Category: pyrazoles-derivatives

Turanov, A. N. published the artcileSynergistic Solvent Extraction of Lanthanides(III) with Mixtures of 4-benzoyl-3-methyl-1-phenylpyrazol-5-one and Some Novel Carbamoyl- and Phosphorylmethoxymethylphosphine Oxides, Application In Synthesis of 4551-69-3, the publication is Solvent Extraction and Ion Exchange (2014), 32(5), 492-507, database is CAplus.

The solvent extraction of La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, and Y from weak acidic hydrochloric acid solutions into an organic phase containing 4-benzoyl-3-methyl-1-phenylpyrazol-5-one (HP) and neutral tridentate organophosphorus ligands R₂P(O)CH₂OCH₂C(O)NBu₂ R = Bu (I), R = Ph (II) and R₂P(O)CH₂OCH₂P(O)R¹₂ R = R¹ = Bu (III); R = Bu, R¹ = Ph (IV); R = R¹ = Ph(V) has been studied. A considerable synergistic effect was observed in the presence of HP in the organic phase containing tetraoctyldiglycolamide (TODGA) and neutral organophosphorus ligands . A successive replacement of C(O)NAlk₂ groups in the diglycolamide extractant mol. by P(O)Ph₂ groups leads to an increase in the extraction efficiency of Ln(III) ions when toluene was used as diluent. Phosphoryl-containing podand possess a higher extraction efficiency towards Ln(III) ions than TODGA. The extraction equilibrium was investigated and the equilibrium constants were calculated It was found that the lanthanide(III) ions are extracted as LnLP₃ and LnL₂P₃ complexes with mixtures of HP and I in toluene from weak acidic solutions

Solvent Extraction and Ion Exchange published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C3H5BN2O2, Application In Synthesis of 4551-69-3.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Turanov, A. N. published the artcileExtraction of Rare Earth Elements(III) with Mixtures of Some New Tridentate Carbamoylmethylphosphine Oxides and 4-Benzoyl-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one from Hydrochloric Acid Solutions, Computed Properties of 4551-69-3, the publication is Russian Journal of General Chemistry (2021), 91(3), 383-388, database is CAplus.

Extraction of rare earths(III) from hydrochloric acid solutions with mixtures of new tridentate carbamoylmethylphosphine oxides Ph₂P(O)CH₂CON(R)CH₂CH₂P(O)Ph₂ (R = Me, Bu, Oct) and 4-benzoyl-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one in organic solvents has been studied. The observed strong synergistic effect has been attributed to the formation of hydrophobic mixed-ligand rare earth complexes in the organic phase. Stoichiometry of the extractable complexes has been determined, and extraction constants have been calculated The effect of organic solvent and composition of the aqueous phase on the extraction efficiency has been analyzed.

Russian Journal of General Chemistry published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C19H15NO3, Computed Properties of 4551-69-3.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Turanov, A. N. published the artcileExtraction of Rare-Earth Elements(III) with Mixtures of 1-Phenyl-3-methyl-4-benzoyl-5-pyrazolone and Phosphoryl-Containing Podands, Formula: C17H14N2O2, the publication is Russian Journal of General Chemistry (2019), 89(9), 1830-1835, database is CAplus.

Extraction of rare-earth elements(III) ions from chloride solutions with mixtures of 1-phenyl-3-methyl-4-benzoyl-5-pyrazolone and phosphoryl-containing podands in organic solvents has been studied. The observed significant synergistic effect is associated with the formation of hydrophobic mixed-ligand complexes of rare-earth elements(III). The stoichiometry of the extracted complexes has been determined, and the extraction constants have been calculated The influence of the phosphoryl-containing podand structure, the organic solvent nature, and the aqueous phase composition on the efficiency of the extraction of rare-earth element(III) ions into the organic phase has been considered.

Russian Journal of General Chemistry published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C11H14O2, Formula: C17H14N2O2.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Turanov, A. N. published the artcileExtraction of Rare Earth Elements(III) with Mixtures of 1-Phenyl-3-methyl-4-benzoyl-5-pyrazolone and 2-Phosphorylphenoxyacetamides, Computed Properties of 4551-69-3, the publication is Russian Journal of Inorganic Chemistry (2019), 64(3), 407-413, database is CAplus.

Extraction of rare earth element(III) (REE) ions from chloride solutions with mixtures of 1-phenyl-3-methyl-4-benzoyl-5-pyrazolone and 2-phosphorylphenoxyacetamides in organic solvents has been studied. Observed considerable synergic effect is related to the formation of hydrophobic mixed-ligand REE(III) complexes. The stoichiometry of extracted complexes has been determined and extraction constants have been calculated Effect of aqueous phase composition, organic solvent nature, and 2-phosphorylphenoxyacetamide structure on the efficiency of REE(III) ions recovery into organic phase has been considered.

Russian Journal of Inorganic Chemistry published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C11H14O2, Computed Properties of 4551-69-3.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Margrey, Kaila A. published the artcilePredictive Model for Site-Selective Aryl and Heteroaryl C-H Functionalization via Organic Photoredox Catalysis, Quality Control of 930-36-9, the publication is Journal of the American Chemical Society (2017), 139(32), 11288-11299, database is CAplus and MEDLINE.

Direct C-H functionalization of aromatic compounds is a useful synthetic strategy that has garnered much attention because of its application to pharmaceuticals, agrochems., and late-stage functionalization reactions on complex mols. On the basis of previous methods disclosed by our lab, we sought to develop a predictive model for site selectivity and extend this aryl functionalization chem. to a selected set of heteroaromatic systems commonly used in the pharmaceutical industry. Using electron d. calculations, we were able to predict the site selectivity of direct C-H functionalization in a number of heterocycles and identify general trends observed across heterocycle classes.

Journal of the American Chemical Society published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C4H6N2, Quality Control of 930-36-9.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Cui, J. Jean published the artcileDiscovery of a Novel Class of Exquisitely Selective Mesenchymal-Epithelial Transition Factor (c-MET) Protein Kinase Inhibitors and Identification of the Clinical Candidate 2-(4-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol (PF-04217903) for the Treatment of Cancer, HPLC of Formula: 763120-58-7, the publication is Journal of Medicinal Chemistry (2012), 55(18), 8091-8109, database is CAplus and MEDLINE.

The c-MET receptor tyrosine kinase is an attractive oncol. target because of its critical role in human oncogenesis and tumor progression. An oxindole hydrazide hit 6 (VI) was identified during a c-MET HTS campaign and subsequently demonstrated to have an unusual degree of selectivity against a broad array of other kinases. The cocrystal structure of the related oxindole hydrazide c-MET inhibitor 10 (X) with a nonphosphorylated c-MET kinase domain revealed a unique binding mode associated with the exquisite selectivity profile. The chem. labile oxindole hydrazide scaffold was replaced with a chem. and metabolically stable triazolopyrazine scaffold using structure based drug design. Medicinal chem. lead optimization produced 2-(4-(1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol (2, II, PF-04217903), an extremely potent and exquisitely selective c-MET inhibitor. 2 Demonstrated effective tumor growth inhibition in c-MET dependent tumor models with good oral PK properties and an acceptable safety profile in preclin. studies. 2 Progressed to clin. evaluation in a Phase I oncol. setting.

Journal of Medicinal Chemistry published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C3H5BN2O2, HPLC of Formula: 763120-58-7.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Patel, N. C. published the artcileSynthesis and application of some bisazo disperse dyes based on 4-hydroxyquinolinoquinazoline system on polyester fabric, Name: 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, the publication is Journal of Indian Council of Chemists (2001), 18(2), 83-86, database is CAplus.

Ten 3-(4′-R-azo-1′-phenylazo)-4-hydroxyquinolino-[1,2-b]-4-oxoquinazolines were prepared by coupling diazotized 3-(4′-amino-1′-phenylazo)-4-hydroxyquinolino-[1,2-b]-4-oxoquinazoline with various coupling components. 4-Hydroxyquinolino-[1,2-b]-4-oxoquinazoline (I) was prepared by the condensation of 2-methyl-1,3-benzoxazin-8-one with anthranilic acid, giving initially 2-methyl-3-(1-carboxyphenyl)-4-oxoquinazoline followed by the ring closure. I was coupled with diazotized p-aminoacetanilide followed by hydrolysis to give 3-[4′-amino-1′-phenylazo]-4-hydroxyqinolino[1,2-b]-4-oxoquinazoline. The bisazo disperse dyes were characterized by elemental and spectral analyses and their dyeing performance on polyester fabric was assessed. These compounds when applied on polyester fabric, gave shades with poor to good light fastness, very good to excellent wash fastness and poor to excellent exhaustion.

Journal of Indian Council of Chemists published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C10H9ClN2O, Name: 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Patel, N. C. published the artcileSynthesis of bisazo disperse dyes based on 4-hydroxyl-1-phenylquinolin-2(1H)-one system and their dyeing performance on polyester fabric, Application In Synthesis of 14580-22-4, the publication is Journal of Indian Council of Chemists (2001), 18(1), 59-62, database is CAplus.

Ten 3-[4-(arylazo)phenylazo]-4-hydroxy-1-phenyl-2(1H)-quinolinone dyes were prepared by coupling diazotized 3-(4-aminophenylazo)-4-hydroxy-1-phenyl-2(1H)-quinolinone with various coupling components. 4-Hydroxy-1-phenyl-2(1H)-quinolinone (I) was prepared by the condensation of o-chlorobenzoic acid and aniline giving N-phenylanthranilic acid followed by acetylation giving N-acetyl-N-phenylanthranilic acid and ring closure. I was coupled with diazotized 4-aminoacetanilide giving a monoazo compound which on hydrolysis gave the diazo component for disazo dye preparation The dyes were characterized by elemental and spectral analyses and their dyeing performance on polyester fabric was assessed. The dyes when applied on polyester fabric gave shades with poor to good light fastness, very good to excellent wash fastness, and poor to excellent exhaustion.

Journal of Indian Council of Chemists published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C10H9ClN2O, Application In Synthesis of 14580-22-4.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Wang, Guofang published the artcileDenitrogenative Pd/Cu-catalyzed Suzuki-type Cross-coupling of Aryltrifluoroborates with Arylhydrazine Hydrochlorides in Water under Room Temperature, Related Products of pyrazoles-derivatives, the publication is Applied Organometallic Chemistry (2018), 32(3), n/a, database is CAplus.

In the presence of Pd(NH₃)₂Cl₂ and CuCl₂ using K₂CO₃, potassium aryltrifluoroborates (and a styryltrifluoroborate) underwent green and aerobic denitrogenative coupling reactions with arylhydrazine monohydrochlorides in water to yield biaryls and trans-stilbene in 62-95% yields.

Applied Organometallic Chemistry published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C10H18O, Related Products of pyrazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Parekh, Nikhil M. published the artcileColorimetric studies of heterocyclic monoazo dyes on various fibres, Recommanded Product: 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, the publication is Indian Journal of Fibre & Textile Research (2012), 37(4), 372-377, database is CAplus.

A series of heterocyclic monoazo quinazolinone based heterocyclic monoazo dyes derived by the diazotization of 3-(4-aminophenyl)-2-phenylquinazolin-4(3H)-one with various Ph pyrazolones based coupling components has been studied. These dyes give mostly yellow shades. All the heterocyclic monoazo dyes have been characterized by their % yield, UV-VIS spectroscopy, IR spectroscopy, ¹H NMR spectroscopy, and dyeing performance on silk, wool, nylon, and polyester fibers. The percentage dye bath exhaustion on different fibers is found to be reasonably good and acceptable. The dyed fibers show moderate to very good light fastness and good to excellent washing and rub fastness properties. Spectral properties and colorimetric data (L*, a*, b*, C*, H*, K/S) have also been investigated.

Indian Journal of Fibre & Textile Research published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C10H9ClN2O, Recommanded Product: 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics