Category: pyrazoles-derivatives

Related Products of 155377-19-8, These common heterocyclic compound, 155377-19-8, name is Ethyl 3-(trifluoromethyl)pyrazole-4-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 122: Preparation of l-difluoromethyl-3-trifluoromethyl-l//-pyrazole-4- carboxylic acid ethyl ester and 2-difluoromethyl-3-trifluoromethyl-2/:/-pyrazole-4- carboxylic acid ethyl esterSodium hydride (60% in mineral oil) (320 mg, 7.93 mmol) was washed with hexane (2x 10 ml) and suspended in tetrahydrofiiran (20 ml) in a three necked flask. 3- Trifluoromethyl-l//-pyrazole-4-carboxylic acid ethyl ester (1.5 g, 7.21 mmol) (prepared according to JP 2000/044541) in tetrahydrofiiran (10 ml) was added dropwise and the solution stirred at room temperature for 30 minutes. Chlorodifluoromethane was bubbled through the solution for 5 minutes and then the mixture was stirred at room temperature for 3 hours, with additional chlorodifluoromethane bubbled through the solution after every hour for 5 minutes. The reaction mixture was stored at room temperature for 16 hours. The reaction mixture was quenched by addition of water and extracted with ethyl acetate. The organic extract was washed with water and brine, dried over magnesium sulfate and concentrated. The residue was purified by column chromatography on silica gel (eluent: 0-25% ethyl acetate in hexane) to give l-difluoromethyl-3-trifluoromethyl- l//-pyrazole-4-carboxylic acid (isomer A) (870 mg, 47% yield) and 2-difluoromethyl-3- trifluoromethyl-2H-pyrazole-4-carboxylic a’cid (isomer B) (500 mg, 27% yield). Isomer A 1H-NMR (400 MHz, CDCl3): 1.37 (t, 3H, Me), 4.37 (q, 2H, CH2), 7.37 (t, IH, CH), S.07 (s, IH, CH) ppm. Isomer B 1H-NMR (400 MHz, CDCl3): 1.37 (t, 3H, Me), 4.37 (q, 2H, CH2), 7.22 (t, IH, CH), 8.43 (s, IH, CH) ppm.

Statistics shows that Ethyl 3-(trifluoromethyl)pyrazole-4-carboxylate is playing an increasingly important role. we look forward to future research findings about 155377-19-8.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 948570-75-0, name is 1-(2-Methoxyethyl)-4-nitro-1H-pyrazole, A new synthetic method of this compound is introduced below., Safety of 1-(2-Methoxyethyl)-4-nitro-1H-pyrazole

To a solution of l-(2-methoxyethyl)-4- nitro-pyrazole (3.0 g, 17.53 mmol) in MeOH (50 ml) was added 10 % Pd/C (300 mg) under N2. The suspension was degassed and purged with H2 several times. The mixture was stirred under a H2 atmosphere at 25 C for 3 h. The reaction mixture was filtered. The filtrate was concentrated under reduced pressure to give the title compound as a red oil (Y = 97 %). NMR (400 MHz, chloroform-rf) d ppm 7.16 (s, 1H), 7.09 (s, 1H), 4.16 (t, J= 5 Hz, 2H), 3.69 (t, J= 5 Hz, 2H), 3.32 (s, 3H), 2.93 – 2.83 (hr. s, 2H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 35277-02-2, name is 4-Fluoro-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 35277-02-2, name: 4-Fluoro-1H-pyrazole

Step 1: 5-(4-fluoro-1H-pyrazol-1-yl)pyrazine-2-carbonitrile To a solution of 5-chloropyrazine-2-carbonitrile (280 mg, 2.0 mmol) in DMF was added 4-fluoro-1H-pyrazole (170 mg, 2.0 mmol), and potassium acetate (395 mg, 4.0 mmol). The mixture was stirred at the 100 C. for 4 hours. The reaction mixture was cooled to 20 C., poured into brine (25 mL), and extracted with ethyl acetate. The organic layer was dried over sodium sulfate, concentrated and purified by column chromatography (hexane:ethyl acetate=5:1) to give 5-(4-fluoro-1H-pyrazol-1-yl)pyrazin-2-carbonitrile (310 mg, Yield 82%). The structure was confirmed by LC-MS.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Fluoro-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 118430-73-2, name is 3-(tert-Butyl)-1-methyl-1H-pyrazol-5-amine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C8H15N3

[140] To a 100 mL oven dried flask, was added 5-AMINO-3-TETT-BUTYL-1-METHYLPYRAZOLE (2.00 G, 13.1 MMOL), methyl 2-bromo-5-methoxybenzoate (2.67 g, 10.9 MMOL), cesium carbonate (4.96 g, 15.2 mmol), Pd2 (dba) 3 (337 mg, 0.33 MMOL), BINAP (338 mg, 0.54 MMOL), and toluene (35 mL). The reaction mixture was degassed, placed under an N2 atmosphere, and then stirred at 110C for 16 h. The reaction mixture was cooled to rt, and ethyl acetate (30 mL) was added. The mixture was filtered, the filter cake washed with EtOAc (10 mL), and the filtrate concentrated under reduced pressure. The residue was purified by silica gel flash chromatography (eluent : 10 to 30% EtOAc in hexane) to give the title compound as a light yellow oil (1.34 g, 38%).’H NMR (400 MHz, CDCIG) 8 1. 28 (s, 9H), 3.63 (s, 3H), 3.78 (s, 3H), 3.94 (s, 3H), 5.97 (s, 1H), 6.82 (d, 1H), 7.10 (dd, 1 H), 7.47 (d, 1 H).

The synthetic route of 118430-73-2 has been constantly updated, and we look forward to future research findings.

Electric Literature of 41680-34-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 41680-34-6, name is 3-Amino-1H-pyrazole-4-carboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 5-amino-i H-pyrazole-4-carboxylic acid (1 .00 g, 7.87 mmol) and ethyl 2-formyl-3- oxopropanoate (2.0 ml, 16 mmol) in acetic acid (6.0 ml) was heated for 1 h at 1100 in a microwave reactor (Biotage Initator). Upon cooling to room temperature, the precipitate wascollected by filtration, washed with water and dried under high vacuum at SOC to give the title compound (900 mg, 48% yield).[C-MS (Method 1): R = 0.68 mm; MS (ESIpos): m/z = 236.1 [M+i]iH-NMR (400 MHz, DMSO-d6): 6 [ppm] = 12.59 (5, iH), 9.72 (d, iH), 9.13 (d, iH), 8.76 (5, 1 H), 4.41 (q, 2H), 1.38 (t, 3H).

The synthetic route of 3-Amino-1H-pyrazole-4-carboxylic acid has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3528-45-8, name is 1-(4-Methoxybenzyl)-1H-pyrazol-5-amine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. name: 1-(4-Methoxybenzyl)-1H-pyrazol-5-amine

In a stirred solution of 1a (15.0 g, 74 mmol) and diethyl acetylmalonate (15.0 g, 74 mmol), in POCI3 (110 mL) at O0C, a stream of dry HCI gas is passed over the solution for a period of about 15 min. The reaction mixture is gradually warmed to RT, stirred for about 2 h and then heated to 60 0C for about 4 h. POCI3 is distilled under reduced pressure. The reaction mixture is quenched with ice and extracted with EtOAc (3 x 75 mL). The combined organic layers are washed with water, brine, dried over anhydrous Na2SO4 and concentrated under reduced pressure. The pure intermediate 1b (9.0 g, 31.5% yield) is isolated as a yellow oil by flash chromatography with Petroleum ethenEtOAc (85:15 v/v).

The synthetic route of 3528-45-8 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16034-46-1, name is 1-Methyl-1H-pyrazole-5-carboxylic acid, A new synthetic method of this compound is introduced below., Computed Properties of C5H6N2O2

A mixture of 2-methyl-4-(6-(trifluoromethyl)quinolin-2-yl)aniline (10 g, 33.08 mmol, 1.00 equiv), l-methyl-lH-pyrazole-5-carboxylic acid (4.4 g, 34.89 mmol, 1.05 equiv), DIPEA (8.5 g, 65.77 mmol, 2.00 equiv) and HATU (4.4 g, 11.57 mmol, 1.50 equiv) in DMF (200 mL) was stirred overnight at room temperature. The reaction was quenched by the addition of 600 mL of water, extracted three times with 200 mL of ethyl acetate and the combined organic layers washed with 50 mL of water. Volatiles were eliminated under reduced pressure. The crude product was purified by recrystallization with methanol to afford the desired final product as a yellow solid in 76% yield. (ES, m/z): [M+H]+ 411; -NMR (DMSO-de, 300MHz, ppm): 52.40(s,3H), 54.12(s,3H), 57.12-7.13(d,lH), 57.57-7.61(m,2H), 58.00-8.04(d,lH), 58.19-8.36(m, 4H), 58.54 (s, 1H), 58.66-8.69 (d, 1H), 510.00 (s,lH).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 876343-24-7,Some common heterocyclic compound, 876343-24-7, name is 1-Ethyl-1H-pyrazol-4-amine, molecular formula is C5H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[3]; 2-(6-Chlorobenzotriazol-l-yl)-l,l,3,3-tetramethyluronium tetrafluoroborate was used in place of 2-(7-azabenzotriazol-l-yl)-l,l,3,3-tetramethyluronium hexafluorophosphate(V) as the coupling agent. The product gave the following characterising data :- H NMR Spectrum: (DMSOd6) 1.32 (t, 3H), 3.6 (s, 2H), 3.77 (s, 3H), 4.02 (s, 3H), 4.07 (q, 2H), 6.51 (d, IH), 6.88 (m, IH), 7.03 (d, IH), 7.23 (s, IH), 7.36 (d, IH), 7.42 (s, IH), 7.88 (s, IH), 8.77 (d, IH), 9.43 (s, IH), 10.04 (s, IH); Mass Spectrum: M+H4 434.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Ethyl-1H-pyrazol-4-amine, its application will become more common.

Electric Literature of 1904-31-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1904-31-0, name is 1-Methyl-1H-pyrazol-3-amine, This compound has unique chemical properties. The synthetic route is as follows.

Under the protection of nitrogen,The compound 1-methyl-1H-pyrazol-3-amine (200 mg, 2.06 mmol) was suspended in THF (5 mL).Then, CuI (431 mg, 2.27 mmol) and CH2I2 (0.5 mL, 6.18 mmol) were added thereto.Next addNitrosoisoamyl ester(8.30 mL, 61.78 mmol).The mixture was heated to reflux for 5 hours and then cooled to room temperature.Then diluted with EtOAc (15 mL).The resulting mixture was washed with aq. aq.Filtered through a silica gel pad,The filtrate was washed with saturated brine (10 mL).The organic phase was dried over anhydrous sodium sulfate and then evaporated.The residue was chromatographed on silica gel (EtOAc /EtOAcThe title compound was obtained as a yellow liquid (233 mg, 54.4%).

The chemical industry reduces the impact on the environment during synthesis 1-Methyl-1H-pyrazol-3-amine. I believe this compound will play a more active role in future production and life.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 31037-02-2, name is Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate, A new synthetic method of this compound is introduced below., SDS of cas: 31037-02-2

Step 3.1 : 5-Amino-1 -methyl- 1 H-pyrazole-4-carboxylic acid5-Amino-1-methyl-1 H-pyrazole-4-carboxylic acid ethyl ester (16.4 g, 97 mmol) is heated to reflux in 97 ml of 2 M sodium hydroxide solution and 100 ml of ethanol. After complete saponification, the mixture is acidified to pH 5 with 6 M HCI solution, and the formed precipitate is isolated by filtration. The product is dried at the high vacuum pump and the title compound is isolated as a white solid. HPLC: tR = 4.65 min; MS-ES+: (M+H)+ = 142 ; TLC*: Rf = 0.24.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.