate = 10:10:1). The target substance was concentrated to obtain 5.21 g (22.0 mmol) of compound 4 (yield: 70.0%). Nine protons were assigned by 1H- NMR (CDCl3:7.95 (s, 1H) , 7.71 ppm (d, 1H) , 7.42-7.39 ppm (m, 2H), 7.26 ppm (t, 1H) , 6.53 ppm (d, 1H) , 3.96 ppm (s, 3H) ) . When analyzed with a gas chromatograph-mass spectrometer (GS-MS), a peak was observed at m/z = 236. The product was confirmed to be the target substance.

According to the analysis of related databases, 149739-65-1, the application of this compound in the production field has become more and more popular.

Related Products of 5334-40-7,Some common heterocyclic compound, 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, molecular formula is C4H3N3O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A 2OL reaction vessel equipped with a digital thermometer and stirrer was charged with 4-nitro-1H-pyrazole-3- carboxylic acid (1.117 Kg, 7.11 mol, 1 wt) and methanol (8.950 L, 8 vol). The reaction mixture was stirred under nitrogen, cooled to 0 to 5 C, thionyl chloride (0.581 L, 8.0 mol, 0.52 vol) added over 180 minutes and the resultant mixture allowed to warm to and stir at 18 to 22 C overnight, after which time 1H NMR analysis (dbeta- DMSO) indicated reaction completion. The reaction mixture was concentrated under reduced pressure at 40 to 45 C, the residue treated with toluene and re-concentrated (3x 2.250 L, 3x 2vol) under reduced pressure at 40 to 45 C to give 4-nitro-1H-pyrazole-3-carboxylic acid methyl ester as an off-white solid (1.210 Kg, 99.5%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Nitro-1H-pyrazole-3-carboxylic acid, its application will become more common.

Chemistry is an experimental science, Category: pyrazoles-derivatives, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 2075-46-9, Name is 4-Nitro-1H-pyrazole, molecular formula is C3H3N3O2, belongs to pyrazoles-derivatives compound. In a document, author is An, Yan.

Neuroprotective effect of novel celecoxib derivatives against spinal cord injury via attenuation of COX-2, oxidative stress, apoptosis and inflammation

A novel series of celecoxib derivatives were synthesized and evaluated for cyclooxygenase (COX-1/COX-2) in-hibitory activities for benefit in spinal cord injury (SCI). The title compounds were synthesized by conventional methods in good yields and subsequently tested for inhibitory activity against COX-1/COX-2. The most potent COX-2 inhibitor among the tested derivatives was further assayed for protective effect against experimental SCI of Sprague-Dawley rats. The designed compounds showed considerable inhibition of COX-2 as compared to COX -1 revealing compound 7m as most potent inhibitor of COX-2 isoenzyme (IC50 = 0.04 mu M). The expression of mitochondrial apoptotic genes (Bcl-2 and Bax) together with COX-2 and iNOS was restored near to normal as evidenced by western blot analysis in SCI rats. Taken altogether, compound 7m was identified as most potent inhibitor of COX-2. It also showed protective action against SCI via attenuation of COX-2, oxidative stress and apoptosis and inflammation in Male Sprague-Dawley rats.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 2075-46-9, in my other articles. Category: pyrazoles-derivatives.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Electric Literature of 2075-46-9, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 2075-46-9, Name is 4-Nitro-1H-pyrazole, SMILES is C1=N[NH]C=C1[N+]([O-])=O, belongs to pyrazoles-derivatives compound. In a article, author is Pogaku, Vinay, introduce new discover of the category.

Synthesis and biological evaluation of new benzo[d][1,2,3]triazol-1-yl-pyrazole-based dihydro-[1,2,4]triazolo[4,3-a]pyrimidines as potent antidiabetic, anticancer and antioxidant agents

A series of new benzo[d][1,2,3]triazol-1-yl-pyrazole-based dihydro-[1,2,4]triazolo[4,3-a]pyrimidine derivatives 4a-p were synthesized and well characterized by using IR, H-1,C-13 NMR and mass spectral data. Finally, the structure of the compound 4l was solved unambiguously by single-crystal X-ray diffraction (SXRD) which confirms all the structures 4a-p. The in vitro alpha-glucosidase inhibition, anticancer (A549 and MCF-7 cell lines) and antioxidant studies of the title compounds 4a-pwere screened. Among all the compounds, 4g, 4h and 4n exhibited significant alpha-glucosidase inhibition activity with the IC(50)values 20.12 +/- 0.19 mu M, 21.55 +/- 0.46 mu M and 24.92 +/- 0.98 mu M. Similarly, the compounds 4h, 4d and 4e showed potent anticancer activity against A549 (human lung carcinoma) cell line with IC(50)values 3.64 mu M, 4.73 mu M and 4.56 mu M, respectively, whereas the compounds 4c and 4 o displayed potent anticancer activity against human breast cancer (MCF-7) cell line with IC50 values of 2.66 mu M and 2.11 mu M. In addition, the antioxidant activity revealed that the compounds 4e and 4h exhibited potent antioxidant activity (IC50: 4.25 mu M and 5.40 mu M). To determine the safety profile of the most active compounds4c,4d,4e,4g,4h,4n and 4o were tested against non-cancer HEK293 cell line (human embryonic kidney 293), results in the lower toxicity of these compounds. [GRAPHICS] .

Electric Literature of 2075-46-9, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 2075-46-9.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Related Products of 50-33-9, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 50-33-9, Name is Phenylbutazone, SMILES is O=C(C1CCCC)N(C2=CC=CC=C2)N(C3=CC=CC=C3)C1=O, belongs to pyrazoles-derivatives compound. In a article, author is Moremi, Mamolatelo J., introduce new discover of the category.

The crystal structure of fac-tricarbonyl(4,4-dimethyl-2,2-dipyridyl-kappa N-2,N ‘-(pyrazole-kappa N)rhenium(I) nitrate, C18H16O3N4Re

C18H16O3N4Re, monoclinic, P2(1)/c (no. 14), a = 9.8409(6) angstrom, b = 14.0933(9) angstrom, c = 13.9153(9) angstrom, beta = 90.558(2)degrees, V = 1929.8(2) angstrom(3), Z = 4, R-gt(F) = 0.0266, wR(ref)(F-2) = 0.0584, T = 100(2) K.

Related Products of 50-33-9, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 50-33-9.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.37622-90-5, Name is Ethyl 4-pyrazolecarboxylate, SMILES is C1=N[NH]C=C1C(OCC)=O, belongs to pyrazoles-derivatives compound. In a document, author is Lopera, Alberto, introduce the new discover, Recommanded Product: Ethyl 4-pyrazolecarboxylate.

Hybrid GMP-polyamine hydrogels as new biocompatible materials for drug encapsulation

Here we present the preparation and characterization of new biocompatible materials for drug encapsulation. These new gels are based on positively charged [1+1] 1H-pyrazole-based azamacrocycles which minimise the electrostatic repulsions between the negatively charged GMP molecules. Rheological measurements confirm the electroneutral hydrogel structure as the most stable for all the GMP-polyamine systems. Nuclear magnetic resonance (NMR) was employed to investigate the kinetics of the hydrogel formation and cryo-scanning electron microscopy (cryo-SEM) was used to obtain information about the hydrogel morphology, which exhibited a non-homogeneous structure with a high degree of cross-linking. It is possible to introduce isoniazid, which is the most employed antibiotic for tuberculosis treatment, into the hydrogels without disrupting the hydrogel structure at appropriate concentrations for oral administration.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 37622-90-5 is helpful to your research. Recommanded Product: Ethyl 4-pyrazolecarboxylate.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 83-07-8, Name is 4-Aminoantipyrine, SMILES is O=C1N(C2=CC=CC=C2)N(C)C(C)=C1N, belongs to pyrazoles-derivatives compound. In a document, author is Dai Hong, introduce the new discover, Recommanded Product: 83-07-8.

Synthesis and Biological Activities of Novel Pyrazole Amide Compounds Containing Substituted Oxazole Unit

In search of new pyrazole amide derivatives with wonderful bioactivities, fifteen novel pyrazole amide compounds were designed and synthesized by introducing substituted oxazole unit into pyrazole amide skeleton based on the lead compound tebufenpyrad. The structures of the title compounds were confirmed by H-1 NMR, C-13 NMR and elemental analysis. The preliminary bioassay data exhibited that most of target compounds had more than 90% insecticidal activities against Oriental armyworm at the concentration of 500 mu g/mL. At the concentration of 500 mu g/mL, one compound displayed 100% mortality rate against Aphis medicaginis. In addition, two compounds showed 30% insecticidal activity against Tetranychus cinnabarinus at the concentration of 500 mu g/mL.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 83-07-8 is helpful to your research. Recommanded Product: 83-07-8.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 2075-46-9, Name is 4-Nitro-1H-pyrazole, SMILES is C1=N[NH]C=C1[N+]([O-])=O, in an article , author is Kang, Jin Mi, once mentioned of 2075-46-9, Recommanded Product: 2075-46-9.

Discovery of 1-(1H-indazol-4-yl)-3-((1-phenyl-1H-pyrazol-5-yl)methyl) ureas as potent and thermoneutral TRPV1 antagonists

A series of 1-indazol-3-(1-phenylpyrazol-5-yl)methyl ureas were investigated as hTRPV1 antagonists. The structure-activity relationship study was conducted systematically for both the indazole A-region and the 3-trifluoromethyl/t-butyl pyrazole C-region to optimize the antagonism toward the activation by capsaicin. Among them, the antagonists 26, 50 and 51 displayed highly potent antagonism with Ki(CAP) = 0.4-0.5 nM. Further, in vivo studies in mice indicated that these derivatives both antagonized capsaicin induced hypothermia, consistent with their in vitro activity, and themselves did not induce hyperthermia. In the formalin model, 51 showed antinociceptive activity in a dose-dependent manner.

Interested yet? Read on for other articles about 2075-46-9, you can contact me at any time and look forward to more communication. Recommanded Product: 2075-46-9.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.176969-34-9, Name is 3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid, SMILES is O=C(C1=CN(C)N=C1C(F)F)O, belongs to pyrazoles-derivatives compound. In a document, author is Ghorbanpour, Monireh, introduce the new discover, HPLC of Formula: C6H6F2N2O2.

Novel pyrazolate-bridged binuclear Ni(II), Cu(II) and Zn(II) complexes: Synthesis, X-ray crystal structure and nonlinear optical studies

In this paper, a pyrazole based ligand (1) containing nitrogen and sulfur donors was prepared and used in the synthesis of the following new binuclear Ni(II), Cu(II), and Zn(II) complexes [Ni-2(EtNCSPz(Me2))(2)(mu-Pz(Me2))(2)] (2), [Cu-2(EtNCSPz(Me2))(2)(mu-Pz(Me2))(2)] (3) and [Zn-2(EtNCSPz(Me2))(2)(mu-Rz(Me2))(2)] (4). The ligand and complexes were characterized by spectroscopic and physico-chemical methods. The crystal structure of [Ni-2(EtNCSPz(Me2))(2)(mu-Pz(Me2))(2)] was determined by X-ray diffraction analysis. Crystal structure of the (2) describes a binuclear complex, in which nickel ions are bonded by N3S donor atoms set in distorted square planar coordination geometry and the dimethyl pyrazolate groups are placed as the bridge among the metal centers. The nonlinear optical responses of the prepared ligand and metal complexes were investigated under irradiation of 35 mW continuous wave He-Ne (632.8 nm) laser. The z-scan technique was applied for measurement the second-order refractive index (n(2)) of the synthesized samples. Results show that copper complex (3), demonstrates the highest value of the measured n(2) ( – 10.18 x 10(-7) mmW(-1)).

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 176969-34-9 is helpful to your research. HPLC of Formula: C6H6F2N2O2.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 4233-33-4, Name is 4-Phenyl-3H-1,2,4-triazole-3,5(4H)-dione, SMILES is O=C1N=NC(=O)N1C1=CC=CC=C1, belongs to pyrazoles-derivatives compound. In a document, author is Elkanzi, Nadia A. A., introduce the new discover, Computed Properties of C8H5N3O2.

Synthesis, in vitro evaluation and molecular docking of new pyrazole derivatives bearing 1,5,10,10a-tetrahydrobenzo[g]quinoline-3-carbonitrile moiety as potent antibacterial agents

In the current study, a new series of pyrazole derivatives4a-d,5a-dand6a-dpossessing 1,5,10,10a-tetrahydrobenzo[g]quinoline-3-carbonitrile moiety were synthesized by treating chalcones (3a-d) with hydrazine monohydrate/acetic anhydride, hydrazine monohydrate/formic acid and 4-chlorophenylhydrazine in ethanol, respectively. These reactions proceeded smoothly with satisfactory yields, and the obtained compounds were characterized using FTIR,H-1-NMR,C-13-NMR and elemental analyses. All the synthesized compounds were subjected to antibacterial activity againstBacillus subtilis,Staphylococcus aureus,Escherichia coli, andPseudomonas aeruginosabacteria and molecular docking studies. The antibacterial studies showed that all compounds exhibited good to excellent antibacterial activity against the tested bacterial strains. The structure-activity relationship studies revealed that the compounds3b,4b,5band6bbearing a chlorine atom at the para position of the phenyl group attached to pyrazole moiety in displayed the highest antibacterial activity against all the tested bacteria exceeding the standard drug ampicillin. Moreover, the molecular docking results showed that the highest scores docking have been obtained from the most active antibacterial compounds3b,3d,4b,4d,4c,5band6bwith good energy binding score within the active site of topoisomerase II DNA gyrase enzymes (PDB ID: 2XCS), suggesting that they can act by the inhibition of DNA replication. These compounds are auspicious candidates as antibacterial agents that would deserve further investigations.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 4233-33-4 is helpful to your research. Computed Properties of C8H5N3O2.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics